1,720,988 research outputs found
Stroke in Italy: a disease to prevent
No full textStroke, a disease determining an increasing socioeconomic burden in aging populations, represents the second cause of mortality, worldwide and the third cause of mortality in western countries. In our study, crude annual incidence rate of stroke was 2931 100,000. Several conditions and life-style factors have been identified as risk factors for stroke. Their recognition is important to prevent stroke. Atherothrombosis contributes a large proportion of cases; however, conventional stroke risk factors do not fully account for the risk of stroke, and often stroke victims with documented atherosclerosis may, not show any conventional risk factor. A major goal is to promote prevention of stroke through identification and clarification of new risk factors and pathogenic mechanisms. Moreover, early stroke prevention requires a comprehensive multidisciplinary strategy to educate and promote adherence to preventive protocols
Symptoms of gait and coordination impairment in a patient with COVID-19 interstitial pneumonia
No full textRuolo dello specialista ORL nella valutazione degli stadi preclinici della malattia di Alzheimer
No full textCon la standardizzazione dei test olfattometrici lo specialista otorinolaringoiatra viene ad assumere un ruolo determinante nella diagnosi delle malattie neurodegenerative ed in particolare negli stadi preclinici della malattia di Alzheimer (AD). Sulla base di queste nuove acquisizioni si propone che la valutazione otorinolaringoiatrica e la somministrazione del test olfattometrico da parte dello specialista venga introdotta nella batteria di test diagnostici per gli stadi preclinici dell’AD. In questo lavoro evidenziamo il ruolo dello Sniffin’ Sticks Screening Test (SSST) nella valutazione del paziente affetto da malattie neurodegenerative anche alla luce dei risultati ottenuti nelle predemenze ed in particolare nei pazienti con amnesic Mild Cognitive Impairment (aMCI)
smell and preclinical Alzheimer disease: study of 29 patients with amnesic mild cognitive impairment
No full textObjectives: To evaluate the olfactory function in patients with amnesic mild cognitive impairment (aMCI) and the relationship to
the progression from aMCI to Alzheimer disease (AD.
Design: Cohort prospective study on aMCI patients at the first evaluation (T0) and at the 18-month follow-up (T1.
Setting: Alzheimer Unit of the University of L’Aquila, Italy.
Methods: Twenty-nine aMCI patients were enrolled in this study.
Main Outcome Measures: Olfactory function was studied with the Sniffin’ Sticks Screening Test (SSST) and the Sniffin’ Sticks
Extended Test (SSET). Olfactory functions were related to neurocognitive functions assessed by the Mini-Mental State Examination
(MMSE) and the Mental Deterioration Battery (MDB.
Results: At T0, aMCI patients showed an olfactory impairment and all of the aMCI patients had lower olfaction scores at T1. At
T1, 9 of the 29 aMCI patients (31%) developed AD and had lower mean SSST and SSET scores than 20 aMCI patients who did not develop AD. The most significant relationship was found between olfactory discrimination and visuospatial ability, language skill,
and the Rey Immediate test of the MDB and between olfactory identification and the Rey Delayed test.
Conclusion: Odour discrimination and identification performance correlated more prominently than detection thresholds with
performance on neuropsychological tests. We concluded that the olfactory deficit occurs early in aMCI, so we suggest introducing
the clinical routine use of the olfactory test for early identification of the progression of the decline from aMCI to AD
Olfactory and neurological evaluation in aMCI patients
No full textOBJECTIVES: Patients with amnesic Mild Cognitive Impairment (aMCI) have a higher risk to develop Alzheimer disease (AD) than general elderly population. The aim of this study is to evaluate the olfactory decrease in patients with aMCI and its correlation with neurocognitive decline. METHODS: 29 aMCI patients (19 women and 10 men, mean age 70.8±5.7) were enrolled in the study and examined at baseline (T0) and at 12 months follow-up (T1). All patients had ENT examination, neuropsycological evaluation, olfactory test and neuroimaging study of the brain. Olfactory function was evaluated by the Sniffin' Sticks Extended Test (SSET) to assess olfactory threshold, discrimination and identification. Neurocognitive functions were assessed by the Mini Mental State Examination (MMSE), the Clinical Dementia Rating (CDR), the Geriatric Depression Scale (GDS) and the Mental Deterioration Battery (MDB). Spearman non parametric correlation was used to evaluate correlation between variables.
RESULTS: Based on the olfactory score 8 patients were normosmic (27.6 %), 20 hyposmic (68.9%) and 1 anosmic (3.5%) at T0. 3 patients were normosmic (10.3 %), 25 hyposmic (86.2 %) and 1 anosmic (3.5%) at T1. 9 of the 29 aMCI patients (31%) developed AD. The higher statistically significant relationship was found between olfactory discrimination and visuo-spatial ability (0.52; p=0.004) and language skill (0.46; p=0.01) of MDB.
CONCLUSIONS: we suggest to introduce the clinical routine use of the SSET test to correlate olfactory and cognitive function in the progression of the decline from aMCI to AD
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Satisfaction and quality of life relative to anesthesiologic and surgical technique in carotid revascularization
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