2,084 research outputs found

    Mutational and functional genetics mapping of chemotherapy resistance mechanisms in relapsed acute lymphoblastic leukemia

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    Oshima, K., Zhao, J., Pérez-Durán, P., Brown, J.A., Patiño-Galindo, J.A., Chu, T., Quinn, A., Gunning, T., Belver, L., Ambesi-Impiombato, A., Tosello, V., Wang, Z., Sulis, M.L., Kato, M., Koh, K., Paganin, M., Basso, G., Balbin, M., Nicolas, C., Gastier-Foster, J.M., Devidas, M., Loh, M.L., Paietta, E., Tallman, M.S., Rowe, J.M., Litzow, M., Minden, M.D., Meijerink, J., Rabadan, R., Ferrando, A

    Realtà, realismo, straniamento : Auerbach e il romanzo cavalleresco fino a Cervantes

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    Auerbach’s research, besides exploring the three main fields the author explicitly names (i.e. the succession of different and differently grounded forms of realism in literary fiction, the alternate splitting and melting of styles, the link between literary work and a Christian vision of the world), in various chapters of Mimesis, and particularly in chs. 2, 6, 12, 14 and 20, is also focused, albeit only implicitly, on the developments of a further distinctive feature in Western literature, which is the emergence of subjectivity in the representation of reality. Focusing mainly on the chapter on courtly romance (ch. 6) and on the Quijote (ch. 14), this essay will examine Auerbach’s interpreting work on texts that adopt, in different ways, a ‘subjective point of view’; this kind of interpretation is, in part, unexpectedly similar to the approach of other critics and theorists of literature contemporary to Auerbach, like Bachtin, Américo Castro and Viktor Šklovskij

    Shedding light on the black hole: The roll-out of broadband access networks by private operators

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    Several market studies have indicated that the roll-out of broadband has significant economic and social relevance. The investments in broadband infrastructures needed to realise these economic and social benefits are, however, high-risk. This is firstly caused by the fact that the roll-out of access networks is extremely costly and requires high initial investments. Moreover, the multidisciplinary environment and involvement of many actors with diverging objectives and interests cause high complexity. Moreover, the market for broadband is changing fast and continuously. Although broadband has been on the academic research agenda for quite some time, this has as yet not resulted in a structured insight into the decision-making process around the upgrading of broadband networks, seen from the perspective of private operators and taking into account the vast complexity of the surroundings in which this decision-making process takes place in. The objective of this research was to provide a unifying theory combining technical, economic, market-related and regulatory factors with regard to an evolutionary, flexible approach of network upgrading from a decision-maker perspective. The result of this research is a robust, explanatory, parsimonious model for the impact and outcomes of broadband roll-out. This model provides a certain degree of stability in this multidisciplinary, unpredictable and highly dynamic research field.Technology, Policy and Managemen

    Mutational landscape, clonal evolution patterns, and role of RAS mutations in relapsed acute lymphoblastic leukemia

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    Chemotherapy Foundation; R01 CA185486, NIH, National Institutes of Health; U10 CA98543, NIH, National Institutes of Health; U54 CA193313, NIH, National Institutes of Health; St. Baldrick's FoundationOshima, K., Khiabanian, H., Da Silva-Almeida, A.C., Tzoneva, G., Abate, F., Ambesi-Impiombato, A., Sanchez-Martin, M., Carpenter, Z., Penson, A., Perez-Garcia, A., Eckert, C., Nicolas, C., Balbin, M., Sulis, M.L., Kato, M., Koh, K., Paganin, M., Basso, G., Gastier-Foster, J.M., Devidas, M., Loh, M.L., Kirschner-Schwabe, R., Palomero, T., Rabadan, R., Ferrando, A.A

    “Maistre (certa)”. Niveaux de savoir et conception du monde chez Guillaume IX d’Aquitaine

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    Starting with a study by M. Black (Models and Archetypes, 1958), the author examines the possibility of broadening this heuristic perspective to include literature. In particular, she analyses a text by William IX, in which the troubadour seems identify himself with God

    Oltre lo specchio: il Joufroi de Poitiers e la cultura lirica del suo autore

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    Come è stato a più riprese osservato, il Joufroi de Poitiers, romanzo d’autore borgognone collocabile verso la metà del XIII secolo, si ispira molto da vicino alla figura di Guglielmo IX d’Aquitania, grande signore e primo trovatore di cui ci siano giunti i componimenti. Ma a quali materiali si ispira veramente l’autore del Joufroi? Alla vida provenzale conservata, o piuttosto a una più ampia biografia latina perduta, o ad altri testi ancora? La presente ricerca cercherà di mettere in luce quali siano state le effettive fonti del romanzo e di abbozzare un’ipotesi che spieghi le motivazioni di questi recuperi.As has been repeatedly noted, Joufroi de Poitiers, a novel written by a Burgundian author and composed around the middle of the thirteenth century, is based very closely on the figure of William IX of Aquitaine, great lord and first troubadour whose poems have been compiled. But what materials did truly inspire the author of Joufroi? The extant Provençal vida, or rather a lost broader Latin biography, or still other texts? This research will try to shed light on what were the actual sources of the novel and to outline a hypothesis that explains the motivations of these works

    Proceedings of the Per Bruun Symposium

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    Holocene sea level rise, shoreline erosion and the Bruun Rule-overview (J.J. Fisher) The Bruun Rule: A historical perspective (M.L. Schwartz and V. Milicic) Hypothetical shore profiles in response to rising water level (R.N. Dubois) Shoreline erosion, Rhode Island and North Carolina coasts-test of Bruun Rule (J. J. Fisher) An application of the Bruun Rule in the Chesapeake Bay (P.S. Rosen) Bruun's Concept applied to the Great Lakes (E.B. Hands) Enigma of the Bruun's formula in shore erosion (H. Allison) The 11 Bruun Rule", Discussion on boundary conditions (P. Bruun)KWP-collectio

    Realtà, realismo, straniamento: Auerbach e il romanzo cavalleresco fino a Cervantes

    No full text
    Auerbach’s research, besides exploring the three main fields the author explicitly names (i.e. the succession of different and differently grounded forms of realism in literary fiction, the alternate splitting and melting of styles, the link between literary work and a Christian vision of the world), in various chapters of Mimesis, and particularly in chs. 2, 6, 12, 14 and 20, is also focused, albeit only implicitly, on the developments of a further distinctive feature in Western literature, which is the emergence of subjectivity in the representation of reality. Focusing mainly on the chapter on courtly romance (ch. 6) and on the Quijote (ch. 14), this essay will examine Auerbach’s interpreting work on texts that adopt, in different ways, a ‘subjective point of view’; this kind of interpretation is, in part, unexpectedly similar to the approach of other critics and theorists of literature contemporary to Auerbach, like Bachtin, Américo Castro and Viktor Šklovskij

    La guerra interdetta : "Il campo 29" di Sergio Antonielli

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    Il campo 29 is the debut as novelist of Sergio Antonielli. It was published in Milan in 1949 by “Edizioni Europee” and in 1976 by “Editori Riuniti”. The novel tells the personal experience of imprisonment in British Raj during the Second World War with other ten thousand Italian officers. Through the analysis of the text and documents from the archives of the author, stored in the Centro Apice, I would like to discuss the techniques of composition that make this work a peculiar case in the post-world war literary system. Antonielli, forcing himself to overcome the tragedy suffered, commits to the writing a dual purpose: to avoid mere “documentarismo” without overindulging in the romance, and to take the advantage of the exceptional nature of his experience to create a work that exceed all individual and historical contingencies. In respect of these moral and stylistic imperatives, the writer refuses the autobiography and choices a choral intonation, different from sentimental style, typical of other writers involved in the literature of war. His critic studies and the introductions, written by author for two editions, show distinct interpretations about his work and about typical methods and category of neorealist literature: document, diary, autobiographical novel. The story does not give way to political disquisitions or to sentimental parenthesis, but it consists of representation of the life in prison camps. A “city of prisoners” comes alive, where coexist vices and virtues of the normal society, and where the war is banned
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