440 research outputs found
Clean hydrogen and power from impure water
No full textThis paper presents a new photoelectrochemical (PEC) H2 production system which is capable of providing clean energy and water, and multi-generation of H2, electricity, heat and industrial chemicals from a single clean, abundant and renewable source: sun. This novel system maximizes solar spectrum utilization and increases system efficiencies by generating more outputs from solar energy alone. The hybrid PEC-chloralkali system, coupled with PV/T (Photovoltaic Thermal), is capable of producing H2, Cl2, electricity, and heat simultaneously. Incoming solar light is split into high-energy photons (with wavelengths lower than 400 nm) and low-energy photons. The high-energy portion is used to generate photocurrent in the reactor, and the remaining part is sent to the PV/T. This PV/T supports the electricity needs of the system and also provides electricity output for the end user. Moreover, the heat recovered from PV/T is a system output. The findings suggest that this system is capable of producing H2 and Cl2 as well as heat and electricity with higher efficiencies than the reported PV electrolysis and PEC-based H2 production efficiencies in the literature
Creighton University Magazine Winter 1999
No full textCREIGHTON STUDY SHEDS LIGHT ON INTERCHURCH MARRIAGES / INTERCHURCH MARRIAGES:
A Creighton study finds that sharing religious activities and managing religious differences play a vital role in marital success. Page 8.
GAMELAN: THE SOUND MOONLIGHT / THE SOUND OF MOONLIGHT:
Creighton's Lied Education Center for the Arts is home to a 71-piece Javanese gamelan. Page 12.
AT THE END OF A MISSION: MICHAEL G. MORRISON, S.J. / AT THE END OF A MISSION:
The Rev. Michael G. Morrison, S.J., tells writer Bob Reilly that life as Creighton's 22nd president has been more than a job - it's been a mission. Fr. Morrison has announced he will step down as the University's chief executive on or before June 30, 2000. Now in his 19th year, Creighton's longest-serving president will leave behind a legacy of accomplishments. Page 14.
ETCHED IN STONE? TWO TABLETS, 10 COMMANDMENTS, A MULTITUDE OF MEANINGS / EXPLORING THE TEN COMMANDMENTS:
Are the Ten Commandments etched in stone? Biblical scholar Leonard Greenspoon, Ph.D., Creighton's Klutznick Chair in Jewish Civilization, provides insights into how changes in cultural, social and historical circumstances have shaped one of the most recognizable of Old Testament doctrines. Page 22.
THE MILLENNIUM IN WESTERN SOCIETY:
History professor Eileen Dugan, Ph.D., investigates how people have viewed the millennium and the end of time. She writes that while millennialism has its roots in the Judeo-Christian anticipation of a Messiah, it has evolved over time to a more secular celebration. Page 30.
SILAS HAS CHARLOTTE BUZZING / HOOP DREAMS:
The NBAs Charlotte Hornets name Creighton alumnus Paul Silas, BSBA64, as the franchises fifth head coach. Page 36.
ORGAN DONORS:
Creighton alumnus Robert Metzger, MD'64, serves on two national committees within the transplant field. Article Not Included.
A VOICE FOR THE HILLS:
CU alumna Janice Marcantonio, BSN'83, works to preserve a unique land formation shaped by the runoff from ancient glaciers. Article Not Included.
LETTERS REVEAL THE OTHER SIDE OF HENRY JAMES / THE OTHER SIDE OF HENRY JAMES:
Usually depicted as an ultra-proper, uptight, reclusive and elitist writer, renowned American author Henry James reveals a warm, tender, informal side in his personal letters. Page 51
Evidence supporting oxidative stress in a moderately affected area of the brain in Alzheimer's disease
No full textThe pathogenesis of Alzheimer’s disease (AD) remains to be elucidated. Oxidative damage and excessive beta-amyloid oligomers are components of disease progression but it is unclear how these factors are temporally related. At post mortem, the superior temporal gyrus (STG) of AD cases contains plaques, but displays few tangles and only moderate neuronal loss. The STG at post mortem may represent a brain region that is in the early stages of AD or alternately a region resistant to AD pathogenesis. We evaluated expression profiles and activity of endogenous anti-oxidants, oxidative damage and caspase activity in the STG of apolipoprotein ε4-matched human AD cases and controls. Total superoxide dismutase (SOD) activity was increased, whereas total glutathione peroxidase (GPX), catalase (CAT) and peroxiredoxin (Prx) activities, were decreased in the AD-STG, suggesting that hydrogen peroxide accumulates in this brain region. Transcripts of the transcription factor NFE2L2 and inducible HMOX1, were also increased in the AD-STG, and this corresponded to increased Nuclear factor erythroid 2-related factor (NRF-2) and total heme-oxygenase (HO) activity. The protein oxidation marker 4-hydroxynonenal (4-HNE), remained unchanged in the AD-STG. Similarly, caspase activity was unaltered, suggesting that subtle redox imbalances in early to moderate stages of AD do not impact STG viability.Full Tex
Accelerated loss of hypoxia response in zebrafish with familial Alzheimer's disease-like mutation of Presenilin 1
No full textAgeing is the major risk factor for Alzheimer's disease (ad), a condition involving brain hypoxia. The majority of early onset familial ad (EOfAD) cases involve dominant mutations in the gene PSEN1. PSEN1 null mutations do not cause EOfAD. We exploited putative hypomorphic and EOfAD-like mutations in the zebrafish psen1 gene to explore the effects of age and genotype on brain responses to acute hypoxia. Both mutations accelerate age-dependent changes in hypoxia-sensitive gene expression supporting that ageing is necessary, but insufficient, for ad occurrence. Curiously, the responses to acute hypoxia become inverted in extremely aged fish. This is associated with an apparent inability to upregulate glycolysis. Wild type PSEN1 allele expression is reduced in post-mortem brains of human EOfAD mutation carriers (and extremely aged fish), possibly contributing to EOfad pathogenesis. We also observed that age-dependent loss of HIF1 stabilisation under hypoxia is a phenomenon conserved across vertebrate classes.Morgan Newman, Hani Moussavi Nik, Greg T Sutherland, Nhi Hin, Woojin S Kim, Glenda M Halliday ... et al
Evidence for and against a pathogenic role of reduced gamma-secretase activity in familial Alzheimer's disease
No full textPublished 23 May 2016The majority of mutations causing familial Alzheimer's disease (fAD) have been found in the gene PRESENILIN1 (PSEN1) with additional mutations in the related gene PRESENILIN2 (PSEN2). The best characterized function of PRESENILIN (PSEN) proteins is in γ-secretase enzyme activity. One substrate of γ-secretase is encoded by the gene AMYLOID BETA A4 PRECURSOR PROTEIN (AβPP/APP) that is a fAD mutation locus. AβPP is the source of the amyloid-β (Aβ) peptide enriched in the brains of people with fAD or the more common, late onset, sporadic form of AD, sAD. These observations have resulted in a focus on γ-secretase activity and Aβ as we attempt to understand the molecular basis of AD pathology. In this paper we briefly review some of the history of research on γ-secretase in AD. We then discuss the main ideas regarding the role of γ-secretase and the PSEN genes in this disease. We examine the significance of the "fAD mutation reading frame preservation rule" that applies to PSEN1 and PSEN2 (and AβPP) and look at alternative roles for AβPP and Aβ in fAD. We present a case for an alternative interpretation of published data on the role of γ-secretase activity and fAD-associated mutations in AD pathology. Evidence supports a "PSEN holoprotein multimer hypothesis" where PSEN fAD mutations generate mutant PSEN holoproteins that multimerize with wild type holoprotein and dominantly interfere with an AD-critical function(s) such as autophagy or secretion of Aβ. Holoprotein multimerization may be required for the endoproteolysis that activates PSENs' γ-secretase activity.Tanya Jayne, Morgan Newman, Giuseppe Verdile, Greg Sutherland, Gerald Münch, Ian Musgrave, Seyyed Hani Moussavi Nik and Michael Lardell
Hearing Faces and Seeing Voices: The Integration and Interaction of Face and Voice Processing
No full textCognitive understanding of voice recognition has borrowed much from the area of face processing, both in terms of the theoretical framework within which results are interpreted, and the methodology used to assess performance. A considerable body of research now exists to suggest that voice recognition may proceed in parallel with face recognition, and that the two pathways may combine to inform person recognition. However, rather than being independent or equivalent, these parallel pathways appear to interact to reveal interesting interference effects. The present paper reviews a series of studies that focus on a considerable and growing literature. The vulnerability of voice processing will be explored relative to face processing, and the interaction of these two pathways will be examined with reference to broader theoretical frameworks for person recognition
Bioconjugate techniques /
No full textBioconjugate Techniques, 3rd Edition, is the essential guide to the modification and cross linking of biomolecules for use in research, diagnostics, and therapeutics. It provides highly detailed information on the chemistry, reagent systems, and practical applications for creating labeled or conjugate molecules. It also describes dozens of reactions, with details on hundreds of commercially available reagents and the use of these reagents for modifying or crosslinking peptides and proteins, sugars and polysaccharides, nucleic acids and oligonucleotides, lipids, and synthetic polymers. *Offers a one-stop source for proven methods and protocols for synthesizing bioconjugates in the lab *Provides step-by-step presentation makes the book an ideal source for researchers who are less familiar with the synthesis of bioconjugates *Features full color illustrations *Includes a more extensive introduction into the vast field of bioconjugation and one of the most thorough overviews of immobilization chemistry ever presented.Revised edition of: Bioconjugate techniques / Greg T. Hermanson. 2nd edition. 2008.Includes bibliographical references and index.Introduction to bioconjugation -- Functional targets for bioconjugation -- The reactions of bioconjugation -- Zero-length crosslinkers -- Homobifunctional crosslinkers -- Heterobifunctional crosslinkers -- Trifunctional crosslinkers -- Dendrimers and dendrons -- Cross-bridges and cleavable reagent systems -- Fluorescent probes -- (Strept)avidin-biotin systems -- Isotopic labeling techniques -- Silane coupling agents -- Microparticles and nanoparticles -- Immobilization of ligands on chromatography supports -- Buckyballs, fullerenes, and carbon nanotubes -- Chemoselective ligation; bioorthogonal reagents -- Pegylation and synthetic polymer modification -- Vaccines and immunogen conjugates -- Antibody modification and conjugation -- Liposome conjugates and derivatives -- Enzyme modification and conjugation -- Nucleic acid and oligonucleotide modification and conjugation -- Bioconjugation in the study of protein interactions.Bioconjugate Techniques, 3rd Edition, is the essential guide to the modification and cross linking of biomolecules for use in research, diagnostics, and therapeutics. It provides highly detailed information on the chemistry, reagent systems, and practical applications for creating labeled or conjugate molecules. It also describes dozens of reactions, with details on hundreds of commercially available reagents and the use of these reagents for modifying or crosslinking peptides and proteins, sugars and polysaccharides, nucleic acids and oligonucleotides, lipids, and synthetic polymers. *Offers a one-stop source for proven methods and protocols for synthesizing bioconjugates in the lab *Provides step-by-step presentation makes the book an ideal source for researchers who are less familiar with the synthesis of bioconjugates *Features full color illustrations *Includes a more extensive introduction into the vast field of bioconjugation and one of the most thorough overviews of immobilization chemistry ever presented.Online resource; title from electronic title page (ScienceDirect, viewed April 9, 2018).Elsevie
Evaluating Communication in the British Parliamentary Public Sphere
No full textThis article begins with a re-evaluation of political communication research based on Habermas' original theory of the public sphere. It presents Habermas' alternative framework for assessing communication in contemporary ‘actually existing democracies’. The model is then tested with a case study of the UK parliamentary public sphere based on 95 semi-structured interviews with political actors (politicians, journalists and officials). It concludes that parliament today operates rather better, according to public sphere norms, than the public sphere described in Habermas' accounts of 18th and 19th-century England. Such a finding, on its own, is clearly at odds with public perception. The research accordingly offers two explanations for this disparity and the (perceived) crisis of political legitimacy in UK politics
Bibliographics for the 983 eprints in the live archives of E-LIS : trends and status report up to 7th July 2004, based on author-self-archiving metadata
No full textThe priority for ideas and philosophy related to "Network Theory" have been traced back and documented by Braun(2004),and credit goes to Karinthy(1929).The IT has empowered to realise it, as the most practical phenomena and it is no more a humour. The OAI (Open Archives Initiatives)and ACIS (Academic Contributor Information System)are progressive in the direction ,which may lead to realise the "Collective Genius" at global level. Focus of present study is on Author-Self-Archiving (A-S-A)Metadata of the 983 Eprints in the Live Archives of the E-LIS (EPrints of Library and Information Science),which were approved till 7th July 2004.The A-S-A Metadata was used for librametric analysis. Self-explanatory bibliographics are illustrated.The highlights include: Conference papers (34%); highest approval, June 2004 (28%); published archives (76%);not refereed (52%); not in public domain (60%); highest self-archiving-author (De Robbio, Antonella).The Nos. of EPrints having single JITA domain specifications were: Theoretical and general aspects of libraries and information(27); Information use and sociology of information(80);Users,literacy and reading(13);Libraries as physical collections(30);Publishing and legal issues(57);Management(13);Industry, profession and education(36);Information sources, supports, channels(113) ; Information treatment for information services, Information functions and techniques (101); Technical services libraries, archives and museums(25); Housing technologies(1); Information technology and library technology(92); and Inter-domainery (395) i.e. having specifications of two or more than two JITA classes
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