408 research outputs found
Chinese literary works translated into Baba Malay: a bibliographical study
Get PDFAnalyses 68 unique titles of Baba translated works published between 1889 and 1950. The titles are held in the libraries of the University of Malaya (UM), Science University Malaysia (USM), National University of Malaysia (UKM), the Dewan Bahasa dan Pustaka (DBP), National University of Singapore (NUS), National Library of Singapore (NLS) and the British Library (BL). The results reveal three periods of active publication of Baba translated works. A total of 18 works were translated before World War I, followed by 10 just after the war, 39 titles were published before the break of the World War II and 1 was identified in 1950. There were 103 persons involved in the 68 translated works, some of whom are responsible for more than one title. The most prominent translators were Chan Kim Boon, Wan Boon Seng, Seow Chin San and Lee Seng Poh. Some of the translators were also be editors, illustrators or editors. There were 31 publishers and 21 printing presses involved, all were located in Singapore. The most active publishers were Wan Boon Seng, Kim Seck Chy Press and Nanyang Romanised Malay Book Co. The translated works mainly cover historical classical Chinese stories, chivalrous stories, romances, folklore and legends. The titles were priced between 10 cents to 2 dollars in Straits currency. The University of Malaya Library held the largest number of unique title (62) out of which 15 were unique titles
AP057 Implementation of 2010 ILCOR CPR guidelines in Singapore by National Resuscitation Council in Singapore (NRCS)
No full textTOURISM AND ITS IMPACT ON HOTEL INDUSTRY
No full textBachelor'sBACHELOR OF SCIENCE (ESTATE MANAGEMENT
THE SINGAPORE NIGHT SAFARI : A SUCCESSFUL TOURIST ATTRACTION!
No full textBachelor'sBACHELOR OF SCIENCE (ESTATE MANAGEMENT
Slitrk2 controls excitatory synapse development via PDZ-mediated protein interactions
Get PDFMembers of the Slitrk (Slit- and Trk-like protein) family of synaptic cell-adhesion molecules control excitatory and inhibitory synapse development through isoform-dependent extracellular interactions with leukocyte common antigen-related receptor protein tyrosine phosphatases (LAR-RPTPs). However, how Slitrks participate in activation of intracellular signaling pathways in postsynaptic neurons remains largely unknown. Here we report that, among the six members of the Slitrk family, only Slitrk2 directly interacts with the PDZ domain-containing excitatory scaffolds, PSD-95 and Shank3. The interaction of Slitrk2 with PDZ proteins is mediated by the cytoplasmic COOH-terminal PDZ domain-binding motif (Ile-Ser-Glu-Leu), which is not found in other Slitrks. Mapping analyses further revealed that a single PDZ domain of Shank3 is responsible for binding to Slitrk2. Slitrk2 forms in vivo complexes with membrane-associated guanylate kinase (MAGUK) family proteins in addition to PSD-95 and Shank3. Intriguingly, in addition to its role in synaptic targeting in cultured hippocampal neurons, the PDZ domain-binding motif of Slitrk2 is required for Slitrk2 promotion of excitatory synapse formation, transmission, and spine development in the CA1 hippocampal region. Collectively, our data suggest a new molecular mechanism for conferring isoform-specific regulatory actions of the Slitrk family in orchestrating intracellular signal transduction pathways in postsynaptic neurons. © 2019, The Author(s).1
Metal nanoparticles decorated PET/PET-TiO2 bi-component filaments by photocatalytic deposition
No full textGold, silver, and platinum nanoparticles were immobilized on the surface of TiO2 in the sheath part of bi-component filaments. The processes involved include the spinning process used to prepare polyethylene terephthalate (PET)/PET-TiO2 bi-component filaments and the photocatalytic deposition process of gold, silver and platinum nanoparticles. The core part and the sheath part consist of virgin PET and 4 wt.% of TiO2 compounded PET, respectively. The sheath: core ratio of the filament was 50:50. For the photo-deposition of metal nanoparticles, adsorption of the metal ions on the surface of the fabrics was performed by immersing them in AgNO3, HAuCl4, and H2PtCl6 aqueous solutions, with simultaneous addition of methanol as a sacrificial agent. Photo-deposition was then carried out under UV light with an irradiation time of 60 seconds. The structural and antibacterial properties of the bi-component filaments were characterized. The nano-sized noble metal particles in a polka dot form were observed around the surface of the TiO2 particles in sheath region of bi-component filaments after photocatalytic deposition. Ag, Au, and Pt metal photo-deposited fabrics showed excellent antimicrobial effect against the two types of bacteria Staphylococcus aureus and Klebsiella pneumoniae under dark conditions. © The Author(s) 2012 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.
Update on the use of cardiac markers in the diagnosis of acute coronary syndrome
No full textAbstractAccurate identification of the cause of chest pain is a challenge to the emergency physician because a significant proportion of patients with acute coronary syndrome (ACS) present atypically. Cardiac troponins are the most sensitive and specific biochemical markers of myocardial damage, and are an important diagnostic tool in the evaluation of ACS. High-sensitivity troponins (hsTn) have been introduced in recent years, and have been shown to have increased accuracy in the diagnosis of acute myocardial infarction (AMI), both at presentation and upon early onset of chest pain. A combination of hsTn readings at presentation and at either 2 hours or 3 hours after the onset of symptoms increases the sensitivity of diagnosing AMI as compared to at presentation alone, and this combination may negate the need for other cardiac markers. The absolute change in hsTn 2 hours after presentation was also found to be useful in the diagnosis of AMI, but not the relative change. However, hsTn has lower specificity in comparison with traditional troponin, and its levels may be elevated even in certain non-ACS settings. The interpretation of troponin values in patients with chronic renal failure must also be done with caution, as their baseline may be elevated, even in the absence of an acute event. Given these pitfalls, the assessment of ACS must still be global, comprising clinical history, electrocardiogram changes, troponin increase, and/or a new wall-motion abnormality on echocardiogram or nuclear scan showing new loss of viable myocardium. High-sensitivity troponin also has a potential use in prognosticating atherosclerotic disease in chronic renal patients as well as population screening of cardiovascular risk factors, although these uses have not been well studied. Identification of patients with unstable angina without myocardial infarction also remains a challenge, as the sensitivity of cardiac troponin in this area remains moderate to low. However, new cardiac markers such as copeptin, ischemia-modified albumin, and heart-type acid binding protein, are still being studied and provide a window of hope in the diagnosis of unstable angina
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