111,909 research outputs found
Rilievi anatomo-istopatologici e caratterizzazione immunoistochimica del medulloblastoma del vitello
No full textGli AA. descrivono i risultati delle indagini anatomo-istopatologiche ed imminuoistochimiche in un caso di neoplasia encefalica con metastasi polmonari osservato in una vitella chianina di 2 mesi di età.
I dati microscopici sono apparsi indicativi per una diagnosi di medulloblastoma; l' applicazione delle tecniche immunoistochimiche ha permesso di accertare la presenza di neurofilamenti (200 Kd) ed assenza di citocheratine, vimentina e Proteina Acida Gliare Fibrillare (GFAP) caratterizzando la differenziazione istogenetica delle cellule neoplastiche verso la linea neuroblastica/neuronale
Lentivirosi ovina: confronto fra metodiche diagnostiche in pecore infettate sperimentalmente.
No full text
Espressione immunoistochimica di Vascular Endothelial Growth Factor (VEGF) ed analisi della microvessel density (MVD) nelle neoplasie mammarie del cane: correlazione con parametri istopatologici e prognostici
No full textEmangiosarcoma cutaneo nella pecora: Rilievi anatomoistopatologici, immunocitochimici ed ultrastrutturali
No full textParaneoplastic hypereosinophilia in a dog with intestinal T-cell lymphoma
No full textA 9-year-old, intact male Doberman Pinscher was examined because of anorexia and weakness. Results of a CBC showed severe, microcytic, hypochromic anemia with mild eosinophilia (2944 cells/mu L, reference interval 100-1250/mu L) and thrombocytosis. Hypoferremia, hypoferritinemia, and a positive fecal occult blood test supported a diagnosis of iron deficiency anemia secondary to chronic intestinal hemorrhage. Abdominal ultrasound evaluation showed a thickened small intestinal loop, of which representative specimens were obtained during exploratory laparotomy. Histologically, the intestinal wall was infiltrated by a neoplastic population of large, round, lymphoid cells with vesicular chromatin, 1 or more prominent nucleoli, and a high number of mitotic figures. The cells were closely admixed with mature eosinophils, but were negative for metachromatic granules with toluidine blue. Immunohistochemically, tumor cells were positive for CD3, and negative for CD21, Pan B, and CD79a. A diagnosis of intestinal T-cell lymphoma was made. Chemotherapy was begun, with 30 mg/m(2) of doxorubicin administered intravenously every 3 weeks. Eosinophil concentration was 880/mu L 2 weeks after surgery (on day 15 after presentation) but increased markedly to 62,914/mu L on day 30, 62,400/mu l on day 37, and 39,444/mu L on day 58 after presentation. An association between hypereosinophilia and T-cell lymphoma is well established in human patients, in whom production of IL-5 by neoplastic T cells has been demonstrated. Hypereosinophilia has been reported only rarely with intestinal lymphoma in cats and horses, and with T-cell lymphoma in dogs
Medulloblastoma in a calf. Anatomo-histopathological, immuno-histochemical and electron-microscopical findings.
No full textIl medulloblastoma è un tumore raro e maligno del vitello normalmente localizzato a livello cerebellare; sono riportati rari casi di metastasi.
Questo lavoro descrive un medulloblastoma nel cervello di una vitella di razza chianina di 2 mesi, affetta da sintomatologia neurologica sin dalla nascita.
E' stata ritrovata nell' emisfero destro connessa con il terzo ventricolo, una massa rotonda, simile ad un mandarino, di dimensioni di 4x3x2.5 cm.
Due metastasi extracraniche sono state osservate nel lobo craniale del polmone destro.
All' esame istologico il neoplasma mostrava una forte cellularità, scarsa componente stromale e poche strutture vasali.
Le cellule tumorali erano allungate con un nucleo denso, scuro ed ovoidale e scarso citoplasma.
Le indagini condotte attraverso l' immunoistochimica con l' uso di anticorpi mono- e poli-clonali unitamente alle osservazioni al microscopio elettronico, hanno contribuito a caratterizzare la natura dello sviluppo neoplastico nel cervello, così come nel polmone
author-bios-SRD-19-0063.R1 – Supplemental material for The Network Structure of Police Misconduct
No full textSupplemental material, author-bios-SRD-19-0063.R1 for The Network Structure of Police Misconduct by George Wood, Daria Roithmayr and Andrew V. Papachristos in Socius</p
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Feline Immunodeficiency virus (FIV)-associated nephropathy in domestic cats: An animal model of HIV-nephropathy
No full textFlY is a newly discovered lentivirus isolated from domestic cats with an
acquired immunodeficiency syndrome-like condition. Unspecified renal abnormalities were reported in some infected cats. In the present report morphological and clinical aspects of the nephropathy observed in cats
naturally infected with FlY are described in detail. Fifteen FIV-infected cats were examined: they included 11 males and four females ranging in age from 3.5 to 13 years. Proteinuria was present in 14 of 15 cats (>1
g/liter in 7 animals). BUN values were greater than normal in 11 cats (80
to 327 mg/dl vs. 20 to 65 mg/dl); eight of these had increased serum creatinine values (1.7 to 3.2 mg/dl vs. l.6 mg/dl). At necropsy, blocks of renal tissue were collected for histological, ultrastructural and IF
studies. Renal tissue damage was evident in 12 of 15 animals. It included glomerular lesions (consisting of a diffuse increase of mesangial
matrix and/or a focal and segmental sclerosis) as well as tubulointerstitial
lesions (consisting of focal tubular degenerative changes,
focal tubular ectasia, prominent interstitial inflammation of lymphocytes
and plasma cells and occasional interstitial fibrosis). Glomeruli
were positive for 1gM and C3, with coarsely granular deposits in mesangium and in a few peripheral capillary walls. Our findings
demonstrated that naturally Fl V-infected cats may have renal disorders that share considerable features with HIV-related nephropathy. Thus,
FIV-infected cats may also represent a useful animal model for this aspect of HIV-induced pathology
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