3,235 research outputs found

    John Stuart Mill’s projected science of society: 1827-1848

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    The purpose of the thesis is to examine John Stuart Mill’s political thought from about 1827 to 1848 as an exercise in intellectual history. It focuses, first, on Mill’s view, formulated by the late 1830s, that contemporary society was ‘civilized’, and second, on his project of a science of society, which he aspired to develop in the late 1830s and early 1840s. By the late 1830s, Mill came to the view that his contemporary society was a ‘commercial society or civilization’, dominated by the middle, commercial class. The first part of my thesis, constituted by Chapters 2-4, discusses the way in which Mill formed his notion of civilization, and what he meant by the term ‘civilization’. Mill paid attention to the implications of the rise of the middle class, and regarded such phenomena of contemporary society as the corruption of the commercial spirit and excessive social conformity as an inevitable consequence of the rise of the middle class. The second part of the thesis, constituted by Chapters 5-9, examines Mill’s projected science of society. In the late 1830s and early 1840s, Mill attempted to develop a new science of society whose subject-matter was the nature and prospects of commercial, civilized society. This aspiration culminated in A System of Logic, published in 1843. In examining Mill’s projected science, I pay particular attention to the fact that he conceived new sciences of history and of the formation of character, both of which were indispensable in his project, although he failed to give a complete account of these sciences. My thesis shows that the implications of his interest both in history and in the formation of character are more significant than Mill scholars have assumed

    Mesenchymal stem cell secretome as an emerging cell-free alternative for improving wound repair

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    The use of mesenchymal stem cells (MSC) for the treatment of cutaneous wounds is currently of enormous interest. However, the broad translation of cell therapies into clinical use is hampered by their efficacy, safety, manufacturing and cost. MSCs release a broad repertoire of trophic factors and immunomodulatory cytokines, referred to as the MSC secretome, that has considerable potential for the treatment of cutaneous wounds as a cell-free therapy. In this review, we outline the current status of MSCs as a treatment for cutaneous wounds and introduce the potential of the MSC secretome as a cell-free alternative for wound repair. We discuss the challenges and provide insights and perspectives for the future development of the MSC secretome as well as identify its potential clinical translation into a therapeutic treatment.Parinaz Ahangar, Stuart J. Mills and Allison J. Cowi

    The crystal structure of Yb2(SO4)3·3H2O and its decomposition product, β-Yb2(SO4)3

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    Yb-2(SO4)(3)center dot 3H(2)O, synthesised by hydrothermal methods at 220(2) degrees C, has been investigated by single crystal X-ray diffraction. Yb-2(SO4)(3)center dot 3H(2)O crystallises in space group Cmc2(1) and is isostructural with Lu-2(SO4)(3)center dot 3H(2)O. The crystal structure has been refined to R-1=0.0145 for 3412 reflections [F-o > 3 sigma(F)]. and 0.0150 for all 3472 reflections. The structure of Yb-2(SO4)(3)center dot 3H(2)O is a complex framework of YbO6 octahedra, YbO8 and YbO5(H2O)(3) polyhedra and SO4 tetrahedra. Thermal data shows that Yb-2(SO4)(3)center dot 3H(2)O decomposes between 120 and 190 degrees C to form beta-Yb-2(SO4)(3). The structure of a twinned crystal of beta-Yb-2(SO4)(3) was solved and refined using an amplimode refinement in R3c with an R-1=0.0755 for 8944 reflections [F-o > 3 sigma(F)], and 0.1483 for all 16,361 reflections. beta-Yb-2(SO4)(3) has a unique structural topology based on a 3D network of pinwheels. (C) 2011 Elsevier Inc. All rights reserved

    New minerals and nomenclature modifications approved in 2015 and 2016 (IMA-CNMNC Newsletter 29)

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    The information given here is provided by the IMA Commission on New Minerals, Nomenclature and Classification for comparative purposes and as a service to mineralogists working on new species. Each mineral is described in the following format: Mineral name, if the authors agree on its release prior to the full description appearing in press Chemical formula Type locality Full authorship of proposal E-mail address of corresponding author Relationship to other minerals Crystal system, Space group; Structure determined, yes or no Unit-cell parameters Strongest lines in the powder X-ray diffraction pattern Type specimen repository and specimen number Citation details for the mineral prior to publication of full description Citation details concern the fact that this information will be published in the Mineralogical Magazine on a routine basis, as well as being added month by month to the Commission’s web site. It is still a requirement for the authors to publish a full description of the new mineral

    Survey of receiving-water environmental impacts associated with discharges from pulp mills: 2. Gonad size, liver size, hepatic erod activity and plasma sex steroid levels in white sucker

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    Fish collected from the receiving areas of 12 Canadian pulp mills were examined, including sites receiving effluent from kraft mills using chlorine as well as sulfite mills. Field collections included sampling of receiving water for chemistry and toxicity testing, and sampling of local fish for organ weights, hepatic MFO (ethoxyresorufin-O-deethylase, EROD) activity, plasma steroid levels, and levels of liver dioxins. The main objectives of this study were to determine whether the discharge of effluent from pulp mills to sites other than Jackfish Bay was associated with physiological or biochemical disruptions in wild fish, whether there was any correlation between waste treatment and the presence of biological responses in wild fish, and whether there was any association between the use of chlorine as a bleaching agent and these responses. Although white sucker collected near bleached kraft mills exhibited the highest EROD induction and dioxin levels, elevated enzyme activity was observed in fish from sites that did not use chlorine, and depressions in plasma sex steroid levels was not correlated with the level of EROD activity. The absence of chlorine bleaching or the presence of secondary treatment did not eliminate responses in fish, including decreased circulating levels of sex steroids, decreased gonadal size, and increased liver size. This survey has shown that (a) induction of hepatic EROD enzymes and depressions of plasma sex steroid levels during gonadal growth are found downstream of several pulp mills; (b) these changes are seen at some mills without chlorine bleaching and at mills that have secondary treatment; (c) substantial dilutions of nontoxic effluent do not appear to remove these responses; (d) the dominant factor determining the presence or absence of responses appeared to be dilution level; and (e) lab toxicity tests on invertebrates, rainbow trout, and fathead minnows could not predict the presence of these responses in wild fish.PT: J; UT: BIOSIS:PREV199497379511Source type: Electronic(1

    MJLMills/rhorix: Rhorix Version 1.0.0 (Initial Release)

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    <p>This is the initial public release of the Blender Add-On Rhorix, for creating images of the output of quantum chemical topology calculations. At time of release only the author has used the code to produce images, so be prepared for difficulties. Please contact the author with problems encountered.</p&gt

    Inequitable use of health services for Indigenous mothers who experience stillbirth in Australia

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    Vol. 49(2) pp 194-201Objectives: The purpose of this study was to identify differences in health service expenditure on Indigenous and non-Indigenous women who experience a stillbirth, women's out-of- pocket costs, and health service use. Methods: The project used a whole-of- population linked data set called “Maternity1000,” which includes all women who gave birth in Queensland, Australia, between July 1, 2012, and June 30, 2018 (n = 396 158). Multivariable analysis was undertaken to assess differences in mean health service expenditure; and number of health care services accessed between Indigenous and non-Indigenous women who had a stillbirth from birth to twelve months postpartum. Costs are presented in 2019/20 Australian dollars. Results: There was a total of 1864 babies stillborn to women in Queensland between July 1, 2012, and June 30, 2018, with 135 being born to Indigenous women and 1729 born to non-Indigenous women. There was significantly lower total expenditure per woman for Indigenous women compared with non-Indigenous women (16083and16 083 and 18 811, respectively). This was consistent across public hospital inpatient (12564comparedwith12 564 compared with 14 075), outpatient (1127comparedwith1127 compared with 1470), community-based services (198comparedwith198 compared with 313), pharmaceuticals (8comparedwith8 compared with 22), private hospital (434comparedwith434 compared with 1265), and for individual out-of- pocket fees (21comparedwith21 compared with 86). Mean expenditure on emergency department services per woman was higher for Indigenous women compared with non-Indigenous women (947comparedwith947 compared with 643). Indigenous women who experienced a stillbirth accessed fewer general practitioners, allied health, specialist, obstetrics, and outpatient services, and fewer pathology and diagnostic test than their non-Indigenous counterparts. Conclusions: Inequities in access to health services exist between Indigenous and non-Indigenous women who experience a stillbirth.Emily Callander, Haylee Fox, Kyly Mills, Deanna Stuart-Butler, Philippa Middleton, David Ellwood, Joseph Thomas,Vicki Flenad

    New minerals and nomenclature modifications approved in 2016 and 2017 (IMA-CNMNC Newsletter 35)

    No full text
    The information given here is provided by the IMA Commission on New Minerals, Nomenclature and Classification for comparative purposes and as a service to mineralogists working on new species. Each mineral is described in the following format: Mineral name, if the authors agree on its release prior to the full description appearing in press Chemical formula Type locality Full authorship of proposal E-mail address of corresponding author Relationship to other minerals Crystal system, Space group; Structure determined, yes or no Unit-cell parameters Strongest lines in the X-ray powder diffraction pattern Type specimen repository and specimen number Citation details for the mineral prior to publication of full description Citation details concern the fact that this information will be published in the European Journal of Mineralogy on a routine basis, as well as being added month by month to the Commission’s web site. It is still a requirement for the authors to publish a full description of the new mineral. NO OTHER INFORMATION WILL BE RELEASED BY THE COMMISSIO
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