350 research outputs found
Campus climate reporting tools / by Marybeth Sullivan (senior legislative attorney), Christine McCluskey (senior legislative librarian)
No full text1 online resource (4 pages)"March 5, 2021."Discusses anonymous campus climate reporting tools used by colleges and universities in other states. Also provides data on rates of alcohol or drug consumption on campuse
Legislative history of filling constitutional officer vacancies / by Jennifer Proto (principal analyst), Christine McCluskey (librarian)
No full text1 online resource (3 pages)"December 23, 2020."Discusses the legislative history of CGS § 9-213, which addresses how four of the state's constitutional officers (the attorney general, comptroller, secretary of the state (SOTS), and treasurer) are appointed if there is a vacanc
Player agency in interactive narrative: audience, actor & author
Get PDFThe question motivating this review paper is, how can
computer-based interactive narrative be used as a constructivist learn-
ing activity? The paper proposes that player agency can be used to
link interactive narrative to learner agency in constructivist theory,
and to classify approaches to interactive narrative. The traditional
question driving research in interactive narrative is, ‘how can an in-
teractive narrative deal with a high degree of player agency, while
maintaining a coherent and well-formed narrative?’ This question
derives from an Aristotelian approach to interactive narrative that,
as the question shows, is inherently antagonistic to player agency.
Within this approach, player agency must be restricted and manip-
ulated to maintain the narrative. Two alternative approaches based
on Brecht’s Epic Theatre and Boal’s Theatre of the Oppressed are
reviewed. If a Boalian approach to interactive narrative is taken the
conflict between narrative and player agency dissolves. The question
that emerges from this approach is quite different from the traditional
question above, and presents a more useful approach to applying in-
teractive narrative as a constructivist learning activity
Generic types as design patterns for planning domain specifications
No full textIn this paper we investigate the use of ‘Generic Types’ as design patterns to assist in the specification of planning domains. Current planning technology uses induced patterns discovered in a domain specification to speed up plan creation. We argue that such generic types can also be used to help a domain author to develop a design for a domain at specification time using concepts at a much higher level of abstraction than is normally provided by domain specification languages
DNA fusion gene vaccination mobilizes effective anti-leukemic cytotoxic T lymphocytes from a tolerized repertoire
No full textThe majority of known human tumor-associated antigens derive from non-mutated self proteins. T cell tolerance, essential to prevent autoimmunity, must therefore be cautiously circumvented to generate cytotoxic T cell responses against these targets. Our strategy uses DNA fusion vaccines to activate high levels of peptide-specific CTL. Key foreign sequences from tetanus toxin activate tolerance-breaking CD4+ T cell help. Candidate MHC class Ibinding tumor peptide sequences are fused to the C terminus for optimal processing and presentation. To model performance against a leukemia-associated antigen in a tolerized setting, we constructed a fusion vaccine encoding an immunodominant CTL epitopederived from Friend murine leukemia virus gag protein (FMuLVgag) and vaccinated tolerant FMuLVgag-transgenic (gag-Tg) mice. Vaccination with the construct induced epitopespecificIFN-c-producing CD8+ T cells in normal and gag-Tg mice. The frequency and avidity of activated cells were reduced in gag-Tg mice, and no autoimmune injury resulted. However, these CD8+ T cells did exhibit gag-specific cytotoxicity in vitro and in vivo. Also, epitope-specific CTL killed FBL-3 leukemia cells expressing endogenous FMuLVgag antigen and protected against leukemia challenge in vivo. These results demonstrate a simple strategy to engage anti-microbial T cell help to activate epitope-specific polyclonal CD8+ T cell responses from a residual tolerized repertoire
The construction of formal specifications : an introduction to the model-based and algebraic approaches / J.G. Turner, T.L. McCluskey.
No full textIncludes bibliographical references and indexes.xii, 420 pages.
"One Set of Lines to See, Another Set of Lines to Be": Andrew Hussie’s Homestuck as a Case Study on Author & Audience Authority in Participatory Hypertext
No full textHomestuck, a multimodal webcomic created by author and artist Andrew Hussie has been
long cited as an excellent example of modern hypertextual, participatory literature. Despite its
ostensible audience participation and its potential to function as an activist space by uplifting
marginalized voices, the work takes a significantly more conservative approach to the
coauthoring between writer and readership. By performing a detailed analysis of Homestuck
through the lenses of Reader Response Theory and Post-Structuralism—specifically the lenses of
Critical Race Theory, paired with Gender Studies and Queer Theory—we can gain insight into
the mechanics of power structures and their influence on the clash of authority between the
author, audience, and the social norms that shape their perspectives through their consumption
and interpretation of literary texts. The Interpretive Communities that shape the worldviews of
both readers and writers are ultimately the key force in determining the meaning of a text.
Neither the author nor their audience is a single authority, and by remembering this fact, we may
become more cognizant of what it means to engage with literature in a meaningful and socially
conscious way
Beyond the library: reflections from a librarian in an academic faculty
No full textThis feature focuses upon information literacy in health courses in Higher Education. In particular, it places emphasis on the importance of faculty-library cooperation in promoting and teaching information skills and reflects upon the time the author spent carrying out roles in each area
PET-labelled phosphonium cations for mitochondria imaging
Get PDFThis thesis details the characterisation of lipophilic cation radiotracers for biomedical imaging. The radiotracers discussed are based on triphenylphosphonium cations which can accumulate in the mitochondria and are radiolabelled with either [18F] or [11C].
Implementation of existing radiotracers and development of novel [11C] based di- phosphonium di-cation radiotracers is described in Chapter 3. The chemistry required to produce precursors, reference compounds and radiolabelling is discussed and resulted in implementation of three existing [18F] radiotracers and development of four novel [11C] radiotracers.
The later chapters focus on assessment of biological properties of the tracers. This is achieved through studies carried out in vitro, including characterisation in cells and work carried out on an isolated perfused heart model, as well as in vivo studies. In all biological systems radiotracers were assessed under standard conditions and under challenge conditions. The challenge conditions included treatment with a mitochondrial membrane uncoupler, mitochondrial complex inhibitor and a chemotherapy agent. Alteration in radiotracer properties were compared between radiotracers. This work provides a strong foundation for justifying the translation of one of the investigated compounds into man.Open Acces
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