3,531 research outputs found
MARC 21 para recursos contínuos
Full text linkTranslation and adaptation of the MARC 21 Format for Bibliographic Data, and MARC 21 Format for Holdings Data, Network Development and MARC Standards Office, Library of Congress, USA, by Angela Salles. Rio de Janeiro, 2010. 2 v. V.1 MARC 21 format for bibliographic data (updated until October 2010). V.2 MARC 21 format for data collection (Holdings) (updated until October 2008)
Gossypin-Loaded Ethosome Gel for Cutaneous Administration:A Preliminary Study on Melanoma Cells
Full text linkA preformulative study was conducted to produce and characterize ethosomes for the transdermal delivery of gossypin. This plant-derived compound possesses many pharmacological properties, including antitumoral potential. Ethosome dispersions were designed as transdermal delivery systems for gossypin, employing two different production procedures. The evaluation of vesicle size distribution by photon correlation spectroscopy, morphology by cryogenic transmission electron microscopy, and gossypin entrapment capacity, as well as in vitro release and permeation by vertical diffusion cells, enabled us to select a production strategy based on the injection of a phosphatidylcholine ethanolic solution in water. Indeed, vesicles prepared by this method were almost unilamellar and measured roughly 150 nm mean diameter while displaying an entrapment capacity higher than 94%. Moreover, vesicles prepared by the ethanol injection method enabled us to control gossypin release and to improve its permeation with respect to the solution of the drug. To obtain semi-solid forms suitable for cutaneous gossypin administration, ethosome dispersions were thickened with 0.5% w/ w xanthan gum, selected by a spreadability test. These ethosome gels were then further characterized by small- and wide-angle X-ray scattering, while their antioxidant activity was demonstrated in vitro by a radical scavenging assay. Finally, in vitro biological studies were conducted on A375 melanoma cell lines. Namely, wound healing and cell migration assays confirmed the potential antitumoral effect of gossypin, especially when loaded in the selected ethosomal gel. The promising results suggest further investigation of the potential of gossypin-loaded ethosomal gel in the treatment of melanoma. </p
MARC 21 para recursos contínuos.
Full text linkTradução e adaptação de MARC 21 Format for Bibliographic Data e MARC 21 Format for Holdings Data, da Network Development and MARC Standards Office, da Library of Congress, USA, por Angela Salles
CCDC 1452254: Experimental Crystal Structure Determination
No full textRelated Article: Sander J. Wezenberg, Christelle M. Croisetu, Marc C. A. Stuart, Ben L. Feringa|2016|Chemical Science|7|4341|doi:10.1039/C6SC00659K,An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Energy transfer from a fluorescent hydrogel to a hosted fluorophore
No full textThe fluorescent properties of a new 1,3,5-cyclohexyltricarboxamide-based low-molecular-weight hydrogelator (1) derivatized with one hydrophobic fluorophore and two hydrophilic substituents have been investigated. Gels of I are composed of long, nonbranched fibers of uniform diameter, as shown by cryo-transmission electron microscopy (cryo-TEM). The aggregation of the naphthalene fluorophore moieties of the gelator molecules in the gel fibers favors the occurrence of a fast energy migration process that allows a very efficient sensitization of the fluorescence of a hosted fluorophore. Such processes have been investigated by the addition of propyldansylarnide (PDNS). at two different concentrations, to gels of 1. Around 30% of the total PDNS added to the gels was found to be incorporated in the gel fibers, as confirmed by deconvolution of the fluorescence spectrum. excited-state lifetime measurements, and steady-state and time-resolved fluorescence anisotropy measurements. Moreover. anisotropy measurements show that the fluorophore that is incorporated within the gel fibers is almost completely immobilized. indicating that the interactions of PDNS with the gelator moieties are very strong. This particular configuration of donor (1) and acceptor (PDNS) molecules leads to a very efficient antenna effect. where 50% of the absorbed photons are funneled through to the dansyl derivative when one PDNS molecule is incorporated in the gel fibers for every 100 gelator molecules. A 5-fold higher concentration of PDNS increases the percentage of funneled photons to 75%
Analysis of Readex's Serial Set MARC records: improving the data for the library catalog
Full text linkColorado State University Libraries (CSUL) purchased the digitized United States Congressional Serial Set, 1817-1994 and American State Papers (1789-1838) from the Readex Division of NewsBank, inc and, once funds and records were available, the accompanying MARC records. The breadth of information found in the Serial Set is described, along with the difficulties in using the print version (incorporated in the literature review, which includes citations of announcements of the digital collections and reviews of the software). The digital version of the Serial Set has its advantages, but there are additional rewards (much greater discovery opportunities) when items in the digital collection are directly accessible from the library catalog. The purchased MARC records, while overall excellent, had problems that needed to be corrected before they were loaded into CSUL's Innovative Interfaces library catalog. Patron access impact was used as a criterion when determining which of the records would be fixed before loading. High impact problems were identified and solutions derived for: multiple 245 (title) fields; 245 second indicator zero with titles beginning with a, an, or the; dollar sign used in text; fixed field date; languages; subject headings; creating proxy URLs; classification numbers; and author authority control (e.g. corporate entries and presidential entry errors)
Beauty for the Present: Mill, Arnold, Ruskin and Aesthetic Education
Full text linkThe present thesis examines the idea of aesthetic education of three eminent Victorians: John Stuart Mill, Matthew Arnold and John Ruskin. By focusing on the essence of what they meant with ‘the cultivation of the beautiful’ and, more importantly, the way their ideas of beauty informed their criticism of society, my study aims to contribute to our understanding of the idea of aesthetic education in the Victorian context and, further, to participate in a recent debate about the nature of beauty and aesthetic education.
Chapter One focuses on John Stuart Mill’s concept of ‘feeling’ in a series of essays. I will demonstrate how Mill’s idea of ‘aesthetic education’ was an ‘education of feelings,’ and moreover, how this idea was integrated into his literary criticism, his later critique of democratisation, his description of an ideal liberal society and even his own style of writing. Chapter Two contains a comparative study of Matthew Arnold and Friedrich Schiller. Through a rereading of Arnold, I will argue that his idea of aesthetic education is essentially Schillerian and that their resemblance consists primarily in their stress on the importance of aesthetic unity for modern life, which was becoming increasingly fragmentary and multitudinous. Chapter Three examines John Ruskin’s idea of aesthetic education and concentrates particularly on the cultivation of perception. Perception, as I shall show, was pivotal in Ruskin’s idea of aesthetic education. Just as what happened in Mill and Arnold, the emphasis on the education of seeing continued from his early writings well into his art and social criticisms. It not only differentiated him from his fellow art critics; the conviction that people should perceive with a pure heart also enabled him to link observation of artistic details with moral criticism of contemporary society and, thereby, to turn the cultivation of the beautiful into a moral-aesthetic experience
Integrated Nonlinear Photonics in AlGaAs-on-insulator Waveguides
No full textThe heterogeneous integration of AlGaAs-on-insulator (AlGaAs-OI) has proven to be a highly efficient material platform for nonlinear photonics. When AlGaAs is bonded to silica, there is a large difference in refractive index which results in waveguides with a strong modal confinement and enhanced nonlinearities. This, in combination with low linear and nonlinear losses, makes AlGaAs-OI an ideal platform for exploring nonlinear phenomena. In this talk we present recent progress on the design, fabrication and testing of AlGaAs-OI waveguides for efficient second harmonic generation, supercontinuum generation and the creation of photon pairs
Equilibrium transition study for a hybrid MAV
Full text linkWind tunnel testing was performed on a VTOL aircraft in order to characterize longitudinal flight behavior during an equilibrium transition between vertical and horizontal flight modes. Trim values for airspeed, pitch, motor speed and elevator position were determined. Data was collected by independently varying the trim parameters, and stability and control derivatives were identified as functions of the trim pitch angle. A linear fractional representation model was then proposed, along with several methods to improve longitudinal control of the aircraft
J.C. Bach's London keyboard sonatas : style and context
Full text linkJ. C. Bach's keyboard works include several sets of accompanied sonatas, a genre that enjoyed a wide popularity during the Classical era, but never
found its way into the concert repertoire. The accompanied sonata was a genre meant for domestic performance; the solo keyboard sonata, on
the other hand, was adopted in due course by concert audiences. J. C. Bach composed works within both genres during most of his productive years, and his output constitutes a corpus of remarkable consistency. J. C. Bach's removal to London in 1762 coincided with his clear adoption of a galant style, marked by the Italianate influence, and the abandonment of most Baroque traits. The British milieu provided additional factors: the rise of the pianoforte, a thriving music-publishing market, and a great interest in domestic music making among the affluent classes. These factors marked J. C. Bach's output at various levels. Keyboard works had to conform to the proficiency of the amateur performer, a
fact reflected in the accompanied output mostly. The number of movements, their length, and the inclusion of particular technical devices are readily observable differences between the two genres. The most remarkable
distinction lies perhaps in the preference for binary sonata format in the accompanied. sonatas from the mid 1760s to the 1770s, in spite of a later tendency for tripartite designs in both genres. J. C. Bach's lifelong preference for motivic phrase structure conditioned his keyboard production and partly explains the gap in quality between some of his works and sonatas composed around the same time by Haydn and Mozart, who developed more effective means to connect the melodic material
to higher structural units. J. C. Bach's influence, however, endured in Mozart's handling of melody, and his keyboard production constitutes, in spite of some flaws, a noteworthy example of elegance and craftsmanship
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