196 research outputs found
Apposition, attribut, épithète : même combat prédicatif ?
No full textMats Forsgren - Apposition, attribut, épithète : même combat prédicatif ?
This contribution deals with a plaidoyer for unifying the description of the much- debated category of apposition, viewed here as one of three syntactic modes of semantic predication on referents of noun phrases, the two others being modification (fr. épithète) and attribution (fr. attribut). Starting from the pragmatic view-point that apposition represents primarily a propositional speech act — a secondary predication — and a discourse strategy, the author attempt to find common denominators at langue level, in terms of basic constructional and semantic criteria, which are hierarchically ordered, with the aim to isolate some prototypical appositive predicates, as invariants covering the different contextual cognitive interpretations, as described by others (eg. Blumenthal, 1980; Combettes, 1998; Neveu, 1998a and b). Special attention is given to identifying and locative appositive predicates.Forsgren Mats. Apposition, attribut, épithète : même combat prédicatif ?. In: Langue française, n°125, 2000. Nouvelles recherches sur l'apposition, sous la direction de Franck Neveu. pp. 30-45
Presence of ChAT mRNA and a very marked alpha 7nAChR immunoreaction in the synovial lining layer of the knee joint
No full textAims: The aim was to examine if there is evidence of acetylcholine (ACh) production within the synovial lining layer and to examine the pattern of alpha 7nAChR expression in the layer. This layer is of relevance clinically as it becomes thickened in response to both rheumatoid arthritis (RA) and osteoarthritis (OA) and as it has been shown to produce proteases that are involved in the cartilage destruction. Main methods: Synovial tissue specimens from the knee joint of patients with RA and OA undergoing prosthetic surgery were examined. In situ hybridization and immunohistochemistry were used for the evaluation of ChAT reaction patterns. Immunohistochemistry was utilized for demonstration of activity of alpha 7nAChR. Key findings: There were ChAT mRNA reactions in the synovial lining layer of both patient categories. On the other hand, no ChAT immunoreactions were detected in the layer. There was a very marked alpha 7nAChR immunoreaction. Significance: There is a potential for ACh production within the synovial lining layer as there are ChAT mRNA reactions. However, the level of ACh production is apparently very low. It is thus possible that there is a down-regulation of ACh production but an apparent upregulation in expression level of alpha 7nAChR. Based on the knowledge that the non-neuronal cholinergic system can have anti-inflammatory effects, the low level of ACh production in the synovial lining layer can be a drawback for the arthritic joints. (C) 2012 Elsevier Inc. All rights reserved.</p
Differentiation of heart Purkinje fibres [Elektronisk resurs] : an immuno- and enzyme histochemical and ultrastructural study
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New data favouring that neurotrophins are of importance in arthritis
No full textNeurotrophins are important in inflammation. In an article in Arthritis Research & Therapy, Barthel and collaborators give new information on the existence of neurotrophin production in the synovial tissue of arthritic joints. These findings, together with other recent findings, stress that neurotrophins should be considered important factors in arthritis. This is reinforced by the facts that they are also produced by articular chondrocytes and that receptors for these are present in the synovial tissue and on chondrocytes. The importance of neurotrophins in joints should be further studied, including examinations on the efficacy of interfering with their effects in arthritis.</p
The Differentiation of the Purkinje Fibers in the Mammalian Heart — Comparisons with the Ordinary Myocytes
No full textThe Cholinergic System Can Be of Unexpected Importance in Osteoarthritis
No full textThe main belief is that joints such as the knee and ankle joints are not innervated by nerves with a cholinergic function. That includes the assumption that these joints are not innervated by the vagus nerve (van Maanen et al., 2009a, see also Grimsholm et al., 2008). Accordingly, there is actually no morphologic proof of a cholinergic innervation of the knee joint, nor of the ankle joint. Despite this fact, it is shown that electrical and pharmacological stimulation of the vagus nerve has a diminishing effect on carragenan-induced paw inflammation in rats (Borovikova et al., 2000a) and that interference with the effects of the vagus nerve leads to effects on the knee joint arthritis as seen experimentally (van Maanen et al., 2009b). There are also other findings which show the potential effects that interference with vagal effects has on joint inflammation. These will be discussed below. It is actually strange that interference with cholinergic effects, as via manpulations of the vagus nerve, has effects in knee joint inflamed synovium without presence of a vagal nerve innervation. One possibility is that the effects are indirect, via an occurrence of vagal effects on other sites such as the spleen (Huston et al., 2006, see also van Maanen et al., 2009a). However, another possibility is that there is a non-neuronal production of acetylcholine (ACh) within the synovial tissue itself. This has actually been shown to be the case (Grimsholm et al., 2008) (see further in paragraph 3).</p
The distribution of terminal sympathetic nerve fibers in bundle branch�s and false tendons of the bovine heart
No full textDifferentiation of heart Purkinje fibres : an immuno- and enzyme histochemical and ultrastructural study
No full textS. 1-26: sammanfattning, s. 29-96: 5 uppsatserdigitalisering@um
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