1,720,996 research outputs found
First come, last primed: FN400 reflects post-encoding editing of the memory trace
No full textExplicit associative memory relies on different neural substrates depending on similarity of the items associated. Extant literature dissociates old/new effects elicited by homogeneous and heterogeneous pairs. However, current results scarcely address potential priming effects induced by the presentation sequence.In the present ERP study, participants learned associations between two pictures, which either belonged to the same semantic category (e.g., animal-animal), or to different categories (e.g., animal-scene). Pictures forming a pair were shown sequentially, allowing for investigation of the different neural processes related to presentation of the first and the second item. After the study phase, participants performed a recognition judgment. After recognition, participants were asked to recall the associated picture.During retrieval, between 260 and 350. ms post-stimulus there was a significant frontal effect of category (i.e., same-category versus different-category), but only for items shown first within a pair. In the 350-600. ms time window the parietal old/new effect was unaffected by semantic category, but was modulated by presentation order. Exploratory analyses revealed even earlier effects in the time windows 40-90. ms and 150-200. ms.This evidence supports the priming account of the FN400 and highlights the importance of sequence effects in electrophysiological activity during episodic retrieval
Asymmetric hemispheric contribution to ERPs in associative memory indexes goal relevance and quantity of information
No full textExplicit encoding requires humans to select the information relevant to their goals, yet not all irrelevant information is discarded. The present study addressed how different quantity and relevance of information modulate the electrophysiological activity during the encoding and retrieval phases of a recognition memory task. Subjects learned associations between two semantically unrelated pictures, and then performed a recognition judgment. After recognition, subjects were asked to recall the associated picture by using the recognized image as a cue. Cues yielded either high quantity of information (the cue evoked two associations, only one of them being relevant to the task), or low quantity of information (the cue evoked a single, relevant association). At encoding, a negative peak (400. ms) showed reduced negativity at left sites for the associative trials compared to the non-associative ones, while at right frontal sites the peak was more negative for goal-unrelated associations, compared to goal-related ones. Late right negativity during the test phase (800-1000 ms) discriminated hits followed either by correct or by no recall, but only when the cue evoked multiple associations. Frontal electrophysiological asymmetry at encoding was affected by the behavioral goal, i.e. activity reflected goal-related encoding on the left and goal-unrelated encoding on the right. The late right effect at retrieval suggests a link between this activity during encoding and the evaluation of the higher quantity of information in light of the behavioral goal during retrieval. Overall, the results indicate that different mechanisms and/or neuronal populations are involved in goal-related versus goal-unrelated association
Associative learning beyond the medial temporal lobe: many actors on the memory stage
Full text linkDecades of research have established a model that includes the medial temporal lobe, and particularly the hippocampus, as a critical node for episodic memory. Neuroimaging and clinical studies have shown the involvement of additional cortical and subcortical regions. Among these areas, the thalamus, the retrosplenial cortex and the prefrontal cortices have been consistently related to episodic memory performance.This article provides evidences that these areas are in different forms and degrees critical for human memory function rather than playing only an ancillary role. First we briefly summarize findings on the involvement of the hippocampus and the medial temporal lobe in recognition memory and recall. We then focus on the clinical and neuroimaging evidence available on thalamo-frontal and thalamo-retrosplenial networks. The role of these networks in episodic memory has been considered secondary, partly because disruption of these areas does not always lead to severe impairments; to account for this evidence, we discuss methodological issues related to the investigation of these regions. We propose that these networks contribute differently to recognition memory and recall, and also that the memory stage of their contribution shows specificity to encoding or retrieval in recall tasks. We note that the same mechanisms may be in force when humans perform non-episodic tasks, e.g., semantic retrieval and mental time travel. Functional disturbance of these networks is related to cognitive impairments not only in neurological disorders, but also in psychiatric medical conditions, such as schizophrenia. Finally we discuss possible mechanisms for the contribution of these areas to memory, including regulation of oscillatory rhythms and long-term potentiation. We conclude that integrity of the thalamo-frontal and the thalamo-retrosplenial networks is necessary for the manifold features of episodic memory
Semantic features of associatively encoded pairs modulate early source memory effects during retrieval
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
The involvement of the thalamus in semantic retrieval: A clinical group study
No full textThere is increasing attention about the role of the thalamus in high cognitive functions, including memory. Although the bulk of the evidence refers to episodic memory, it was recently proposed that the mediodorsal (MD) and the centromedian–parafascicular (CM–Pf ) nuclei of the thalamus may process general operations supporting memory performance, not only episodic memory. This perspective agrees with other recent fMRI findings on semantic retrieval in healthy participants. It can therefore be hypothesized that lesions to the MD and the CM–Pf impair semantic retrieval. In this study, 10 patients with focal ischemic lesions in the medial thalamus and 10 healthy controlsmatched for age, education, and verbal IQ performed a verbal semantic retrieval task. Patients were assigned to a target clinical group and a control clinical group based on lesion localization. Patients did not suffer from aphasia and performed in the range of controls in a categorization and a semantic association task. However, target patients performed poorer than healthy controls on semantic retrieval. The deficit was not because of higher distractibility but of an increased rate of false recall and, in some patients, of a considerably increased rate of misses. The latter deficit yielded a striking difference between the target and the control clinical groups and is consistent with anomia. Follow-up high-resolution
structural scanning session in a subsample of patients revealed that lesions in the CM–Pf and MD were primarily associated with semantic retrieval deficits. We conclude that integrity of the MD and the CM–Pf is required for semantic retrieval, possibly because of their role in the activation of phonological representations
TMS over the posterior cerebellum modulates motor cortical excitability in response to facial emotional expressions
No full textEvidence suggests that the posterior cerebellum is involved in emotional processing. Specific mechanisms by which the cerebellum contributes to the perception of and reaction to the emotional state of others are not well-known. It is likely that perceived emotions trigger anticipatory/preparatory motor changes. However, the extent to which the cerebellum modulates the activity of the motor cortex to contribute to emotional processing has not been directly investigated. In this study, we assessed whether the activity of the posterior cerebellum influences the modulation of motor cortical excitability in response to emotional stimuli. To this end, we transiently disrupted the neural activity of the left posterior cerebellum using 1 Hz repetitive transcranial magnetic stimulation (rTMS) and examined its effect on motor cortical excitability witnessed during emotional face processing (in comparison to the effects of sham rTMS). Motor excitability was measured as TMS-based motor evoked potentials (MEPs) recorded from bilateral first dorsal interosseous (FDI) muscles during the viewing of negative emotional (i.e. fearful) and neutral facial expressions. In line with previous evidence, we found that MEP amplitude was increased during the viewing of fearful compared to neutral faces. Critically, when left posterior cerebellar activity was transiently inhibited with 1 Hz rTMS, we observed a reduction in amplitude of MEPs recorded from the contralateral (right) motor cortex during the viewing of emotional (but not neutral) faces. In turn, inhibition of the left posterior cerebellum did not affect the amplitude of MEPs recorded from the ipsilateral motor cortex. Our findings suggest that the posterolateral (left) cerebellum modulates motor cortical response to negative emotional stimuli and may serve as an interface between limbic, cognitive, and motor systems
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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