44 research outputs found
Role of folic acid supplementation in level of c-reactive protein in metabolic syndrome : evidence based case report
No full textIntroduction: The prevalence of metabolic syndrome is increasing, its progression involves an inflammatory response that has an important impact on the initiation, progressivity, and complications of several diseases such as heart disease, stroke, type 2 diabetes mellitus, and cancer. C-reactive protein (CRP) is one of the inflammation markers increased in patients with metabolic syndrome. Folic acid has a role in metabolizing homocysteine and improving endothelial function. There have been many studies conducted, but the results are still inconsistent.
Method: Literature searching was conducted using PubMed, Cochrane Library, and Embase databases. MeSH terms, advanced search and eligibility criteria were used for title/abstract screening before journal review.
Results: One systematic review and meta-analysis (SR-MA) and one RCT met the PICO and eligibility criteria. The SR-MA found that folic acid administration can reduce CRP level (WMD -0.94 (95% CI -1.56 – 0.32; p=0.00) at a dose of 0.15 mg/day for 12 weeks to 10 mg/day for 2 weeks, while the RCT found an insignificant result.
Conclusion: Folic acid supplementation has a potential benefit to decrease CRP levels in metabolic syndrome
Effect of isolated and synthetic dietary fibers on markers of metabolic diseases in human intervention studies: A systematic review [Advance Access]
No full textCanadian Institutes of Health Researc
Application of Box-Behnken Design for the Extraction of Padina australis
No full textOptimization extraction of the brown algae Padina australis using the Box-Behnken design has been carried out. Box-Behnken design in relation to Response Surface Methodology analysis was conducted with four experimental factors (i.e., solvent concentration, temperature, extraction time, and sample to solvents ratio) towards the responses of yield antioxidant, anti-tyrosinase, anti-glycation, total phenolic content, and fucoxanthin content, completing with 29 running experiments. P. australis extraction's optimum condition was acquired at 79.99% solvent concentration, 18.48 hours extraction time, 44.50ºC temperature, and 1:9 ratio powders and solvents. The optimum condition provided a 7.30% extraction yield, 43.94% antioxidant activity, 86.83% anti-tyrosinase, 98.06% anti-glycation, 9.53 mg GAE/g total phenolic content, and 347.55 µg/g fucoxanthin content. Respond Surface Methodology analysis with the Box-Behnken design succeeded in making the appropriate model for producing the optimum P. australis extract
Quantitative Physiology of Non-Energy-Limited Retentostat Cultures of Saccharomyces cerevisiae at Near-Zero Specific Growth Rates
No full textSo far, the physiology of Saccharomyces cerevisiae at near-zero growth rates has been studied in retentostat cultures with a growth-limiting supply of the carbon and energy source. Despite its relevance in nature and industry, the near-zero growth physiology of S. cerevisiae under conditions where growth is limited by the supply of non-energy substrates remains largely unexplored. This study analyzes the physiology of S. cerevisiae in aerobic chemostat and retentostat cultures grown under either ammonium or phosphate limitation. To compensate for loss of extracellular nitrogen- or phosphorus-containing compounds, establishing near-zero growth rates (μ < 0.002 h-1) in these retentostats required addition of low concentrations of ammonium or phosphate to reservoir media. In chemostats as well as in retentostats, strongly reduced cellular contents of the growth-limiting element (nitrogen or phosphorus) and high accumulation levels of storage carbohydrates were observed. Even at near-zero growth rates, culture viability in non-energy-limited retentostats remained above 80% and ATP synthesis was still sufficient to maintain an adequate energy status and keep cells in a metabolically active state. Compared to similar glucose-limited retentostat cultures, the nitrogen- and phosphate-limited cultures showed aerobic fermentation and a partial uncoupling of catabolism and anabolism. The possibility to achieve stable, near-zero growth cultures of S. cerevisiae under nitrogen or phosphorus limitation offers interesting prospects for high-yield production of bio-based chemicals.IMPORTANCE The yeast Saccharomyces cerevisiae is a commonly used microbial host for production of various biochemical compounds. From a physiological perspective, biosynthesis of these compounds competes with biomass formation in terms of carbon and/or energy equivalents. Fermentation processes functioning at extremely low or near-zero growth rates would prevent loss of feedstock to biomass production. Establishing S. cerevisiae cultures in which growth is restricted by the limited supply of a non-energy substrate therefore could have a wide range of industrial applications but remains largely unexplored. In this work we accomplished near-zero growth of S. cerevisiae through limited supply of a non-energy nutrient, namely, the nitrogen or phosphorus source, and carried out a quantitative physiological study of the cells under these conditions. The possibility to achieve near-zero-growth S. cerevisiae cultures through limited supply of a non-energy nutrient may offer interesting prospects to develop novel fermentation processes for high-yield production of bio-based chemicals.Accepted Author ManuscriptOLD BT/Cell Systems EngineeringBT/Biotechnologi
A closed-loop supply chain inventory model for manufacturer - Collector system with inspection, waste disposal and price-quality dependent return rate
No full textPENGARUH SENAM HAMIL TERHADAP PENURUNAN NYERI PUNGGUNG BAWAH PADA IBU HAMIL TRIMESTER III DI PUSKESMAS BUMI BARU
No full textPregnancy is a process that starts from the conception stage until the birth of the fetus, which lasts for 40 weeks starting from the first day of the last menstruation. When the fetus grows in the womb there will be changes that occur in the mother\u27s body, these changes will cause discomfort such as back pain. This type of research is a quasi-experimental research with a prepost test design with one group test. The number of samples used was 28 pregnant women at Bumi Baru Community Health Centers obtained using the total sampling technique. The data analysis technique uses the Paired-T Test. The results obtained in this study were that before being given pregnancy exercise, 1 person (3.83%) experienced very severe pain, 8 (30.7%) had moderate pain, 7 (26.92%) had moderate pain and 10 people (38) had mild pain. .46%). After being given pregnancy exercises, no one experienced very severe or severe pain, moderate pain was reduced to 2 people (7.69%), mild pain to 14 people (53.84%) and no pain to 10 people (38.46%) , and there were 10 people (33.3%) who no longer felt pain. The average pain level obtained before pregnancy exercise was 5.69 and after pregnancy exercise was 2.23, resulting in a decrease of 3.46 and this decrease was significant with a p value of 0.000.Pregnancy is a process that starts from the conception stage until the birth of the fetus, which lasts for 40 weeks starting from the first day of the last menstruation. When the fetus grows in the womb there will be changes that occur in the mother\u27s body, these changes will cause discomfort such as back pain. This type of research is a quasi-experimental research with a prepost test design with one group test. The number of samples used was 28 pregnant women at Bumi Baru Community Health Centers obtained using the total sampling technique. The data analysis technique uses the Paired-T Test. The results obtained in this study were that before being given pregnancy exercise, 1 person (3.83%) experienced very severe pain, 8 (30.7%) had moderate pain, 7 (26.92%) had moderate pain and 10 people (38) had mild pain. .46%). After being given pregnancy exercises, no one experienced very severe or severe pain, moderate pain was reduced to 2 people (7.69%), mild pain to 14 people (53.84%) and no pain to 10 people (38.46%) , and there were 10 people (33.3%) who no longer felt pain. The average pain level obtained before pregnancy exercise was 5.69 and after pregnancy exercise was 2.23, resulting in a decrease of 3.46 and this decrease was significant with a p value of 0.000
Antibody production of wild-type and enzyme V279F variants of PAF-AH as a risk factor for Cardiovascular disease
No full textEFEKTIVITAS MEDIA PENYULUHAN MENGGUNAKAN VIDIO TERHADAP PENGETAHUAN REMAJA TENTANG HIV/AIDSDI SMPN 1 BLAMBANGAN KECAMATAN BLAMBANGAN PAGAR KOTABUMI LAMPUNG UTARA
No full textHuman Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS) merupakan penyakit yang menjadi salah satu permasalahan serius di dunia. Angka kejadian hiv di Indonesia pada tahun 2020 sebanyak 543.100 orang dengan jumlah infeksi baru sebanyak 29.557 orang dan kematian sebanyak 30.137 orang. dengan angka kejadian di Provinsi Lampung sebanyak 589 kasus di Kecamatan Blambangan Sebanyak 20 Kasus. Berbagai cara dapat ditempuh guna meningkatkan edukasi tentang kesehatan reproduksi untuk para remaja, salah satunya adalah penyuluhan. Media penyuluhan yang dapat digunakan sangat banyak. Media penyuluhan berupa video edukasi yang memuat atau yang bertema kesehatan reproduksi remaja menjadi salah satu cara yang diharapkan dapat meningkatkan pengetahuan. Tujuan penelitian diketahui efektivitas media penyuluhan menggunakan video terhadap pengetahuan remaja tentang HIV/AIDS di SMPN 1 Blambangan Kecamatan Blambangan Pagar Kotabumi Lampung Utara. Jenis penelitian ini kuantitatif dengan rancangan penelitian pra eksperimen desain dengan pendekatan one group pretes and post test design. Populasi dalam penelitian ini adalah seluruh siswa di SMPN 1 Blambangan kelas VII dengan sampel yang digunakan sebanyak 54 responden menggunakan teknik total sampling. Pengumpulan data menggunakan lembar observasi. Analisis secara univariat dan bivariat (uji t-test). Hasil penelitian diketahui rata-rata pengetahuan remaja tentang HIV/AIDS sebelum penyuluhan kesehatan dengan media video adalah 6.2 dan sesudah penyuluhan kesehatan dengan media video adalah 10,07. Ada pengaruh efektivitas media penyuluhan menggunakan video terhadap pengetahuan remaja tentang HIV/AIDS di SMPN 1 Blambangan Kecamatan Blambangan Pagar Kotabumi Lampung Utara (p-value = 0,000). Saran bagi petugas kesehatan dapat memberikan promosi kesehatan melalui video tentang HIV/AIDS. Kata Kunci : Pengetahuan, penyuluhan, remaja tentang HIV/AID
Cultural Encounters: a Linguistic Study of EFL Arab Learners Encoding and Decoding Idioms
No full textIdioms are universal to all languages, and figurative language ispervasive in everyday discourse. However, idiom studies rarelytouch on the problems figurative language can present to nonnative speakers. This book sets out to provide an original analysisof the issue, focusing on a number of languages, including Arabic,Berber, French and English. The author addresses the questionof idiomaticity from linguistic, psycholinguistic and pedagogicalperspectives, highlighting in particular the strategies used byArab learners (primarily Saudis and Algerians) to decode andencode idioms.The book explores in detail the process of identifying idiomsand the factors that affect comprehension. The author alsoanalyses the current state of bilingual Arabic–English–Arabicdictionaries and asks to what extent learners can rely on themas a source for decoding idioms
Cultural Encounters: a Linguistic Study of EFL Arab Learners Encoding and Decoding Idioms
No full textIdioms are universal to all languages, and figurative language ispervasive in everyday discourse. However, idiom studies rarelytouch on the problems figurative language can present to nonnative speakers. This book sets out to provide an original analysisof the issue, focusing on a number of languages, including Arabic,Berber, French and English. The author addresses the questionof idiomaticity from linguistic, psycholinguistic and pedagogicalperspectives, highlighting in particular the strategies used byArab learners (primarily Saudis and Algerians) to decode andencode idioms.The book explores in detail the process of identifying idiomsand the factors that affect comprehension. The author alsoanalyses the current state of bilingual Arabic–English–Arabicdictionaries and asks to what extent learners can rely on themas a source for decoding idioms
