358 research outputs found
The Post Office Horizon system and Seema Misra
No full textThe author highlights the significance of the Seema Misra case in raising questions about the reliablity of the Post Office Horizon system and more widely suggesting that all digital systems have the possibility of latent defects, and these can never be discounted. He argues that when the efficacy of digital systems is called into question in legal proceedings, the onus of proof must be placed on the supplier of these systems and not the accuser.Index words: Post Office; Horizon; prosecutions; software errors; disclosure Full transcript of the trial Regina v Seema Misra, T2009007 (England & Wales; theft; electronic evidence; Post Office Horizon System; ‘reliability’ of computers) with case commentary and index to original papers held in the Documents Supplement of Volume 12: 2015
Erratum: Myocardial ischaemia and valve insufficiency caused by a dysplastic aortic valve cusp: A previously unreported unique morphologic anomaly (Cardiology in the Young (2020) (1-4) DOI: 10.1017/S1047951120001377)
No full text© The Author(s), 2020. The authors apologise that upon publication of this case report an author was left off. The online version of this article has been updated to list the authors correctly. Sharmeen Samuel, Preeta Dhanantwari, Nilanjana Misra, and David B. Meyer
Symmetry breaking during homodimeric assembly activates an E3 ubiquitin ligase
No full textCitation: Ye, Z., Needham, P. G., Estabrooks, S. K., Whitaker, S. K., Garcia, B. L., Misra, S., . . . Camacho, C. J. (2017). Symmetry breaking during homodimeric assembly activates an E3 ubiquitin ligase. Scientific Reports, 7(1). doi:10.1038/s41598-017-01880-4C-terminus of Hsc/p70-Interacting Protein (CHIP) is a homodimeric E3 ubiquitin ligase.Each CHIP monomer consists of a tetratricopeptide-repeat (TPR), helix-turn-helix (HH), and U-box domain.In contrast to nearly all homodimeric proteins, CHIP is asymmetric.To uncover the origins of asymmetry, we performed molecular dynamics simulations of dimer assembly.We determined that a CHIP monomer is most stable when the HH domain has an extended helix that supports intra-monomer TPR-U-box interaction, blocking the E2-binding surface of the U-box.We also discovered that monomers first dimerize symmetrically through their HH domains, which then triggers U-box dimerization.This brings the extended helices into close proximity, including a repulsive stretch of positively charged residues.Unable to smoothly unwind, this conflict bends the helices until the helix of one protomer breaks to relieve the repulsion.The abrupt snapping of the helix forces the C-terminal residues of the other protomer to disrupt that protomer's TPR-U-box tight binding interface, swiftly exposing and activating one of the E2 binding sites.Mutagenesis and biochemical experiments confirm that C-terminal residues are necessary both to maintain CHIP stability and function.This novel mechanism indicates how a ubiquitin ligase maintains an inactive monomeric form that rapidly activates only after asymmetric assembly. © 2017 The Author(s)
Good Governance and Development
No full textThe concept of good governance plays a very important role in the modern government system. Today people are conscious and they always aware of the day to day functioning of the government. So the government also tries to satisfy the general people. Where good governance creates an environment which fosters strong and equitable development and it is an essential to complement to sound economic policies. With the advent of the new economic order, manifested in the form of globalisation, liberalisation, and Privatisation has brought in a new governance paradigm prescriptively being referred to as good governance. Since the 1990s the concept of good governance has become one of the most widely used in debates in development, public policy and international relations. The first part of this paper is related to be an overview of Governance, Good Governance in India and second part of this paper is related to Good governance and development with different sectors.
Article DOI : 10.5958/2347-6869.2017.00008.
Parallel session 9 : Institutional management
No full textPresented Titles: Living in Uncertainty: The COVID-19 Pandemic and Higher Education in Hong Kong [Authors: Jisun Jung; Hugo Horta; Gerard A. Postiglione] Internalisation of China’s Higher Education and It’s Development Model [Author: Rochester Lima] Unprepared Cost of Survival: Revisiting Academic Returnees’ Cross-border Capital and Cultural Adaptation in Shanghai Universities [Authors: Jiaxin Chen; Xiaoxin Du] Us and Them: How Regions Shape the Boundaries of Elite Higher Education? [Author: Debananda Misra
Supporting Cyber-Physical Systems with Wireless Sensor Networks: An Outlook of Software and Services
No full textSensing, communication, computation and control technologies are the essential building blocks of a cyber-physical system (CPS). Wireless sensor networks (WSNs) are a way to support CPS as they provide fine-grained spatial-temporal sensing, communication and computation at a low premium of cost and power. In this article, we explore the fundamental concepts guiding the design and implementation of WSNs. We report the latest developments in WSN software and services for meeting existing requirements and newer demands; particularly in the areas of: operating system, simulator and emulator, programming abstraction, virtualization, IP-based communication and security, time and location, and network monitoring and management. We also reflect on the ongoing
efforts in providing dependable assurances for WSN-driven CPS. Finally, we report on its applicability with a case-study on smart buildings
Panchayati Raj System after the Constitution (Seventy-Third) Amendment Act, 1992: Problems and Possibilities
No full textGood Governance and Development
No full textThe concept of good governance plays a very important role in the modern government system. Today people are conscious and they always aware of the day to day functioning of the government. So the government also tries to satisfy the general people. Where good governance creates an environment which fosters strong and equitable development and it is an essential to complement to sound economic policies. With the advent of the new economic order, manifested in the form of globalisation, liberalisation, and Privatisation has brought in a new governance paradigm prescriptively being referred to as good governance. Since the 1990s the concept of good governance has become one of the most widely used in debates in development, public policy and international relations. The first part of this paper is related to be an overview of Governance, Good Governance in India and second part of this paper is related to Good governance and development with different sectors. DOI:10.5958/2347-6869.2017.00008.
Publication metrics: Types, utility, and caveats
No full textPublication metrics enable the assessment of the performance of citations or utilization of published work. Journal-level metrics depend on the database whose citations are analyzed. Publication metrics from the Web of Science include the widely-used journal impact factor (JIF) and other indices such as Journal Citation Impact, Eigenfactor, normalized Eigenfactor, and Article Influence Score. Metrics from Scopus include the CiteScore, Source Normalized Impact Factor, and SCImago Journal Rank. Author-level metrics such as total citations, h-index, i10-index, and g-index inevitably increase with time and can be inflated by self-citations. Article-level metrics such as total citations and online attention scores derived from Scopus (PlumX Metrics) or Altmetric indicate the extent of utilization and discussion in scientific circles of a particular article. Publication metrics are useful to provide a bird's eye view of how well an individual journal or article has been cited or used. They do not necessarily reflect article quality. As an example, some of the articles with the highest Altmetric Attention Scores are actually retracted publications that attained high scores due to the negative debate that they elicited. Journal-level metrics such as the JIF are fluid and prone to historical fluctuations from year to year, most recently observed by increases in the JIF of journals which published a lot of coronavirus disease 19-related content. Research assessment of individual scientists often misuses publication metrics such as the JIF, when they should instead rely on a critical appraisal of research articles by assessors
Field Model Identification and Control of a Mobile Electromagnet for Remote Actuation of Soft Robots
No full textThe actuation of miniaturized robots through external magnetic fields has great potential formedical applications. The controllability properties of the miniaturized robots are affected by magnetic field generation modality. In this work, themagnetic field of a mobile electromagnet, notably capable to generate a desired magnetic field in large 3D workspaces, has been identified first. Then, a control model of the field generation system has been developed to produce a desired magnetic field designed to generate a locomotion gait in a legged miniaturized robot. Preliminary experiments prove the viability of the approach
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