43,836 research outputs found
Sparse multiway canonical correlation analysis for multimodal stroke recovery data
No full textConventional canonical correlation analysis (CCA) measures the association between two datasets and identifies relevant contributors. However, it encounters issues with execution and interpretation when the sample size is smaller than the number of variables or there are more than two datasets. Our motivating example is a stroke-related clinical study on pigs. The data are multimodal and consist of measurements taken at multiple time points and have many more variables than observations. This study aims to uncover important biomarkers and stroke recovery patterns based on physiological changes. To address the issues in the data, we develop two sparse CCA methods for multiple datasets. Various simulated examples are used to illustrate and contrast the performance of the proposed methods with that of the existing methods. In analyzing the pig stroke data, we apply the proposed sparse CCA methods along with dimension reduction techniques, interpret the recovery patterns, and identify influential variables in recovery.
Seminário sobre aquacultura 14 a 16 de dezembro de 1983
No full textA necessidade de desenvolver a aquacultura em Portugal obriga à escolha das espécies mais indicadas para tal finalidade. A propósito o autor chama a atenção para as graves consequências que podem advir das introduções e/ou transferências de animais aquáticos, quer para as espécies locais e meio ambiente, como para a para a saúde pública.Concerning the need to choose the most convenient species to cultivate in order to implement aquaculture in Portugal, the author draws the attention to the deleterious consequences of introductions and transfers of aquatic animals.Caixa Geral de Depósito
Redox-Responsive Nanocapsules for the Spatiotemporal Release of Miltefosine in Lysosome: Protection against Leishmania
No full textLeishmaniasis, a vector-borne disease, is caused by intracellular parasite Leishmania donovani. Unlike most intracellular pathogens, Leishmania donovani are lodged in parasitophorous vacuoles and replicate within the phagolysosomes in macrophages. Effective vaccines against this disease are still under development, while the efficacy of the available drugs is being questioned owing to the toxicity for nonspecific distribution in human physiology and the reported drug-resistance developed by Leishmania donovani. Thus, a stimuli-responsive nanocarrier that allows specific localization and release of the drug in the lysosome has been highly sought after for addressing two crucial issues, lower drug toxicity and a higher drug efficacy. We report here a unique lysosome targeting polymeric nanocapsules, formed via inverse mini-emulsion technique, for stimuli-responsive release of the drug miltefosine in the lysosome of macrophage RAW 264.7 cell line. A benign polymeric backbone, with a disulfide bonding susceptible to an oxidative cleavage, is utilized for the organelle-specific release of miltefosine. Oxidative rupture of the disulfide bond is induced by intracellular glutathione (GSH) as an endogenous stimulus. Such a stimuli-responsive release of the drug miltefosine in the lysosome of macrophage RAW 264.7 cell line over a few hours helped in achieving an improved drug efficacy by 200 times as compared to pure miltefosine. Such a drug formulation could contribute to a new line of treatment for leishmaniasis.A. Das acknowledges SERB (India) Grants (CRG/2020/000492 and JCB/2017/000004) and DBT Grant (BT/PR22251/NNT/28/1274/2017) for supporting this research. N. Mukherjee acknowledges SERB (India) Grant PDF/2016/001437 and K. Das acknowledges the grant EMR/2015/001674 for supporting this research. Financial support from DST (DST/INSPIRE/03/2017/002477) is acknowledged by R.T. This manuscript bears CSMCRI registration no 7/2021.Pramanik, SK (corresponding author), CSIR Cent Salt & Marine Chem Res Inst, Bhavnagar 364002, Gujarat, India.
Mukherjee, N (corresponding author), CSIR Indian Inst Chem Biol, Canc Biol & Inflammatory Disorder Div, Kolkata 700032, India.
Chattopadhy, S (corresponding author), BITS Pilani, Pilani 403726, Goa, India.
Das, A (corresponding author), Indian Inst Sci Educ & Res Kolkata, Mohanpur 741246, W Bengal, India.
[email protected]; [email protected]; [email protected]
Interview with Indra Das
No full textIndra Das is most well-recognized as the author of The Devourers (2015), a novel that won the Lambda Literary Award for straddling the genres of sci-fi, speculative, and fantasy fiction alongside LGBT themes. Das’s short fiction is widely published is horror and sci-fi anthologies, as well as magazines like Tor.com, Strange Horizons, and Asimov’s Science Fiction. He spoke candidly with Alok Amatya over email about the current literary landscape, the work of writing transgressive genre fiction, and his own experiences as an upcoming global author
"PULS." - Ein Blog als Online-Magazin für Medizinstudierende der Goethe-Universität Frankfurt
No full textIm Herbst 2009 forderten Studierende im Rahmen landesweiter Proteste auch am Fachbereich Medizin/Zahnmedizin der Goethe-Universität Frankfurt mehr Transparenz und Kommunikation zu Angelegenheiten ihres Studiums. Einen innovativen Lösungsansatz, um diesen Forderungen nachzukommen, bietet eines der Web 2.0 Werkzeuge: ein auf einer Blog-Software basierendes Online-Magazin für Studierende und andere Mitglieder des Fachbereichs.
Das öffentlich zugängliche Online-Magazin "PULS." (https://newsmagazin.puls.med.uni-frankfurt.de/wp/) wird mit einer freien Blog-Software (wordpress Version 3.1.3.) realisiert und von einer Online-Redakteurin konzipiert und geschrieben. Die Beiträge entstehen nach eigenen Recherchen sowie aus Anregungen und Gesprächen mit verschiedenen Personengruppen des Fachbereichs. Die datenschutzkonforme Auswertung der Zugriffe erfolgt über eine open-source Webanalyse-Software (Piwik). Zusätzlich werden jährlich mit dem Online-Umfrage-Tool Survey Monkey die Nutzer anonym befragt.
"PULS." ist seit dem 14.02.2010 ununterbrochen online und hat seitdem 806 Beiträge (Stand: 27.11.2012) publiziert und wird von ca. 2400 Besuchern monatlich gelesen. Das Themenspektrum ist zentriert auf die Anliegen der Frankfurter Medizin- und Zahnmedizinstudierenden. Die enge Zusammenarbeit mit verschiedenen Gruppierungen des Fachbereichs – Dekanat, Studierende und Lehrende – garantiert darüber hinaus ein fachbereichs-relevantes Themenspektrum. Das Online-Magazin begleitet komplexe Projekte und Entscheidungen mit Hintergrundinformationen und kommuniziert sie verständlich. Eine jährliche Nutzer-Evaluierung zeigt eine wachsende Leserzahl und eine sehr hohe Zustimmung für das Online-Magazin, seine Inhalte und seinen Stil. Das Web 2.0-Medium "Blog" und seine web-typische Sprache entsprechen dem Medienverhalten der Zielgruppe, d.h. den Studierenden des Fachbereichs Medizin.
"PULS." hat sich als ein geeignetes und strategisches Instrument erwiesen, um größere Transparenz, mehr Kommunikation und letztendlich eine stärkere Identifikation der Studierenden mit ihrem Fachbereich voranzutreiben
???? The Twin Ropes of Time and Life
No full textThis paper presents the Twin Ropes Theory, a comprehensive metaphysical framework that revolutionizes our understanding of temporal existence through the lens of parallel dimensional constructs. The theory conceptualizes Time and Life as two infinite ropes stretching through the fabric of existence, each with fundamentally different natures and origins that create the foundation of conscious experience. The Asymmetrical Genesis: The framework posits that Life begins with the first breath, the initial spark of consciousness—marking the first point on its rope. Time, conversely, originates from an unseen place, potentially from Life's completion, creating a mysterious cosmic loop that challenges linear temporal assumptions. This asymmetrical beginning establishes the foundational tension that drives all temporal experience. Dynamic Point Intersections: At every moment of existence, individual points of Life meet corresponding points of Time, yet these intersections are not fixed alignments. The theory demonstrates that when consciousness intensifies—when souls burn bright through purposeful action—subjective time accelerates while universal "meridian time" maintains its steady flow. This creates personalized temporal experiences where individuals operate on private clocks that deviate from collective chronometry based on the intensity of their existential engagement. Relativistic Life-Time Dynamics: Drawing parallels to Einstein's relativity, the theory proposes that each life forms its own temporal reference frame. Two individuals sharing the same objective moment may experience radically different temporal flows based on their Life-Time connection intensity. This establishes a new form of temporal relativity where consciousness, rather than velocity, becomes the primary factor in time dilation. Cosmic Entanglement Mechanics: The ropes of Life and Time exist in quantum-like entanglement, functioning as two threads in a cosmic braid. Life chooses direction and meaning, while Time serves as the recording mechanism, the cosmic canvas upon which Life paints its journey. The faster Life pulls forward through purposeful action, the more Time responds by stretching, bending, and adjusting its flow—creating a dynamic feedback loop between existence and temporality. Circular Temporal Architecture: The theory suggests a profound circular relationship between beginnings and endings. Life may start where Time waits in anticipation, while Time concludes where Life completes its path. This creates a breathing relationship where one rope gives meaning to the other, establishing existence as a collaborative dance between temporal flow and conscious experience. Individual Temporal Sovereignty: The framework's revolutionary conclusion asserts that humans are not passive participants living within time, but active creators of their own temporal reality. Each soul operates on its own rope of Time, uniquely connected to its Life journey. The intensity of purpose, the depth of awareness, and the brightness of existential engagement determine how dramatically one's private clock diverges from universal temporality. This establishes the concept of temporal sovereignty—the ability of consciousness to govern its own temporal experience within the broader cosmic framework. Implications for Consciousness Studies: The Twin Ropes Theory offers profound implications for understanding consciousness, suggesting that temporal experience is not merely subjective perception but an active creation of reality through the entanglement of Life and Time. This framework provides new perspectives on flow states, mindfulness, purposeful living, and the relationship between meaning-making and temporal experience, potentially bridging metaphysical philosophy with practical applications in psychology, neuroscience, and existential therapy
Die Türkei und das andere Europa : Phantasmen der Identität im Beitrittsdiskurs /
No full textDiese Studie analysiert das dialogische Zusammenspiel zwischen den europäischen und türkischen Diskursen um den möglichen EU-Beitritt der Türkei. Die Differenzen stellen in der Perspektive postkolonialer Theorien ein ambivalentes und formatives Moment für die Bildung einer europäischen Identität dar: Die Europäer nehmen die Beitrittsverhandlungen zum Anlass, über ihr Selbstverständnis zu reflektieren, wobei diverse Ost-West-Repräsentationen kommuniziert und strukturiert werden. Die muslimischen Migranten in Europa und die Minderheiten in der Türkei fungieren dabei als interne Symptome, die die Unvollständigkeit der europäischen bzw. türkischen Identitäten sichtbar machen.Diese Studie analysiert das dialogische Zusammenspiel zwischen den europäischen und türkischen Diskursen um den möglichen EU-Beitritt der Türkei. Die Differenzen stellen in der Perspektive postkolonialer Theorien ein ambivalentes und formatives Moment für die Bildung einer europäischen Identität dar: Die Europäer nehmen die Beitrittsverhandlungen zum Anlass, über ihr Selbstverständnis zu reflektieren, wobei diverse Ost-West-Repräsentationen kommuniziert und strukturiert werden. Die muslimischen Migranten in Europa und die Minderheiten in der Türkei fungieren dabei als interne Symptome, die die Unvollständigkeit der europäischen bzw. türkischen Identitäten sichtbar machen.Bülent Küçük (Dr. phil.) ist Soziologe und arbeitet im Forschungsprojekt "Eurosphere" an der Sabancà Universität in Istanbul. Seine Forschungsschwerpunkte sind Öffentlichkeits-, Diskurs- und Postkoloniale Theorien.Online resource; title from PDF title page (publisher's Web site, viewed October 7 2015).Includes bibliographical references.JSTO
Solving the Quantum Heisenberg model with neural-network quantum states
No full textSolving quantum many-body systems is a fundamental challenge in physics. Traditional computational methods often struggle to solve them due to the exponential growth of the system’s Hilbert space. In recent times, Neural-Network Quantum States (NNQS) has emerged as a promising tool to approximate quantum wave functions based on machine learning methodologies. Using machine learning enables efficient computation of high-dimensional quantum systems which are otherwise unfeasible to compute. This work investigates two foundational models in quantum mechanics: One dimensional transverse field Ising and Heisenberg model, and predicts the expected energies and other properties with the help of machine learning.
To implement the NNQS, predefined neural network functions from the NetKet library is used. The methodology uses Monte Carlo sampling techniques along with gradient descent optimizer to find the approximate solution. Using these methods we predict the ground state energy, magnetization and magnetic susceptibility in transverse and longitudinal fields for each of the Ising system and the Heisenberg system.
Later, the Barren Plateau is also investigated. In a Barren plateau, gradient based optimization methods struggle to find the optimal solution. In this work, this was a significant problem to reach the approximate solution. Lastly, the results are attached after which we summarize our findings and compare the methodologies and give a final reflection on the work
???? The Twin Ropes of Time and Life
No full textThis paper presents the Twin Ropes Theory, a comprehensive metaphysical framework that revolutionizes our understanding of temporal existence through the lens of parallel dimensional constructs. The theory conceptualizes Time and Life as two infinite ropes stretching through the fabric of existence, each with fundamentally different natures and origins that create the foundation of conscious experience. The Asymmetrical Genesis: The framework posits that Life begins with the first breath, the initial spark of consciousness—marking the first point on its rope. Time, conversely, originates from an unseen place, potentially from Life's completion, creating a mysterious cosmic loop that challenges linear temporal assumptions. This asymmetrical beginning establishes the foundational tension that drives all temporal experience. Dynamic Point Intersections: At every moment of existence, individual points of Life meet corresponding points of Time, yet these intersections are not fixed alignments. The theory demonstrates that when consciousness intensifies—when souls burn bright through purposeful action—subjective time accelerates while universal "meridian time" maintains its steady flow. This creates personalized temporal experiences where individuals operate on private clocks that deviate from collective chronometry based on the intensity of their existential engagement. Relativistic Life-Time Dynamics: Drawing parallels to Einstein's relativity, the theory proposes that each life forms its own temporal reference frame. Two individuals sharing the same objective moment may experience radically different temporal flows based on their Life-Time connection intensity. This establishes a new form of temporal relativity where consciousness, rather than velocity, becomes the primary factor in time dilation. Cosmic Entanglement Mechanics: The ropes of Life and Time exist in quantum-like entanglement, functioning as two threads in a cosmic braid. Life chooses direction and meaning, while Time serves as the recording mechanism, the cosmic canvas upon which Life paints its journey. The faster Life pulls forward through purposeful action, the more Time responds by stretching, bending, and adjusting its flow—creating a dynamic feedback loop between existence and temporality. Circular Temporal Architecture: The theory suggests a profound circular relationship between beginnings and endings. Life may start where Time waits in anticipation, while Time concludes where Life completes its path. This creates a breathing relationship where one rope gives meaning to the other, establishing existence as a collaborative dance between temporal flow and conscious experience. Individual Temporal Sovereignty: The framework's revolutionary conclusion asserts that humans are not passive participants living within time, but active creators of their own temporal reality. Each soul operates on its own rope of Time, uniquely connected to its Life journey. The intensity of purpose, the depth of awareness, and the brightness of existential engagement determine how dramatically one's private clock diverges from universal temporality. This establishes the concept of temporal sovereignty—the ability of consciousness to govern its own temporal experience within the broader cosmic framework. Implications for Consciousness Studies: The Twin Ropes Theory offers profound implications for understanding consciousness, suggesting that temporal experience is not merely subjective perception but an active creation of reality through the entanglement of Life and Time. This framework provides new perspectives on flow states, mindfulness, purposeful living, and the relationship between meaning-making and temporal experience, potentially bridging metaphysical philosophy with practical applications in psychology, neuroscience, and existential therapy
Climate and anthropogenic change in aquatic environments: A cross ecosystem perspective
No full textThe chapter, "Climate and anthropogenic change in aquatic environments: A cross ecosystem perspective" was written by the listed authors including Jessica L. Clasen (Douglas College Faculty). The Ecological Dissertations in the Aquatic Sciences (Eco-DAS) symposia bring together 35-40 recent PhD recipients for one week in alternate years. Eco-DAS VIII was held in 2008. Eco-DAS is sponsored by the Center for Microbial Oceanography: Research and Education (C-MORE), the University of Hawai`i School of Ocean and Earth Science and Technology (SOEST) and its Department of Oceanography, and the Association for the Sciences of Limnology and Oceanography (ASLO). The Proceedings of Eco-DAS VIII includes nine chapters published in open access.
In an effort to foster collaboration among researchers across diverse ecosystems, a group of early career scientists whose interests span the aquatic sciences, convened at the University of Hawai’i to participate in the 2008 Eco-DAS symposium. During a break out session of the symposium in which participants were charged with discussing how to best approach mitigation of climate and anthropogenic threats to aquatic ecosystems, participants concluded that effective mitigation will depend upon prioritizing threats across ecosystems. These priorities were documented using a thought experiment in which participants defined their ecosystem of expertise, and then ranked the highest-priority threats to them. Results revealed that marine (open ocean, deep sea, coastal oceans, and rocky intertidal) researchers ranked climate-related impacts (i.e., temperature and ocean acidification) as the highest priority threats whereas estuarine, marsh, wetland, stream, and lake/reservoir researchers ranked the direct anthropogenic impacts of land-use change and nutrient inputs (eutrophication) highest. With such a diverse group, it became apparent that working across ecosystems is limited by issues rang- ing from a lack of large-scale, long-term monitoring to provide baseline data, to broader questions of how changes in one ecosystem cascade across interconnected ecosystems. Here we summarize the discussions, offer insight into the rankings for specific ecosystems, and propose ideas of how past, current, and future research can be used to support a cross-ecosystem perspective on climate and anthropogenic change.book chapterPublished
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