13,299 research outputs found
Ms. Courtney Chartier, RWWL AUC, August 2011
No full textThis video is a conversation with Ms. Courtney Chartier. Ms. Chartier talks about her work on the "New Georgia Encyclopedia" and "Online Voter Education Project." Andrea Jackson, AUC Woodruff Library, is the interviewer
Ms. Neely Terrell, RWWL AUC, March 2012
No full textThis video is a conversation with Ms. Neely Terrell. Ms. Terrell talks about her book, "Super Singles Activate". Anthony Kinsey and Jahnesta Horney, AUC Woodruff Library, are the interviewers
Personal Papers (MS 80-0002)
No full textInvoice for Daniel W. Kempner by Sutherland International Despatch, including charges for international car registration, international number plates, airmail postage of documents, etc. worth $328
Personal Papers (MS 80-0002)
No full textInvoice for services rendered to Daniel W. Kempner by Sutherland International Despatch, Inc., including international car registration, international number plates, international driving permit, etc
Personal Papers (MS 80-0002)
No full textCopy of a letter from a secretary on behalf of Daniel W. Kempner to Frank E. Dawson discussing a payment of $328.80 to Sutherland International Despatch, Inc
Personal Papers (MS 80-0002)
No full textLetter from Daniel W. Kempner to Sutherland International Despatch with an enclosed check of $292.50 covering automobile and marine insurance
Ms. Felesha Love, Spelman College, January 2016
No full textThis video is a conversation with Felesha Love. Ms. Love talks about her book, "Brave Leap to Freedom: Integrating Mind, Body, and Spirit to Cultivate Healthy Relationships". Jordan Moore, AUC Woodruff Library, is the interviewer
Plan of Windheuvel, Sutherland
No full text247.A.1.E.5.1(53).jpg derived from archival TIFF file. Digital copies were created from a selection of drawings in the original James Walton manuscript collection (MS 247) held in the Manuscripts Section of the Stellenbosch Library and Information Service Collection.This illustration was published in Old Cape farmsteads by James Walton. Cape Town : Human & Rousseau, 1989, p.117.Drawing of a plan of Windheuvel, Sutherland, depicting detail of a hearth (0.20m high), a kitchen and a livingroom (1.66m and 1.89m high)
Personal Papers (MS 80-0002)
No full textLetter from Sutherland International Despatch and Andrew Kelly to Daniel W. Kempner confirming his carnet has been received and discharged and enclosing a check for $100.00
LC-API/MS in Drug Metabolism and Pharmacokinetic Studies
No full textThe use of API interfaces with quadrupole mass spectrometers has been shown to give rise to good sensitivity, selectivity, and robustness for the interfacing of LC to MS. Since their introduction in the 1990s the technique has rapidly become widespread, but at the outset of this research programme, there were still a number of problems associated with it, particularly when dealing with complex sample matrices. The aim of this research programme was to study illustrative examples of the kinds of problems associated with the analysis of biological samples using LC-API-MS in an attempt to arrive at strategies which could be employed to eliminate, or at least compensate for, the problems.
Commonly reported problems include the occurrence of matrix effects - a change in response of the target analyte(s) as a result of the presence in the samples of co /late eluting interferences. An investigation which compared ESI with APCI ionisation illustrated a significant drawback in the accepted methodology for the elimination of matrix effects.
Optimal LC conditions for a number of assays may use non-MS-friendly mobile phases. A simple and convenient solution to this problem was found to be the post column addition of organic modifier, which reproducibly and reliably enhanced sensitivity. This approach was initially used for a range of dihydropyridine calcium channel blockers and was subsequently applied to a range of chiral compounds from different therapeutic groups to illustrate that this was applicable as a generic technique for increasing sensitivity (typically by around an order of magnitude) in low organic mobile phases.
Strategies to develop and validate methods for the determination of endogenous analytes in a biological fluid were investigated. This involved the use of a surrogate matrix, to develop a method for the determination of endogenous testosterone in human serum and the use of non-matrix calibration standards for the successful development and validation of a method for the analysis of indolyl 3 acryloylglycine (IAG) in human urine.
As a result of observations suggesting promotion of ionisation of deltamethrin in liver tissue sample extracts, it was postulated that this was due to the presence of high concentrations of surfactants. After confirming the effect, a series of systematic investigations were performed to attempt to understand the mechanism to be able to utilise this as a general method for the enhancement of signal with low sensitivity analytes. It was found that the type of surfactant and concentration used was directly associated with an increased (or decreased) response.
Although there remain a number of problems associated with the use of LC-API-MS, the work undertaken for this thesis has successfully demonstrated a number of techniques that can be applied to overcome these problems. Knowledge of the nature of the sample undergoing analysis, the required analytical conditions, and where required careful application of one of the techniques described will ensure that a robust method can be readily developed
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