1,721,038 research outputs found
Artificial damping methods for stable computations with linearized Euler equations
No full textIn this work, new methods are developed to facilitate stable and accurate numerical solutions of linearized Euler equations, which are often used in solving problems in computational aeroacoustics. Solutions of LEE can suffer from numerical Kelvin-Helmholtz instabilities in the presence of a sheared mean flow. Various methods have been exploited to address this problem; each has its advantages and disadvantages. In this work, two new methods that use artificial damping terms (ADT) are introduced. The first method is constructed to damp the vortical components generated during the computation while the second one is proposed by revisiting the effect of viscosity in the Navier-Stokes equations.An adaptive method is also used to improve the proposed new methods. These methods are tested on two benchmark cases: a) acoustic wave refraction through a strongly sheared jet, and b) mode radiation from a semi-infinite duct with jet. It is found that numerical instabilities can be successfully suppressed with little side effect on the acoustic wave computations.<br/
Geometry effect on the airfoil-gust interaction noise in transonic flows
No full textNumerical simulations are conducted to investigate the impacts of airfoil thickness, the angle of attack and camber on the airfoil-gust interaction noise in transonic flows where locally supersonic regimes and terminating shocks are present. The conclusions about the geometry effects based on the extensively studied subsonic cases are revisited. With the increase of airfoil thickness, the sound generation is reduced in the downstream direction as in subsonic flows. More sound is produced in the upstream direction for thicker airfoils due to the non-uniform mean flow and shocks in the near field. The compensative effect makes the overall sound reduction by the airfoil thickness less than the subsonic cases despite the significant difference in the radiation patterns. The acoustic responses to the single frequency gusts are sensitive to the airfoil angle of attack in transonic flows. However, the overall differences are reduced when multiple wavenumber components are superposed in isotropic turbulence, and the sound pressure levels are therefore close as in subsonic flows. Similarly, the significant variations in single frequency acoustic responses by airfoil camber are averaged by the superposition of various wavenumber components. However, apparent variations are still found in the upstream direction, especially for the turbulences with small integral length scales.</p
The intervention effect of Aitongxiao prescription on primary liver cancer rats was evaluated based on high-throughput miRNA sequencing and bioinformatics analysis
No full textLiver cancer is a common malignant tumor known for its difficult treatment and poor prognosis. As a traditional Chinese medicine prescription, Aitongxiao prescription (ATXP) has been used in clinical treatment of primary liver cancer (PLC) for more than ten years, and its therapeutic effect is obvious and has been verified over time. However, the mechanism of ATXP in treating PLC has not been fully elucidated. This study aimed to detect the liver-protective effect of ATXP on a PLC rat model and explore its potential mechanism from the perspective of plasma extracellular vesicle miRNAs. Fifty SPF male SD rats were randomly selected, with six rats as the control group, and the remaining rats were injected with DEN to establish a primary liver cancer model. The model rats were randomly divided into the model group and the ATXP group. After 4 weeks of intervention, the liver-protective effect of ATXP was evaluated using plasma biochemical indicators and histopathological methods. Plasma extracellular vesicles were isolated and extracted, and identified by transmission electron microscopy, nanoparticle tracking analysis, and western blot. Significant differentially expressed miRNAs in extracellular vesicles were screened by Illumina sequencing to explore the therapeutic targets of ATXP and conduct functional analysis. The results showed that ATXP significantly reduced plasma liver function in PLC rats and alleviated liver pathological damage. In addition, plasma extracellular vesicles were isolated and identified. According to the results of GO and KEGG analysis, they were related to multiple biological processes and covered multiple signaling pathways (PI3K-Akt and MAPK signaling pathways, etc.). The interaction between miR-199a-3p and MAP3K4 was determined by bioinformatics methods and dual-luciferase reporter gene detection, confirming that MAP3K4 is the target gene of miR-199a-3p. In conclusion, ATXP protects the liver from DEN-induced PLC, which may be related to the regulation of plasma extracellular vesicle miR-199a-3p. This study further reveals the mechanism of ATXP in treating liver cancer and provides a theoretical basis for subsequent research
A numerical investigation of the airfoil-gust interaction noise in transonic flows: Acoustic processes
No full textThe sound produced by airfoil-gust interaction is a significant source of broadband noise in turbofan engines or contra-rotating open rotors (CRORs). There are competing mechanisms in this regime because of the presence of shocks that were seldom considered in the previous subsonic studies. A numerical investigation of airfoil-gust interaction noise at transonic speeds is undertaken in this work. By introducing vortical gust/synthetic turbulence to specified regions in the computational domain to interact with different elements in the flow field, it is shown that the dominant sound source is caused by leading edge-gust interaction. It is demonstrated that both streamwise and transverse disturbances interact with the near-field non-uniform mean flow and shocks can produce sound using a local gust injection method. The propagation of sound is significantly influenced by the presence of the shocks, and the far field radiation pattern is changed. We also study the effect of gust strength on the near and far field properties. The linearity is maintained for gust strength smaller than 1.0% of the mean flow velocity. Otherwise, the shocks may experience oscillations that will alter the near-field aerodynamics and far-field radiation.</p
The specific contribution of object's origin on artifacts categorization
No full textGelman and Bloom found that adults and children's object naming was sensitive to how an object was created (man-made or not), but they did not reveal on which specific level of conceptual system this effect was. Using a free-naming task and a force-choice task, two experiments were conducted to test a hypothesis that this effect was specifically on domain level ("artifact/non-artifact" distinction). In Experiment 1, participants were asked to name shortly-depicted objects, rate their confidence, and report their reasons for each naming response. Results showed that most of the naming responses in "man-made" condition were in artifact domain, and most in "natural" condition were in non-artifact domain, although in both conditions names were very divergent on basic level. In Experiment 2, another group of participants were asked to choose one from two names (one in artifact domain and the other in non-artifact domain) to match the same shortly-depicted objects presented in the first experiment. Results of Experiment 1 on domain level were replicated in Experiment 2. These convergent findings supported the hypothesis that the effect of object's origin is specifically on domain level of conceptual system of objects. Reasons explicitly reported for naming responses in Experiment 1 suggested that participants might automatically infer objects' functions in "man-made" condition but not in "natural" condition. Here the function-based hypothesis of artifacts classification is discussed.Gelman and Bloom found that adults and children's object naming was sensitive to how an object was created (man-made or not), but they did not reveal on which specific level of conceptual system this effect was. Using a free-naming task and a force-choice task, two experiments were conducted to test a hypothesis that this effect was specifically on domain level ("artifact/non-artifact" distinction). In Experiment 1, participants were asked to name shortly-depicted objects, rate their confidence, and report their reasons for each naming response. Results showed that most of the naming responses in "man-made" condition were in artifact domain, and most in "natural" condition were in non-artifact domain, although in both conditions names were very divergent on basic level. In Experiment 2, another group of participants were asked to choose one from two names (one in artifact domain and the other in non-artifact domain) to match the same shortly-depicted objects presented in the first experiment. Results of Experiment 1 on domain level were replicated in Experiment 2. These convergent findings supported the hypothesis that the effect of object's origin is specifically on domain level of conceptual system of objects. Reasons explicitly reported for naming responses in Experiment 1 suggested that participants might automatically infer objects' functions in "man-made" condition but not in "natural" condition. Here the function-based hypothesis of artifacts classification is discussed
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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