861 research outputs found
Bronze image casting in Tanjavur District, Tamil Nadu: Ethnoarchaeological and archaeometallurgical insights
No full textThe profusion of metal images made in the Tanjavur region, going back to the early medieval Chola
bronzes of the 9th-13th century ranks amongst the finest of Indian artistic expressions. Clusters of artistic and
artisanal activities have thrived over generations in the Tanjavur district including metalworking workshops for
bronze and bell metal casting of images and ritual objects especially around Swamimalai and Kumbakonam.
Ethnometallurgical and archaeometallurgical insights on the making of icons at Swamimalai are highlighted from
observations made over the past couple of decades, especially in relation to making comparisons with historical
practices of bronze casting going back to Chola times. Since the processes are rapidly undergoing change, to get
a better sense of the trajectory of past practices, this paper particularly aims to highlight unpublished observations
made by the author going back to her first visits in 1990-1, as background to her doctoral work (Srinivasan 1996)
and in relation to observations reported by other scholars going back to the early landmark efforts of Reeves (1962).
These observations were particularly made by the author at the workshop of late master craftsman Devasena
Sthapathy, in his time the most renowned of Swamimalai Sthapathis. His son Radhakrishna Sthapathy has now
inherited this mantle. While Levy et al (2008) give a more recent account of image casting at the workshop of
Radhakrishna Sthapathy, this paper attempts to also contextualise the previous trajectory that has not been covered
much therein. Since their workshop now goes under the name of Sri Jayam Industries, for the sake of convenience
it will be referred here by the same name
Redescrição de Cymodoce madrasensis (Srinivasan, 1959) combinação nova (Sphaeromatidae: Isopoda: Crustacea) de Madras, Índia
No full textO autor estudou quase todas as espécies da família Sphaeromatidae (Isopoda), da Coleção de Crustacea do USNM, e a espécie constante do catálogo 102151 USNM, na época, não possuia identificação razão pela qual o autor enquadrou no gênero Cymodoce. Hoje está classificada como Exosphaeroma madrasensis Srinivasan, 1959. Este gênero não condiz com as características da espécie motivo pelo qual o autor procedeu a transferência para o gênero Cymodoce Leach, 1814, e estabeleceu nova combinação Cymodoce madrasensis (Srinivasan, 1959).The author studying a male of Exosphaeroma madrasensis Srinivasan, 1959, catalog 102151 Division of Crustacea - USNM, describes and transfers the species to the genus Cymodoce Leach, 1814 establishing a new combination Cymodoce madrasensis (Srinivasan, 1959)
A class of gorenstein artin algebras of embedding dimension four
No full textIn this article, we study height four graded Gorenstein ideals I in k[x, y, z, w] such that I2 is of height one and generated by three quadrics. After a suitable linear change of variables, I ∩ k[x, y, z] is either Gorenstein or of type two. The former case was studied by Iarrobino and Srinivasan [8] where they give the structure of the ideal and its resolution. We study the latter case and give the structure of these ideals and their minimal resolution. We also explicitly write the form of the generators of I and the maps in the free resolution of R-I. © Taylor andamp; Francis Group, LLC.Artin E., 1957, INTERSCIENCE TRACTS, V3; BROWN A, 1984, THESIS BRANDEIS U WA; BROWN AE, 1987, J ALGEBRA, V105, P308, DOI 10.1016-0021-8693(87)90196-7; BUCHSBAUM DA, 1977, AM J MATH, V99, P447, DOI 10.2307-2373926; BUCHSBAU.DA, 1973, J ALGEBRA, V25, P259, DOI 10.1016-0021-8693(73)90044-6; Eisenbud D., 1994, GRADUATE TEXTS MATH, V150; ELKHOURY S, 2007, THESIS U MISSOURI MI; Iarrobino A, 2005, J PURE APPL ALGEBRA, V201, P62, DOI 10.1016-j.jpaa.2004.12.015; KUSTIN A, 1982, T AM MATH SOC, V270, P287, DOI 10.2307-1999773; Macaulay F. S., 1994, ALGEBRAIC THEORY MOD; Srinivasan H., 2003, ADV ALGEBRA GEOMETRY, P93; SRINIVASAN H, 1977, CONT MATH, V99, P44711
The Role of the Glucocorticoids in Developing Resilience to Stress and Addiction
No full textThere is emerging evidence that individuals have the capacity to learn to be resilient by developing protective mechanisms that prevent them from the maladaptive effects of stress that can contribute to addiction. The emerging field of the neuroscience of resilience is beginning to uncover the circuits and molecules that protect against stress-related neuropsychiatric diseases, such as addiction. Glucocorticoids (GCs) are important regulators of basal and stress-related homeostasis in all higher organisms and influence a wide array of genes in almost every organ and tissue. Glucocorticoids, therefore, are ideally situated to either promote or prevent adaptation to stress. In this review, we will focus on the role of GCs in the HPA axis and extra-hypothalamic regions in regulating basal and chronic stress responses. GCs interact with a large number of neurotransmitter and neuropeptide systems that are associated with the development of addiction. Additionally, the review will focus on two pathways the orexinergic and cholinergic neurotransmission and highlight their role in stress and addiction. We will provide examples of interactions between GCs and these wherever studied. GCs play a key role in promoting the development of resilience or susceptibility associated with the development of stress-induced addiction and represent important pharmacotherapeutic targets that can reduce the impact of a maladapted stress system for the treatment of stress-induced addiction
Identification and validation of SNP markers linked to seed toxicity in Jatropha curcas L
No full textNot AvailableEdible/non-toxic varieties of Jatropha curcas L. are gaining increasing attention, providing both oil as biofuel feed stock or even as edible oil and the seed kernel meal as animal feed ingredient. They are a viable alternative to the limitation posed by the presence of phorbol esters in toxic varieties. Accurate genotyping of toxic/non-toxic accessions is critical to breeding management. The aim of this study was to identify SNP markers linked to seed toxicity in J. curcas. For SNP discovery, NGS technology
was used to sequence the whole genomes of a toxic and non-toxic parent along with a bulk of 51 toxic and 30 non-toxic F2 plants. To ascertain the association between SNP markers and seed toxicity trait, candidate SNPs were genotyped on 672 individuals segregating for seed toxicity and two collections of J. curcas composed of 96 individuals each. In silico SNP discovery approaches led to the identification of 64 candidate SNPs discriminating non-toxic and toxic samples. These SNPs were mapped on Chromosome 8 within the Linkage Group 8 previously identified as a genomic region important for phorbol ester biosynthesis. The association study identified two new SNPs, SNP_J22 and SNP_J24 significantly linked to low toxicity with R2 values of 0.75 and 0.54, respectively. Our study released two valuable SNP markers for high-throughput, marker-assisted breeding of seed toxicity in J. curcas.Not Availabl
R19. Investigation of Taste Masking Efficiency of Caffeine Citrate by Lipids Utilizing Hot Melt Extrusion Technology
No full textCorresponding author (Pharmaceutics and Drug delivery): Priyanka Srinivasan, [email protected]://egrove.olemiss.edu/pharm_annual_posters/1018/thumbnail.jp
Notch Signaling: Mechanistic And Functional Studies In Intestinal Stem Cells And Colorectal Cancer Cells
No full text: The study of stem cell regulation in intestinal and colonic tissues is an area of significant focus within the scientific community, providing mechanistic insight into biological process and offering translational clinical potential. In this thesis we address the contribution of NOTCH signaling in maintaining the stem cell niche by modulating the mode of stem cell division and receptor-ligand interactions for cell-cell communication. Furthermore, we examine NOTCHmediated spatiotemporal recovery of the intestinal stem cell (ISC) niche following single cell ablation. Finally, we demonstrate that elevated NOTCH signaling exists under conditions of physiological stress and in colon cancer initiating cells (CCICs), promoting tumorigenic potential of the intestinal epithelium. Overall, our research highlights the underlying complexities of NOTCH signaling as an essential pathway to maintain intestinal homeostasis and may inspire development of novel CRC therapeutic strategies. Research efforts and findings during my graduate study have been consolidated into the following peer-reviewed publications, of which the four first co-author manuscripts are described in detail in this dissertation. 1. Srinivasan, Tara; Walters, Jewell; Bu, Pengcheng; Than, Elaine B.; Tung, Kuei-Ling; Chen, Kai-Yuan; Panarelli, Nicole; Milsom, Jeff; Augenlicht, Leonard; Lipkin, Steven M; Shen, Xiling. "NOTCH Signaling Regulates Asymmetric Division of Fast- and Slow-Cycling Colon Cancer Initiating Cells." Cancer Research, 2016. (in press) 2. Srinivasan, Tara; Than, Elaine B.; Bu, Pengcheng; Tung, Kuei-Ling; Chen, Kai-Yuan; Augenlicht, Leonard; Lipkin, Steven M.; Shen, Xiling. "NOTCH Signaling Regulates Fast- and Slow-Cycling Intestinal Stem Cells." Scientific Reports, 2016. (in press) 3. Chen, Kai-Yuan*; Srinivasan, Tara*; Choi, Jiahn*; Bu, Pengcheng; Tung, Kuei-Ling; Nishimura, Nozomi; Shen, Xiling. "Dynamic regulation of intestinal stem cell niche recovery in real-time." Cell Systems, 2015. (in review) 4. Murthy, Preetish KL*; Srinivasan, Tara*; Bochter, Skye; Bu, Pengcheng; Cole, Susan; Shen, Xiling. "FRINGE-dependent modification of NOTCH Ligands in Intestinal Stem Cells." 2016. (in preparation) 5. Rothschild, Daniel; Srinivasan, Tara; Aponte-Santiago, Linette; Shen, Xiling; Irving, Allen. "The Ex Vivo Culture and Pattern Recognition Receptor Stimulation of Mouse Intestinal Organoids." JoVE, 2015. (in press) 6. Bu, Pengcheng*; Wang, Lihua*; Chen, Kai-Yuan; Srinivasan, Tara; Lakshminarasimha, Preetish; Tung, Kuei-Ling; Varanko, Anastasia; Ai, Yiwei; Lipkin, Steven; Shen, Xiling. "miR34a and Numb synergize for asymmetric cell fate determination." Cell Stem Cell, 2016 Feb 4;18(2):189-202. 7. Crespo, Miguel; Tsai, Su-Yi; Srinivasan, Tara; Pipalia, Nina; Maxfield, Nina; Lipkin, Steven M; Evans, Todd; Chen, Shuibing. "Colonic Organoids Derived from Human Pluripotent Stem Cells for Modeling Colorectal Cancer and Drug Testing." Nature Medicine, 2015. (in review) 8. Wang, Lihua*; Bu, Pengcheng*; Ai, Yiwel; Srinivasan, Tara; Lipkin, Steven M; Shen, Xiling. "A Long Non-Coding RNA Targets MicroRNA miR-34a to Regulate Colon Cancer Stem Cell Asymmetric Division." eLife, 2016. (in press
Classification of Grain Amaranths Using Chromosome-Level Genome Assembly of Ramdana, A. hypochondriacus
No full textIn the age of genomics-based crop improvement, a high-quality genome of a local landrace adapted to the local environmental conditions is critically important. Grain amaranths produce highly nutritional grains with a multitude of desirable properties including C4 photosynthesis highly sought-after in other crops. For improving the agronomic traits of grain amaranth and for the transfer of desirable traits to dicot crops, a reference genome of a local landrace is necessary. Toward this end, our lab had initiated sequencing the genome of Amaranthus (A.) hypochondriacus (A.hyp_K_white) and had reported a draft genome in 2014. We selected this landrace because it is well adapted for cultivation in India during the last century and is currently a candidate for TILLING-based crop improvement. More recently, a high-quality chromosome-level assembly of A. hypochondriacus (PI558499, Plainsman) was reported. Here, we report a chromosome-level assembly of A.hyp_K_white (AhKP) using low-coverage PacBio reads, contigs from the reported draft genome of A.hyp_K_white, raw HiC data and reference genome of Plainsman (A.hyp.V.2.1). The placement of A.hyp_K_white on the phylogenetic tree of grain amaranths of known accessions clearly suggests that A.hyp_K_white is genetically distal from Plainsman and is most closely related to the accession PI619259 from Nepal (Ramdana). Furthermore, the classification of another accession, Suvarna, adapted to the local environment and selected for yield and other desirable traits, is clearly Amaranthus cruentus. A classification based on hundreds of thousands of SNPs validated taxonomy-based classification for a majority of the accessions providing the opportunity for reclassification of a few
Neural geolocation prediction in Twitter
No full textInferring the location of a user has been a valuable step for many applications that leverage social media, such as marketing, security monitoring and recommendation systems. Motivated by the recent success of Deep Learning techniques for many tasks such as computer vision, speech recognition, and natural language processing, we study the application of neural models to the problem of geolocation prediction and experiment with multiple techniques to analyze neural networks for geolocation inference based solely on text. Experimental results on the dataset suggest that choosing appropriate network architecture can all increase performance on this task and demonstrate a promising extension of neural network based models for geolocation prediction. Our systematic extensive study of four supervised and three unsupervised tweet representations reveal that Convolutional Neural Networks (CNNs) and fastText best encode the the textual and geoloca- tional properties of tweets respectively. fastText emerges as the best model for low resource settings, providing very little degradation with reduction in embedding size.Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2019-05-01The student, Pramod Srinivasan, accepted the attached license on 2017-04-25 at 12:15.The student, Pramod Srinivasan, submitted this Thesis for approval on 2017-04-25 at 12:51.This Thesis was approved for publication on 2017-04-25 at 18:42.DSpace SAF Submission Ingestion Package generated from Vireo submission #11043 on 2017-08-10 at 14:32:36Made available in DSpace on 2017-08-10T19:52:23Z (GMT). No. of bitstreams: 2
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