383 research outputs found
In conversation with Tullio Pericoli
Full text linkIs narrating with words an experience comparable to that of narrating with images? Can one exist without the other? Can there be a visual imagination without the words that mold us or a verbal experience that is free from the images that we carry inside? In his long and successful career Tullio Pericoli has never ceased to contemplate these questions, and has answered them with his art, his curiosity, his extraordinary ability to watch and listen to faces, behaviors, but also trees, clouds, soil. As a political and cultural cartoonist, as illustrator of literary works, as a world-famous author of writers’ portraits, as landscape painter, set designer, and finally as a theorist of his own artwork, Pericoli teaches us that behind every stroke of the pen or the brush, there are a thousand stories. With lucidity and generosity, Pericoli opens the gates of his art and invites the curious viewer to stroll between the lines of his paintings – lines which, as he likes to say, have a history, a physiognomy, a grammar and even an interiority
La conciencia y la vida: Un homenaje a Tullio Seppilli
Full text linkIn this short text, the author makes a portrait of Tullio Seppilli. The portrait highlights Tullio Seppilli’s choice for critical rationalism, the role of his political convictions and the academic ethics of an outstanding master of medical anthropology.In questo breve testo, l'autore traccia un ritratto di Tullio Seppilli nel quale si sottolinea la sua scelta per un razionalismo critico, il ruolo delle sue convinzioni politiche e l'etica accademica di un eccezionale maestro dell'antropologia medica.En este breve texto, el autor realiza una semblanza de Tullio Seppilli. En esa semblanza se destaca la opción de Tullio Seppilli por un racionalismo crítico, el papel de sus convicciones políticas y la ética académica de un maestro excepcional de la antropología médica.In questo breve testo, l'autore traccia un ritratto di Tullio Seppilli nel quale si sottolinea la sua scelta per un razionalismo critico, il ruolo delle sue convinzioni politiche e l'etica accademica di un eccezionale maestro dell'antropologia medica
Tullio Ilomets - igiliikur: Tullio Ilomets - perpetuum mobile
No full textIn jubilee interviews, Tullio Ilomets, the perpetuum mobile in the title of this article, has also been dubbed the Spirit of Tartu. Thereby hejoins the long line of his fellow Tartu residents who have borne thesame title: Jaan Tõnisson, Villem Ernits, and Arnold Matteus.The article shall provide a short overview of how the author metTullio Ilomets in 1968 and their future contacts over the course ofdecades. One focus will be Tullio Ilomets’ activities since the beginning of the 1960s in the keeping and maintenance of the graves ofUniversity of Tartu faculty members at Vana-Jaani and other Tartucemeteries, an activity that particularly intensified after the establishment of the Academic Heritage Society (AMS) at the end of the1980s. The need for the maintenance of the graves of other facultymembers and cultural figures associated with the alma mater, bothat home and abroad, is also highlighted. Although the requisite listsof names were already in place by 2001, practical work has not yetcome up to speed.In addition, the article offers an overview of public speeches initiated by Tullio Ilomets of the AMS and its Graduates’ Club concerning many problems of Estonian history and culture. Active intervention by the AMS enabled the resolution of the fate of the residence ofJaan Poska, architect of the Tartu Peace Treaty; the building is located in Tallinn, Kadriorg on the banks of the Liivaoja (J. Poska Street 8in 1927); in the wave of privatisations in the 1990s, it had been planned to give the building to a religious sect for a worship space. Thewish to preserve the memory of Poska also arose. As the chairman ofthe AMS, Tullio Ilomets intervened in an already lengthy discussionon this topic in 2000, and his persistence showed its results when on28 February 2008, the 142nd anniversary of Jaan Poska’s birth, thereception hall of the Tallinn City Government was opened in the Poska house, where there is also a Jaan Poska memorial room.However, the most numerous marks have been left in our educational and cultural history by Tullio Ilomets’ activities in the establishment of the University of Tartu Museum, which was driven bythe desire to save and preserve even a part of the cultural heritageconnected with the University of Tartu. Ilomets also played an important role in the restoration of the monument to Swedish king GustavII Adolf, the founder of the University of Tartu; for this reason, at theunveiling of the monument on 23 April 1992, Ilomets was entrustedwith the opening speech of the ceremony in the presence of the Swedish royal couple.The article also provides a partial overview of the honorary titlesand awards bestowed on Tullio Ilomets. He was an honorary member of the Estonian Heritage Society and recipient of its award forservice. On his 95th jubilee, he was officially awarded the shoulderribbon of the Estonian Heritage Society’s Service Award. In fall ofthe same year, the Estonian Heritage Society established the TullioIlomets Heritage Award, the first recipient of which was his student,Jüri Peets. Tullio Ilomets, who was 96 at the time, participated inthe awards ceremony in the White Hall of the University of TartuMuseum
Preclinical and clinical investigations as an approach to rational phytotherapy in prostate diseases
Full text linkPhytotherapeuticals have gained widespread usage in the treatment of symptomatic
benign prostatic hyperplasia (BPH). Among these phytotherapeutics, the most
popular and extensively studied are extracts of the dried ripe fruit of Serenoa repens
(SRE). The commercially available hydroethanolic (96%) SRE, Me180, is already
used as a medical treatment of symptomatic BPH. However, this extract was so far
neither investigated in vitro nor in vivo. The other extracts tested herein, derived from
Vitex agnus-castus (VAC), are so far not described to be used for treatment of
prostatic diseases or tested on prostate cells.
In a first part of the present studies, an in vitro screening system was established,
representative for different prostate disease stages. BPH and prostate cancer (PCA)
are multifactorial disease processes. Both diseases are age-related proliferative
disorders of the human prostate and with disturbed homeostasis in both conditions by
upsetting the balance between prostate cell proliferation and apoptosis. Thus, the
inhibition of proliferation and the reversion of the imbalance of homoeostasis is a
desired therapeutic option in both diseases.
Three different cell lines (BPH-1, LNCaP, PC-3) were chosen, representing different
disease stages. To evaluate the potential effects of selected plant extracts in
proliferative prostate diseases, several methodological approaches were used:
Crystal violet staining and WST-8 (tetrazolium based assay) were conducted to
establish the effects on cell proliferation and viability. To further elucidate the
mechanisms of cell death, FACScan analysis was performed to detect effects on cell
cycle distribution and apoptosis. Apoptosis was further investigated by co-treatment
of the cells with a pan-caspase inhibitor Z-VAD-fmk and by DNA fragmentation
assays. In addition, cytotoxicity was determined by measurement of lactate
dehydrogenase (LDH) in cell supernatants.
Proliferation of BPH-1 and PC-3 cells was modestly inhibited by Serenoa repens
extract Me180 in a dose-dependent manner with IC50 values of 100μg/ml, whereas in
androgen-responsive LNCaP cells, lower IC50 values of 35μg/ml, indicated a
possible mechanism through androgen-receptors. Me180 exerted similar effects in
vitro as other SRE’s previously investigated. Additional SRE’s, which varied with
respect to ripeness conditions of the raw material and the choice of solvents (hexane or ethanol) displayed no crucial differences in potency of growth inhibitory activities.
Moreover, Me180 exhibited a dose-dependent apoptotic effect in LNCaP cells, with
additional low cytotoxic effects. A low apoptotic effect was found in BPH-1 cells
without a cytotoxic effect, whereas PC-3 cells were almost insensitive to the Me180
treatment.
In addition, using the same methodology, these preclinical investigations were the
first to examine the effects of VAC fruit and leaf extracts on prostate cell proliferation.
The two different VAC’s were found to be effective inhibitors in all three cell lines
(with IC50 values < 10μg/ml after exposure to fruit extract and < 20μg/ml for leaf
extract, respectively) inducing apoptosis, and a low cytotoxic effect. Our new results
suggest that extracts of VAC, by modulating the cell cycle and the apoptotic
machinery, may possess a potential for development as an agent for prevention
and/or therapy of benign and malign prostatic hyperplastic diseases. Additional
studies are however required to further clarify their mechanisms of action and to
investigate their effects in vivo.
The in vitro data indicate that the chosen screening model system is suitable for the
detection of growth inhibitory activities of plant extracts in human prostate cell lines
and may help to find new phytotherapeuticals for this field of indication.
The objective of the second part was a clinical pilot study to compare the
therapeutical effects, tolerability and safety of treatment with Serenoa repens extract
Me180 (SabCaps®) versus tamsulosin (Pradif®) in patients with obstructive BPH. Due
to stringent exclusion criteria and hence difficulties in patient recruitment, the planned
patient number of 70 could not be achieved within a reasonable time for the thesis.
Only 19 patients, aged 50-79 years, with obstructive BPH (mean Qmax < 10ml/s for a
voiding volume of 150ml or assessed by flow-pressure study) were therefore included
in the study. Patients were randomised with either 320mg Me180 or Tamsulosin
0.4mg, given over a scheduled treatment period of 26 weeks in a double-blind
manner. The primary outcome measures were the change in peak urinary flow rate
(Qmax) and International Prostate Symptom Score (IPSS) with quality-of-life score
during the treatment. The secondary outcome measures included average urinary
flow rate (Qave), post-void residual urine volume and prostate volume, assessed by
transabdominal ultrasound. In addition, the International Index of Erectile Function
(IIEF) score was determined and adverse events were recorded. No significant differences were found in baseline parameters between the two
treatment groups. The treatment over 26 weeks was completed by 18 patients. In the
tamsulosin group, one patient withdrew from the study because of continuous
dizziness. There was no significant difference between the two treatments over the
26 weeks of the study with respect to IPSS, Qmax, Qave, residual urine, prostate
volume, and IIEF. During this pilot study all participants had some improvements in
their symptoms of BPH, but there was no significant difference in the beneficial effect
of either medication over the 26-weeks treatment time. With respect to the overall
incidence of adverse effects, Me180 was found significantly superior to the
tamsulosin group (p = 0.013).
The present data describe for the first time clinical results obtained with Me180.
Based on this pilot study, future clinical trials with larger patient numbers and longer
periods of treatment will be needed to assert if Me180 is an efficacious alternative
medical therapy for men with obstructive BPH
"Tullio Pericoli's Beckettian 'Facescapes'"
No full textIn occasione della mostra dei numerosi ritratti di Beckett di Tullio Pericoli alla casa di Oscar Wilde in Dublino l'autrice, che ha anche allestito la mostra, fa un'analisi comparata del gioco di illusione e realtà che caratterizza l'interpretazione di Beckett da parte di T. Pericoli con il bufalo istoriato sulla moneta di incerto valore creata dal drammaturgo David Mamet, uno dei più seri ammiratori di Beckett.On the occasion of the exhibition of Tullio Pericoli's "Becketts" at Oscar Wilde house in Dublin, the author (who has also put up the exhibition) compares the ambiguous game of appearance and reality going on in Pericoli's interpretation of Beckett to the uncertain value of the buffalo-headed coin of playwright David Mamet, one of Beckett's most serious admirers
Meenutades Tullio Ilometsa: Remembering Tullio Ilomets
No full textTullio Ilomets (13 July 1921 in Paide – 22 August 2018 in Tartu), anassociate professor of organic chemistry at the University of Tartu,was one of the authors of the idea of establishing the University ofTartu Museum and its lifelong supporter. As an active member of theheritage protection movement, he frequently spoke about questionsregarding the preservation of the University’s cultural heritage andthe protection of the old university.The author of this article, the chief curator of the University ofTartu museum in the years 1979–2015, developed a very good collaboration with Tullio Ilomets on the collection and preservation of theheritage objects of the university over the decades.Tullio Ilomets worked at the university for over 65 years. His final(and very fruitful) years were spent working as a consultant to themuseum in its Toome Hill building. Despite his advanced age, he wrote his most interesting overviews on the history of science in theseyears, based on the museum’s collections, on topics such as laboratoryglass, historic scales, the photographic collection of the University’sphotographer Kald, etc.Tullio Ilomets’ extensive activities in the area of heritage protection received attention and awards: the Order of the White Star,Third Class was bestowed on him in 2001. He was an honorary citizen of Tartu and recipient of the Tartu Suurtäht decoration (2001).The writer of this article has also attempted to reflect on TullioIlomets as a person, his friendly, humorous, but very purposeful andresilient personality
Tullio De Mauro e Emilio Garroni
No full textA study of the relationship between the work of Tullio De Mauro and that of Emilio Garroni would require lengthy research on their respective texts, in-depth theoretical reflection, and constant comparison with the Italian and international philosophical-cultural debate contemporary to them, with which they maintained a constant dialogue. Such investigation would also constitute an important chapter in the history of Italian culture from the second half of the 20th century to the present. Of this rich and articulated mosaic, a few individual tiles are considered here. To begin probing the “distance in proximity” that I believe characterizes the relationship between the two scholars, the essay in fact takes its cue from the different way of reading a passage from an author dear to both, paragraph 90 of Wittgenstein’s Philosophical Investigations. A theoretical knot from which a dialogue unravels, sometimes explicit, sometimes subterranean, centered on the nature of “sense” in human experience and that of linguistic and philosophical (mis)understanding. Two often divergent perspectives emerge, but rooted in a deep ethical consonance
Ravenscar Design Patterns? Reflections on Use of the Ravenscar Profile
No full textIndustrial developers have started to use the Ravenscar Profile in challenging application domains. The thorough feedback that begins to emerge from these experiences is of great interest to the community (i.e. the IRTAW group) that first conceived and promoted the Profile. This paper undertkes a first analysis of a specific experience report to which the author had early and privileged access
Frontmatter, Table of Contents, Preface, Workshop Organization, List of Authors
No full textFrontmatter, Table of Contents, Preface, Workshop Organization, List of Author
Ultrasonographic cervical length and risk of hemorrhage in pregnancies with placenta previa
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