1,721,195 research outputs found
Synthesis of polypeptide models of collagen Poly(Pro-Ile-Gly), poly(Ile-Pro-Gly), poly(Pro-Nle-Gly) and poly(Nle-Pro-Gly)
No full textIt is well known that the amino acid sequence of collagen contains a large number of tripeptide units such as Y-X-Gly, where Y and X can be any amino acid residue but most frequently are proline or hydroxyproline. Accordingly, several sequential polytripeptides, including repeating sequences of that type containing one or two imino acid residues, have been synthesized and studied in solution and/or in the solid state (1–14).
In this paper we describe in detail the syntheses via active esters of four polytripeptides of the type poly(Pro-X-Gly) and poly(X-Pro-Gly), where X is isoleucine or norleucine. The general objective was to study the influence of hydrophobic residues on the stability of collagen three-dimensional structure; in particular we were interested in the introduction of branching at Cβ in view of the recent calculations of Némethy & Scheraga (15). The Nle residue was introduced in order to obtain reference polymers without any branching in the side chain. By way of comparison, we have shown earlier that polymeric sequences where X is leucine (branching at the Cγ) possess collagen-like structures in an appropriate milieu (10, 11). The results of both theoretical and experimental conformational studies on the polymers will be published in a forthcoming paper.
Syntheses via p-nitrophenyl esters are described for poly(Pro-Ile-Gly), poly(Ile-Pro-Gly), poly(Pro-Nle-Gly) and poly(Nle-Pro-Gly), four synthetic polytripeptide analogues of the non-polar regions of collagens. The obtained polymers exhibit molecular weights in the range 5000–10000 as judged from viscosity measurements
Conformazioni “ folded” in peptidi e proteine
No full textConformazioni “ folded” in peptidi e protein
Polypeptides synthetiques en relation au collagene et à l’elastine
No full textPolypeptides synthetiques en relation au collagene et à l’elastin
Classical and fractal description of elastin structure
No full textProceedings of an international workshop held in Siena, Italy, 8-12 November 199
Structural studies of CMV-D and CMV-S: Two strains of cucumber mosaic cucumovirus with a different biological behaviour
No full textSynthesis, characterization and interaction with DNA of dichlorobiscyclo-(glycil-L-methionyl)platinum(II).
No full textCorrection to: Socially Assistive Robot for Providing Recommendations: Comparing a Humanoid Robot with a Mobile Application (International Journal of Social Robotics, (2018), 10, 2, (265-278), 10.1007/s12369-018-0469-4)
No full textIn the original publication, authors Silvia Rossi and Anna Tamburro’s affiliations have been incorrectly reversed and should to be read correctly as “Department of Electrical Engineering and Information Technology”
Studi strutturali su CMV-D e CMV-S: due ceppi di un virus delle piante con diverso comportamento biologico
No full text- …
