813 research outputs found
Dr. Gerd J. Horten Professor of History - Concordia University Portland
No full textGerd Horten, author of the book \u27Radio Goes to War: The Cultural Politics of Propaganda during World War II\u27, discusses World War II propaganda and censorship. Recorded by Phil Sedgwick.
Video uploaded by Phil Sedgwick under Standard YouTube Licensehttps://commons.cu-portland.edu/humfacultymedia/1000/thumbnail.jp
Generation of recombinant fowlpox virus using the non-essential F11L orthologue as insertion site and a rapid transient selection strategy.
No full textAvipoxviruses show an abortive replication phenotype in mammalian cells and are under evaluation as safe vectors for vaccination. Non-essential gene sequences located in highly conserved regions of virus genomes are considered particularly useful to integrate heterologous DNA. Fowlpox virus F11L orthologue is described in this paper as a suitable locus for insertion into fowlpox virus genome. Disruption of the F11L coding sequence by integration of an expression cassette for the Escherichia coli lacZ and guanine phosphoribosyltransferase marker genes resulted in the isolation of replication competent knockout viruses. Growth of F11L-knockout viruses in primary chicken embryo fibroblasts was unimpaired in comparison to wild type-virus. To test the generation of vector viruses, an insertion plasmid was constructed that contains F11L-specific sequences for homologous recombination, the E. coli lacZ and gpt genes as transient selectable marker, and the vaccinia virus early/late promoter P7.5 for transcriptional control of target gene expression. The coding sequence of the melanoma-associated antigen tyrosinase was chosen as model recombinant gene. Isolation of tyrosinase-recombinant viruses, which produced stably the insert, demonstrated the usefulness of the F11L-insertion site for the generation of fowlpox vectors. Rapid isolation of those recombinants was achieved by using a double selective system and linearising the vector plasmid before transfection
Comparison of virus production in chicken embryo fibroblasts infected with the WR, IHD-J and MVA strains of vaccinia virus: IHD-J is most efficient in trans-Golgi network wrapping and extracellular enveloped virus release
No full textModified vaccinia virus Ankara (MVA) is an attenuated strain derived from vaccinia virus (VV) Ankara that grows efficiently in primary chicken embryo fibroblasts (CEFs) and baby hamster kidney cells only. MVA produces significantly more of the enveloped forms of VV in infected CEFs compared with VV strain Copenhagen. In the present study, production of the different infectious forms of VV was compared in CEFs infected with MVA or with two well-characterized replication-competent VV strains, WR and IHD-J. In a time-course experiment, the infectivity associated with the extracellular enveloped virus (EEV), the cell-associated enveloped virus (CEV) and intracellular mature and enveloped viruses was determined. Further, the production of the different viral forms was quantified by electron microscopy (EM). The data collectively indicate that IHD-J is most efficient in producing all of the trans-Golgi network-wrapped forms and releases the highest titres of EEVs into the extracellular medium, with WR being least efficient. MVA initially replicated with faster kinetics, resulting in more intracellular virus and CEVs between 8 and 24 h post-infection (p.i.). As assessed by EM, the faster growth kinetics of MVA resulted in 3·5-fold more CEVs at the cell surface at 24 h p.i., compared with both WR and IHD-J. Accordingly, we found that despite the presence of two in-frame deletions in the A36R gene of MVA, this virus was able to make actin tails in CEFs
Endogenous Fixprices and Sticky Price Adjustment of Risk-averse Firms
Get PDFA risk-averse price-setting firm which knows the quantity demanded at the status quo price but has imperfect information otherwise may choose not to change it although an otherwise identical risk-neutral firm would do so, provided the variance of the firm's subjective probability distribution over quantities demanded as a function of price displays a kink at the status quo. This is equivalent to risk aversion of order one. When no such endogenous fixprice exists, the size of price adjustment still tends to zero as risk aversion tends to infinity, and to any arbitrarily small menu cost there exists a degree of risk aversion so that the firm will not adjust.fixed prices, price adjustment, risk aversion, menu cost
Köln im Kreuzverhör
No full textSchriften I Unter der Rubrik "Schriften" sollen nicht mehr oder bislang noch nicht verfügbare Texte zugänglich gemacht werden. Gerd Schwerhoff: Köln im Kreuzverhör. Kriminalität, Herrschaft und Gesellschaft in einer frühneuzeitlichen Stadt, Bonn/Berlin 1991 Die Druckfassung der 1989 an der Universität Bielefeld eingereichten Dissertation wurde 1991 im Bouvier-Verlag publiziert, nachdem sie 1990 mit dem August-Sutter-Preis ausgezeichnet worden war. Sie war spätestens seit Ende der 90er ..
GENES IN DEVELOPMENT: RE-READING THE MOLECULAR PARADIGM
No full textIntroduction / Eva M. Neumann-Held and Christoph Rehmann-Sutter -- Pt. I. Empirical approaches -- Ch. 1. Genome analysis and developmental biology: the nematode Caenorhabditis elegans as a model system / Thomas R. Burglin -- Ch. 2. Genes and form: inherency in the evolution of developmental mechanisms / Stuart A. Newman and Gerd B. Muller -- Pt. II. Looking back into history -- Ch. 3. From genes as determinants to DNA as resource: historical notes on development and genetics / Sahotra Sarkar -- Pt. III. Theorizing genes -- Ch. 4. The origin of species: a structuralist approach / Gerry Webster and Brian C. Goodwin -- Ch. 5. On the problem of the molecular versus the organismic approach in biology / Ulrich Wolf -- Ch. 6. Genes, development, and semiosis / Jesper Hoffmeyer -- Ch. 7. The fearless vampire conservator: Philip Kitcher, genetic determinism, and the informational gene / Paul E. Griffiths -- Ch. 8. Genetics from an evolutionary process perspective / James Griesemer -- Ch. 9. Genes - causes - codes: deciphering DNA'S ontological privilege / Eva M. Neumann-Held -- Ch. 10. Boundaries and (constructive) interaction / Susan Oyama -- Ch. 11. Beyond the gene but beneath the skin / Evelyn Fox Keller -- Ch. 12. Poiesis and praxis: two modes of understanding development / Christoph Rehmann-Sutter -- Pt. IV. Social and ethical implications -- Ch. 13. Developmental emergence, genes, and responsible science / Brian C. Goodwin -- Ch. 14. Nothing like a gene / Jackie Leach Scully -- Contributors -- Inde
Treating gastro-oesophageal reflux disease (GERD) with sense
No full textGastro-esophageal reflux disease (GERD) is a common disorder that affects an estimated 5 % to 7 % of the global population. Management of GERD often poses a number of challenges. In this article, the author presents a number of management modalities for this condition.peer-reviewe
La place de la guerre de 1914-1918 dans l'histoire culturelle de l'Allemagne
No full textThe place of the 1914-1918 war in the cultural history of Germany, Gerd Krumeich.
Through his study of war accounts and memories, the author analyses the impact of the war experience on German culture in its individual as well as its collective aspects. That impact brought about the continuation and the diffusion of militarism and nationalism in much of the German society of the 1920s and 1930s.Krumeich Gerd. La place de la guerre de 1914-1918 dans l'histoire culturelle de l'Allemagne. In: Vingtième Siècle, revue d'histoire, n°41, janvier-mars 1994. La guerre de 1914-1918. Essais d'histoire culturelle. pp. 9-17
Differences in cerebral response to esophageal acid stimuli and psychological anticipation in GERD subtypes-An fMRI study
No full textBackground: To evaluate whether there are differences in the cerebral response to intraesophageal acid and psychological anticipation stimuli among subtypes of gastroesophageal reflux disease (GERD)
Augmenting a pH Medical Study with Wearable Video for Treatment of GERD
No full textIn this paper we present an augmentation to the wearable computers typically used to determine if a patient is a candidate for surgery to correct problems associated with Gastroesophageal Reflux Disease (GERD). A wearable camera was used by the first author while participating in a 24–hour stomach acid pH study. After the study’s conclusion, an examination of the captured video and pH record revealed some results that allowed the first author to avoid many of the activities that result in symptoms related to GERD. 1 GERD and Medical Testing Gastroesophageal Reflux Disease is a medical condition that affects 2 % of the adult population of the United States. GERD refers to the reflux of stomach acid into the esophagus and can lead to complications such as esophageal cancer and lung damage. The most common symptom of GERD is heartburn. Typical treatments for GERD include diet modification and medication; however, for some patients these treatments may prove ineffective, and the patient may be evaluated for more drastic measures such as surgery. If surgery to correct GERD is considered an option, the patient usually undergoes a 24 – or 48–hour pH study to measure the percentage of time that the patient is in reflux during normal daily activities. In the 24–hour study, a pH probe is inserted into the subject’s nose and lowered through the esophagus to a position above the stomach. Since the probe is attached to a line that is retained in the patient’s nose and throat, several pH sensors can be placed at varying locations along the patient’s esophagus. The probe is attached to a wearable computer which records the patient’s pH levels for 24 hours. The patient typically uses the wearable computer to record times of meals, periods spent in a supine position (e.g. sleeping), and occurrences of symptoms. The first author suffered from severe and relatively un
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