2,814 research outputs found
Correction: Professor (Dr) Sukh Dev: an iconic scientist with an innate sixth sense who radicalized natural product synthesis & organic chemistry
No full text<jats:p>Correction for ‘Professor (Dr) Sukh Dev: an iconic scientist with an innate sixth sense who radicalized natural product synthesis &amp; organic chemistry’ by Harry Kochat <jats:italic>et al.</jats:italic>, <jats:italic>Org. Biomol. Chem.</jats:italic>, 2024, <jats:bold>22</jats:bold>, 5466–5469, https://doi.org/10.1039/D4OB90071E.</jats:p>
Biogenetic concepts in terpene structure elucidation
No full textIn the development of Natural Products Chemistry,biogenetic
considerations have played an important and useful role. In
this article, the author cites examples from his work in the area of Terpene Chemistry to highlight the usefulness of these concepts. To illustrate their application in structure elucidation, an example each from sesquiterpene, diterpene, triterpene and sesterterpene chemistry
has been described. Role of these concepts in the search for new structural types, congeners and precursors has been brought out. The usefulness of Absolute Stereochemistry Biogenetic Rule has been pointed out
Studies in sesquiterpenes-XVIII. The proton magnetic resonance spectra of some sesquiterpenes and the structure of humulene
No full textThe nuclear magnetic resonance spectra of longifolene, zerumbone, humulene, and their hydroderivatives have been studied in order to gauge the potentialities of this new tool in the field of sesquiterpenes. On the basis of present study, it has been possible to unequivocally fix the positions of the ethylene linkages in humulene and thus provide a straightforward solution of this hitherto unsolved problem
Studies in sesquiterpenes-XVI. Zerumbone, a monocyclic sesquiterpene ketone
No full textThe structure, previously assigned to zerumbone, has been found to be untenable. The ketone has been shown to be monocyclic containing three ethylenic linkages, and has been further correlated with humulene. Results from ozonolysis, and base-catalysed cleavage allowed the compound to be formulated as 2,6,9,9-tetramethyl-2,6,10-cyclo-undecatrien-1-one
Impact of natural products in modern drug development
No full textUsage of natural substances as therapeutic agents in modern medicine has sharply declined from the predominant position held in the early decades of last century, but search for bioactive molecules from nature (plants, animals, microflora) continues to play an important role in fashioning new medicinal agents. With the advent of modern techniques, instrumentation and automation in isolation and structural characterisation, we have on hand an enormous repository of natural compounds. In parallel to this, biology has also made tremendous progress in expanding its frontiers of knowledge. An interplay of these two disciplines constitutes the modern thrust in research in the realm of compounds elaborated by nature. The purpose of this article is to underline how natural products research continues to make significant contributions in the domain of discovery and development of new medicinal products. It is proposed to present the material under several heads, each of which has made natural products research relevant in the search for new and better medication
Systematic investigation of trench filling with photo materials
No full textAuthor Amal Dev Raj VilayilMasterarbeit Universität Linz 2022Arbeit auf den öffentlichen PCs in den Bibliotheken der JKU+Medizin abrufba
Reactions of Bis-(halomethyl)-dimethylsilanes with Metals
No full textIn an attempt to synthesize 1,1-dimethylsilicocyclopropane, the reactions of bis- (chloromethyl)-dimethylsilane and bis-(iodomethyl)-dimethylsilane with zinc and magnesium have been investigated under conditions where 1,3-dihalopropanes give high yields of the corresponding cyclopropanes
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