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Sporulation of Saccharomyces cerevisiae in the absence of mitochondrial translation is arrested before completion of meiosis I. Ultrastructural analysis of the nuclear and cytosolic variations
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Preliminary analysis of morphology and ultrastructure of the dymorphic yeast Endomycopsis capsularis by fluorescence and electron microscopy
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Risk and pre-morbid factors versus the neurological outcome of HIV infection: findings in the years 1986-1987 and more recently
No full textRelationship between cell growth and mitochondrial function in Candida: antimicotic effects of some antibiotics and central nervous system drugs.
No full textRelationship between growth inhibition and mitochondrial function in petite-negative yeasts. I. Effects of antibiotics and dyes upon pathogenic and non-pathogenic Candida species.
No full textAntibiotics and dyes which preclude growth of Saccharomyces cerevisiae in media containing oxidizable carbon sources arrested the growth of Candida albicans, Candida tropicalis and Candida utilis even in glucose medium. The growth in the presence of sub-inhibitory concentrations of the various antibiotics and dyes determined a reduction in the cell survival but with no accumulation of respiratory deficient mutants. Under these culture conditions, the total respiration declined leaving a residual antimycin A-resistant--hydroxamate-sensitive O2 uptake, and the amount of the respiratory cytochromes aa3 and b synthesized was reduced. SDS gel electrophoresis of soluble proteins prepared from the antibiotic-treated cells showed some bands in the MW range 92-100 K, which became faint after the cells were grown in the presence of some mitochondrial inhibitors. The ultrastructural analysis of these cells evidenced disappearance of the mitochondrial cristae and their replacement by unfolded membranes. The data obtained suggest that the petite negative trait of Candida could depend on the non-viability or on the very low viability of those cells which have lost their mitochondrial function
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