269 research outputs found
The immediate effect of lumbosacral thrust joint manipulation on hip and knee muscle strength and squatting in patients with patellofemoral pain – a randomized, placebo-controlled, clinical trial
No full textPatellofemoral pain syndrome (PFPS) is a persistent, pervasive, disabling musculoskeletal disorder that entails impaired squatting and leg muscle strength that are potentially related to muscle inhibition. There is evidence that lumbosacral thrust joint manipulation (TJM) reduces muscle inhibition and improves muscle strength, but there are discrepancies and deficiencies in the literature regarding the use of lumbosacral TJM to improve squatting and leg strength in patients with PFPS. The study aims are to assess the immediate effect of lumbar TJM on the ability to squat deeper without pain and hip and knee muscle strength in patients with PFPS. The primary research questions were as follows:
1)Does lumbosacral TJM increase hip (extension, abduction and external rotation) muscle strength more than a manual placebo in patients with PFPS?
2)Does lumbosacral TJM increase quadriceps muscle strength more than a manual placebo in patients with PFPS?
3)Does lumbosacral TJM increase pain-free squat depth more than a manual placebo in patients with PFPS?
This prospective, double-blind, randomized controlled clinical trial included a lumbosacral TJM treatment arm and a manual placebo-control arm. In the manipulation group, the within-group changes were significant for hip abduction and external rotation, but not hip or knee extension or pain-free squat range of motion. In the manual placebo group, no within-group changes were significant. The between-group changes were not significant for any outcome. Future research should assess the utility of lumbar TJM as adjunctive treatment to therapeutic exercise for improving these outcomes.Ph.D.Includes bibliographical reference
Remote sensing in civil engineering.
No full textA book written for practising engineers, civil engineers, geologists and surveyors. After an introduction examines; photographic systems, scanning systems, digital processing, applications in civil engineering, topographic mapping, regional planning, site investigations, highway engineering, environmental engineering and water resource engineering. The 11 chapters are separately abstracted in Geographical Abstracts G.-after Author
Pelaksanaan Perjanjian Kerjasama Antara PT. Safari Riau Dengan Koperasi Terantang Jaya Mandiri Di Desa Terantang Manuk Kecamatan Pangkalan Kuras Kabupaten Pelalawan Provinsi Riau
No full textThe agreement is a bond of two or more people who bind themselves to make a cooperation agreement, where the cooperation agreement in question is a cooperation agreement between PT. Safari Riau with the Cooperative Terantang Jaya Mandiri located in Terantang Manuk Village, Pangkalan Kuras District, Pelalawan Regency, Riau Province. The main problem in this study is How is the Implementation of the Cooperation Agreement between the Challenged Cooperative Jaya Mandiri and PT. Safari Riau in Manantang Village, Pangkalan Kuras District, Pelalawan Regency, Riau Province. What are the Obstacles to Debt Repayment from the Jaya Mandiri Mandiri Cooperative to PT. Safari Riau in Manantang Village, Pangkalan Kuras District, Pelalawan Regency, Riau Province. This type of research used in this study is observational research, is by direct surveillance of spaciousness by using the interview method as a data collection tool. While based on its nature this research is descriptive in nature, the writer gives a clear and detailed description. Based on the results of research conducted by the author, that there is one party that broke the promise or default, which agreement they made was in accordance with the terms of the agreement and both parties have signed the cooperation agreement, but in the implementation there is one party that break the promise or default where the broken promise is Kop-TJM, because Kop-TJM does not pay its debt to PT. Safari Riau, and the obstacle to repaying the debt is Kop-TJM feels the calculation of the amount of debt made by PT. Safari Riau is not suitable and they do their own harvesting of Fresh Fruit Bunches (TBS), and they no longer pay their debts to PT. Riau Safari
On finite type invariants of welded string links and ribbon tubes
No full text23 pagesInternational audienceWelded knotted objects are a combinatorial extension of knot theory, which can be used as a tool for studying ribbon surfaces in -space. A finite type invariant theory for ribbon knotted surfaces was developped by Kanenobu, Habiro and Shima, and this paper proposes a study of these invariants, using welded objects. Specifically, we study welded string links up to -equivalence, which is an equivalence relation introduced by Yasuhara and the second author in connection with finite type theory. In low degrees, we show that this relation characterizes the information contained by finite type invariants. We also study the algebraic structure of welded string links up to -equivalence. All results have direct corollaries for ribbon knotted surfaces
The biogeography of the Plastisphere : implications for policy
No full textAuthor Posting. © Ecological Society of America, 2015. This article is posted here by permission of Ecological Society of America for personal use, not for redistribution. The definitive version was published in Frontiers in Ecology and the Environment 13 (2015): 541–546, doi:10.1890/150017.Microplastics (particles less than 5 mm) numerically dominate marine debris and occur from coastal waters to mid-ocean gyres, where surface circulation concentrates them. Given the prevalence of plastic marine debris (PMD) and the rise in plastic production, the impacts of plastic on marine ecosystems will likely increase. Microscopic life (the “Plastisphere”) thrives on these tiny floating “islands” of debris and can be transported long distances. Using next-generation DNA sequencing, we characterized bacterial communities from water and plastic samples from the North Pacific and North Atlantic subtropical gyres to determine whether the composition of different Plastisphere communities reflects their biogeographic origins. We found that these communities differed between ocean basins – and to a lesser extent between polymer types – and displayed latitudinal gradients in species richness. Our research reveals some of the impacts of microplastics on marine biodiversity, demonstrates that the effects and fate of PMD may vary considerably in different parts of the global ocean, and suggests that PMD mitigation will require regional management efforts.This work was supported by a US National Science
Foundation (NSF) collaborative grant to LAA-Z
(OCE-1155571), ERZ (OCE-1155379), and TJM
(OCE-1155671), and was partially funded by an NSF
TUES grant (DUE-1043468) to LAA-Z and ERZ, and
by the Richard Saltonstall Charitable Foundation to
TJM. GP was funded through the OCE-1155379 grant
and assisted with identification of plastic resins via
ATR-FTIR
Co-movement of astral microtubules, organelles and F-actin by dynein and actomyosin forces in frog egg cytoplasm
No full text© The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Pelletier, J. F., Field, C. M., Furthauer, S., Sonnett, M., & Mitchison, T. J. Co-movement of astral microtubules, organelles and F-actin by dynein and actomyosin forces in frog egg cytoplasm. Elife, 9, (2020): e60047, https://doi.org/10.7554/eLife.60047.How bulk cytoplasm generates forces to separate post-anaphase microtubule (MT) asters in Xenopus laevis and other large eggs remains unclear. Previous models proposed that dynein-based, inward organelle transport generates length-dependent pulling forces that move centrosomes and MTs outwards, while other components of cytoplasm are static. We imaged aster movement by dynein and actomyosin forces in Xenopus egg extracts and observed outward co-movement of MTs, endoplasmic reticulum (ER), mitochondria, acidic organelles, F-actin, keratin, and soluble fluorescein. Organelles exhibited a burst of dynein-dependent inward movement at the growing aster periphery, then mostly halted inside the aster, while dynein-coated beads moved to the aster center at a constant rate, suggesting organelle movement is limited by brake proteins or other sources of drag. These observations call for new models in which all components of the cytoplasm comprise a mechanically integrated aster gel that moves collectively in response to dynein and actomyosin forces.This work was supported by NIH grant R35GM131753 (TJM) and MBL fellowships from the Evans Foundation, MBL Associates, and the Colwin Fund (TJM and CMF). JFP was supported by the Fannie and John Hertz Foundation, the Fakhri lab at MIT, the MIT Department of Physics, and the MIT Center for Bits and Atoms
Mortality From Falls in Dutch Adults 80 Years and Older, 2000-2016
No full textFalls are a leading cause of health care consumption, morbidity, and mortality among older adults.1,2 Falls mortality in persons 80 years and older in the Netherlands decreased from 1969 through 1999, and then slightly increased from 2000 through 2008.3 We assessed trends in falls mortality in persons 80 years and older from 2000 through 2016.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Applied Ergonomics and Desig
Current laboratory requirements for adrenocorticotropic hormone and renin/aldosterone sample handling are unnecessarily restrictive.
No full textThis is the author accepted manuscript. The final version is available from the publisher via the DOI in this record.Samples for adrenocorticotropic hormone (ACTH) and aldosterone/renin analysis usually require rapid transport to the receiving laboratory for immediate separation and freezing. In practice, this means assessment is limited to hospital settings and many samples are rejected. We examined whether these requirements are necessary by assessing the stability of ACTH, aldosterone and renin over 48 hours in whole blood collected in serum gel and EDTA plasma from 31 participants. Our results show that ACTH collected into EDTA plasma is stable at room temperature for at least 6 hours, mean change at 6 hours -2.6% (95% CI -9.7 to 4.5). Both aldosterone and renin were stable collected on serum gel at room temperature for at least 6 hours: mean change aldosterone +0.2% (95% CI -3.6 to 4.0), renin -1.9% (95% CI -7.0 to3.2). Therefore, by using appropriate preservatives, ACTH and aldosterone/renin can be measured on samples collected at room temperature and processed within 6 hours. This would facilitate outpatient and emergency room assessment of these analytes.This project was funded by the Royal Devon and Exeter NHS
Foundation Trust NIHR Small Grant Scheme and by the Exeter NIHR
Clinical Research Facility. AGJ was an NIHR doctoral research fellow
and is an NIHR clinician scientist. TJM is an NIHR CSO fellow. BAK is
a core staff member of the NIHR Exeter Clinical Research Facility
Serum snoRNAs as biomarkers for joint ageing and post traumatic osteoarthritis
No full text\ua9 2017 The Author(s). The development of effective treatments for the age-related disease osteoarthritis and the ability to predict disease progression has been hampered by the lack of biomarkers able to demonstrate the course of the disease. Profiling the expression patterns of small nucleolar RNAs (snoRNAs) in joint ageing and OA may provide diagnostic biomarkers and therapeutic targets. This study determined expression patterns of snoRNAs in joint ageing and OA and examined them as potential biomarkers. Using SnoRNASeq and real-time quantitative PCR (qRT-PCR) we demonstrate snoRNA expression levels in murine ageing and OA joints and serum for the first time. SnoRNASeq identified differential expression (DE) of 6 snoRNAs in young versus old joints and 5 snoRNAs in old sham versus old experimental osteoarthritic joints. In serum we found differential presence of 27 snoRNAs in young versus old serum and 18 snoRNAs in old sham versus old experimental osteoarthritic serum. Confirmatory qRT-PCR analysis demonstrated good correlation with SnoRNASeq findings. Profiling the expression patterns of snoRNAs is the initial step in determining their functional significance in ageing and osteoarthritis, and provides potential diagnostic biomarkers and therapeutic targets. Our results establish snoRNAs as novel markers of musculoskeletal ageing and osteoarthritis
Not all nitrogen is created equal: differential effects of nitrate and ammonium enrichment in coastal wetlands
No full text© The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Bowen, J. L., Giblin, A. E., Murphy, A. E., Bulseco, A. N., Deegan, L. A., Johnson, D. S., Nelson, J. A., Mozdzer, T. J., & Sullivan, H. L. Not all nitrogen is created equal: differential effects of nitrate and ammonium enrichment in coastal wetlands. Bioscience, 70(12), (2020): 1108-1119, doi:10.1093/biosci/biaa140.Excess reactive nitrogen (N) flows from agricultural, suburban, and urban systems to coasts, where it causes eutrophication. Coastal wetlands take up some of this N, thereby ameliorating the impacts on nearshore waters. Although the consequences of N on coastal wetlands have been extensively studied, the effect of the specific form of N is not often considered. Both oxidized N forms (nitrate, NO3−) and reduced forms (ammonium, NH4+) can relieve nutrient limitation and increase primary production. However, unlike NH4+, NO3− can also be used as an electron acceptor for microbial respiration. We present results demonstrating that, in salt marshes, microbes use NO3− to support organic matter decomposition and primary production is less stimulated than when enriched with reduced N. Understanding how different forms of N mediate the balance between primary production and decomposition is essential for managing coastal wetlands as N enrichment and sea level rise continue to assail our coasts.This work was supported by the following funding sources: National Science Foundation (NSF) grant no. DEB 1902712 to LAD, JLB, DSJ, and TJM; NSF grant no. DEB 1902695 to AEG; NSF grant no. DEB 1902704 to JAN; NSF grant no. DEB 1354214 to TJM; NSF grant no. DEB 1350491 to JLB; NSF grant no. OCE 1637630 to AEG and LAD; and additional funding from the Dorr Foundation, the Department of the Interior Northeast Climate Science Center (grant no. DOI G12AC00001), and a Bullard Fellowship (Harvard University) to LAD and from the National Academies of Science, Medicine, and Engineering Gulf Research Program to JAN. Resources purchased with funds from the NSF Biological Field Stations and Marine Laboratories program (grant no. DBI 1722553, to Northeastern University) were used to generate the data for the manuscript. Initial conversations on the effects of nutrient enrichment in marshes with Scott Warren and Bruce Peterson were critical in informing the work described in the manuscript. Sam Kelsey and Jane Tucker contributed to much of the N cycling biogeochemistry; Caitlin Bauer, Frankie Leach, Paige Weber, Emily Geoghegan and Sophie Drew assisted with field work; and Joe Vineis assisted with metagenomic analysis. This is contribution 3941 from the Virginia Institute of Marine Science. The data were compiled from multiple published sources. Links to published data can be found here: https://pie-lter.ecosystems.mbl.edu/data. The sequence data used to derive figure 6 are publicly available on the MG-RAST website under project number mgp84173
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