172 research outputs found
Molecular insights to explore abietane diterpenes as new LOX inhibitors
No full textLipoxygenase (LOX) inhibitors are well known for their anti-inflammatory effects derived from both natural products and synthetic sources. Taxus wallichiana Zucc is traditionally used in the treatment of various diseases including inflammation. In a recent study, it was used to conduce the isolation of the bioactive compounds from Taxus wallichiana Zucc. thanks to its ethnopharmacological use in diseases including inflammation. Phytochemical studies lead to the isolation of abietane diterpenoids, namely Taxusabietane C (TC) and Taxamairin F (TF). Test compounds showed significant LOX inhibitory effects. IC50 values of TC and TF were 69 +/- A 0.31 and 73 +/- A 0.14 mu M, respectively. The standard compound Baicalein and Tenidap sodium showed the IC50 value being 22.1 +/- A 0.03 and 41.6 +/- A 0.02 mu M. Significant LOX inhibitory activities were supported by a molecular docking simulation to explore molecular interactions of the compounds with the active (catalytic) site of LOX
Kami 8: SI+SA Exhibition: visualization of experience and comprehension in an artwork / Nur Adibah Nadiah Mohd Aripin, Sharifah Raudzah Syed Mahadi and Mohd Fawazie Arshad
No full textSI+SA exhibition provided an opportunity and platform to the artists especially those who are also academicians to participate. It was an impactful exhibition both to the artists and the general public. Through visuals generated based on experience and comprehension, the artists were able to express themselves in their artwork which were closely related to two locations namely SI (Seri Iskandar), Perak + SA (Shah Alam), Selangor. The difference in locations was not a constraint for the artists to keep abreast of the current local art industry development. In fact, the distance provides an opportunity to stay ahead in the industry. Experience can be classified as a surge of idea for the artist to begin his step in producing artwork. Hence, experience does not only revolve around life events, but it also related to a social category as well as aesthetic element of art. It is the beginning of a complete production process according to the artists’ idea. From an observation on the SI+SA exhibition most artists produced artwork based on their experience, related to the main location selected. Analysis was made based on categories of visuals and artwork description that was inclusive of the artwork’s underlying meaning. Several artwork from SI+SA exhibition were made as references according to their categories. Visualising experience is not an easy task since the public’s understanding can be very subjective as it comes from different perspectives. Nevertheless, such understanding has a huge impact on an artwork’s appreciation
Synthesis, Identification, and Characterization of a Novel 1,2,5-Selenadiazole Derivative as a Microtubule Targeting Agent That Overcomes Multidrug Resistance
No full textABSTRACTMicrotubules are crucial for various cellular processes, including cell division, where they form highly dynamic spindle fibers for chromosomal alignment and segregation. Interference with microtubule dynamics through microtubule targeting agents (MTAs) blocks progression through mitosis, ultimately resulting in apoptosis. Although MTAs have been effectively used as a frontline treatment for various cancers, multidrug resistance (MDR) often limits their effectiveness. This study focuses on selenadiazoles, a group of organic selenium compounds with anticancer activities. Eighteen novel 1,2,5-selenadiazole derivatives were synthesized, three of which (9d, 9f, and 9i) showed potent antiproliferative activity in HCT116 colorectal cancer cells. Treatment of cells with 9f (SSE1706), one of the most potent compounds (GI50 value of 1.89 ± 0.99 µM), disrupted mitotic spindle formation, leading to G2/M arrest. 9f inhibited microtubule polymerization in cell-based assays, and long-term treatment with 9f stabilized p53 and induced apoptosis. Moreover, 9f effectively inhibited the growth of mouse and human colon cancer-derived organoids. Finally, 9f exhibited potent antiproliferative activity against MDR-1 overexpressing KB-V1 cells, highlighting its potential to overcome MDR. These findings suggest 9f as a lead compound for further optimization studies, particularly targeting MDR.This study received support from two Faculty Initiatives Fund grants (FIF-842) and (FIF-406) awarded by the Lahore University of ManagementSciences (LUMS) to Rahman Shah Zaib Saleem and Amir Faisal, respectively. Further support came from the Pakistan Science Foundation grant PSF/Res/P-LUMS/Chem (617) which was also awarded to Rahman Shah Zaib Saleem and Amir Faisal.This study received support from two Faculty Initiatives Fund grants(FIF-842) and (FIF-406) awarded by the Lahore University of Management Sciences (LUMS) to Rahman Shah Zaib Saleem and AmirFaisal, respectively. Further support came from the Pakistan ScienceFoundation grant PSF/Res/P-LUMS/Chem (617) which was alsoawarded to Rahman Shah Zaib Saleem and Amir Faisa
Women’s figure in the works of the exhibition of SI + SA / Mohamad Quzami An-Nuur Ahmad Radzi... [et al.]
No full textSome artist implemented women figure as their main subject matter in their artwork. Women figures carried message in different ways. However, it will be based on overall art exhibition theme. The target audience also must be studied before doing any artwork especially when working with women figure. Past research stated, past artists had manipulated women figure in their artwork. They had used women figure as main subject matter follow with supporting element and visuals. In this paper, researchers had studied past literature on implemented of women figure on the artwork and discussed the artwork for Si+Sa exhibition at Shah Alam Gallery, Selangor, Malaysia
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The Shi'a Muslims of the United Provinces of India, c 1890-1940
No full textThis dissertation examines religious, social and political change among the Shia
Muslims of the United Provinces of colonial India, c. 1890-1940. Focusing especially,
upon the towns of Lucknow and Amroha but discussing the region as a whole, it traces
the formation of a community identity among Shia Muslims, and questions how
disparate Shi'a populations were able to construct a consciousness of solidarity. The
dissertation is based on a combination of archival and printed sources in English and
Urdu.
The first chapter assesses processes of sectarian organisation and the formation of a
number of Shia institutions and societies in Lucknow in the thirty year period from
1890, including several madrasas and the All India Shi'a Conference. The second chapter
examines manifestations of religious renewal among Indian Shi'as. Forms of religious
proselytisation are discussed, particularly the contribution of the printing press and the
changing role of preaching. The development of religious conflict is outlined, through
examinations of religious debates and the reformation of Muharram rites.
A third chapter examines Shia responses to the so-called '`Aligarh movement',
considering reactions to educational reform and the Muhammadan Anglo-Oriental
College at `Aligarh. A fourth chapter discusses Shia responses to the campaigns of jihad
and pan-Islamism current among many Muslims in the early twentieth century. Together,
these two chapters demonstrate the expansion and politicisation of sectarian differences,
and the attempts by some Shi'as to organise separately from wider Muslim institutions.
The final chapter assesses a series of Shi'a-Sunni conflicts in Lucknow in the 1930s. It
examines some of the contributory factors and discusses the conflicts in the light of the
processes of sectarian organisation discussed in earlier chapters. The conclusion
evaluates the implications of the thesis for our understanding of Indian Shia Muslims
and, more generally, of sectarian identities and conflicts in Indian Islam
Value Relevance of Firm Specific Corporate Governance and Macroeconomic Variables: Evidence from Karachi Stock Exchange
No full textThis study examines the value relevance of firm specific corporate governance and macroeconomic variables of public listed non-financial companies in Karachi stock exchange (KSE) and also answers how a firm can increase its value relevance by incorporating most value relevant drivers in their financial management systems. The sample of the study is drawn by stratified systematic sampling technique to capture most representative sample on the basis of market capitalization. A total 12 years secondary data from 2000 to 2011 is used as the study period. This time frame is chosen because the Securities and Exchange Commission of Pakistan (SECP) issued corporate governance code in year 2002; moreover this time frame also covers the mandatory adoption of International Financial Reporting Standards (IFRSs) in 2005. The results of the study found that book value, earnings per share; quality corporate governance and real gross domestic product growth rate significantly determine the stock price. But the regression coefficients of inflation and money supply are statistically insignificant. The study also found that there is a positive and significant impact of the issuance of code of corporate governance and mandatory adoption of IFRSs on the value relevance of book value and earnings. This implies that the relevance of published financial statement has been increased for the investors
Value relevance of firm specific corporate governance and macroeconomic variables: Evidence from Karachi stock exchange
No full textThis study examines the value relevance of firm specific corporate governance and macroeconomic variables of public listed non-financial companies in Karachi stock exchange (KSE) and also answers how a firm can increase its value relevance by incorporating most value relevant drivers in their financial management systems. The sample of the study is drawn by stratified systematic sampling technique to capture most representative sample on the basis of market capitalization. A total 12 years secondary data from 2000 to 2011 is used as the study period. This time frame is chosen because the Securities and Exchange Commission of Pakistan (SECP) issued corporate governance code in year 2002; moreover this time frame also covers the mandatory adoption of International Financial Reporting Standards (IFRSs) in 2005. The results of the study found that book value, earnings per share; quality corporate governance and real gross domestic product growth rate significantly determine the stock price. But the regression coefficients of inflation and money supply are statistically insignificant. The study also found that there is a positive and significant impact of the issuance of code of corporate governance and mandatory adoption of IFRSs on the value relevance of book value and earnings. This implies that the relevance of published financial statement has been increased for the investors
Colour psychology in a Malay feminine artist installation: her emotion towards colour shades / Nor Idayu Ibrahim ... [et al.]
No full textThis research paper is a part of an art appreciation for the Sri Iskandar and Shah Alam Art Exhibition recently, that only focus on Miss Salawati oeuvre entitle Warna-warna Kehidupan. This research emphasize on the colour psychology in A Malay feminine artist installation. In another way, colour of an object in daylight is intuitively regarded as one of its physical characteristics, and human brain realign for the condition of illumination whenever the correction is necessary and possible. We are surrounded by colour for every single tiny things. There are few things in design that are more subjective, even more important than the use of colour. Implementing the right choice of colour can evoke one reaction of a person may arouse another opposite reaction. Colour bring major message and personality from the person itself or by the observers. It’s used for decorative elements since long time ago. The colour prism found by Sir Isaac Newton in a beam of sunlight portray seven solar spectrum, they are red, orange, yellow, green, blue, indigo, and violet. This colour dispersion form a spectrum similar to seven colours of rainbow. This research aim to discuss on the feminine artist emotion portray towards her oeuvre. That lays in a mother and daughter bonding; as a research theme. In a nut shell, researcher found that artist tend to play around in three colour shades, they are lively shades, sentimental shades and sombre shades. Overall, this research will provide an invaluable source of information about Malay feminine artist psychology that will benefited to the local art
scene and many art critics that subject to the feminine artist personality
Does Bilateral Market and Financial Integration Explains International Co-Movement Patterns1
No full textThis study aims to explore the relationship between market integration, foreign portfolio equity holding and inflation rates on international stock market linkages between Pakistan and India. To measure stock equity interlinkage, we constructed international co-movement index through rolling beta estimation. Market integration variable between these two countries is constructed using the International Capital Asset Pricing Model (ICAPM). To check the impact of market integration, foreign portfolio equity holding and inflation rate on Pakistan-Indian stock market co-movement, we applied autoregressive distributed lag (ARDL) estimation. ARDL estimation is applied due to different stationarity levels of the included variables. The level of convergence speed is measured by the introduction of error correction term (ECT) followed by variance decomposition analysis. Results of the study indicated presence of long term relationship among the included variables along with significance variance in bilateral co-movement due to inflation rate differential. The significance of inflation rate differences between these two countries are in accordance with portfolio balance theory stating that investors possess information about the macroeconomic variables thereby readjusting their portfolios for effective diversification
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