504 research outputs found
Bill T. Ridgeway
No full textBlack and white portrait photograph of Bill T. Ridgeway, Professor in Zoology, 1966-1993. Dr. Ridgeway also served as chair of Afro-American Studies from 1971 to 1973.https://thekeep.eiu.edu/archives_faculty_mr/1274/thumbnail.jp
Ethnic identity, political identity and ethnic conflict: simulating the effect of congruence between the two identities on ethnic violence and conflict
No full textThis thesis outlines and presents an alternative hypothetical process to the emergence of ethnic conflict. Ethnic conflicts, rather than being dependent upon pre-existing 'ancient hatreds', are instead the result of a congruence between ethnic and political identity which grants individuals the ability to use ethnicity to identify and eliminate political threats. This hypothesis is formed by the examination of three case studies of ethnic conflict: Lebanon, Northern Ireland and Croatia. This hypothesis is then formalised and tested using an agent based simulation in which agent interactions are dependent upon ethnic and political identity and the congruence between the two. As predicted there was a strong positive correlation between how accurately ethnic identity reflected political identity and the level of ethnically motivated violence in the simulation, although the relationship was not linear. Furthermore the effect of a shift in congruence was found to be roughly comparable to the effect of initialising agents with a moderate level of pre-existing ethnic antagonism
Joyce (T. A.). The Weeping God (Le dieu qui pleure). Essays and studies presented to William Ridgeway on his sixtieth birthday, p. 365-375. 13 figures. Cambridge University press. 1913.
No full textPoutrin . Joyce (T. A.). The Weeping God (Le dieu qui pleure). Essays and studies presented to William Ridgeway on his sixtieth birthday, p. 365-375. 13 figures. Cambridge University press. 1913. In: Journal de la Société des Américanistes. Tome 11, 1919. p. 278
Combat, Memory and Remembrance in Confederation Era Canada: The Hidden History of the Battle of Ridgeway, June 2, 1866
No full textOn June 1, 1866, one thousand heavily-armed Irish-American Fenian insurgents invaded Upper Canada across the Niagara River from Buffalo, NY. The next day near the town of Ridgeway, 800 Fenians battled with 850 Canadian volunteer soldiers, including a small company of 28 University of Toronto students who ended up taking the brunt of the attack. The Battle of Ridgeway (or Lime Ridge or Limestone Ridge) ended with a disastrous rout of the Canadians who in their panicked retreat left their dead and wounded on the field. It was the last major incursion into Canada, the last battle in Ontario and the first modern one fought by Canadians, led in the field exclusively by Canadian officers, and significantly fought in Canada.
The Fenian Raid mobilized some 22,000 volunteer troops and resulted in the suspension of habeas corpus in the colonial Province of Canada by its Attorney General and Minister of Militia John A. Macdonald, but the battle which climaxed this crisis is only prominent by its obscurity in Canadian historiography. Almost everything known and cited about Ridgeway springs from the same sources—four books and pamphlets—three of them published in the summer of 1866 immediately after the event and the remaining one in 1910.
This dissertation argues that the history of the battle was distorted and falsified by these sources and by two military board of inquiries staged to explicitly cover up the extent of the disaster. This study investigates the relationship between the inquiries and the contemporary author-historians of two of the sources: Alexander Somerville, an investigative journalist in Hamilton, Ontario, a recent immigrant from Britain with a controversial history; and George T. Denison III, a prominent young Toronto attorney, a commander of a troop of volunteer cavalry, a former Confederate secret service agent, author-commentator on Canada’s military policy and presiding judge on both boards of inquiry.
This study describes the process by which Ridgeway’s history was hidden and falsified and its possible scope and significance in Canadian historiography. New archival and published sources are identified, assessed and assembled for a newly restored and authenticated micro-narrative of the battle.Ph
Combat, Memory and Remembrance in Confederation Era Canada: The Hidden History of the Battle of Ridgeway, June 2, 1866
No full textOn June 1, 1866, one thousand heavily-armed Irish-American Fenian insurgents invaded Upper Canada across the Niagara River from Buffalo, NY. The next day near the town of Ridgeway, 800 Fenians battled with 850 Canadian volunteer soldiers, including a small company of 28 University of Toronto students who ended up taking the brunt of the attack. The Battle of Ridgeway (or Lime Ridge or Limestone Ridge) ended with a disastrous rout of the Canadians who in their panicked retreat left their dead and wounded on the field. It was the last major incursion into Canada, the last battle in Ontario and the first modern one fought by Canadians, led in the field exclusively by Canadian officers, and significantly fought in Canada.
The Fenian Raid mobilized some 22,000 volunteer troops and resulted in the suspension of habeas corpus in the colonial Province of Canada by its Attorney General and Minister of Militia John A. Macdonald, but the battle which climaxed this crisis is only prominent by its obscurity in Canadian historiography. Almost everything known and cited about Ridgeway springs from the same sources—four books and pamphlets—three of them published in the summer of 1866 immediately after the event and the remaining one in 1910.
This dissertation argues that the history of the battle was distorted and falsified by these sources and by two military board of inquiries staged to explicitly cover up the extent of the disaster. This study investigates the relationship between the inquiries and the contemporary author-historians of two of the sources: Alexander Somerville, an investigative journalist in Hamilton, Ontario, a recent immigrant from Britain with a controversial history; and George T. Denison III, a prominent young Toronto attorney, a commander of a troop of volunteer cavalry, a former Confederate secret service agent, author-commentator on Canada’s military policy and presiding judge on both boards of inquiry.
This study describes the process by which Ridgeway’s history was hidden and falsified and its possible scope and significance in Canadian historiography. New archival and published sources are identified, assessed and assembled for a newly restored and authenticated micro-narrative of the battle.Ph
The Ridgeway Gold-Copper Deposit: A High-Grade Alkalic Porphyry Deposit in the Lachlan Fold Belt, New South Wales, Australia
No full textRidgeway is a high-grade gold-copper porphyry deposit (54 Mt at 2.5 g/t Au and 0.77% Cu), related to an alkalic intrusive complex of monzonitic composition. The deposit occurs within the Cadia district of New South Wales, Australia, which consists of a cluster of four Late Ordovician gold-copper porphyry deposits and two iron-copper-gold skarn deposits with a combined gold resource in excess of 574 metric tonnes (t). The deposits lie on a 7-km-long, northwest-oriented corridor of alteration and mineralization, transverse to the axis of the postulated volcanic arc. Alteration and mineralization at Ridgeway are zoned around a vertically attenuated intrusive complex of monzodioritic to quartz monzonitic composition. Distinct styles of veining and alteration are related to different intrusive phases of the monzonite complex, with the intensity of alteration and grade of mineralization decreasing from early- to late-mineral intrusions. Early-mineral intrusions are associated with intense actinolite-magnetite-biotite (calc-potassic) alteration and up to four stages of high-grade quartz-magnetite-sulfide veining. Bornite is the most abundant sulfide formed during early-stage alteration and correlates well with gold. Moderate- to weak-intensity orthoclase-biotite ± magnetite (potassic) alteration accompanies the inter- and late-mineral intrusions, this alteration being associated with chalcopyrite- and pyrite-rich quartz-orthoclase veins. Propylitic and sodic (albite-pyrite) alteration assemblages are peripheral to, and locally overprint, the potassic alteration. Phyllic alteration is restricted to the margins of late-stage faults. The fluid inclusion assemblage comprises one and two salt-bearing brine inclusions, in addition to aqueous liquid-vapor inclusions of low to moderate salinity. No low-density, vapor-rich inclusions are present, indicating that the fluids from which the quartz veins precipitated did not enter the liquid-vapor field of the H 2O-NaCl system. The brine inclusions undergo final homogenization to liquid via halite dissolution. This phenomenon, in addition to the absence of low-density vapor inclusions, suggests that the mineralizing fluids at Ridgeway were non-boiling hypersaline brines that exsolved directly from the crystallizing magma. The presence of mineralized aplitic vein dikes and comb quartz layering are interpreted to indicate that the early and transitional stages of mineralization at Ridgeway formed at the transition between magmatic and hydrothermal conditions
OGT Glycosylation of Histones in T Cells May Participate in Systemic Lupus Erythematosus
No full textSystemic Lupus Erythematosus (SLE) is a chronic autoimmune disease that primarily affects women. The etiology is not known yet, but genetics and environmental factors trigger the disease. These epigenetic changes modify gene expression and contribute to the development of the disease. It is known that T cells from patients with lupus overexpress genes that may contribute to the onset and progression of the disease. Dr. Gorelik has shown that OGT (O-linked N-acetyl-Glucosamine Transferase), which is an X-linked gene, is overexpressed in women with SLE. OGT adds b-N-acetylglucosamine (O-GlcNAc) to serine and threonine residues of proteins. OGT may play a critical role in chromatin structure by O-GlcNAcylation of histones. Furthermore, O-GlcNAc is considered part of the histone code. The effect of OGT in T cells is unknown, but its overexpression may play a role in T cell dysfunction in lupus. This evidence led us to investigate molecular targets of OGT in T cells, particularly its role in the post-translational modification of histones. This work was done with primary T cells isolated form the peripheral blood of healthy female donors. The cells underwent various treatment and protein expression was analyzed via SDS-PAGE electrophoresis. Our results strongly suggest that H2B is a molecular target of OGT in healthy T cells, and the overexpression of OGT in lupus T cells may increase H2B glycosylation. In consequence, it may also modify chromatin structure, causing changes in gene expression, and may be an epigenetic modulator in lupus, explaining the female preponderance to develop SLE
The Author of a Fictional Slave Advertisement
No full textColson Whitehead’s 2016 novel, The Underground Railroad, describes the adventures of Cora, a runaway slave from a Georgian plantation. Although a historical entity, Whitehead’s railroad deviates from history’s figurative railroad to a physical one. While Whitehead’s interpretation of the underground railroad is divergent from historical fact, he still grounds his work with the inclusion of all but one authentic runaway slave advertisement. My focus within this essay is centered on Whitehead\u27s final advertisement, which is for Cora. In examining the poster and the unique characteristics of Ridgeway (the slave-catcher), Homer (Ridgeway’s companion), Cora, and Terrance Randall (owner of the Georgia plantation), I attempt to determine the author of the final slave advertisement in The Underground Railroad
The aryl hydrocarbon receptor links T(H)17-cell-mediated autoimmunity to environmental toxins
No full textThe aryl hydrocarbon receptor ( AHR) is a ligand- dependent transcription factor best known for mediating the toxicity of dioxin(1). Environmental factors are believed to contribute to the increased prevalence of autoimmune diseases, many of which are due to the activity of T(H)17 T cells, a new helper T- cell subset characterized by the production of the cytokine IL- 17. Here we show that in the CD4(+) T- cell lineage of mice AHR expression is restricted to the T(H)17 cell subset and its ligation results in the production of the T(H)17 cytokine interleukin ( IL)- 22. AHR is also expressed in human T(H)17 cells. Activation of AHR by a high-affinity ligand during T(H)17 cell development markedly increases the proportion of T(H)17 T cells and their production of cytokines. CD4(+) T cells from AHR- deficient mice can develop T(H)17 cell responses, but when confronted with AHR ligand fail to produce IL- 22 and do not show enhanced T(H)17 cell development. AHR activation during induction of experimental autoimmune encephalomyelitis causes accelerated onset and increased pathology in wild- type mice, but not AHR- deficient mice. AHR ligands may therefore represent co- factors in the development of autoimmune diseases
Characterization of lysine demethylase KDM5 family: Substrate specificity and identification of potential novel non-histone substrates
No full textA major regulatory influence over cell biology is lysine methylation and demethylation within histone proteins. The KDM5/JARID1 sub-family are 2-oxoglutarate and Fe(II)-dependent lysine-specific histone demethylases that are characterized by their Jumonji catalytic domains. This enzyme family is known to facilitate the removal of tri-/di-methyl modifications from lysine 4 of histone H3 (i.e., H3-K4me3/2), a mark associated with active gene expression. As a result, studies to date have revolved around KDM5's influence on disease through their ability to regulate H3-K4me2/3. Recently, evidence has demonstrated that KDM5's may influence disease beyond H3-K4 demethylation, making it critical to further investigate KDM5 demethylation of non-histone proteins. In efforts to help identify potential non-histone substrates for the KDM5 family, we developed a library of 180 permutated peptide substrates (PPS), with sequences that are systematically altered from the WT H3-K4me3 sequence. From this library, we characterized recombinant KDM5A/B/C/D substrate preference. Subsequently we developed recognition motifs for each KDM5 demethylase and used them to predict potential substrates for KDM5A/B/C/D. Demethylation activity was then profiled to generate a list of high/medium/low-ranking substrates for further in vitro validation for each of KDM5A/B/C/D. Through this approach, we analyzed prediction success rate and identified 66 high-ranking substrates in which KDM5 demethylases displayed significant in vitro activity towards. We further shown the ability to monitor changes in cellular methylation in a handful of the 66 high ranking candidate substrates in response to KDM5 inhibition. Specifically, we focused validation efforts on a high-ranking KDM5A novel substrate: p53-K370me3. We demonstrated significant recombinant KDM5A(1-588ΔAP) and KDM5A(1-801) activity towards the p53-K370me3 substrate in vitro. We then monitored KDM5A-mediated demethylation of the p53-K370me3/2 substrate in HCT 116 cells using a combination of wild-type KDM5A and inactive-mutant KDM5A(H483A) overexpression plasmids, along with immunoblotting, (co-) immunoprecipitation and mass spectrometry analysis. Furthermore, we have shown that KDM5A expression influences the established p53-53BP1 interaction. Finally, we identified a novel p53-TAF5 interaction dominated through the p53-K370me3 state and how KDM5A expression might affect this interaction. Ultimately, we have provided the first evidence of a KDM5 demethylase targeting a non-histone substrate for demethylation, via the novel KDM5A demethylation of the p53-K370me3 substrate
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