57 research outputs found
Parallelization of the exact diagonalization of the t−t′-Hubbard model
No full textWe present a new parallel algorithm for the exact diagonalization of the t−t′-Hubbard model with the Lanczos method. By invoking a new scheme of labeling the states we were able to obtain a speedup of up to four on 16 nodes of an IBM SP2 for the calculation of the ground state energy and an almost linear speedup for the calculation of the correlation functions. Using this algorithm we performed an extensive study of the influence of the next-nearest hopping parameter t′ in the t−t′-Hubbard model on ground state energy and the superconducting correlation functions for both attractive and repulsive interaction
Boleslaus Lukaszewski (Father Luke) Photographs. Roll 0275, Image 011
No full textRoll 275. Campus Thief at Police Station; Husslein Hall / ICEBREAKER / Casselly's House razing. Image 6 of 6. (25 September, 1956) [PHO 1.275.11]. Some images from this roll are restricted.The Boleslaus Lukaszewski (Father Luke) Photographs contain more than 28,000 images of Saint Louis University people, activities, and events between 1951 and 1970. The photographs were taken by Boleslaus Lukaszewski (Father Luke), a Jesuit priest and member of the University's Philosophy Department faculty
Boleslaus Lukaszewski (Father Luke) Photographs. Roll 0275, Image 009
No full textRoll 275. Campus Thief at Police Station; Husslein Hall / ICEBREAKER / Casselly's House razing. Image 4 of 6. (25 September, 1956) [PHO 1.275.9]. Some images from this roll are restricted.The Boleslaus Lukaszewski (Father Luke) Photographs contain more than 28,000 images of Saint Louis University people, activities, and events between 1951 and 1970. The photographs were taken by Boleslaus Lukaszewski (Father Luke), a Jesuit priest and member of the University's Philosophy Department faculty
Rita G. Adams Photographs. Series 02 (Jesuit Groups), Image 0692
No full textGroup of Jesuits on a porch at Loyola Villa, date unknown. Caption: "Quinlan, Dolan, Mackey, O'Bryan, Gorman, Marsin, Davis, O'Connor, Daly, J. Lyons, Falley, Kircher, Barlow, McMenamy, Mullens, Shannon, Roehrig, Devlin,
Siefke, T. Sherman, Kister(?), Miles, Nicholas,
Wolking, Husslein, Milet, Danahy, Whelan, Synnot(?), Blakeley, P. Breen,
Dinneen(?), Garraghan, Fox, L. Lyons, Marrin, Ragor, Murphy, Kammerer,
Eline, V. Fusz, Frumweller(?), McCormick, McClorey, Schierman, Henry, Wise, Moerel
Daly, L. Fusz, Siedenburg, Anderson, Doyle, F. Breen, Weiand, McNichols.
Boleslaus Lukaszewski (Father Luke) Photographs. Roll 0275, Image 010
No full textRoll 275. Campus Thief at Police Station; Husslein Hall / ICEBREAKER / Casselly's House razing. Image 5 of 6. (25 September, 1956) [PHO 1.275.10]. Some images from this roll are restricted.The Boleslaus Lukaszewski (Father Luke) Photographs contain more than 28,000 images of Saint Louis University people, activities, and events between 1951 and 1970. The photographs were taken by Boleslaus Lukaszewski (Father Luke), a Jesuit priest and member of the University's Philosophy Department faculty
Activation of the canonical wingless/T-cell factor signaling pathway promotes invasive differentiation of human trophoblast
No full textThe molecular mechanisms governing invasive differentiation of human trophoblasts remain largely elusive. Here, we investigated the role of Wnt-beta-catenin-T-cell factor (TCF) signaling in this process. Reverse transcriptase-polymerase chain reaction and Western blot analyses demonstrated expression of Wnt ligands, frizzled receptors, LRP-6, and TCF-3/4 transcription factors in total placenta and different trophoblast cell models. Immunohistochemistry of placental tissues and differentiating villous explant cultures showed that expression of TCF-3/4 strongly increased in invading trophoblasts. Some of these cells also accumulated dephosphorylated beta-catenin in the nucleus. Wnt3A treatment of primary cytotrophoblasts and SGHPL-5 cells induced activity of TCF-luciferase reporters. Accordingly, the ligand provoked in teraction of TCF-3/4 with beta-catenin as assessed in electrophoretic mobility shift assays (EMSAs) and upregulation of Wnt/TCF target genes as observed by Western blot analyses. Wnt3A stimulated trophoblast migration and invasion through Matrigel, which could be blocked by addition of Dickkopf-1, mediating inhibition of canonical Wnt signaling. Dickkopf-l also reduced basal migration, invasion, and proliferation of cytotrophoblasts, suggesting expression of endogenous Wnt ligand(s). Immunohistochemistry revealed that the percentage of extravillous trophoblasts containing nuclear beta-catenin was significantly higher in placentas of complete hydatidiform mole pregnancies as compared to normal placentas. Thus, canonical Wnt signaling may promote invasive trophoblast differentiation, and exaggerated activation of the pathway could contribute to trophoblastic hyperplasia and local invasion
Endothelial nitric oxide synthase gene polymorphism (Glu298Asp) and development of pre-eclampsia: a case-control study and a meta-analysis.
No full textBackground:
Pre-eclampsia is thought to have an important genetic component. Recently, pre-eclampsia has been associated in some studies with carriage of a common eNOS gene Glu298Asp polymorphism, a variant that leads to the replacement of glutamic acid by aspartic acid at codon 298.
Method:
Healthy women with singleton pregnancies were recruited from 7 district general hospitals in London, UK. Women at high risk of pre-eclampsia were screened by uterine artery Doppler velocimetry at 22–24 weeks of gestation and maternal blood was obtained to genotype the eNOS Glu298Asp polymorphism. Odds ratios (OR) and 95%CI, using logistic regression methods, were obtained to evaluate the association between the Glu298Asp polymorphism and pre-eclampsia. A meta-analysis was then undertaken of all published studies up to November 2005 examining the association of eNOS Glu298Asp genotype and pre-eclampsia.
Results:
89 women with pre-eclampsia and 349 controls were included in the new study. The Glu298Asp polymorphism in a recessive model was not significantly associated with pre-eclampsia (adjusted-OR: 0.83 [95%CI: 0.30–2.25]; p = 0.7). In the meta-analysis, under a recessive genetic model (1129 cases & 2384 controls) women homozygous for the Asp298 allele were not at significantly increased risk of pre-eclampsia (OR: 1.28 [95%CI: 0.76–2.16]; p = 0.34). A dominant model (1334 cases & 2894 controls) was associated with no increase of risk of pre-eclampsia for women carriers of the Asp298 allele (OR: 1.12 [95%CI: 0.84–1.49]; p = 0.42).
Conclusion:
From the data currently available, the eNOS Glu298Asp polymorphism is not associated with a significant increased risk of pre-eclampsia. However, published studies have been underpowered, much larger studies are needed to confirm or refute a realistic genotypic risk of disease, but which might contribute to many cases of pre-eclampsia in the population
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