10,631 research outputs found
Opere del conte Algarotti.
No full textIncludes index in vol. 7.Added t.p. in vol. 1, engraved by Giuseppe Patrini. Engraved portrait medallion of the author on t.p. in vol. 1, small woodcut title-vignettes on title pages in vol. 2-10.Mode of access: Internet
Poesie del conte Gio: Batta Giovio ...
No full textUniversity of Illinois Library bookplate "From the library of Conte Antonio Cavagna Sangiuliani di Gualdana Lazelada di Bereguardo, purchased 1921" on the inside front cover.Page clx misnumbered lx.Engraved t.-p. by Teodoro Viero.Con licenza de'superiori.Mode of access: Internet
Closing high-level address [by Giuseppe Conte, Prime Minister, Italy, at SOU2020 special online edition]
No full textThis contribution was delivered online on 8 May 2020 on the occasion of the EUI State of the Union dedicated to 'Europe: managing the COVID-19 crisis'.This closing high-level address by Giuseppe Conte, Prime Minister, Italy, was delivered online on 8 May 2020 on the occasion of the EUI State of the Union dedicated to 'Europe: managing the COVID-19 crisis'
Les Quatre Facardins, Conte.
No full textLES QUATRE FACARDINS, CONTE.
Oeuvres Du Comte Antoine Hamilton (-)
Les Quatre Facardins, Conte. (T. 3) (1)
Cover (1)
Titelseite (7)
Les Quatre Facardins, Conte (9)
De L'Usage De La Vie Dans La Vieillesse (265)
Poesies (274
Fleur D' Épine, Conte
No full textFLEUR D' ÉPINE, CONTE
Oeuvres Du Comte Antoine Hamilton (-)
Fleur D' Épine, Conte (T. 2) (1)
Cover (1)
Titelseite (7)
Histoire De Fleur D'Epine, Conte (9)
Histoire De Phenix (161)
Histoire De Serene (189)
Chansons (215
Le Bellier, Conte.
No full textLE BELLIER, CONTE.
Oeuvres Du Comte Antoine Hamilton (-)
Le Bellier, Conte. (T. 4) (1)
Cover (1)
Titelseite (7)
Avis Du Libraire (9)
Le Béllier, Conte (11)
Histoire De Pertharite Et De Ferandine (80)
Histoire De La Mere Aux Gaines (218)
Poésies (271
Influence of chondroitin 6-sulfate oligosaccharide unit addition on the immunopathogenicity of human thyroglobulin in cba/j(h-2k) mice. Multiple effects on antigen processing and t cell responses
No full textThe site of type D (chondroitin 6-sulfate) oligosaccharide unit addition to human thyroglobulin (hTg) was localized. Furthermore, hTg and its fractions endowed with chondroitin 6-sulfate oligosaccaride units (hTg-CS) and devoid of it (hTg-CS-), were compared, with respect to their ability to induce experimental autoimmune thyroiditis (EAT) in CBA/J(H-2k) mice, by subcutaneous administration, in the presence of complete adjuvant.
HTg was chromatographically separated into hTg-CS and hTg-CS- molecules, on the base of their uronic acid content. In an ample number of hTg preparations, the fraction of hTg-CS in total hTg ranged from 32.0 to 71.6 percent. By exploiting the electrophoretic mobility shift and metachromasia conferred by chondrotin-6-sulfate upon the products of limited proteolysis of hTg, chondroitin 6-sulfate was first restricted to a carboxy-terminal region, starting at residue 2513. A single chondroitin 6-sulfate-containing nonapeptide was isolated in pure form from the products of digestion of hTg with endoproteinase Glu-C, and its sequence was determined as being LTAGXGLRE (residues 2725-2733, X being Ser2729 linked to the oligosaccharide chain). In an in vitro assay of enzymatic iodination, hTg-CS produced higher yields of 3,5,5’-triiodothyronine (T3) (171%) and 3,5,3’,5’-tetraiodothyronine (T4) (134%), than hTg-CS-. Unfractionated hTg behaved as hTg-CS. Thus, chondroitin 6-sulfate addition to a subset of hTg molecules enhanced the overall level of T4 and, particularly, T3 formation. Furthermore, the chondroitin 6-sulfate oligosaccharide unit of hTg-CS protected peptide bond Gly2713-Lys2714 from proteolysis, during the limited digestion of hTg-CS with trypsin.
Although immunization with all forms of hTg was accompanied by thyroid cell damage, as judged from the increase of T4 in blood, a higher degree of mononuclear infiltration of the thyroid was associated with unfractionated hTg, in comparison both with hTg-CS and with hTg-CS-. Thus, it appears that both hTg subfractions contributed to the immunopathogenic potency of unfractionated hTg, as neither one reproduced fully the histological picture associated with the latter. Significant differences were observed also upon restimulation in vitro of splenic lymphocytes obtained from mice immunized in vivo with the different forms of hTg. Restimulation in vitro with hTg-CS of splenocytes from mice immunized with the same antigen was followed by low-level, dose-dependent proliferation and IFN-γ production, whereas cross-stimulation with hTg-CS- of the same cells was followed by proliferative and secretory responses of even lower degree. On the other hand, restimulation in vitro with hTg-CS- of splenocytes primed in vivo with the same antigen was followed by higher-level, dose-dependent increases of IFN-γ production, accompanied by proliferative responses of low degree and inversely related with the antigen dose, while cross-stimulation with hTg-CS of the same cells was followed by dose-dependent increases, both of proliferation and IFN-γ production, of the highest level observed in this study. Similar results were obtained when splenocytes, primed in vivo with hTg-CS-, were restimulated with purified glycopeptide hTg-CSgp, containing the chondroitin 6-sulfate unit, but not with its non-glycosylated, synthetic homologue. These data indicate that hTg-CS- was more effective than hTg-CS in priming autoreactive T lymphocytes, recognizing thyroiditogenic epitopes shared between murine and human Tg, whereas hTg-CS was a stronger inducer of proliferation of antigen-sensitized T cells. Moreover, different molecular signals, including structural determinant(s) associated with the chondroitin 6-sulfate chain, were required, in addition to epitope recognition, for the activation of T cell proliferation, together with IFN-γ production.
These findings provide insights into the molecular mechanism of regulation of the hormonogenic efficiency and of the T4/T3 ratio in hTg, and may bear important implications in the processing and presentation of hTg as an autoantigen, and in the mechanisms of activation of Th-1-mediated and cytotoxic lymphocyte responses involved in EAT
L’accesso ai documenti relativi all’amministrazione straordinaria di banche nell’ordinamento europeo: il caso Banca Carige (nota a Corte di Giustizia EU, 28 settembre 2022 - Case T-552/19 OP e 29 giugno 2022 - Case T‐501/19)
No full textLa Sezione IV della Corte di Giustizia dell’Unione Europea, con le sentenze del
28 settembre 2022 (Malacalza Investimenti v European Central Bank – T-552/19 OP)
e del 29 giugno 2022 (Corneli v European Central Bank – T-501/19) si è pronunciata
sulla vicenda che ha interessato Banca Carige, confermando che la Banca Centrale
Europea non avrebbe potuto negare alla Malacalza Investimenti s.r.l. e alla Sig.ra
Corneli l’accesso ai documenti con i quali era stata decretata l’amministrazione straordinaria della Banca
The hidden author: an interpretation of Petronius' Satyricon
No full textThe Satyricon of Petronius, a comic novel written in the first century A.D., is famous today primarily for its amazing banquet tale, "Trimalchio's Feast." But this episode is only one part of the larger picture of life during Nero's rule presented in the work. In this accessible discussion of Petronius's masterful use of parody, Gian Biagio Conte offers an interpretation of the Satyricon as a whole. He combines the scholarly precision of close reading with a significant, original theoretical model.At the heart of his interpretation, Conte reveals the technique of the "hidden author" that Petronius employs at the expense of his characters, in particular the teller of the story, Enclopius. By remaining hidden outside the narrative, Petronius invites the reader to smile at the folies de grandeur that occur in a culture of scholars and declaimers. Yet as Conte shows, behind the parody and inexhaustible humor of the Satyricon lies an unexpectedly serious lament. For those familiar with the Satyricon, as well as for new readers, Conte's book will be a reliable, enjoyable guide to the wonders the Satyricon contains
New polynomial delay bounds for maximal subgraph enumeration by proximity search
No full textIn this paper we propose polynomial delay algorithms for several maximal subgraph listing problems, by means of a seemingly novel technique which we call proximity search. Our result involves modeling the space of solutions as an implicit directed graph called “solution graph”, a method common to other enumeration paradigms such as reverse search. Such methods, however, can become inefficient due to this graph having vertices with high (potentially exponential) degree. The novelty of our algorithm consists in providing a technique for generating better solution graphs, reducing the out-degree of its vertices with respect to existing approaches, and proving that it remains strongly connected. Applying this technique, we obtain polynomial delay listing algorithms for several problems for which output-sensitive results were, to the best of our knowledge, not known. These include Maximal Bipartite Subgraphs, Maximal k-Degenerate Subgraphs (for bounded k), Maximal Induced Chordal Subgraphs, and Maximal Induced Trees. We present these algorithms, and give insight on how this general technique can be applied to other problems
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