1,721,037 research outputs found
The Hot Mustard Receptor's Role in Gut Motor Function
No full textL. Ashley Blackshaw, Stuart M. Brierley, Patrick A. Hughes, Andrea M. Harringto
Innervation of the gastrointestinal tract by spinal and vagal afferent nerves
No full textStuart M. Brierley, Patrick Hughes, Andrea Harrington and L. Ashley Blacksha
Cytokine modulation of visceral afferents via cation channels is switched in chronic visceral hypersensitivity
No full textAbstract 776Patrick A. Hughes, Andrea Harrington, Stuart M. Brierley, Lochana Maldeniya, Chris Martin, Jenny Persson, Tobias Liebregts, Birgit Adam, Gerald Holtmann, Jane M. Andrews and L. Ashley Blackshawhttp://www.gastrojournal.org/search/quic
The neurobiology of visceral nociceptors
No full textStuart M. Brierley and L. Ashley Blackshawhttp://trove.nla.gov.au/work/3483387
Acute colitis chronically alters immune infiltration mechanisms and sensory neuro-immune interactions.
No full textAbstract not availableMelissa A. Campaniello, Chris Mavrangelos, Samuel Eade, Andrea M. Harrington, L. Ashley Blackshaw, Stuart M. Brierley, Scott D. Smid, Patrick A. Hughe
TRPA1 contributes to specific mechanotransduction currents in isolated DRG neurons
No full textStuart M. Brierley, Andrea M. Harrington, Patrick A. Hughes, Joel Castro, Amanda J. Page, David P. Corey, Kelvin Y. Kwan, Grigori Y. Rychkov & L. Ashley Blacksha
C-IBS patients lack monocyte derived beta-endorphin which results in disinhibition of colonic afferent mechanosensitivity
No full textPatrick A. Hughes, Ian C. Nicholson, Daniel Bird, Sarah To, Nicole Issacs, Dallas J. Grasby, Jenny Persson, Andrea M. Harrington, Stuart M. Brierley, Heddy Zola, Jane M. Andrews, L. Ashley Blackshaw, Doreen Krumbiege
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Experimental colitis models
No full textInflammatory Bowel Diseases (IBD) are life-threatening chronic and relapsing disorders of the immune system affecting the lower gastrointestinal tract. Despite the considerable efforts of many researchers, much remains to be learnt of their causes and appropriate treatment options. Crohn’s disease and ulcerative colitis comprise the majority of clinical IBD cases but differ considerably in terms of clinical representation and likely underlying mechanisms. As such, different animal models have been developed over the last 20 years to best characterize these diseases. It is widely accepted that DSS-induced colitis models ulcerative colitis, while TNBS induced colitis models Crohn’s disease. More recently, these models have been extended to investigate the mechanisms underlying the reciprocal regulation of the neuro-immune axis, both in times of acute inflammation and post-inflammation, with the latter modeling aspects of Irritable Bowel Syndrome. We describe the methodology involved in setting up, maintenance and evaluation of these two models of colitis, both of which are simply and economically achieved in a standard laboratory environment.Patrick A. Hughes, Stuart M. Brierley, Joel Castro, Andrea M. Harrington and L. Ashley Blacksha
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