1,721,076 research outputs found
VEGF-C, VEGF-D und sVEGF-R3 als Faktoren der Lymphangiogenese bei Patienten mit einer hydropisch-dekompensierten Leberzirrhose
No full textDie Lymphangiogenese spielt eine zentrale Rolle in der Flüssigkeitshomöostase, trotzdem ist ihre Rolle bei der Aszitesentstehung aufgrund einer Leberzirrhose unzureichend untersucht. Während einer hepatischen Dekompensation kommt es zu einer zunehmenden systemischen Inflammation. Die Zusammenhänge zwischen der Lymphangiogenese und Inflammation sind jedoch ebenfalls nicht vollständig verstanden. Daher war das Hauptziel unserer Arbeit die Lymphangiogenese in Zusammenhang mit der Inflammation bei Patienten mit hydropisch dekompensierter Leberzirrhose zu untersuchen.Daher wurden die Lymphangiogenesemarker VEGF-C, VEGF-D und sVEGF-R3 sowie der Inflammationsmarker IL-6 bei gesunden Probanden (n=38), Patienten mit kompensierter Leberzirrhose (n=38) und Patienten mit hydropisch-dekompensierter Leberzirrhose (n=35), welche eine TIPS-Anlage erhielten, untersucht. Zusätzlich wurden die Marker bei den Patienten in der TIPS-Gruppe zum Zeitpunkt des Eingriffes aus Lebervene und Pfortader sowie im Verlauf von frühestens 4 Wochen nach dem Eingriff aus peripherem Blut untersucht. Diese Werte wurden dann mit unterschiedlichen klinischen Werten korreliert. Hier fanden sich deutlich niedrigere VEGF-C Werte bei allen Patienten mit Leberzirrhose im Vergleich zur gesunden Kontrollgruppe und VEGF-C korrelierte mit der bei Leberzirrhose vorliegenden Thrombozytopenie. Weiterhin zeigten sich die VEGF-D Werte bei Patienten mit kompensierter Leberzirrhose höher als bei Patienten mit dekompensierter Leberzirrhose und es zeigte sich ein Anstieg von VEGF-D nach TIPS. SVEGF-R3 war bei Patienten mit Leberzirrhose erhöht im Vergleich zur gesunden Kontrollgruppe. IL-6 war deutlich höher bei einer dekompensierten Leberzirrhose im Vergleich zu den beiden anderen Gruppen und fiel bei Patienten mit Aszitesansprechen nach TIPS ab, wohingegen IL-6 bei Patienten ohne Aszitesansprechen sogar anstieg.Unsere Daten zeigten in vivo eine gesteigerte Lymphangiogenese auf Plasmaebene bei Patienten mit Leberzirrhose sowie einen Zusammenhang zwischen Lymphangiogenese und Inflammation. Die genauen Prozesse und pathophysiologischen Vorgänge sollten aber noch weiter charakterisiert werde
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Charakterisierung der unmittelbaren und verzögerten biomechanischen Reaktion der menschlichen Augenhornhaut durch UVA-Crosslinking
No full textZytokinadsorption bei Patienten mit extrakorporaler Membranoxygenierung bei schwerer COVID-19 Pneumonie
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