605 research outputs found
Estimating Passenger Car Equivalent Factors for Heterogeneous Traffic Using Occupancy-Density Linear Regression Model
No full textA variety of methods have been proposed in the existing literature for the estimation of passenger car equivalent (PCE) factors. These methods are based on the comparison of selected attributes of different vehicles. This research, for the first time, utilizes the basic notion of the linear relationship between road area occupancy and density for the estimation of PCE factors for different vehicle types in heterogeneous traffic. Aerial photographs obtained from an unmanned aerial vehicle (UAV) were analyzed to estimate the road area occupancy and the number of vehicles classified in seven selected groups. A linear least-squares regression model was developed between road area occupancy and classified vehicle count. The coefficients of the occupancy-density linear regression model were used to estimate PCE and motorcycle equivalent (MCE) factors. The comparison of the estimated set of PCE values with the values reported in the literature shows that PCE factors estimated using the proposed method are reasonable and produce a better occupancy-density relationship than the other studies. In comparison with the existing methods that rely on lane-based measurements, the proposed method is well suited for traffic with weak/no lane discipline, as it considers the entire road width and the dynamics of lateral movement of different types of vehicles. The proposed method does not need extensive traffic data of speeds, headways, flow rates, and so forth, and is applicable on aerial photographs obtained from other sources, such as satellites.Funding
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research was supported with funding from Exascale Open Data Analytics Lab, National Center for Big Data and Cloud Computing (NCBC) and the Higher Education Commission of Pakistan.
Acknowledgments
The authors are thankful to research students Syed Hassan Ali, Haseeb Ahmed, Zohaib Ahmed, Aqib Abbasi, Asad Rehan, Mirza Ali Haider, Syed Abbas Hasan Zaidi, and Omema for their help in this research
sj-docx-1-onc-10.1177_11795549221084832 – Supplemental material for Body Mass Index and Diabetes Mellitus May Predict Poorer Overall Survival of Oral Squamous Cell Carcinoma Patients: A Retrospective Cohort From a Tertiary-Care Centre of a Resource-Limited Country
No full textSupplemental material, sj-docx-1-onc-10.1177_11795549221084832 for Body Mass Index and Diabetes Mellitus May Predict Poorer Overall Survival of Oral Squamous Cell Carcinoma Patients: A Retrospective Cohort From a Tertiary-Care Centre of a Resource-Limited Country by Yumna Adnan, Syed Muhammad Adnan Ali, Muhammad Sohail Awan, Nida Zahid, Muhammad Ozair Awan, Hammad Afzal Kayani and Hasnain Ahmed Farooqui in Clinical Medicine Insights: Oncology</p
sj-docx-2-npx-10.1177_1934578X211031148 - Supplemental material for Antileishmanial Potential of Berberine Alkaloids From <i>Berberis glaucocarpa</i> Roots: Molecular Docking Suggests Relevant <i>Leishmania</i> Protein Targets
No full textSupplemental material, sj-docx-2-npx-10.1177_1934578X211031148 for Antileishmanial Potential of Berberine Alkaloids From Berberis glaucocarpa Roots: Molecular Docking Suggests Relevant Leishmania Protein Targets by Muhammad Alamzeb, Saqib Ali, Mamoon-Ur-Rashid, Behramand Khan, Ihsanullah, Adnan, Muhammad Omer, Asad Ullah, Javed Ali, William N. Setzer, Syed M. Salman, Ajmal Khan and Akram Shah in Natural Product Communications</p
sj-docx-1-npx-10.1177_1934578X211031148 - Supplemental material for Antileishmanial Potential of Berberine Alkaloids From <i>Berberis glaucocarpa</i> Roots: Molecular Docking Suggests Relevant <i>Leishmania</i> Protein Targets
No full textSupplemental material, sj-docx-1-npx-10.1177_1934578X211031148 for Antileishmanial Potential of Berberine Alkaloids From Berberis glaucocarpa Roots: Molecular Docking Suggests Relevant Leishmania Protein Targets by Muhammad Alamzeb, Saqib Ali, Mamoon-Ur-Rashid, Behramand Khan, Ihsanullah, Adnan, Muhammad Omer, Asad Ullah, Javed Ali, William N. Setzer, Syed M. Salman, Ajmal Khan and Akram Shah in Natural Product Communications</p
The Significance of Androgen Receptor in Oncogenesis and Cancer Treatment: Emphasis on Oral Squamous Cell Carcinoma
No full textThe androgen receptor (AR) is a transcription factor that is dependent upon ligand activation and is a member of the nuclear receptor superfamily. AR has been found to have a role in cancers of the prostate, breast, ovarian, nasal cavity, and lung. It has been seen that AR plays a significant role in both the early and later stages of prostate cancer as AR is expressed in almost every primary prostate cancer. An evolving prognostic and therapeutic role of AR also exists in breast cancer as increased expression of AR has been linked to improved survival. In the case of OSCC, the role of hormonal therapy as a prognostic marker remains to be explored. Some reports have failed to identify the expression of AR in oral cavity cancers or any significant associations, while others have predicted AR-expressing tumours to have a worse prognosis. This review narrates the current research on AR and how it can be applied in future research
Conflict of law and the methodology of Tarjīẖ : a study in Islamic legal theory
No full textIslamic law never achieved unity but expressed itself in, at least, four surviving schools. More interestingly, contemporary Muslim communities are still divided among themselves on a number of issues related to their laws. This work describes how problem of legal conflicts have been tackled by Muslim jurists. It is an attempt to examine closely the phenomenon of conflict in Islamic law from the standpoint of usūl-al-fiqh or Islamic legal theory. In fact, much is heard nowadays of the contradiction in the body of Islamic law. Whilst in contrast, little is presented in terms of the methodology of removing this conflict. The present work therefore, attempts to redress this balance. The emphasis of the work will be concerned primarily with tarjīh methodology ; how to give preference to one piece of evidence or argument over the other when they conflict. Nevertheless, considerable concern is given to investigating the background to the conflict of law in the Shari'ah.
This study of a neglected area in Islamic legal scholarship will be an important source of reference to students, both practising and theoretical jurists or to anyone who merely wishes to increase his knowledge of legal themes, particularly legal conflict. The very aim of the work is to argue that conflict is a natural and unavoidable consequence of legal study because legal conflict is only conflicting principles and arguments adduced by both the classical and modern jurists to reach what is actually intended by God in the target case. Therefore, conflicts are inevitable in most of the cases in fiqh owing to the variety of principles set out to deal with one piece of legal evidence, let alone with all the pieces of legal evidence in question.
Tarjīh is therefore, an important and workable instrument in the re-examination of these conflicts and in arriving at the most accurate principle for establishing the law for as long as this is possible. It is hoped that the discovery of new facts and the increase of knowledge which results from the broadening and deepening of the research will positively contribute to the process of unification of Islamic law
Microbial biotransformation of male specific pheromone α-copaene with cunninghamella elegans and antibacterial activity of its transformed products / Syed Adnan Ali Shah ... [et al.]
No full textPharmaceutical industries are increasingly turning to microbial transformation instead of chemical methods. This is because microbial biotransformation is a more effective way to produce pharmacologically active molecules with high specificity and efficient yield. Additionally, it is a step towards eco-friendly synthesis. α-Copaene (1), a tricyclic sesquiterpene, is a potent attractant of the male Mediterranean fruit fly Ceratitis capitata. This paper presents the utilization of the filamentous fungus Cunninghamella elegans TSY 0865 for large-scale biotransformation of 1. α-Copaene (1) has been incubated with Cunninghamella elegans for 11 days and extracted with CH 2 Cl 2 . Four new hydroxylated metabolites 10,13-dihydroxycopaene (2); 11,13-dihydroxycopaene (3); 11-hydroxycopaen-5-one (4); and 11-hydroxy-13-copaenic acid (5) were afforded. The structures of the new metabolites were elucidated by 1D ( 1 H, 13 C) and 2D NMR (COSY, HMBC, HMQC, and NOESY) techniques and MS analyses. Metabolite 5 exhibited significant antibacterial activity against Bacillus subtilis and Pseudomonas aeruginosa
A reappraisal of attitudes to the 'People of the Book' in the Qur'an and hadith, with particular reference to Muslim fiscal policy and the covenant of 'Umar
No full textEThOS - Electronic Theses Online ServiceGBUnited Kingdo
Profit-Sharing Deposit Accounts in Islamic Banking: Analysing the Perceptions and Attitudes of the Malaysian Depositors
No full textIslamic banking deposits are fundamentally structured in a different way than the conventional banking deposits. Each type of Islamic banking deposits, such as savings, demand, and timed deposits, is devised using the approved Shari’ah contracts such as qard, wadiah, murabahah, and mudarabah. These contracts are opposed to the conventional concepts, as they are based on the concept of a ‘lender-borrower’ relationship. In addition, the Shari’ah-approved contracts are unique as they feature a different nature of risk and return. This is especially the case for mudarabah contracts (henceforth referred to as profit-sharing contracts). The uniqueness of profit-sharing contracts in deposit products has been given due recognition in theory and also in practice, as most of the Islamic banks in Malaysia offered this product. In addition, the unique features and characteristics of profit-sharing based deposit accounts are also highlighted in the prudential standards issued by prominent regulatory bodies such as AAOIFI and IFSB which, have been adopted by the Bank Negara Malaysia (Central Bank of Malaysia).
Nevertheless, it is argued by many Islamic banks practitioners, especially in Malaysia, that the concept of profit-sharing in deposits products is not practical in reality, because the depositors do not behave according to, nor accept the principles that have been laid down in the Shari’ah. Thus it is argued that both the depositors and the Islamic bankers have treated the product similar to any other conventional banking deposits products.
The main aim of this study, hence, is to explore and examine the level of awareness, knowledge, perceptions, and attitude of the Islamic banking depositors in Malaysia towards characteristics of profit-sharing deposits accounts in accordance with the fundamental Shari’ah principles but also the regulations prevailing. In addition, this research also attempts to explore the significant determinant factors that encourage the depositors to engage with Islamic banking deposits accounts in general and profit-sharing deposits accounts in particular.
In fulfilling the aim of the study, primary data collection research was adopted through a survey questionnaire technique. The questionnaires were distributed to eight Islamic banks representing various types of Islamic banks in Kuala Lumpur and Selangor. The questionnaire asked various pertinent questions, which intended to elicit the depositors’ opinions, perceptions, and attitudes towards the unique characteristics of profit-sharing contract as specified in Shari’ah muamalah principles. The characteristics among others are: (i) concept of uncertain deposits returns; (ii) concept of non-guarantee for the deposits; (iii) concept of profit equalization reserve. A total 649 of the returned questionnaires were complete and fit for analysis purpose. The data were analysed using various statistical analysis techniques ranging from simple frequency distribution analysis to the more advanced analyses such as non-parametric statistical analysis, factor analysis, and logistic regression.
In general, the results of the study show that the level of awareness of the need to have Islamic banking deposits accounts because of religious reasons is considered as high among the Malaysian depositors. Nevertheless, the results also indicate that a high level of awareness is not being translated into a high level of understanding concerning the objectives of the products which are structured in accordance to the Shari’ah-compliant contracts. This can be seen in the major findings of this study: the characteristics of profit-sharing contracts, which arguably are the most desirable Shari’ah-compliant contracts, are not acceptable to the depositors. This indirectly implies that they are still strongly influenced by the nature of conventional banking products. In addition, the logistics regression results further proved that related factors (‘financial services’ and ‘income’) emerged as the main determinants in creating demand for profit-sharing deposits accounts.
The results of the research should draw the attention of the Islamic bankers and also the regulators to finding ways for improving the level of understanding among the depositors. However, the critical successful factor in educating the depositors is highly dependent on the level of knowledge exhibited by the Islamic bankers themselves, which can be a real concern as highlighted by the findings of this study
Hormone receptors AR, ER, PR and growth factor receptor Her-2 expression in oral squamous cell carcinoma: Correlation with overall survival, disease-free survival and 10-year survival in a high-risk population
No full textOral squamous cell carcinoma (OSCC) comprises most of head and neck neoplasms and is one of the highest-ranking and lethal cancers in Pakistan due to prevailing mouth habits. Growth and hormonal receptors act as prognostic markers and targets for therapy in some cancers, but their application in OSCC is largely unexplored. This study aimed to evaluate the expression of growth and hormonal receptors in OSCC patients and correlate it with 10-year, overall and disease-free survival. To achieve this objective, immunohistochemistry for Her-2, AR, ER and PR was performed on 100 formalin-fixed paraffin-embedded primary OSCC specimens. Receptor expression was correlated with mouth habits and clinicopathological features and patient survival was analyzed using Kaplan-Meier method and Cox regression univariate analysis. We observed that in 100 patients, there were 57 males and 43 females. Immunopositive Her-2 expression was observed in 21% of patients, AR in 13%, ER in 3% and 0% for PR. Patients with betel quid/areca nut mouth habits had significantly absent Her-2 expression (P=0.035). Also, Her-2 negative patients were also negative for AR expression (P=0.002). Her-2 positive patients had poor 10-year survival (P=0.041). A trend of low survival and high recurrence rate was observed in AR positive patients, but this was not significant (P=0.072). No statistically relevant correlations were seen in the case of ER and PR. In conclusion, Her-2 may be a valuable marker for predicting long-term prognosis of OSCC patients.README file provided with this dataset details the descriptions for the dataset files and all the variables included in the files.Funding provided by: Higher Education Commision, PakistanCrossref Funder Registry ID: http://dx.doi.org/10.13039/501100010221Award Number: 9516/Sindh/NRPU/R&D/HEC/2017Data of 100 OSCC patients was collected retrospectively from patient medical records and subsequent follow-up visits at clinics. Patient demographics, risk factor usage history, clinical characteristics and survival were correlated with experimental data (biomarker expression). Overall survival (OS) (minimum follow up 60 months) and 10-year survival (minimum follow up 120 months) was taken as number of months from diagnosis until last follow-up (if alive) or date of death (if dead). Disease-free survival (DFS) was calculated as the number of months starting from surgery until date of recurrence or if no recurrence then until last follow-up (if alive) or date of death. SPSS version 19 (IBM, USA) was used for statistical analysis. Statistical tests included chi-square, Fisher's Exact test, logistic regression, Kaplan-Meier analysis and cox regression univariate analysis
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