11 research outputs found
Theoretical studies on molecular structure and vibrational spectra of 8-hydroxyquinolinium picrate (vol 79, pg 1425, 2011)
No full textThe authors regret to inform that the oxygen atom in 8-hydroxyquinolinium was forgotten during the initial calculations and then these calculations were repeated according to the correct molecular structure. But in the above article incorrect Fig. 1, Fig. 3, Fig. 4 and Table 2, Table 4 were accidentally submitted to publication. This situation has been noticed. The correct forms of them are given as follows
Theoretical studies on molecular structure and vibrational spectra of 8-hydroxyquinolinium picrate
No full textQuantum chemical calculations of geometrical structure and vibrational wavenumbers of 8-hydroxyquinolinium picrate (8-HQP) were carried out by ab initio HF and density functional (DFT/B3LYP) method with 6-31++G(dp) basis set. The calculated geometric parameters of 8-HQP are presented. A detailed interpretation of the infrared spectra of 8-hydroxyquinolinium picrate (8-HQP) are also reported. Theoretical molecular frontier orbital energies of the title compound have been calculated using the method mentioned above in order to understand this phenomenon in the context of molecular orbital picture. The molecular HOMOs and LUMOs generated via HF and B3LYP method have been outlined. (C) 2011 Elsevier B.V. All rights reserved
Theoretical Magnetic Behavior of NbO-type Cu2 MOF
No full textThis study reports the temperature dependences of magnetic properties of NbO-type Cu-2 metal organic frameworks (MOF). Using the isotropic Heisenberg Hamiltonian and the coupling constant, which is taken in the literature, it is found that the Neel temperature of these complexes is too low. It is suggested that the Neel temperature may be increased by some geometrical distortion
Surgical results in pediatric Spetzler-Martin grades I-III intracranial arteriovenous malformations
No full textObjects: The goal of cerebral arteriovenous malformation (AVM) therapy in pediatric patients should be complete resection or obliteration of the AVM to eliminate subsequent hemorrhage, because of high mortality and morbidity rates related to hemorrhage in addition to the longer life expectation. Despite advances in Gamma knife radiosurgery and in endovascular embolization, surgical resection is still the gold standard for treating cerebral AVMs. Methods: Between 1986 and 2003, 20 children were surgically treated for cerebral AVMs. The AVMs were graded I, II, and III using the Spetzler - Martin ( S - M) Grading Scale. Good recovery was achieved in 18 out of 20 patients ( 90%) and only 1 patient was moderately disabled (5%). There was one mortality ( 5%) related to the preoperative deep comatose state of the patient. The total obliteration rate was 89% ( 17 out of 19). Conclusion: For S - M grade I - III AVMs, surgical resection is the treatment of choice, considering its high cure rate and low morbidity and mortality rates
Diffusion and perfusion MRI findings with clinical correlation in patients with subarachnoid haemorrhage related vasospasm
No full textBackground. Early radiological diagnosis of vasospasm as well as the detection of ischemic areas and the definition of cerebral perfusion changes may have an impact on the Current unfavorable results in patients with vasopasm. We investigated diffusion weighted (DW) and perfusion weighted (PW) magnetic resonance (MR) changes together with catheter angiography findings and tried to correlate radiological and clinical findings
Diffusion and perfusion MRI findings with clinical correlation in patients with subarachnoid haemorrhage related vasospasm
No full textThe Influence of Emotional Intelligence and Stress Management on Innovative Work Behavior and Employee's Performance
No full text Human resources are one of the important assets in an organization or company. They are one of the factors of production that play an important role in directing the company, maintaining and developing the company in the various demands of society. The COVID-19 virus has affected various sectors, and this has had a domino effect, such as an increase in the number of unemployed and a decrease in the quality of life of the community. So, to improve performance, several things need to be considered by an employee, namely emotional qualities. High emotional intelligence will help individuals deal with conflicts appropriately and create passionate working conditions, resulting in high work performance. The purpose of this study was to determine the effect of emotional intelligence and stress management on employee performance and innovative work behavior on employees at PT PLN (Persero) UPDK Kapuas. This research was done in the Pontianak area with a sample of 57 participants. In this research, the data analysis method used is the Structural Equation Model Partial Least Square (SEMPLS) method. To conduct analysis using the PLS method, this research is using SEM-PLS 3 software. The hypotheses of the research are H1: Emotional intelligence has a positive effect on employee performance. H2: Emotional intelligence has a positive effect on employees' innovative work behavior. H3: Stress management has a significant effect on employee performance. H4: Stress management has a positive effect on employees' innovative work behavior. H5: Innovative work behavior has a significant effect on employee performance. H6: Innovative work behavior mediates the relationship between stress management and employee performance H7: Innovative work behavior mediates the relationship between emotional intelligence and employee performance. The results of this study indicate that there is a significant influence of Emotional Intelligence and Stress Management on Innovative Work Behavior and Employee Performance among employees at PT PLN UPDK Kapuas Pontianak.BIBLIOGRAPHYAbdillah, W. (2009). Partial Least Square (PLS) Alternatif SEM Dalam Penelitian Bisnis. Penerbit Andi.Abdullah. (2015). Metodologi Penelitian Kuantitatif. Aswaja Pressindo.Agarwal, V. (2016). Investigating the convergent validity of organizational trust. February 2013. https://doi.org/10.1108/13632541311300133Amstrong, M., & Taylor, S. (2014). Armstrong’s Handbook of Human Resource Management Practice. Kogan Page Publisher.Arikunto, S. (2006). Prosedur Penilaian. Rineka Cipta.Barsade, S. G. (2002). The ripple effect: Emotional contagion and its influence on group behavior. Administrative Science Quarterly, 47(4), 644–675. https://doi.org/10.2307/3094912Beckman, T. (1997). A Methodology for Knowlege Management. IASTED.Boyatzis, R. E., & Goleman, D. (n.d.). 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The light responsive transcriptome of the zebrafish: function and regulation.
No full textMost organisms possess circadian clocks that are able to anticipate the day/night cycle and are reset or "entrained" by the ambient light. In the zebrafish, many organs and even cultured cell lines are directly light responsive, allowing for direct entrainment of the clock by light. Here, we have characterized light induced gene transcription in the zebrafish at several organizational levels. Larvae, heart organ cultures and cell cultures were exposed to 1- or 3-hour light pulses, and changes in gene expression were compared with controls kept in the dark. We identified 117 light regulated genes, with the majority being induced and some repressed by light. Cluster analysis groups the genes into five major classes that show regulation at all levels of organization or in different subset combinations. The regulated genes cover a variety of functions, and the analysis of gene ontology categories reveals an enrichment of genes involved in circadian rhythms, stress response and DNA repair, consistent with the exposure to visible wavelengths of light priming cells for UV-induced damage repair. Promoter analysis of the induced genes shows an enrichment of various short sequence motifs, including E- and D-box enhancers that have previously been implicated in light regulation of the zebrafish period2 gene. Heterologous reporter constructs with sequences matching these motifs reveal light regulation of D-box elements in both cells and larvae. Morpholino-mediated knock-down studies of two homologues of the D-box binding factor Tef indicate that these are differentially involved in the cell autonomous light induction in a gene-specific manner. These findings suggest that the mechanisms involved in period2 regulation might represent a more general pathway leading to light induced gene expression
Circadian rhythmicity and light sensitivity of the zebrafish brain
No full textLight is important for entraining circadian rhythms, which regulate a wide range of biological processes. Zebrafish have directly light responsive tissues (Whitmore et al 2000) and are thus a useful vertebrate model for circadian rhythmicity and light sensitivity. Recent studies show the pineal regulates locomotor rhythms (Li et al 2012). However, there are many unresolved questions concerning the neurobiological basis of the zebrafish clock, such as whether neuronal pacemakers, which drive rhythms in other tissues, are present throughout the brain. In this study, per3-luc zebrafish confirm that both central and peripheral tissues are directly light sensitive and have endogenous circadian rhythmicity. Chromogenic in situ hybridization reveals localised expression of several core zebrafish clock genes, a rhythmic gene, per3, and two light responsive genes, cry1a and per2. Adult brain nuclei with expression include the suprachiasmatic nucleus, periventricular grey zone of the optic tectum, and granular cells of the rhombencephalon. Pilot experiments using high-resolution spatial recording of per3-luc brain slices show some of these regions can display robust rhythmicity in DD. Some of the cells expressing clock genes are neurons, and therefore neurons were further investigated. C-fos, a marker for neuronal activity in mammalian photoreceptors, is upregulated in at least four different responses to light in zebrafish, in different brain nuclei. This suggests the brain contains several types of photosensitive cells, which respond to different lighting conditions. Zebrafish larvae exhibit developmental changes in spatial circadian gene expression of per3 and light induction of c-fos. Finally, the photopigment group of opsins were investigated for their potential role in light entrainment. Exorh was prominent solely in the pineal. Rgr1 was found in numerous nuclei, many of which had shown expression of cry1a, per2 and per3. Overall, this thesis shows that the zebrafish brain is not uniformly light sensitive. Localised regions in the zebrafish brain with strong rhythmicity and light sensitivity are neuronal pacemaker candidates
Transcriptional regulation in skeletal muscle of zebrafish in response to nutritional status, photoperiod and experimental selection for body size
No full textIn the present study, the ease of rearing, short generation time and molecular research tools available for the zebrafish model (Danio rerio, Hamilton) were exploited to investigate transcriptional regulation in relation to feeding, photoperiod and experimental selection.
Chapter 2 describes transcriptional regulation in fast skeletal muscle following fasting and a single satiating meal of bloodworms. Changes in transcript abundance were investigated in relation to the food content in the gut. Using qPCR, the transcription patterns of 16 genes comprising the insulin-like growth factor (IGF) system were characterized, and differential regulation between some of the paralogues was recorded. For example, feeding was associated with upregulation of igf1a and igf2b at 3 and 6h after the single-meal was offered, respectively, whereas igf1b was not detected in skeletal muscle. On the other hand, fasting triggered the upregulation of the igf1 receptors and igfbp1a/b, the only binding proteins whose transcription was responsive to a single-satiating meal. In addition to the investigation of the IGF-axis, an agnostic approach was used to discover other genes involved in transcriptional response to nutritional status, by employing a whole-genome microarray containing 44K probes. This resulted in the discovery of 147 genes in skeletal muscle that were differentially expressed between fasting and satiation. Ubiquitin-ligases involved in proteasome-mediated protein degradation, and antiproliferative and pro-apoptotic genes were among the genes upregulated during fasting, whereas satiation resulted in an upregulation of genes involved in protein synthesis and folding, and a gene highly correlated with growth in mice and fish, the enzyme ornithine decarboxylase 1.
Zebrafish exhibit circadian rhythms of breeding, locomotor activity and feeding that are controlled by molecular clock mechanisms in central and peripheral organs. In chapter 3 the transcription of 17 known clock genes was investigated in skeletal muscle in relation to the photoperiod and food content in the gut. The hypothesis that myogenic regulatory factors and components of the IGF-pathway were clock-controlled was also tested. Positive (clock1 and bmal1 paralogues) and negative oscillators (cry1a and per genes) showed a strong circadian pattern in skeletal muscle in anti-phase with each other. MyoD was not clock-controlled in zebrafish in contrast to findings in mice, whereas myf6 showed a circadian pattern of expression in phase with clock and bmal. Similarly, the expression of two IGF binding proteins (igfbp3 and 5b) was circadian and in phase with the positive oscillators clock and bmal. It was also found that some paralogues responded differently to photoperiod. For example, clock1a was 3-fold more responsive than clock1b. Cry1b did not show a circadian pattern of expression. These patterns of expression provide evidence that the molecular clock mechanisms in skeletal muscle are synchronized with the molecular clock in central pacemaker organs such as eyes and the pineal gland.
Using the short generation time of zebrafish the effects of selective breeding for body size at age were investigated and are described in chapter 4. Three rounds of artificial selection for small (S-lineage) and large body size (L-lineage) resulted in zebrafish populations whose average standard length were, respectively, 2% lower and 10% higher than an unselected control lineage (U-lineage). Fish from the L-lineage showed an increased egg production and bigger egg size with more yolk, possibly contributing to the larger body size observed in the early larval stage (6dpf) of fish from this lineage. Fish from S- and L-lineage exposed to fasting and refeeding showed very similar feed intake, providing evidence that experimental selection did not cause significant changes in appetite control. Investigation of the expression of the IGF-axis and nutritionally-response in skeletal muscle after fasting and refeeding revealed that the pattern of expression was not different between the selected lineages, but that a differential responsiveness was observed in a limited number of genes, providing evidence that experimental selection might have changed the way fish allocate the energy acquired through feeding. For example, a constitutive higher expression of igf1a was recorded in skeletal muscle of fish from the L-lineage whereas igfbp1a/b transcripts were higher in muscle of fish from the S-lineage. These findings demonstrate the rapid changes in growth and transcriptional response in skeletal muscle of zebrafish after only three rounds of selection. Furthermore, it provides evidences that differences in growth during embryonic and larval stages might be related to higher levels of energy deposited during oogenesis, whereas differences in adult fish were better explained by changes in energy allocation instead of energy acquisition.
In chapter 5 the main findings made during this study and their impact on the literature are discussed.European Community's Seventh Framework Programme (FP7/2007-2013) under grant agreement n° 222719 – LIFECYCLEFunded by the Seventh Framework Programme (European Commission); Programme Alβan, the European Union Programme of High Level Scholarships for Latin America (scholarship n° E07D402823BR); the Capes Foundation, Ministry of Education of Brazil (scholarship nº BEX 0449-10-5); and the Sir Harold Mitchell Fun
