1,720,958 research outputs found
A NEW APPROACH TO TREATMENT OF MALE-INFERTILITY - SUPPLEMENTATION WITH LACTOGENIC HORMONES
No full textA NEW APPROACH TO TREATMENT OF MALE-INFERTILITY - SUPPLEMENTATION WITH LACTOGENIC HORMONE
HUMAN PLACENTAL BETA-ENDORPHIN (HP-BETA-EP)
No full textThe previous finding that the placenta is capable of synthesising an
ACTH-like peptide, human chorionic corticotrophin (hCC)(l) and the observate
that both ACTH andP. EP are part of the same glycoprotein of 31K daltons in t~
p i tui tary (2) led us to investigate the presence of" EP in placental e x t r ac cs
Freshly collected, sliced ~nd cold saline Ivashed placenta was extractei
with acid acetone (l) to obtain a placental powder (PP)(5.8mg PP/g placenta'
protein content 460ug/mg) which was then tested EorfiEP in a radioreceptor
assay (RRA). For this assay 3H-D-ala-enkephalin was used a s t r a c e r and)lEP i.
Tris-HCl 50mM pH 7.4+Bacitracin 50ug/ml as standard. Membranes were obtaip.=~
by homogenisation of rat forebrains in 25 volumes of Tris-HCl (Polytron set =
for 15sec) a nd c e n t-r i f ug a t i o n at 15,000rpm x 15min (JA 20 ro t o r ) . The memb:--
anes were diluted with 5ml MnC12 60mM (frozen), 125ul Bacitracln stock solu:-
ion and 24.875ml 50Mrn Tris-HCl pH 7.4 buffer. Fo r the assay, 500).11. membrane
suspension, 100ul tracer, 100).1m standard or unknown sample and buffer up to ::.
mi were used. After 2hr incubation and shaking at 26°C, filtration was per:-
ormed on Millipore with cold buffer washing solution. PP prepared as above
gave a dilution curve p a r a l I e I to that oEPEP and a potency o f 5.15ngpEP/mb
PP protein. These re~ult$ re~ain qp~n çq criticis~ due to the lack of spec-
ificity of the RRA
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Evaluation of an ELISA kit for epidemiological detection of antibodies to Plasmodium falciparum sporozoites in human sera and bloodspots eluates
No full textAntibodies to Plasmodium falciparum sporozoites represent a serological transmission indicator, which can be applied in epidemiological studies to estimate the intensity of malaria transmission. An ELISA method has been developed as an industrial kit to detect these antibodies, using a chemically synthesized (NANP)40 peptide as antigen. The results obtained with this kit are compared in the present paper with those obtained by an ELISA test already applied in epidemiological studies. In testing sera from individuals living in endemic areas, a high diagnostic concordance (92.1%) was obtained between the two assays. The absorbances of these sera correlated well, as shown by a correlation coefficient r = 0.877. Sera from individuals never exposed to malaria gave very low absorbances with the kit. This minimum non-specific binding increases the probability of comparable results in different studies. When the two ELISAs were evaluated for analytical sensitivity and precision, similar satisfactory results were achieved. The test can be performed not only with sera but also with eluates from filterpaper bloodspots. Modifications of the kit to reduce its cost and suggestions regarding distribution and funding are also propose
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