305,675 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
The application of vascular immune organoids from human pluripotent stem cells in cancer immunotherapy and SARS-CoV-2 modeling
No full textOrganoid technology has advanced our understanding of development and disease models. Organoids derived from either human pluripotent stem cells or tissue stem cells offer us the amenable platform to genetically intervene in human organ development. The advance of genetic engineering and stem cell technology pushed the limit of what organoids can do. However, the current lack of both vasculatures and immune cells hinders the understanding of how vasculatures and immune cells regulate organ development as well as their role in pathologic conditions such as cancer and infection. We have previously established a unique organoid system from human pluripotent stem cells (Ohta et al., 2019; Sugimura et al., 2020, 2017). Followed by mesodermal patterning and hemato-endothelial specification with define factors, we achieved vascular immune organoids (VIOs). We identified the highly vascularized structure of VIOs. The repertoire of cells encompasses innate immune cells such as macrophages, neutrophils, erythroblasts, and NK cells, which demonstrated functional maturity. In this talk, we will share our recent efforts in i) engineering functional immune cells for cancer immunotherapy, ii) modeling vasculitis in SARS-CoV-2 infection. We propose that VIOs could further enhance the organoid technology in both cancer immunotherapy and SARS-CoV-2 modeling. References Ohta, R., Sugimura, R., Niwa, A., Saito, M.K., 2019. Hemogenic Endothelium Differentiation from Human Pluripotent Stem Cells in A Feeder- and Xeno-free Defined Condition. J. Vis. Exp. JoVE. https://doi.org/10.3791/59823 Sugimura, R., Jha, D.K., Han, A., Soria-Valles, C., da Rocha, E.L., Lu, Y.-F., Goettel, J.A., Serrao, E., Rowe, R.G., Malleshaiah, M., Wong, I., Sousa, P., Zhu, T.N., Ditadi, A., Keller, G., Engelman, A.N., Snapper, S.B., Doulatov, S., Daley, G.Q., 2017. Haematopoietic stem and progenitor cells from human pluripotent stem cells. Nature 545, 432–438. https://doi.org/10.1038/nature22370 Sugimura, R., Ohta, R., Mori, C., Li, A., Mano, T., Sano, E., Kosugi, K., Nakahata, T., Niwa, A., Saito, M.K., Torisawa, Y.-S., 2020. Biomimetic aorta-gonad-Mesonephros-on-a-Chip to study human developmental hematopoiesis. Biomed. Microdevices 22, 34. https://doi.org/10.1007/s10544-020-00488-
The application of vascular immune organoids from human pluripotent stem cells in cancer immunotherapy and SARS-CoV-2 modeling
No full textOrganoid technology has advanced our understanding of development and disease models. Organoids derived from either human pluripotent stem cells or tissue stem cells offer us the amenable platform to genetically intervene in human organ development. The advance of genetic engineering and stem cell technology pushed the limit of what organoids can do. However, the current lack of both vasculatures and immune cells hinders the understanding of how vasculatures and immune cells regulate organ development as well as their role in pathologic conditions such as cancer and infection. We have previously established a unique organoid system from human pluripotent stem cells (Ohta et al., 2019; Sugimura et al., 2020, 2017). Followed by mesodermal patterning and hemato-endothelial specification with define factors, we achieved vascular immune organoids (VIOs). We identified the highly vascularized structure of VIOs. The repertoire of cells encompasses innate immune cells such as macrophages, neutrophils, erythroblasts, and NK cells, which demonstrated functional maturity. In this talk, we will share our recent efforts in i) engineering functional immune cells for cancer immunotherapy, ii) modeling vasculitis in SARS-CoV-2 infection. We propose that VIOs could further enhance the organoid technology in both cancer immunotherapy and SARS-CoV-2 modeling. References Ohta, R., Sugimura, R., Niwa, A., Saito, M.K., 2019. Hemogenic Endothelium Differentiation from Human Pluripotent Stem Cells in A Feeder- and Xeno-free Defined Condition. J. Vis. Exp. JoVE. https://doi.org/10.3791/59823 Sugimura, R., Jha, D.K., Han, A., Soria-Valles, C., da Rocha, E.L., Lu, Y.-F., Goettel, J.A., Serrao, E., Rowe, R.G., Malleshaiah, M., Wong, I., Sousa, P., Zhu, T.N., Ditadi, A., Keller, G., Engelman, A.N., Snapper, S.B., Doulatov, S., Daley, G.Q., 2017. Haematopoietic stem and progenitor cells from human pluripotent stem cells. Nature 545, 432–438. https://doi.org/10.1038/nature22370 Sugimura, R., Ohta, R., Mori, C., Li, A., Mano, T., Sano, E., Kosugi, K., Nakahata, T., Niwa, A., Saito, M.K., Torisawa, Y.-S., 2020. Biomimetic aorta-gonad-Mesonephros-on-a-Chip to study human developmental hematopoiesis. Biomed. Microdevices 22, 34. https://doi.org/10.1007/s10544-020-00488-
Author, publisher and bookseller : a tripartite synergy in Nigerian book industry
No full textThis work is about the roles of Author, Publisher and Bookseller in Book development in
Nigeria. The paper started by delving into the history of Book Publishing in Nigeria after
which it proceeded by defining who an author, a publisher, and a bookseller is and
expatiated on the indispensable roles of these key actors in Nigerian Book Industry and in
the emerging Information Society. Furthermore, the various constraints to book
development were identified while the paper advised on how the Book Industry can be
further promoted in Nigeria. However, the paper concluded and made recommendations
on how the Book sector can help in enhancing scholarship in the country
Direction of associations between personality traits and educational identity processes: Between‐ and within‐person associations
No full textIntroduction: In adolescence, personality traits and educational identity processes are interwoven. Previous studies have shown that personality traits predict healthy identity commitment and exploration in education. However, the direction of associations between personality traits and an identity process that searches for another identity option (i.e., reconsideration of commitment) is unclear. Furthermore, there is a lack of prospective studies regarding the direction of the association between personality traits and the educational identity process using within-person methods. Therefore, this study examined the direction of these associations. Methods: Participants of this four-wave longitudinal study comprised 618 Japanese 13-year-old adolescents (53.3% girls). This study involved a 1-year-interval assessment. Results: Cross-lagged panel models (CLPM) indicated that four personality traits (neuroticism, agreeableness, and conscientiousness) predicted three educational identity processes, while reconsideration of commitment predicted two personality traits (i.e., neuroticism and conscientiousness). Random intercept cross-lagged panel models (RI-CLPM) indicated that agreeableness predicted healthy commitment, while commitment predicted agreeableness at within-person level. Conclusion: The findings from CLPM suggest that reconsideration of commitment is a significant factor to predict healthy (i.e., conscientiousness) and unhealthy (i.e., neuroticism) personality traits in individual differences. Furthermore, the findings from RI-CLPM suggest that agreeableness may be a key trait in promoting healthy educational identity commitment. Theoretical and practical implications of these findings are discussed
Adolescents’ Identity Development Predicts the Transition and the Adjustment to Tertiary Education or Work
No full textAlthough identity development is crucial in individuals’ psychological adjustment from adolescence to adulthood, little is known about its impact in the transition to tertiary education or work. This study examined whether identity development during high school predicts career choices and adjustment (i.e., engagement) and maladjustment (i.e., burnout) after graduation. A total of 357 Japanese adolescents participated throughout the 3-year period of vocational high school (M age = 15.75; 62.75% girls). A follow-up assessment, at 18 months after the school-to-tertiary education or school-to-work transitions, was conducted. Higher identity synthesis during high school years predicted entry into tertiary education, while higher identity confusion predicted transition to work. Furthermore, higher identity synthesis during the high school years predicted higher post-graduation academic engagement, and higher levels of identity confusion predicted higher levels of post-graduation academic or work burnout. Overall, this study contributes to the understanding of the role of identity development in adolescence as a valuable asset for predicting the transition and the adjustment to tertiary education or work
[Report to Chief J. E. Curry, by an unknown author #2]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
[Report to Chief J. E. Curry, by an unknown author #1]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
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