75,976 research outputs found
Geologic atlas of the United States : topography, areal geology, economic geology, structure sections / 146 Rogersville Folio : [Pennsylvania]
No full textH. M. Wilson ; Frank Sutton ; R. D. Cummin ; E. G. Hamilton ; Sledge TatumList of Sheets: Topographic Map, Areal Geology Map, Structure and Economic Geology Ma
Box 34, Neg. No. 6342B: M. L. Sutton
No full textThis black and white photograph features a portrait of M. L. Sutton - he is wearing a suit. M. L. Sutton ordered the photograph.https://scholars.fhsu.edu/stafford_county/5158/thumbnail.jp
Box 34, Neg. No. 6342A: M. L. Sutton
No full textThis black and white photograph features a portrait of M. L. Sutton - he is wearing a suit and a hat. M. L. Sutton ordered the photograph.https://scholars.fhsu.edu/stafford_county/5157/thumbnail.jp
Addendum to the G. M. Sutton Bibliography
No full textSince the publication of The George Miksch Sutton Bibliography (Nebraska BirdReview 65(2): 46-58), the following additional titles have come to light:Sutton, G. M. 1921. Night Voices. Bird Lore 21:108-110.__ 1933. Fifty years of progress in American bird art. pp 181-197 in: Fifty Years\u27Progress of American Ornithology: 1883-1933. American Ornithologists Union, Lancaster, PA.__ 1962. Is bird art art? Living Bird 1 :73-78.__ 1977. A wood duck portrait. Living Bird 16:5-6.__ 1978. Three pine grosbeaks. Living Bird 17:5-6.__ 1980. A yellow rail sketch. Living Bird 18:5-6.__ 1981. A boreal owl portrait. Living Bird 19:5-6.__ 1982. Portrait ofa young cuckoo. Living Bird Quart. 1:16-17.The following titles related to Sutton may be of additional interest:Arbib, R. 1983. In memoriam: George Miksch Sutton, 1898-1982. American Birds 37(2): 135-136.Graham, F. B. 1981. Signals from the wild: the art and science of George Miksch Sutton. Audubon 83(4):33-45.Johnsgard, P. A. 1998 Baby bird portraits by George Miksch Sutton: watercolors in the Field Museum. Univ. of Oklahoma Press, Norman.Pettingill, O. S., Jr. 1984. In memoriam: George Miksch Sutton. Auk 101:246-252
Geologic atlas of the United States : topography, areal geology, economic geology, structure sections / 94 Brownsville - Connellsville Folio : Pennsylvania
No full textMarius R. Campbell ; H. M. Wilson ; Walter R. Harper ; A. C. Roberts ; Frank Sutton ; J. H. Wheat ; T. G. Basinger ; H. C. FrickList of Sheets: Topography, Areal Geology, Economic Geology, Geologic StructureIndirektes handschriftliches Exlibris: "1904, 606", das ist United States Geological Survey Washington Exemplar der ETH-BI
Geologic atlas of the United States : topography, areal geology, economic geology, structure sections / 125 Rural Valley Folio : Pennsylvania
No full textH. M. Wilson ; S. S. Gannett ; E. L. McNair ; Frank Sutton ; R. D. Cummin ; J. D. ForsterList of Sheets: Topography, Areal Geology, Structure and Economic GeologyIndirektes handschriftliches Exlibris: "1906, 509", das ist United States Geological Survey Washington Exemplar der ETH-BI
Geologic atlas of the United States : topography, areal geology, economic geology, structure sections / 133 Ebensburg Folio : Pennsylvania
No full textH. M. Wilson ; H. B. Paige ; Frank Sutton ; R. D. Cummin ; T. G. Basinger ; J. S. B. DaingerfieldList of Sheets: Topography, Areal Geology, Economic Geology, Geological StructureIndirektes handschriftliches Exlibris: "1906, 729", das ist United States Geological Survey Washington Exemplar der ETH-BI
Switching on the activity of 1,5-diaryl-pyrrole derivatives against drug-resistant ESKAPE bacteria
No full textAntibiotic resistance represents a significant threat worldwide. There is an urgent need to discover structurally innovative antibacterial agents for which no pre-existing resistance is known.
With the aim to speed up the drug discovery process and to reduce the limitations of target-based high-through put screenings (HTS) we described the synthesis and biological evaluation of a novel series of 1,5-diphenylpyrroles active against a wide panel of ESKAPE bacteria. In particular, a subsequent structure-activity relationship (SAR) study revealed that the modification of the functional groups can switch the selectivity and the antimicrobial activity from mycobacteria to Gram positive and Gram negative bacteria [1,2].
The new compounds show high activity against both wild type and drug-resistant Gram positive and Gram negative bacteria at concentrations similar than levofloxacin.
Microbiology studies revealed that the plausible target of this class of compounds is the bacterial DNA gyrase, with the pyrrole derivatives displaying similar inhibitory activity to levofloxacin against the wild type enzyme and retaining activity against the fluoroquinolone-resistant enzyme.
References:
[1] Bhakta, S.; Manetti, F.; Castagnolo, D. et al (2016) Design and Synthesis of 1-((1,5-Bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl)methyl)-4-methylpiperazine (BM212) and N-Adamantan-2-yl-N′-((E)-3,7-dimethylocta-2,6-dienyl)ethane-1,2-diamine (SQ109) Pyrrole Hybrid Derivatives: Discovery of Potent Antitubercular Agents Effective against Multidrug-Resistant Mycobacteria. J. Med. Chem.59:2780-2793.
[2] Masci, D.; Hind, C.; K. Islam, M.; Toscani, A.; Clifford, M.; Coluccia, A.; Conforti, I.; Touitou, M.; Wei, X.; Memdouh, S.; La Regina, G.; Silvestri, R; Sutton, M.; Castagnolo, D. (2019) Switching on the activity of 1,5-diaryl-pyrrole derivatives against drug-resistant ESKAPE bacteria: structure-activity relationships and mode of action studies. Eur. J. Med. Chem. 178:500-514
Politicking the personal: examining academic literature and British National Party beliefs and wishes about intimate interracial relationships and mixed heritage
No full textDrawing heavily on our earlier work in this area (Perry and Sutton 2006; forthcoming), this article discusses the issue of intimate interracial relationships (IIRs) within the context of the UK Government's current concerns with social cohesion and provides an overview of the literature on hate and prejudice against those in IIRs in the UK and USA. Following an examination of the official statistics and the numbers of mixed race people in England and Wales, we move on to provide a brief but disturbing glimpse of what it would mean if the BNP's long-term dream of winning a national election were actually to happen in light of their official website published proposed policies against IRRs and mixed heritage people
Microbiology Topics. ABOUT THE AUTHOR Measurement of Microbial Cells by Optical Density
No full text"Microbiology Topics" discusses various topics in microbiology of practical use in validation and compliance. We intend this column to be a useful resource for daily work applications. Reader comments, questions, and suggestions are needed to help us fulfill our objective for this column. Please send your comments and suggestions to column coordinator Scott Sutton at scott. [email protected] or journal coordinating editor Susan Haigney at [email protected]. KEY POINTS The following key points are discussed: Quality control (QC) microbiology tests require controlled levels of inocula and require fresh preparations of cells for those inocula The concentration of cells in a suspension can be estimated by optical density, but this must be confirmed by plate count The optical density readings against cell mass are specific to the microorganism species The qualification of these readings must be confirmed after major maintenance to the bench top spectrophotometer (e.g., after replacement of the bulb). There are, of course, two problems with these instructions. The first is that the technician is instructed to use an inoculum of about 10 8 microorganisms per milliliter and then instructed to determine this by plate count. Colony forming units (CFU) and cells (micro-organisms and spores) are different measures. This will inevitably lead to difficulties as the unfortunate lab worker cannot guarantee the number of cells in the suspension, only the number of CFU found. However, we can accept the scientific inaccuracy, as the numbers will generally work out. The more serious problem is the instruction to use the plate count CFU for determination of the inoculum for the test, and that the suspension shall be used immediately. This quite frankly cannot be done. If you use the suspension immediately, the plate counts are unavailable; if you use the plate counts to set the inoculum, then the suspension is at least a day old. DETERMINATION OF INOCULUM FOR THE AET Contrast these instructions with those in the United States Pharmacopeia (USP) (2) for the same exercise: Scott Sutton are needed to help us fulfill our objective fo fo for this column. Please send your comments an an and d d su u ugg gg gges es etions to column coordinator Scott Su Su Sutt tt tton n n at sc sc scot ot ott. t. t. [email protected] or journal co co coor o o dina a nating e e editor Susan Haigney at shaigney@ y@ [email protected]. KEY POINTS suspending fluid … Add sufficient suspend fluid to reduce the microbial count to about micro-organisms per milliliter…Remove imm ately a suitable sample from each suspension d d de d termine the number of colony-forming u per milliliter in each suspension by plate coun membrane filtration (2.6.12). This value se KEY POINTS The following key points are discuss sed ed: Quality control (QC) microbiolog gy test sts s re equ quire controlled levels of inocula and nd r re equi ire f fresh sh preparations of cells for those inocula The co o onc ncen en ntr tr trat at atio io ion n n of cells in n a a su uspen nsi sion o can be es s sti i imated b b by y y op op opti ti tical dens nsity, y, b but ut this s mu must s be membrane filtration (2.6.12). This value se to determine the inoculum and the baselin use in the test. The suspensions shall be u immediately." There are, of course, two problems with these t t tion n ns. s. s. T T The he he f f fir ir irst st i is s s th th hat at t t th h he t t tec e echnicia an is is i ins nstr truc u te an an an ino no noculum of a a abo out 10 0 0 8 8 8 m m mic croorg gan nisms s pe per m c co conf f fir rmed by p p plate te te c c cou o o nt t Th h he op p ptical den n nsit t ty r re rea adin ings gs a agai inst st cel e l m mass a are r s s sp s ec ec ec e ifi i ic to th h h he e e e m m mi m croo o o org gan an anis is sm specie ie es Th Th Th he q qu l l alif if ifi i ication of the h h se readings mu t t st be confirmed e e e a a a after m m m maj j j jor o o mai ai aint t ten e e ance ce ce t t to o o the e e be b b nc c ch h h t t top sp sp sp spec ec e ect t tropho ho ho hoto to to tom m meter r (e (e (e.g g g., aft fter er er r repla ace ement nt nt of the bulb) a a and d d th th then n n i i instru u ucte e ed to o o d d deter erm mine e thi his s by by plat C C Colony f f fo o orm m ming un n nits ( ( (CF C CFU) U) a and nd ce ells s ( (mi mic cro-or an an and d d d sp p por r res es es es) ) ) ) are d d dif f ffer er er ere e en e t measu ur u es es es. T This w w wil ill l l in l l lead d d d t t t to o o di di di dif fficulties as t t the unfortun t t ate lab wo k k rke guar r r ran a a a tee th th th he e e e numb mb mb ber of f f f ce ce ce cell ll lls s in t t the he he s s sus u u pens ns nsi i i the e e nu nu nu numb m m m er o o of CFU U U foun n n nd d. d. d H H Ho ow o ev ver er r, , w w we can n n a a ac scientific inaccuracy as the numbers will genera of the bulb) ) ). DE DE DE DETE TE TE TERM RM RM RMIN IN IN INAT AT AT ATIO IO IO ION N N N OF OF OF OF I I INO NO NOCU CU CULU LU LUM M M FO FO FOR R R scientific inaccuracy, y as the numbers will g genera ou ou ou out. t t t Th Th Th The e e e mo mo mo more re re re s s ser er er erio io io ious us us us p p p pro r ro robl bl bl blem em em i i is s s th th the e e in in inst st stru ru ruct ct ctio o th th th the e e e pl pl pl plat at at a e e e e co co co coun un un unt t t t CF CF CF CFU U U U fo fo fo for r r r de de de dete te te t rm rm rmin in inat at atio io ion n n of of of t t the he he i i in
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