3,235 research outputs found
John Stuart Mill’s projected science of society: 1827-1848
The purpose of the thesis is to examine John Stuart Mill’s political thought from
about 1827 to 1848 as an exercise in intellectual history. It focuses, first, on Mill’s view,
formulated by the late 1830s, that contemporary society was ‘civilized’, and second, on
his project of a science of society, which he aspired to develop in the late 1830s and
early 1840s.
By the late 1830s, Mill came to the view that his contemporary society was a
‘commercial society or civilization’, dominated by the middle, commercial class. The
first part of my thesis, constituted by Chapters 2-4, discusses the way in which Mill
formed his notion of civilization, and what he meant by the term ‘civilization’. Mill paid
attention to the implications of the rise of the middle class, and regarded such
phenomena of contemporary society as the corruption of the commercial spirit and
excessive social conformity as an inevitable consequence of the rise of the middle class.
The second part of the thesis, constituted by Chapters 5-9, examines Mill’s
projected science of society. In the late 1830s and early 1840s, Mill attempted to
develop a new science of society whose subject-matter was the nature and prospects of
commercial, civilized society. This aspiration culminated in A System of Logic,
published in 1843. In examining Mill’s projected science, I pay particular attention to
the fact that he conceived new sciences of history and of the formation of character,
both of which were indispensable in his project, although he failed to give a complete
account of these sciences. My thesis shows that the implications of his interest both in
history and in the formation of character are more significant than Mill scholars have
assumed
Mesenchymal stem cell secretome as an emerging cell-free alternative for improving wound repair
The use of mesenchymal stem cells (MSC) for the treatment of cutaneous wounds is currently of enormous interest. However, the broad translation of cell therapies into clinical use is hampered by their efficacy, safety, manufacturing and cost. MSCs release a broad repertoire of trophic factors and immunomodulatory cytokines, referred to as the MSC secretome, that has considerable potential for the treatment of cutaneous wounds as a cell-free therapy. In this review, we outline the current status of MSCs as a treatment for cutaneous wounds and introduce the potential of the MSC secretome as a cell-free alternative for wound repair. We discuss the challenges and provide insights and perspectives for the future development of the MSC secretome as well as identify its potential clinical translation into a therapeutic treatment.Parinaz Ahangar, Stuart J. Mills and Allison J. Cowi
IMA Commission on New Minerals, Nomenclature and Classification (CNMNC) Newsletter 47
peer reviewe
The crystal structure of Yb2(SO4)3·3H2O and its decomposition product, β-Yb2(SO4)3
Yb-2(SO4)(3)center dot 3H(2)O, synthesised by hydrothermal methods at 220(2) degrees C, has been investigated by single crystal X-ray diffraction. Yb-2(SO4)(3)center dot 3H(2)O crystallises in space group Cmc2(1) and is isostructural with Lu-2(SO4)(3)center dot 3H(2)O. The crystal structure has been refined to R-1=0.0145 for 3412 reflections [F-o > 3 sigma(F)]. and 0.0150 for all 3472 reflections. The structure of Yb-2(SO4)(3)center dot 3H(2)O is a complex framework of YbO6 octahedra, YbO8 and YbO5(H2O)(3) polyhedra and SO4 tetrahedra. Thermal data shows that Yb-2(SO4)(3)center dot 3H(2)O decomposes between 120 and 190 degrees C to form beta-Yb-2(SO4)(3). The structure of a twinned crystal of beta-Yb-2(SO4)(3) was solved and refined using an amplimode refinement in R3c with an R-1=0.0755 for 8944 reflections [F-o > 3 sigma(F)], and 0.1483 for all 16,361 reflections. beta-Yb-2(SO4)(3) has a unique structural topology based on a 3D network of pinwheels. (C) 2011 Elsevier Inc. All rights reserved
New minerals and nomenclature modifications approved in 2015 and 2016 (IMA-CNMNC Newsletter 29)
The information given here is provided by the IMA Commission on New Minerals, Nomenclature and
Classification for comparative purposes and as a service to mineralogists working on new species.
Each mineral is described in the following format:
Mineral name, if the authors agree on its release prior to the full description appearing in press
Chemical formula
Type locality
Full authorship of proposal
E-mail address of corresponding author
Relationship to other minerals
Crystal system, Space group; Structure determined, yes or no
Unit-cell parameters
Strongest lines in the powder X-ray diffraction pattern
Type specimen repository and specimen number
Citation details for the mineral prior to publication of full description
Citation details concern the fact that this information will be published in the Mineralogical Magazine
on a routine basis, as well as being added month by month to the Commission’s web site.
It is still a requirement for the authors to publish a full description of the new mineral
Survey of receiving-water environmental impacts associated with discharges from pulp mills: 2. Gonad size, liver size, hepatic erod activity and plasma sex steroid levels in white sucker
Fish collected from the receiving areas of 12 Canadian pulp mills were examined, including sites receiving effluent from kraft mills using chlorine as well as sulfite mills. Field collections included sampling of receiving water for chemistry and toxicity testing, and sampling of local fish for organ weights, hepatic MFO (ethoxyresorufin-O-deethylase, EROD) activity, plasma steroid levels, and levels of liver dioxins. The main objectives of this study were to determine whether the discharge of effluent from pulp mills to sites other than Jackfish Bay was associated with physiological or biochemical disruptions in wild fish, whether there was any correlation between waste treatment and the presence of biological responses in wild fish, and whether there was any association between the use of chlorine as a bleaching agent and these responses. Although white sucker collected near bleached kraft mills exhibited the highest EROD induction and dioxin levels, elevated enzyme activity was observed in fish from sites that did not use chlorine, and depressions in plasma sex steroid levels was not correlated with the level of EROD activity. The absence of chlorine bleaching or the presence of secondary treatment did not eliminate responses in fish, including decreased circulating levels of sex steroids, decreased gonadal size, and increased liver size. This survey has shown that (a) induction of hepatic EROD enzymes and depressions of plasma sex steroid levels during gonadal growth are found downstream of several pulp mills; (b) these changes are seen at some mills without chlorine bleaching and at mills that have secondary treatment; (c) substantial dilutions of nontoxic effluent do not appear to remove these responses; (d) the dominant factor determining the presence or absence of responses appeared to be dilution level; and (e) lab toxicity tests on invertebrates, rainbow trout, and fathead minnows could not predict the presence of these responses in wild fish.PT: J; UT: BIOSIS:PREV199497379511Source type: Electronic(1
IMA Commission on New Minerals, Nomenclature and Classification (CNMNC) -Newsletter 76
peer reviewe
MJLMills/rhorix: Rhorix Version 1.0.0 (Initial Release)
<p>This is the initial public release of the Blender Add-On Rhorix, for creating images of the output of quantum chemical topology calculations. At time of release only the author has used the code to produce images, so be prepared for difficulties. Please contact the author with problems encountered.</p>
Inequitable use of health services for Indigenous mothers who experience stillbirth in Australia
Vol. 49(2) pp 194-201Objectives: The purpose of this study was to identify differences in health service expenditure on Indigenous and non-Indigenous women who experience a stillbirth, women's out-of- pocket costs, and health service use. Methods: The project used a whole-of- population linked data set called “Maternity1000,” which includes all women who gave birth in Queensland, Australia, between July 1, 2012, and June 30, 2018 (n = 396 158). Multivariable analysis was undertaken to assess differences in mean health service expenditure; and number of health care services accessed between Indigenous and non-Indigenous women who had a stillbirth from birth to twelve months postpartum. Costs are presented in 2019/20 Australian dollars. Results: There was a total of 1864 babies stillborn to women in Queensland between July 1, 2012, and June 30, 2018, with 135 being born to Indigenous women and 1729 born to non-Indigenous women. There was significantly lower total expenditure per woman for Indigenous women compared with non-Indigenous women (18 811, respectively). This was consistent across public hospital inpatient (14 075), outpatient (1470), community-based services (313), pharmaceuticals (22), private hospital (1265), and for individual out-of- pocket fees (86). Mean expenditure on emergency department services per woman was higher for Indigenous women compared with non-Indigenous women (643). Indigenous women who experienced a stillbirth accessed fewer general practitioners, allied health, specialist, obstetrics, and outpatient services, and fewer pathology and diagnostic test than their non-Indigenous counterparts. Conclusions: Inequities in access to health services exist between Indigenous and non-Indigenous women who experience a stillbirth.Emily Callander, Haylee Fox, Kyly Mills, Deanna Stuart-Butler, Philippa Middleton, David Ellwood, Joseph Thomas,Vicki Flenad
New minerals and nomenclature modifications approved in 2016 and 2017 (IMA-CNMNC Newsletter 35)
The information given here is provided by the IMA Commission on New Minerals, Nomenclature and Classification for comparative purposes and as a service to mineralogists working on new species.
Each mineral is described in the following format:
Mineral name, if the authors agree on its release prior to the full description appearing in press
Chemical formula
Type locality
Full authorship of proposal
E-mail address of corresponding author
Relationship to other minerals
Crystal system, Space group; Structure determined, yes or no
Unit-cell parameters
Strongest lines in the X-ray powder diffraction pattern
Type specimen repository and specimen number
Citation details for the mineral prior to publication of full description
Citation details concern the fact that this information will be published in the European Journal of Mineralogy on a routine basis, as well as being added month by month to the Commission’s web site.
It is still a requirement for the authors to publish a full description of the new mineral.
NO OTHER INFORMATION WILL BE RELEASED BY THE COMMISSIO
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