572 research outputs found
Environmental toxicity, redox signaling and lung inflammation:the role of glutathione
No full textGlutathione (gamma-glutamyl-cysteinyl-glycine, GSH) is the most abundant intracellular antioxidant thiol and is central to redox defense during oxidative stress. GSH metabolism is tightly regulated and has been implicated in redox signaling and also in protection against environmental oxidant-mediated injury. Changes in the ratio of the reduced and disulfide form (GSH/GSSG) can affect signaling pathways that participate in a broad array of physiological responses from cell proliferation, autophagy and apoptosis to gene expression that involve H(2)O(2) as a second messenger. Oxidative stress due to oxidant/antioxidant imbalance and also due to environmental oxidants is an important component during inflammation and respiratory diseases such as chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, acute respiratory distress syndrome, and asthma. It is known to activate multiple stress kinase pathways and redox-sensitive transcription factors such as Nrf2, NF-kappaB and AP-1, which differentially regulate the genes for pro-inflammatory cytokines as well as the protective antioxidant genes. Understanding the regulatory mechanisms for the induction of antioxidants, such as GSH, versus pro-inflammatory mediators at sites of oxidant-directed injuries may allow for the development of novel therapies which will allow pharmacological manipulation of GSH synthesis during inflammation and oxidative injury. This article features the current knowledge about the role of GSH in redox signaling, GSH biosynthesis and particularly the regulation of transcription factor Nrf2 by GSH and downstream signaling during oxidative stress and inflammation in various pulmonary diseases. We also discussed the current therapeutic clinical trials using GSH and other thiol compounds, such as N-acetyl-l-cysteine, fudosteine, carbocysteine, erdosteine in environment-induced airways disease
Biswas-Milovic model and its optical solitons
No full textInternational Conference on Numerical Analysis and Applied Mathematics 2018, ICNAAM 2018 -- 13 September 2018 through 18 September 2018 -- -- 149843In this work, optical solitons are obtained for the Biswas - Milovic equation as a generalized model via the extended generalizing Riccati mapping method. This method reveals several optical solitons including traveling wave solutions. The found solutions are identified with two different forms including the hyperbolic functions, the rational functions and the trigonometric functions. Reliability of our solution is given graphical consequens. © 2019 Author(s)
On connections on principal bundles
No full textAbstractA new construction of a universal connection was given in Biswas, Hurtubise and Stasheff (2012). The main aim here is to explain this construction. A theorem of Atiyah and Weil says that a holomorphic vector bundle E over a compact Riemann surface admits a holomorphic connection if and only if the degree of every direct summand of E is zero. In Azad and Biswas (2002), this criterion was generalized to principal bundles on compact Riemann surfaces. This criterion for principal bundles is also explained
Fabrication of TiO_2-based visible light photocatalyst
No full textArticleこの論文は国立情報学研究所の学術雑誌公開支援事業により電子化されました富山大学ベンチャービジネスラボラトリー年報, 平成18年度, 2006, Page 79-8
Study of TiO_2-thin film in application of photocatalysis and photovoltaic cell
No full textArticleこの論文は国立情報学研究所の学術雑誌公開支援事業により電子化されました富山大学ベンチャービジネスラボラトリー年報, 平成19年度, 2007, Page 87-8
Satellite-retrieved direct radiative forcing of aerosols over North-East India and adjoining areas: climatology and impact assessment
No full textThe article by J. Biswas et al. contained an update in affiliation of author Binita Pathak. The author would like to add another affiliation to her name. Her updated affiliations are the following
Correction: De Francesco et al. In Vitro Characterization of Canine Microfragmented Adipose Tissue Non-Enzymatically Extracted from the Thigh and Lumbar Regions. Animals 2021, 11, 3231
No full textReetuparna Biswas was not included as an author in the original publication [...
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