1,720,964 research outputs found
FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLETS OF PYRIMETHAMINE
No full textBackground: Toxoplasmosis is an opportunistic infection. It is caused by Toxoplasma gondii, which affects the eye, central nervous system and other body systems. It is common in paediatric, geriatric, and patients who are immune-compromised. It results from poor hygiene and improper handling of cats\u27 faeces. Objectives: The treatment of toxoplasmosis typically involves pyrimethamine with folinic acid and other supportive agents. In the current research project, ODT formulations of pyrimethamine have been formulated in three types, namely C1, C2, and C3. These three formulations differ from one another based on the kind of disintegrants used. Methodology: The direct compression method was used for formulating the ODT. Different parameters of the formulated product were studied in its three formulations, C1, C2, and C3. Pre-compression evaluation, including FTIR spectroscopy and other methods, was conducted. Post-compression evaluation, including content assay, dissolution, and stability profile under ambient conditions, was monitored. Results: All official tests complied with the orodispersible tablet specifications outlined by the British Pharmacopoeia (B.P.) and the United States Pharmacopoeia (USP). However, notable differences were observed among the three formulations—C1, C2, and C3 in specific evaluated parameters, indicating variability in performance depending on the formulation components. Conclusion: The use of different disintegration agents resulted in slight variations in tablet behavior. Nevertheless, all formulations met key orodispersible criteria and demonstrated favorable characteristics for patient compliance, particularly for individuals with swallowing difficulties
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Pharmacological evaluation of novel dimers of an arylpropionic acid class of non-selective cyclooxygenase inhibitors
No full textCareer preferences and attitude of first year Doctor of Pharmacy students toward pharmacy profession
No full textObjectives: To evaluate first year Doctor of Pharmacy (PharmD) students′ career preferences, factors involved in this selection, and attitude toward pharmacy profession.
Materials and Methods: First year PharmD students enrolled at University of Peshawar were surveyed through administration of predesigned questionnaire. The anonymous questionnaire sought students′ opinions on the factors influencing their career preferences, attitude and knowledge of pharmacy profession, and importance of pharmacy profession in healthcare system.
Results: Overall response rate was 93.5%. Of the total 73 respondents, 38 (54.9%) were males and 35 (45.1%) were females. Only 12 (16.4%) students were aware of the scope of pharmacy before admission to the pharmacy program. A majority of the students (82%) believed that pharmacy education and practice affect the healthcare system. Very limited numbers of the students (16.4%) were interested in research, while the remaining students were either uninterested (69.8%) or unsure about their decision (13.6%). A significant number of students (61.6%) were unaware of different postgraduate prospects of pharmacy education. More than half of the students (58.9%) wished to undertake nonpharmacy career areas upon graduation. Drug regulation was opted as preferred career choice by 21 (28.7%) students, clinical pharmacy by 18 (24.6%), hospital pharmacy by 11 (15%), and teaching by 8 (10.5%). Factors involved in such selection were family influence (34.2%), anticipated income (24.6%), and personal interest (21.9%).
Conclusions: First year PharmD students showed keen interest to choose drug regulation, clinical pharmacy, and hospital pharmacy as a career upon graduation. Family influence was the most important factor involved in this selection. Few of them were interested in pharmacy-related research activities while most of the students believed that pharmacy education and practice affect the healthcare system
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