139 research outputs found
Safety and efficacy outcomes of double vs. triple antithrombotic therapy in patients with atrial fibrillation following percutaneous coronary intervention: A systematic review and meta-analysis of non-Vitamin K antagonist oral anticoagulant-based randomized clinical trials
No full textAims: To investigate the safety and efficacy of double vs. triple antithrombotic therapy (DAT vs. TAT) in patients with atrial fibrillation (AF) and acute coronary syndrome or who underwent percutaneous coronary intervention (PCI). Methods and results: A systematic review and meta-analysis was performed using PubMed to search for non-Vitamin K antagonist oral anticoagulant (NOAC)-based randomized clinical trials comparing DAT vs. TAT in AF patients undergoing PCI. Four trials encompassing 10 234 patients (DAT = 5496 vs. TAT = 4738) were included. The primary safety endpoint (ISTH major or clinically relevant non-major bleeding) was significantly lower with DAT compared with TAT [risk ratio (RR) 0.66, 95% confidence interval (CI) 0.56-0.78; P < 0.0001; I2 = 69%], which was consistent across all available bleeding definitions. This benefit was counterbalanced by a significant increase of stent thrombosis (RR 1.59, 95% CI 1.01-2.50; P = 0.04; I2 = 0%) and a trend towards higher risk of myocardial infarction with DAT. There were no significant differences in all-cause and cardiovascular death, stroke and major adverse cardiovascular events. The comparison of NOAC-based DAT vs. Vitamin K antagonist (VKA)-TAT yielded consistent results and a significant reduction of intracranial haemorrhage (RR 0.33, 95% CI 0.17-0.65; P = 0.001; I2 = 0%). Conclusion: Double antithrombotic therapy, particularly if consisting of a NOAC instead of VKA and a P2Y12 inhibitor, is associated with a reduction of bleeding, including major and intracranial haemorrhages. This benefit is however counterbalanced by a higher risk of cardiac-mainly stent-related-but not cerebrovascular ischaemic occurrences
Atrial Fibrillation can adversely impact Heart Failure with Preserved Ejection Fraction by its association with Heart Failure Progression and Mortality: A Post-Hoc Propensity Score–Matched Analysis of the TOPCAT Americas Trial
No full textDEVICE DETECTED ATRIAL FIBRILLATION AND RISK FOR STROKE: AN ANALYSIS OF MORE THAN 10,000 PATIENTS FROM THE SOS AF PROJECT (STROKE PREVENTION STRATEGIES BASED ON ATRIAL FIBRILLATION INFORMATION FROM IMPLANTED DEVICES)
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Possible impact of human CYP2E1 polymorphisms on the metabolism of acrylonitrile
No full textCase reports of human accidental poisonings point to significant individual differences in human acrylonitrile metabolism and toxicity. A cohort of 59 persons with industrial handling of low levels of acrylonitrile has repetitively been studied from 1994 through 1999 as part of a medical surveillance programme. The analyses included adduct determinations of N-terminal N-(cyanoethyl)valine in haemoglobin and genotypings of the following cytochrome P-450 2E1 (CYP2E1) polymorphisms: G(-1259)C and C-1019T (two subjects heterozygous), A(-316)G (three subjects heterozygous). T (297)A (15 subjects heterozygous). G(-35)T (eight subjects heterozygous). G(4804)A (two subjects heterozygous), T(7668)A (six subjects heterozygous). N-(Cyanoethyl)valine adduct levels were. if any, only slightly influenced by smoking and mainly determined by the external acrylonitrile exposures. The individual means and medians of N-(cyanoethyl)valine levels over the entire observation period were compared with the CYP2E1 variants (Wilcoxon rank sum test). No influences of the investigated CYP2E1 polymorphisms on the N-(cyanoethyl)valine levels appeared at the 5%. level. However, there was a trend, at a level of Papproximate to0.1, pointing to higher acrylonitrile-specific adduct levels in persons with the A(-316)G mutation. Higher adduct levels would be compatible with a slower CYP2E1-mediated metabolism of acrylonitrile and with lower extents of toxification to cyanide. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved
New insights into the initiation of atrial fibrillation: a detailed intraindividual and interindividual analysis of the spontaneous onset of atrial fibrillation using new diagnostic pacemaker features.
No full textContemporary real life cardioversion of atrial fibrillation: results from the multinational RHYTHM-AF study
No full textAbstract not availableHarry J.G.M. Crijns, Bob Weijs, Anna-Meagan Fairley, Thorsten Lewalter, Aldo P.Maggioni, Alfonso Martín, Piotr Ponikowski, Mårten Rosenqvist, Prashanthan Sanders, Mauricio Scanavacca, Lori D. Bash, François Chazelle, Alexandra Bernhardt, Anselm K. Gitt, Gregory Y.H. Lip, Jean-Yves Le Heuze
210 The predictive value of 6 weeks monitoring for the further development of atrial fibrillation: the role of pacemaker diagnostics
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Der Einfluss emotionaler Erlebensqualitäten auf die Entwicklung der Lernmotivation in universitären Lehrveranstaltungen
No full textAusgehend von der Selbstbestimmungstheorie (Deci/Ryan 1985) beschäftigt sich der Beitrag mit der Bedeutung des Erlebens von Autonomie, Kompetenz und sozialer Eingebundenheit für die Veränderung der selbstbestimmten Motivation während universitärer Lehrveranstaltungen. Dabei werden zwei Komponenten des Autonomieerlebens anhand von Interviewdaten und Strukturgleichungsmodellen auf der Basis längsschnittlicher Fragebogendaten genauer analysiert. Während die quantitativen Befunde die besondere Bedeutung beider Komponenten des Autonomieerlebens unterstützen, kommt in den qualitativen Ergebnissen dem Kompetenzerleben eine besondere Bedeutung zu. (DIPF/Orig.)Based on self-determination theory (Deci/Ryan 1985) the author investigates the function of the experience of autonomy, competence and relatedness for the development of self-determined motivation during university courses. On the basis of interview- and questionnaire data two aspects of the experience of autonomy were analyzed. While the results of structural equation models obtained by a longitudinal survey support the theoretical assumption of the importance of the experience of both aspects of autonomy the qualitative interview data support the importance of the experience of competence. (DIPF/Orig.
Left atrial appendage occlusion for stroke prevention in patients with atrial fibrillation: indications diversity and future perspectives
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