10,660 research outputs found
Sandra Cisneros's Woman Hollering Creek
No full textThis addition to Rodopi Presss Dialogue Series presents a collection of essays solely dedicated to Woman Hollering Creek (1991), Sandra Cisneross groundbreaking collection of short fiction stories and sketches. The emerging and veteran scholars who have.Intro -- SANDRA CISNEROS'S Woman Hollering Creek -- Contents -- General Editor's Preface -- Introduction -- I. Negotiating Borders: Issues of Sociocultural Cooptation -- Amphibious Women: The Complexity of Class in Sandra Cisneros's Woman Hollering Creek and Other Stories -- So You'll Know Who I Am: Inventory and Identity in Woman Hollering Creek and Other Stories -- The Chicana Trinity: Maternal Mestiza Consciousness in Woman Hollering Creek and Other Stories -- Author Dialogue -- II. Toys, Tiny Candies, and Telenovelas: Popular and Material Culture as Storytelling Agents -- Male and Female Roles in Mexican-American Society: Issues of Domestic Violence in "Woman Hollering Creek" -- Reading the Puns in "Barbie-Q" -- The Gummy Bears Speak: Articulating Identity in Sandra Cisneros's "Never Marry a Mexican" -- Author Dialogue -- III. Images of Masculinity -- "Are you my general?": Revising Representation in "Eyes of Zapata" -- Boys to Men: Redefining Masculinities in Woman Hollering Creek and Other Stories -- Author Dialogue -- IV. Images of Women: Role Expectations and Conflict -- Resemantization of Chicana Motherhood and Sexuality Through the Virgin of Guadalupe -- The Cries of La Llorona: Maternal Agency in "Woman Hollering Creek" -- Voicing Taboos in Sandra Cisneros's Woman Hollering Creek and Other Stories -- Author Dialogue -- About the Authors -- IndexThis addition to Rodopi Presss Dialogue Series presents a collection of essays solely dedicated to Woman Hollering Creek (1991), Sandra Cisneross groundbreaking collection of short fiction stories and sketches. The emerging and veteran scholars who have.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
Perimortem skeletal sharp force trauma on postmortem CTs
No full textWhile ethical discussions about identified human bone collections are on the rise, digital skeletal repositories are of increasing importance in forensics. In addition, there is a global trend within anthropology towards anonymized open access radiological databases. However, the validation of osteological methods on the virtual modality is essential. The paucity of research in this area has led us to analyze the usefulness of CT data in conjunction with skeletal sharp force lesions. Furthermore, little data exists so far on the association between soft- and hard-tissue lesions caused by sharp force, on anatomical injury patterns and on the overall rate of sharp force lesions penetrating to the bone.
We collected 41 cases of fatal sharp force trauma from the IRM Bern database and analyzed the pertaining postmortem CT (PMCT) on 2D and 3D, and carried out intra- and interobserver, as well as intermodality agreement tests. We investigated possible correlations between the manner of death (suicide/homicide) and various parameters (sex, age-at-death, presence and number of injuries and affected anatomical regions).
All agreement tests (intra- and interobserver, as well as intermodality) resulted in Cohen's kappa (κ-) values between 0.474 and 1 (moderate to perfect). We found that only 11.4% of all sharp force injuries in our sample penetrated to the bone, differing between the manners of death (3% in suicides, 15.3% in homicides). Overall, bone lesions were most frequent on the thorax. We obtained significant results (P-value <0.05) for the manner of death correlating with age-at-death, and with the number of soft- and hard-tissue injuries.
The insight gained from PMCT is mutually beneficial for all disciplines involved in forensic cases, stressing the added value of collaboration
UBC's Humanities 101 Program - Interview with Sandra Delorme
No full textChildhood educational shortcomings didn't stop Sandra Delorme from becoming a published author later in life. She credits UBC's Humanities 101 program (but deserves most of the credit herself)
Absence of evidence is not evidence of absence: Perimortem skeletal sharp force trauma on postmortem CT
No full textResponding to both modern research sharing requirements and ethical concerns, digital osteological databases are increasingly implemented across the world. Of these, postmortem CT (PMCT) datasets stand as a relevant source of information, especially for forensically oriented research. However, the potential error affecting conclusions based on PMCT observations by anthropologists devoid of a radiological background has not yet been clarified. Here, we address this issue by focusing on the detection of sharp force bone lesions on PMCT images.
We screened the database of the Institut für Rechtsmedizin (IRM), Bern, and selected 41 cases involving inflicted and self-inflicted sharp force trauma. We blindly studied each PMCT dataset and then compared our results with those from the original autopsy and radiology reports. We observed each case by means of both 2D transverse slices and 3D reconstructions. We investigated any association between the manner of death with demographic and injury-related parameters. Moreover, we analyzed the relationship between soft- and hard-tissue lesions caused by sharp force.
Only 11.4% of all sharp force injuries penetrated to the bone, differing between the manners of death (3% in suicides, 15.3% in homicides). Overall, bone lesions were most frequent on the thorax. The obtained results were significant (P-value <0.05) for the manner of death correlating with age-at-death, and with the number of soft- and hard-tissue injuries.
The low ratio between soft-tissue and bone lesions call for caution when inferring violent events from osteological analyses. Our results strongly suggest the potential benefits from the inclusion of virtual observations and virtual protocols into both forensic anthropological and osteoarchaeological curricula
Enhanced long-term transduction and engraftment of CD34+ human hematopoietic stem cells transduced with tyrosine-modified recombinant adeno-associated virus serotypes 2 and 6
No full textThere is significant therapeutic promise in the clinical application of stem cell gene therapy, but it remains limited by problems related to available gene transfer vectors. Recombinant adeno-associated virus (rAAV) vectors are promising for gene transfer into human hematopoietic stem cells (HSCs). However, exposed tyrosine residues on the rAAV vector capsid are involved in premature proteasomal degradation of the vector, reducing overall efficiency of gene transfer. Previous studies show that rAAV vectors (serotypes 2, 8, 9) have greatly improved transduction efficiency by mutating the tyrosine (Y) residues to phenylalanine (F) residues to prevent early degradation. Among the rAAV vectors being examined for gene transfer into HSCs are rAAV serotypes 2 and 6, which differ in tropism and gene transfer efficiency. This thesis reports that novel tyrosine-modified rAAV6 vectors transduce human cord blood-derived HSCs capable of significant transgene expression both in vitro and in vivo.Thesis (M.S.) California State University, Los Angeles, 2012AAV, Beta Thalassemia, HSC, Tyrosine-modifiedCommittee members: Sandra Sharp, Edith Porter, Kirsten Fisher, Saswati Chatterjee, Nancy McQuee
Enhanced long-term transduction and engraftment of CD34+ human hematopoietic stem cells transduced with tyrosine-modified recombinant adeno-associated virus serotypes 2 and 6
No full textThesis (M.S.)
California State University, Los Angeles, 2012Committee members: Sandra Sharp, Edith Porter, Kirsten Fisher, Saswati Chatterjee, Nancy McQueenAAV, Beta Thalassemia, HSC, Tyrosine-modifiedThere is significant therapeutic promise in the clinical application of stem cell gene therapy, but it remains limited by problems related to available gene transfer vectors. Recombinant adeno-associated virus (rAAV) vectors are promising for gene transfer into human hematopoietic stem cells (HSCs). However, exposed tyrosine residues on the rAAV vector capsid are involved in premature proteasomal degradation of the vector, reducing overall efficiency of gene transfer. Previous studies show that rAAV vectors (serotypes 2, 8, 9) have greatly improved transduction efficiency by mutating the tyrosine (Y) residues to phenylalanine (F) residues to prevent early degradation. Among the rAAV vectors being examined for gene transfer into HSCs are rAAV serotypes 2 and 6, which differ in tropism and gene transfer efficiency. This thesis reports that novel tyrosine-modified rAAV6 vectors transduce human cord blood-derived HSCs capable of significant transgene expression both <italic>in vitro</italic> and <italic>in vivo</italic>.Biological Science
Perimortem Skeletal Sharp Force Trauma: Detection Reliability on CT Data, Demographics and Anatomical Patterns from a Forensic Dataset
No full textSIMPLE SUMMARY: The increased use of computed tomography images in forensic anthropology is easily explained with a variety of benefits: among other reasons they are digitally stored, they can easily be shared and they are non-invasive. However, it is not clear how suitable these images are for forensic anthropologists to detect sharp force trauma. Therefore, we analyzed computed tomography images, by observing digital images of 41 forensic cases in different viewing modalities. In addition, we looked for anatomical injury patterns in the soft- and hard-tissues and any significant correlations between the manner of death (suicide or homicide) with different parameters. Our findings indicated a superiority of viewing the images in 2D, but not all bone lesions were detected. The manner of death was significantly correlated to some of the parameters, which could be extrapolated to future forensic anthropological cases. We promote the inclusion of imaging training into the anthropological curricula. ABSTRACT: The increasing importance of trauma analysis by means of postmortem computed tomography (PMCT) is insufficiently reflected in forensic curricula, nor are best practice manuals available. We attempt to detect sharp force bone lesions on PMCT of closed forensic cases with the aims of assessing errors and pointing out patterns in anatomical location and manner of death (MOD). We investigated 41 closed sharp force fatality cases, with available PMCT and forensic reports. Two observers with different radiological training assessed the lesions on PMCT scans (2D and 3D) for comparison with the reports. Between 3% (suicides) and 15.3% (homicides) of sharp force injuries caused visible bone lesions. While our observations were repeatable, each forensic investigation left a similar number of bone lesions undetected. Injury patterns differed between MOD, with thoracic bone lesions being most frequent overall. Soft tissue injury location varied between the MOD. Associations between MOD and age as well as number of injuries were significant. The detection of bone lesions on PMCT for untrained forensic specialists is challenging, curricula and pertinent manuals are desirable. With the low frequency of bone lesions compared to soft tissue injuries, we should be aware when analyzing decomposed bodies
The Importance of Wishes: An Interview with Author Sandra Magsamen
No full textChildren’s author and illustrator Sandra Magsamen holds a beloved place in the hearts of library professionals who know the impact and power of her loving board and picture books. As the author and illustrator of more than sixty children’s and adult books, Magsamen, trained as an art therapist, hopes to create books that offer people a way to reach out and connect in a meaningful and expressive way with someone in their life, and indeed she accomplishes this with her endearing new release, I Wish Wish Wish for You
Development of an assay system to study Id1, Id2, and Twist transcriptional regulation
No full textThe helix-loop-helix (HLH) proteins Id1 and Id2 and the basic HLH transcription factor Twist contribute to the regulation of cell growth and differentiation. This project aimed to develop a luciferase reporter assay system to study transcriptional regulation of Id1, Id2, and Twist in fetal human mesenchymal stem cells differentiating toward muscle and in human breast cancer cells. Id1, Id2, and Twist promoter activity was compared to mRNA accumulation from the corresponding endogenous genes in human breast cancer cell lines BT 549, MCF7, and MDA MB231, and human embryonic kidney cell line HEK 293. Promoter activity and mRNA accumulation were congruent for only some genes in some cell lines. The reporter constructs can be used for studies to determine the contribution of specific regions that regulate their activity. Understanding the regulation of Id1, Id2, and Twist may provide insight into their roles in growth, development, and cancer.Thesis (M.S.) California State University, Los Angeles, 2012Breast cancer, Differentiation, Id1, Id2, Mesenchymal ctem cells, TwistCommittee members: Sandra B. Sharp, Carlotta A. Glackin, Robert M. Nissen, Nancy L. McQuee
Metalicas Suarez: Nuevos Productos
No full textPráctica Académica (Diseño Industrial)-Universidad Católica de Pereira. Facultad de Arquitectura y Diseño, Pereira, 2005Universidad Católica de Pereira ; Tutora : Garcia, Lin
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