6,208 research outputs found
The influence of T cell cross-reactivity on HCV-peptide specific human T cell response
No full textDetection of hepatitis C virus (HCV)-specific T cell response after exposure to hepatitis C in anti-HCV-positive or anti-HCV-negative patients has been associated with an ability to successfully control the infection. However, cross-reactivity between common human pathogens and HCV sequences has been demonstrated. The aim of this study was to investigate the impact of T cell cross-reactivity on HCV-specific T cell responses and their detection in HCV infected and non-infected subjects. The magnitude, function, and cross-reactivity of HCV peptide reactive T cells were studied in non-HCV-infected newborns and adults using a broad array of HCV peptides (601 peptides) spanning the entire HCV sequence. Comparisons were made with responses present in recovered and in chronically HCV-infected patients. HCV peptide reactive T cells are detectable in adults irrespective of previous HCV exposure and cross-reactivity between HCV peptides, and sequences of common pathogens, such as human herpes virus 1, can be demonstrated. Furthermore, the comprehensive magnitude of HCV-peptide reactive T cells present in chronically HCV-infected patients is similar and in some cases even lower than that of HCV-peptide reactive T cell response found in HCV-negative adults. In conclusion, the presence of oligo-specific HCV-peptide reactive T cells in humans does not always reflect a demonstration of previous HCV contact, whereas cross-reactivity with other common pathogens can potentially influence the HCV-specific T cell profile. The conspicuous deficit of HCV-peptide-specific T cells found in chronically HCV-infected patients confirms the profound collapse of virus-specific T cell response caused by HCV persistence. Copyright © 2006 by the American Association for the Study of Liver Diseases
Antecedentes literarios en la ‘niña mala’ de Mario Vargas Llosa
No full textThis article analyzes the literary antecedents and personality of La niña mala (2006) main character. In our opinion, the author takes three heroines of French Literature as a model for his character: Marguerite Gautier – a character who gives life to The Lady of the Camellias (1848) by Alexandre Dumas (son) – and Emma Bovary and Marie Arnoux – respectively protagonists of Madame Bovary (1857) and L’éducation sentimental (1869) by Gustave Flaubert. We will analyze the personality of the heroines and through examples we will highlight similarities with the character created by Mario Vargas Llosa
Evaluation of earthquake resistance of masonry building Mala vas
No full textThe evaluation of the seismic resistance of a masonry building, which is located in the village Mala vas, Posočje, is presented. In the first part, the occurrence of earthquakes, the seismic action on buildings and the impact of earthquakes on masonry buildings are briefly described. In the following part, we present theoretical background for calculation of resistance of masonry walls taking into account different types of failure. The second part of the thesis addresses the seismic performance assessment of masonry building. Seismic forces were determined with the lateral force method and distributed on certain walls. The\ud
material characteristics were assessed based on the literature and the Eurocodes. We first made the evaluation of seismic resistance for each wall at the ground floor taking into account both rectangular directions of the building. Based on the results it can be concluded that the seismic resistance of the residential house Mala vas is not sufficient in terms of requirements of Eurocode
Optimal scaling and diffusion limits for the Langevin algorithm in high dimensions
No full textThe Metropolis-adjusted Langevin (MALA) algorithm is a sampling algorithm which
makes local moves by incorporating information about the gradient of the target density. In this
paper we study the efficiency of MALA on a natural class of target measures supported on an infinite
dimensional Hilbert space. These natural measures have density with respect to a Gaussian random
field measure and arise in many applications such as Bayesian nonparametric statistics and the theory
of conditioned diffusions. We prove that, started at stationarity, a suitably interpolated and scaled
version of the Markov chain corresponding to MALA converges to an infinite dimensional diffusion
process. Our results imply that, in stationarity, the MALA algorithm applied to an N-dimensional
approximation of the target will take O(N1/3) steps to explore the invariant measure. As a by-product
of the diffusion limit it also follows that the MALA algorithm is optimized at an average acceptance
probability of 0.574. Until now such results were proved only for targets which are products of one
dimensional distributions, or for variants of this situation. Our result is the first derivation of scaling
limits for the MALA algorithm to target measures which are not of the product form. As a consequence the rescaled MALA algorithm converges weakly to an infinite dimensional Hilbert space valued
diffusion, and not to a scalar diffusion. The diffusion limit is proved by showing that a drift-martingale
decomposition of the Markov chain, suitably scaled, closely resembles an Euler-Maruyama discretization of the putative limit. An invariance principle is proved for the Martingale and a continuous
mapping argument is used to complete the proof
Estudio de nochebuena mala
No full textEste trabajo de investigación plantea un análisis de la obra Nochebuena mala, de Carlos Francisco Changmarín, la cual tiene como elemento generador de sus relatos: la destrucción, muerte y asesinato de seres ajenos a la cruel invasión. Estos relatos se enmarcan en un momento casi puntual, cuyo tiempo de referencia es: las doce y media de la noche del veinte de diciembre de mil novecientos ochenta y nueve. Nochebuena mala consta de 43 relatos de los cuales he seleccionado 12 de ellos y que nos sirven de apoyo para sustentar que existen elementos unificadores que logran la totalización de la obra. Aunque cada relato tiene independencia con personajes y puntos de vistas diferentes, hay elementos dentro de ellos que sirven para insertarlos en el desarrollo totalizador de la obra. Se proyecta y se sitúa durante la invasión, pues en ellos se reflejan los problemas sociales, económicos y morales comunes en todas las capas sociales del país (Panamá), ya que los grados de corrupción e ideas se proyectan en todos los niveles sociales. Nochebuena mala es una recopilación de todas las consecuencias que se dan producto de la invasión del 20 de diciembre de 1989 en la hora indicada
Estudio de nochebuena mala
No full textEste trabajo de investigación plantea un análisis de la obra Nochebuena mala, de Carlos Francisco Changmarín, la cual tiene como elemento generador de sus relatos: la destrucción, muerte y asesinato de seres ajenos a la cruel invasión. Estos relatos se enmarcan en un momento casi puntual, cuyo tiempo de referencia es: las doce y media de la noche del veinte de diciembre de mil novecientos ochenta y nueve. Nochebuena mala consta de 43 relatos de los cuales he seleccionado 12 de ellos y que nos sirven de apoyo para sustentar que existen elementos unificadores que logran la totalización de la obra. Aunque cada relato tiene independencia con personajes y puntos de vistas diferentes, hay elementos dentro de ellos que sirven para insertarlos en el desarrollo totalizador de la obra. Se proyecta y se sitúa durante la invasión, pues en ellos se reflejan los problemas sociales, económicos y morales comunes en todas las capas sociales del país (Panamá), ya que los grados de corrupción e ideas se proyectan en todos los niveles sociales. Nochebuena mala es una recopilación de todas las consecuencias que se dan producto de la invasión del 20 de diciembre de 1989 en la hora indicada
T-test and suitability of dependent sample t-test.
No full textT-test and suitability of dependent sample t-test.</p
ANALYSIS OF SERVICES PROVIDED IN THERMAL SPA MALA NEDELJA
No full textV diplomski nalogi obravnavam termalni turizem. Potrebe turistov se spreminjajo, zato morajo terme slediti sodobnim trendom in svojo ponudbo prilagajati zahtevam vseh generacij obiskovalcev in gostov. Potrebna je stalna skrb za izboljšanje kakovosti storitev.
V glavnem delu naloge predstavim ponudbo storitev Bioterm Mala Nedelja. Terme ponujajo oddih v naravi, zdravilno termalno vodo, domačo hrano in storitve dobrega počutja. Posebej analiziram ponudbo storitev term in njihovo kakovost. Na podlagi ankete analiziram motive in pričakovanja gostov za obisk term ter njihovo zadovoljstvo z gostinsko ponudbo in s ponudbo storitev dobrega počutja. Ugotavljam, da terme ponujajo okolju prijazne storitve. Ponudbo bi kazalo razširiti še na področje zdravstvenih storitev, kakor tudi izboljšati storitve na področju wellnessa. Z uvajanjem novih storitev bi lahko podaljšali bivanje gostov v hotelu in povečali število dnevnih obiskovalcev in večdnevnih turistov.In my graduation paper, I am examining thermal tourism. The needs of tourists are changing, and thermal resorts need to keep up with the trends and offer something for all generations of guests. There has to be constant attention on improving the quality of tourism services.
In the main part, I am presenting the services of the resort Bioterme, Mala Nedelja. The thermal resort offers nature vacations, thermal water, local food, and wellness services. I am especially analysing the quality of services. Based on a survey I am analysing the motives and expectations of the spa’s guests, as well as their satisfaction with catering and other services. I recognise that the spa offers environmentally friendly services. It would be advisable to extend the scope of offerings to include health services, as well a wide range of wellness services. With the introduction of new services, the spa resort could extend the stay of guests in the hotel and increase the number of visitors and multi-day tourists
Chionanthus mala-elengi Green 1984
No full text5. Chionanthus mala-elengi (Dennst.) Green (1984:124). ≡ Forsythia mala-elengi Dennstedt(1818:31). LECTOTYPE (designated by Green [1984: 124]):—Tab. 55 in Hortus indicus malabaricus 5 by van Rheede tot Drakestein (1685: t. 55). Lectotype image available at https://www.biodiversitylibrary.org/item/14377#page/156/mode/1up Literature: — Green (1996: 767, 2003: 264), Newman et al. (2007: 248), Cho et al. (2016: 141), Jin et al. (2016: 160). Etymology: —The specific epithet “ mala-elengi ” refers to van Rheede tot Drakestein’s (1685) name “Mala Elengi” for this plant, which is translated as “mountain Mimusops elengi L.” from the local language (Green 1984). Notes: —The species is subdivided into three subspecies, two of which, including the type subspecies, are endemic to southern India (Green 1996, 2003, Govaerts & Green 2020). One subspecies in Cambodia, Laos and Vietnam.Published as part of Quang, Bui Hong & Nuraliev, Maxim S., 2021, The genus Chionanthus (Oleaceae) in Cambodia, Laos and Vietnam, pp. 167-195 in Phytotaxa 525 (3) on page 175, DOI: 10.11646/phytotaxa.525.3.1, http://zenodo.org/record/571238
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