193 research outputs found
Motion Control of Dense Robot Colony Using Thermodynamics
No full textIn the last decades the theory of the complex dynamical systemshas come to maturation providing a lot of important results in the field ofmany applied sciences. Also robotics has taken advantages from this new approach in what the behavior-based paradigm is particularly suitable to devise specific sensing activity since sensors usually provide information about the environment in a form which depends on the physics of the interaction. It is not required to be immediately converted into some symbolic representation but, on the contrary, it can be maintained at some physical level as a metaphor of the events observed in the environment. The close connection between the motor schema with its companion perceptual schema seems suggesting the presence of a substratum which underlies both perception and action activities, driving the flow of information accordingly. In the paper we consider a colony of robots immersed in a well-specified thermodinamical substratum where enthalpy and heat flux are devised to go vern the diffusion/merging behavior of a swarm
Determination of stress state in deep subsea formation by combination of hydraulic fracturing in situ test and core analysis: A case study in the IODP Expedition 319
No full text[1] In situ test of hydraulic fracturing (HF) provides the only way to observe in situ stress magnitudes directly. The maximum and minimum horizontal stresses, SHmax and Shmin, are determined from critical borehole pressures, i.e., the reopening pressure Pr and the shut-in pressure Ps, etc, observed during the test. However, there is inevitably a discrepancy between actual and measured values of the critical pressures, and this discrepancy is very significant for Pr. For effective measurement of Pr, it is necessary for the fracturing system to have a sufficiently small compliance. A diagnostic procedure to evaluate whether the compliance of the employed fracturing system is appropriate for SHmax determination from Pr was developed. Furthermore, a new method for stress measurement not restricted by the system compliance and Pr is herein proposed. In this method, the magnitudes and orientations of SHmax and Shmin are determined from (i) the cross-sectional shape of a core sample and (ii) Ps obtained by the HF test performed near the core depth. These ideas were applied for stress measurement in a central region of the Kumano fore-arc basin at a water depth of 2054?m using a 1.6?km riser hole drilled in the Integrated Ocean Drilling Program (IODP) Expedition 319. As a result, the stress decoupling through a boundary at 1285?m below seafloor was detected. The boundary separates new upper layers and old lower ones with an age gap of ~1.8?Ma, which is possibly the accretionary prism. The stress state in the lower layers is consistent with that observed in the outer edge of accretionary prism
Craniofacial Phenotypes and Genetics of DiGeorge Syndrome
No full textThe 22q11.2 deletion is one of the most common genetic microdeletions, affecting approximately 1 in 4000 live births in humans. A 1.5 to 2.5 Mb hemizygous deletion of chromosome 22q11.2 causes DiGeorge syndrome (DGS) and velocardiofacial syndrome (VCFS). DGS/VCFS are associated with prevalent cardiac malformations, thymic and parathyroid hypoplasia, and craniofacial defects. Patients with DGS/VCFS manifest craniofacial anomalies involving the cranium, cranial base, jaws, pharyngeal muscles, ear-nose-throat, palate, teeth, and cervical spine. Most craniofacial phenotypes of DGS/VCFS are caused by proximal 1.5 Mb microdeletions, resulting in a hemizygosity of coding genes, microRNAs, and long noncoding RNAs. TBX1, located on chromosome 22q11.21, encodes a T-box transcription factor and is a candidate gene for DGS/VCFS. TBX1 regulates the fate of progenitor cells in the cranial and pharyngeal apparatus during embryogenesis. Tbx1-null mice exhibit the most clinical features of DGS/VCFS, including craniofacial phenotypes. Despite the frequency of DGS/VCFS, there has been a limited review of the craniofacial phenotypes of DGC/VCFS. This review focuses on these phenotypes and summarizes the current understanding of the genetic factors that impact DGS/VCFS-related phenotypes. We also review DGS/VCFS mouse models that have been designed to better understand the pathogenic processes of DGS/VCFS
Muscle synergy analysis yields an efficient and physiologically relevant method of assessing stroke
Get PDFThe Fugl-Meyer Assessment is widely used to test motor function in stroke survivors. In the Fugl-Meyer Assessment, stroke survivors perform several movement tasks and clinicians subjectively rate the performance of each task item. The individual task items in the Fugl-Meyer Assessment are selected on the basis of clinical experience, and their physiological relevance has not yet been evaluated. In the present study, we aimed to objectively rate the performance of task items by measuring the muscle activity of 41 muscles from the upper body while stroke survivors and healthy participants performed 37 Fugl-Meyer Assessment upper extremity task items. We used muscle synergy analysis to compare muscle activity between subjects and found that 13 muscle synergies in the healthy participants (which we defined as standard synergies) were able to reconstruct all of the muscle activity in the Fugl-Meyer Assessment. Among the standard synergies, synergies involving the upper arms, forearms and fingers were activated to varying degrees during different task items. In contrast, synergies involving posterior trunk muscles were activated during all tasks, which suggests the importance of posterior trunk muscle synergies throughout all sequences. Furthermore, we noted the inactivation of posterior trunk muscle synergies in stroke survivors with severe but not mild impairments, suggesting that lower trunk stability and the underlying activity of posterior trunk muscle synergies may have a strong influence on stroke severity and recovery. By comparing the synergies of stroke survivors with standard synergies, we also revealed that some synergies in stroke survivors corresponded to merged standard synergies; the merging rate increased with the impairment of stroke survivors. Moreover, the degrees of severity-dependent changes in the merging rate (the merging rate–severity relationship) were different among different task items. This relationship was significant for 26 task items only and not for the other 11 task items. Because muscle synergy analysis evaluates coordinated muscle activities, this different dependency suggests that these 26 task items are appropriate for evaluating muscle coordination and the extent of its impairment in stroke survivors. Overall, we conclude that the Fugl-Meyer Assessment reflects physiological function and muscle coordination impairment and suggest that it could be performed using a subset of the 37 task items
Development of Behavioral Transition Model by using Oscillator Network
Get PDFこの論文は国立情報学研究所の電子図書館事業により電子化されました。研究会報告Insects have only a little brain but the behavior is highly adaptive. We consider that physical structure of the neural network works on the creation of the brain function and model the behavioral processor that controlled by its structural disposition. Nonlinear oscillator changes the behavior depends on the connection relationship, and the existence of oscillator and the function have been shown in antennal lobe(AL) of locust. Moreover, the structure of cricket AL changes by battle experience. Therefore, we model the function of AL using an oscillator network. Then, we realized the model with electrical circuit, and proposed a simple robot model which follows a real insect behavior
The essential neutral sphingomyelinase is involved in the trafficking of the variant surface glycoprotein in the bloodstream form of Trypanosoma brucei
No full textSphingomyelin is the main sphingolipid in Trypanosoma brucei, the causative agent of African sleeping sickness. In vitro and in vivo characterization of the T. brucei neutral sphingomyelinase demonstrates that it is directly involved in sphingomyelin catabolism. Gene knockout studies in the bloodstream form of the parasite indicate that the neutral sphingomyelinase is essential for growth and survival, thus highlighting that the de novo biosynthesis of ceramide is unable to compensate for the loss of sphingomyelin catabolism. The phenotype of the conditional knockout has given new insights into the highly active endocytic and exocytic pathways in the bloodstream form of T. brucei. Hence, the formation of ceramide in the endoplasmic reticulum affects post-Golgi sorting and rate of deposition of newly synthesized GPI-anchored variant surface glycoprotein on the cell surface. This directly influences the corresponding rate of endocytosis, via the recycling endosomes, of pre-existing cell surface variant surface glycoprotein. The trypanosomes use this coupled endocytic and exocytic mechanism to maintain the cell density of its crucial variant surface glycoprotein protective coat. TbnSMase is therefore genetically validated as a drug target against African trypanosomes, and suggests that interfering with the endocytic transport of variant surface glycoprotein is a highly desirable strategy for drug development against African trypanosomasis.Peer reviewe
Induction of Cell Death in Growing Human T-Cells and Cell Survival in Resting Cells in Response to the Human T-Cell Leukemia Virus Type 1 Tax.
Get PDFTax1 encoded by the human T-cell leukemia virus type 1 (HTLV-1) has been believed to dysregulate the expression of cellular genes involved in cell survival and mortality, leading to the development of adult T-cell leukemia (ATL). The function of Tax1 in ATL development however is still controversial, primarily because Tax1 induces cell cycle progression and apoptosis. To systemically understand cell growth phase-dependent induction of cell survival or cell death by Tax1, we established a single experimental system using an interleukin 2 (IL-2)-dependent human T-cell line Kit 225 that can be forced into resting phase by IL-2 deprivation. Introduction of Tax1 and HTLV-2 Tax (Tax2B) decreased mitochondrial activity alongside apoptosis in growing cells but not in resting cells. Cell cycle profile analysis indicated that Tax1 and Tax2B were likely to perturb the S phase in growing cells. Studies with Tax1 mutants and siRNA for NF-κB/RelA revealed that Tax1-mediated cell growth inhibition and apoptosis in growing Kit 225 cells depend on RelA. Interestingly, inactivation of the non-canonical NF-κB and p38 MAPK pathways relieved Tax1-mediated apoptosis, suggesting that the Tax1-NF-κB-p38 MAPK axis may be associated with apoptosis in growing cells. Inflammatory mediators such as CCL3 and CCL4, which are involved in oncogene-induced senescence (OIS), were induced by Tax1 and Tax2B in growing cells. In contrast, RelA silencing in resting cells reduced mitochondrial activity, indicating that NF-κB/RelA is also critical for Tax1-mediated cell survival. These findings suggest that Tax1-mediated cell survival and death depend on the cell growth phase. Both effects of Tax1 may be implicated in the long latency of HTLV-1 infection
Multimedia based E-learning tools for dynamic modeling of dc-dc converters
No full textAuthor name used in this publication: C. K. TseRefereed conference paper2005-2006 > Academic research: refereed > Refereed conference paperVersion of RecordPublishedVoR allowe
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