1,682 research outputs found
Craddock, T E, 411869
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/379334Surname: CRADDOCK
Given Name(s) or Initials: T E
Military Service Number or Last Known Location: 411869
Missing, Wounded and Prisoner of War Enquiry Card Index Number: 56413193146
Item: [2016.0049.11627] "Craddock, T E, 411869
Learning theories and interprofessional education: a user's guide
No full textThere is increasing interest in the theoretical underpinning of interprofessional education (IPE) and writers in this field are drawing on a wide range of disciplines for theories that have utility in IPE. While this has undoubtedly enriched the research literature, for the educational practitioner, whose aim is to develop and deliver an IPE curriculum that has sound theoretical underpinnings, this plethora of theories has become a confusing, and un-navigable quagmire. This article aims to provide a compass for those educational practitioners by presenting a framework that summarizes key learning theories used in IPE and the relationship between them. The study reviews key contemporary learning theories from the wider field of education used in IPE and the explicit applications of these theories in the IPE literature to either curriculum design or programme evaluation. Through presenting a broad overview and summary framework, the study clarifies the way in which learning theories can aid IPE curriculum development and evaluation. It also highlights areas where future theoretical development in the IPE field is required
Alessandra R. Giumlia-Mair & Paul T. Craddock, Das schwarze Gold der Alchimisten
No full textBaratte François. Alessandra R. Giumlia-Mair & Paul T. Craddock, Das schwarze Gold der Alchimisten. In: L'antiquité classique, Tome 63, 1994. p. 612
Lie symmetry methods for local volatility models
No full textWe investigate PDEs of the form [Formula presented] which are associated with the calculation of expectations for a large class of local volatility models. We find nontrivial symmetry groups that can be used to obtain Fourier transforms of fundamental solutions of the PDE. We detail explicit computations in the separable volatility case when σ(t,x)=h(t)(α+βx+γx2), g=0, corresponding to the so called Quadratic Normal Volatility Model. We give financial applications and also show how symmetries can be used to compute first hitting distributions
Scientific investigation of copies, fakes and forgeries (Paul Craddock,ed.)
No full textThis book is not dangerous, but probably the most comprehensive account on copies, fakes forgeries and their disclosure ever written. The author, Paul Craddock, former material scientist at the British Museum, wrote numerous publications on metals and their use in antiquities and art. This book, however, describes all kinds of materials encountered in art, archaeological artefacts, and antiques and of course copies, fakes and forgeries. The materials covered range from metals to plastic and..
Water-mediated correlations in DNA-enzyme interactions
No full textIn this letter we consider dipole-mediated correlations between DNA and enzymes in the context of their water environment. Such correlations emerge from electric dipole-dipole interactions between aromatic ring structures in DNA and in enzymes. We show that there are matching collective modes between DNA and enzyme dipole fields, and that a dynamic time-averaged polarization vanishes in the water dipole field only if either DNA, enzyme, or both are absent from the sample. This persistent field may serve as the electromagnetic image that, in popular colloquialisms about DNA biochemistry, allows enzymes to scan or read the double helix. Topologically nontrivial configurations in the coherent ground state requiring clamplike enzyme behavior on the DNA may stem, ultimately, from spontaneously broken gauge symmetries
The treatment of geometrically small structures in FDTD by the modification of assigned material parameters
No full textA number of different improvements to the analysis by finite-difference time-domain (FDTD) of small structures, such as wires, strips and slots have been proposed in the literature. One of these methods takes account of the fringing fields associated with metal edges and wires by empirically modifying the assigned material parameters in neighboring cells. In this contribution it is shown that, in many cases, it is possible to derive these modified assigned material parameters (MAMPs) analytically. In this form, the approach provides an alternative, and novel, way of incorporating Static Field Solutions into the FDTD method which has advantages of simplicity and robustness over existing techniques. Results are presented for a number of structures including wire transmission lines and a microstrip patch antenna.A number of different improvements to the analysis by finite-difference time-domain (FDTD) of small structures, such as wires, strips and slots have been proposed in the literature. One of these methods takes account of the fringing fields associated with metal edges and wires by empirically modifying the assigned material parameters in neighboring cells. In this contribution it is shown that, in many cases, it is possible to derive these modified assigned material parameters (MAMPs) analytically. In this form, the approach provides an alternative, and novel, way of incorporating Static Field Solutions into the FDTD method which has advantages of simplicity and robustness over existing techniques. Results are presented for a number of structures including wire transmission lines and a microstrip patch antenna
Addendum: Montagnier, L.; Aïssa, J.; Capolupo, A.; Craddock, T.J.A.; Kurian, P.; Lavallee, C.; Polcari, A.; Romano, P.; Tedeschi, A.; Vitiello, G. Water Bridging Dynamics of Polymerase Chain Reaction in the Gauge Theory Paradigm of Quantum Fields. Water 2017, 9, 339
No full textThe authors wish to make the following addendum to their paper [1]:
After the publication of our paper, submitted on 11 February 2017, we read the paper “DNA’s
Chiral Spine of Hydration”, by M. Luke McDermott, Heather Vanselous, Steven A. Corcelli, and Poul B.
Petersen, published in ACS Central Science, doi:10.1021/acscentsci.7b00100, on 24 May 2017 [2], where
the authors report their discovery of a chiral water superstructure surrounding DNA under ambient
conditions. This is the first observation of a chiral spine of hydration templated by a biomolecule and
has been obtained by use of chiral sum frequency generation (SFG) spectroscopy, a method analogous
to circular dichroism measurements. In this specific case, water forms a robust chiral superstructure of
the DNA helical structure. The authors report that, at room temperature and in 100 mM NaCl solution,
they “indeed observe that DNA imprints its chirality on the surrounding water molecules, generating
a chiral SFG water response. This confirms the existence of a DNA minor groove spine of hydration at
room temperature and further shows that the chiral structure of biomolecules can be imprinted on the
surrounding solvation structure”. The biological relevance of the discovery is evident.
Here we observe that such a discovery is fully consistent with the predictions presented in our
paper, namely that polymerase chain reaction (PCR) processes rest on the mediating influence of such
hydration structures, templated by the DNA and Taq polymerase biomolecules. In fact, our conclusion
is that, without organized water structures, no PCR processes can occur and no amplification of
DNA can be obtained. The observation reported in [2] of the robustness of the DNA’s chiral spine
of hydration, and the fact that “a change in the hydration state can lead to dramatic changes to the
DNA structure” [2] also confirm that such a water superstructure actually constitutes a detailed mold
or “electromagnetic image”, as we have called it in our paper, of the DNA (and, additionally, other
biomolecules) generating molecular electric dipole interactions. This electromagnetic image imprinted
in the water dipole field is what the polymerase enzyme recognizes in the DNA’s water environment.
These studies open the way toward novel biomolecular “imaging” technologies and new research
disciplines, which have been incited by L. Montagnier’s PCR experiments. The analysis in our paper,
as well as in previous ones along similar research lines, is fully grounded in the quantum field theory
description of the phenomenon and finds experimental support in this latest discovery of the existence
of DNA’s chiral spine of hydration
Engraftment of T-cell-depleted allogeneic haematopoietic stem cells using a reduced intensity conditioning regimen
No full textThe definitive version may be found at www.wiley.comGraft-versus-host disease (GVHD) remains a significant complication in patients undergoing allogeneic stem cell transplantation (SCT) using a reduced intensity conditioning regimen. Although T-cell depletion (TCD) reduces the risk of GVHD after a myeloablative conditioning regimen, it is associated with an increased risk of graft failure. We have therefore examined whether TCD compromises engraftment using a fludarabine-based conditioning regimen. Fifteen patients have been transplanted using such a regimen of whom 13 underwent ex vivo TCD. All but one patient demonstrated durable engraftment and no patient receiving a TCD product developed severe GVHD. Thus, TCD may play a role in GvHD prophylaxis using such regimens.C. Craddock, P. Bardy, S. Kreiter, R. Johnston, J. Apperley, D. Marks, C. Huber, K. Kolbe, R. Goulding, M. Lawler, J. Goldman, T. Hughes and G. Derig
The combination of raltitrexed (Tomudex) and mitomycin-C in the treatment of advanced colorectal cancer - A phase II study
No full textAims
To investigate the combination of raltitrexed and mitomycin-C as first-line chemotherapy treatment in patients with advanced colorectal cancer.Materials and methods
A phase II study.Results
In total, 22 patients were treated with a combination of raltitrexed 3 mg/m2 every 3 weeks and mitomycin-C 7 mg/m2 every 6 weeks for up to 24 weeks. The study was closed early for safety reasons as there were three unexpected treatment-related deaths. The overall response rate was 20%, and a further 40% achieved stable disease. The median time to progression was 3.9 months and the median overall survival time was 11.6 months.Conclusion
Owing to the potential for increased toxicity, the combination of raltitrexed and mitomycin-C cannot be recommended as first-line treatment in patients with advanced colorectal cancer
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