1,721,042 research outputs found
Maternal cardiac dysfunction and remodeling in women with preeclampsia at term.
No full textAbstract—Preeclampsia is a disease associated with significant cardiovascular morbidity during pregnancy and in later life.
This study was designed to evaluate cardiac function and remodeling in preeclampsia occurring at term. This was a
prospective case– control study of 50 term preeclampsia and 50 normal pregnancies assessed by echocardiography and
tissue Doppler analysis. Global diastolic dysfunction was observed more frequently in preeclampsia versus control
pregnancies (40% versus 14%, P0.007). Increased cardiac work and left ventricular mass indices suggest that left
ventricular remodeling was an adaptive response to maintain myocardial contractility with preeclampsia at term.
Approximately 20% of patients with preeclampsia at term have more evident myocardial damage. Diastolic dysfunction
usually precedes systolic dysfunction in the evolution of ischemic or hypertensive cardiac diseases and is of prognostic
value in the prediction of long-term cardiovascular morbidity. The study findings also have significant implications for
the acute medical management of preeclampsia. (Hypertension. 2011;57:85-93.
Prevalence of maternal cardiac defects in women with high-resistance uterine artery Doppler indices.
No full textObjectives: To compare the prevalence of previously undiagnosed cardiac structural abnormalities in pregnant women with normal- and high-resistance midtrimester uterine artery Doppler indices. Methods: Maternal transthoracic echocardiography was undertaken in asymptomatic pregnant women after uterine artery Doppler screening for pre-eclampsia at 21-23 weeks' gestation. Women with a mean uterine artery pulsatility index above the 90 th centile (1.25) for the local population (multiethnic, socially diverse and migrant) were considered to have high-resistance uteroplacental blood flow indices. The prevalence of newly diagnosed cardiac structural defects in these women was recorded. Results: A total of 491 women underwent echocardiography, of whom 205 had high-resistance uterine artery blood flow indices. There were nine previously undiagnosed, functionally significant cardiac defects in the high-resistance uterine artery blood flow group and only one, functionally insignificant cardiac defect in the normal-resistance group (P = 0.005; relative risk = 12.6, 95% confidence interval, 1.60-98.34). Multiple regression analysis demonstrated that both uterine artery Doppler indices (P = 0.024) and ethnicity (P = 0.048) contributed independently towards a higher prevalence of cardiac defects. Conclusions: The prevalence of previously undiagnosed maternal cardiac structural abnormalities is significantly increased in women with high midtrimester uterine artery Doppler resistance indices. This observation has important consequences for the current and longterm medical care provided to these patients. Detailed maternal cardiac assessment with echocardiography may be required in migrant women with high uterine artery Doppler indice
Restrictive left ventricular filling in hypereosinophilic syndrome as a result of partial cavity obliteration by an apical mass: a strain/strain rate study
No full textMolecular and functional analyses of the human and the murine genes coding for AFG3L1p, a metalloprotease homologous to the human spastic paraplegia protein
No full textA new echocardiographic approach to the quantification of myocardial function in congenital heart disease: The "strain" and the "strain rate imaging"
No full textBased on color Doppler methodology, regional myocardial strain rates and strain can now be calculated by comparing local myocardial velocity profiles. These deformation data sets may be an important new approach to quantifying regional function of the left or right ventricle in congenital heart disease. This review will give an introduction to the principles behind the technique and how data are acquired and processed. It will also discuss the findings of clinical studies based on this new technique. © 2003 CEPI Srl
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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