2 research outputs found

    Biological, clinical and population relevance of 95 loci for blood lipids

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    Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides are among the most important risk factors for coronary artery disease (CAD) and are targets for therapeutic intervention. We screened the genome for common variants associated with plasma lipids in >100,000 individuals of European ancestry. Here we report 95 significantly associated loci (P<5 x 10(-8)), with 59 showing genome-wide significant association with lipid traits for the first time. The newly reported associations include single nucleotide polymorphisms (SNPs) near known lipid regulators (for example, CYP7A1, NPC1L1 and SCARB1) as well as in scores of loci not previously implicated in lipoprotein metabolism. The 95 loci contribute not only to normal variation in lipid traits but also to extreme lipid phenotypes and have an impact on lipid traits in three non-European populations (East Asians, South Asians and African Americans). Our results identify several novel loci associated with plasma lipids that are also associated with CAD. Finally, we validated three of the novel genes-GALNT2, PPP1R3B and TTC39B-with experiments in mouse models. Taken together, our findings provide the foundation to develop a broader biological understanding of lipoprotein metabolism and to identify new therapeutic opportunities for the prevention of CAD

    Review for Religious - Issue 11.4 (July 1952)

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    Issue 11.4 of the Review for Religious, 1952.A..M.D. G~ Review for Religious JULY 15, 1952 Parallel Vocations ......... Nicholas H. Rieman Bibles ................ William M. Sfritch Unigeni÷us Dei Filius ........... Pope Plus x~ To a Master of Novices ........ Fra L. Ganganelli ....Higher Education ......... Sister M. Bonaventure National Congress Questions and Answers Modesty Crusade Book Reviews VOLUME NUMBER REViI::W FOR RI::LIGIOUS VOLUME XI JULY, 1952 NUMBER CONTENTS PARALLEL VOCATIONS--Nicholas H. Rieman, S.J .....1..69 BIBLES--William M. Stritch, S.J .............. 177 OUR CONTRIBUTORS ................ 182 REPRINTS OF SPONSA CHRISTI ............ ¯ . 182 UNIGENITUS DEI FILIUS--Pope Plus XI .......... 183 BOOKS FOR.PRIESTS ................. 198 FOR ORGANISTS AND CHOIRMASTERS ........1..98 LETTER TO A MASTER OF NOVICES--Fra Lorenzo Ganganelll 199 TEN-YEAR INDEX STILL AVAILABLE .......... 202 HIGHER EDUCATION AND "REAL RELIGION"-- Sister M. Bonaventure, O.S.F ..... 203 NATIONAL CONGRESS ................. 210 QUESTIONS AND ANSWERS-- 19. Prescriptions for the Chapter of Faults ......... 211 20. Precedence in Receiving Communion . . ¯ ........212 SHALL I START TO DRINK? .............. 213 BOOK REVIEWS~ The Morning Offering; What is the Index?; The Seminarian at His Prie-Dieu; The Carmelite Directory of the Spiritual Life .....214 BOOK NOTICES ................... 217 BOOK ANNOUNCEMENTS ............... 221 PROMOTE THE MODESTY CRUSADE .......... 223 REVIEW FOR RELIGIOUS, July, 1952. Vol. XI, No. 4. Published bi-monthly: January, March, May, July, September, and November at the College Press, 606 Harrison Street; Topeka, Kansas, by St. Mary’s College, St. Marys, Kansas, with ecclesiastical approbation. Entered as second class matter January 15, 1942, at the Post Office, Topeka, Kansas, under the act of March 3, 1879. Editorial Board: Jerome Breunig, S.J.; Augustine G. Ellard, S.J.: Adam C. Ellis, S.J.; Gerald Kelly, S.J. Copyright, 1952, by Adam C. Ellis, S.J. Permission is hereby granted for quota-tions of reasonable length, provided due credit be given this review and the author. Subscription price: 3 dollars a year; 50 cents a copy. Printed in U. S. A. Before writincj to us, please consult notice on Inside back cover. Parallel Voca!:ions Nicholas H. Rieman, S..3. ~yJE RELIGIOUS know the worth of our vocation. We rank it -W among~ur greatest blessin~gs. A precious gift in itself, it car-~ ries .with it numerouk other gifts, such as our. rpraye~-’and Mass, spiritual guidhnce’, our companions," and our apostolic work’. We are glad we took the step knto religion, andewe miss no chance to draw others to religion too. .But perhaps we are not aware that our r~ligious vocation can be partly.sh’ared even with lay folks. A. molag the most effective ways we~h~ve of sha"ring our vocati6n ig encourag-. ing and conducting third 0rd~rs. confra:ernities, so’dalities and simi’- l’ar organizat!ons..~ The present article confines itself to. the parallel vocation as found in the Sodality’of Our Lads,. .’ ¯ There is a special reason why tile possibilities of ~uch a Sqdality should be unfolded to religious.~ It is this: .while the director of-a Sodality must always beLa priest, yet"in a scho01or hospital the’, actual l~andling of aSodality .is often left"to Brother Michael or to -Sister 3oan. Also, besides those who are moderators ofSodalities, many other religious superiors, principals, ¯floor. supervisors in.hos-pitals, teachers, nurses, he’ads of different ~ictivities--can help much.. They.can lend interest and co0pfration to ’insure that the Sodality in their institutions be a true Sodality, and lay people bent on some-thing more than me.dioctity be drawn to its rankS. Many Feligious are, then, in a tposition to forward good Sodalities. By doing so;. they can share many of the benefits of a religious vocation with those who follow the la~; Sodal.ity vocation. - For m’embersbip in the Sodality is also a vocation. Our present Holy Fatber’has clearly in his Apostolic Constitution Bis Saecular~ placed the Sodality in the troop--sof Catboh"c ~-A "ctton. And Catholic Acti0n~-the words are thdse of Plus X’I is "a vocation strictly and properly so .called." ¯ It is not, of course? a religious vocation. Y,et if is ~ vocation, a way of life, a call to perfection.’ The. S6d;ility is open only to those who are ready,.by Go’d’s grace, to-adopt the’de2 .mandihg spiritual.and apostolic progr~am it involves. ’ Btit’why is the Sodality such an ap’t means for sh~iring With lay people something of our religious v6cation? ’F6r.the simple reason that the vocation, of a religious and that of a Sodalist are much alike. ¯ 1.69 NICHOLAS H. RIEMAN Review [or’Religiqus It is nottoo’mu~h t~ call them paraliel vocations, Only a~det~iled comparison will display how far-reaching this parallelism is. Of. course, only true Sodalitiei--those that follow the papal directives and the Sodality rules-~can prodiace this parallelism’and the result-’ ant rich spiritual harvest. So, in pointing oot the resemblances.be-l~ ween t’he two vocations, I shall ~lso suggest how ~a Sodality must be co’nducted in order to secure these benefits. .. What then. are some of the parallels between religious and So-dality life? First, becoming a Sodalist, like becoming a Franciscan or a.Sister of’Merry, is a lifetime,undertaking. Joining the So, dality is not like joining the staff of the school paper or the dramatic club. These latter are hobbies; the Sodality is a vocation, A Sodalist agrees to follow the Sodality way of life not just at school, but when on vacation, when working in a facto.ry or office, when married--in.. short, for life. Pius XII. knows that very well: be never, says, "I wa~ a Sodalist, but always, ’"I am a. Sodahst, although he took his act .of consecration and’ entered the Sodality 56 years ago. More will b~ said later of the Sodality act of consecration. Here it isi’enough to.stress one thing. This consecration, and so the ac-ceptance of Sod, ality obligations that goes with it, is for life. True, a temporary act of consecration for ’a year can" be and sometimes is made in Junior Sodalities (those in grammar schools), since at that age level most of the candidates are sddom mature enough for a life-time dedication. But the ordinary act ofconsecration taken by teen-~ agers and adults is, as clearly, indicated in both its forms in the Sodality Rules, perpetual. The Sodality vocatioia, like a religious vocation, is perpetual. Besides being a. lifetime dedication, becoming a S6dalist is also, l’ike becoming a religious, a full-time occupation. One must be a Sodalist 24 hours a day. Just as being a Christian Brother .affects not only a. man’s Mass and his meal-times, but his work and recrea-tion too, s6 being., a Sodalist doesn’t mean only .attending meet.ings, saying one’s rosary, ’and taking p~art in a cl0thes-for-I~or~a drive, ’Being a Sodalist must--and in a Sodality that follows the rules, does. --affect a boy’s lock~r-room langu;ige, the kind of formal a girl wears to a prom, and every other action that fills the dajr of either of them. Tru.e, a Sodalist does not, as is generally true of religious, have his wgrk assigned by ~uperi0rs. ’Yet a Sodalist, just like any of us, has to show a good example and. beactively ap0s~olic every minute of his waking day. Nor is this an impossible ideal, a pipe. 170 dui~,1952 ~ARALLEL VOCATIONS dream. In Sodalities that follow Plus XII’s stipulations and actually ..require,observance of the. Sgdality rules, this is a normal result, re-alized, if not perfectly,. at least in large measure. The act of consecration to Our Lady which admits one tb the Sodality parallels very close.ly the vows of reli~ious orders. Even the .wgrding of the act of consecration in the St. Francis,de Sales fbrmula, ~clbsely resembles the vow formula of some religious. "It is not a vow, of. course, and so does not bind ur~der sin, but it is a solemn dedication. ~ And What doek the Sodalist promise? Pius XII gives us the’answer. "To apply oneself seriously to sanctity, each in his proper state: to dedicate .oneself, not in any manner whatsoever but ’with ardor, in ~the measure and manner compatible with each one,s social condition to the s’alvation and perfection of others: in a word[ to emplby oneself strenoously in the defense of the Church of Christ: such is the assignment of the Sodalist, freely, resolutely ac-cepted in theact of his con’secration..." In short, he says, "conse-cration to the Mother of God in the Sodality is an entire gift of one-self throughout life and for all eternity." It is the solemn, acceptance of a way of life forall one’s future vears. The act’ of consecration is the cornerstone of the Sodality vocation, even though not absolutely required for valid reception. It should be for the incoming Sodalist a thing only a little less tremendous than. the taking of vows i’s to .religious This act of consecration is often renewed by earnest So-dalistS, .just as rdligious often renew their vows, even though they are perpetual. The Sodality~onsecration is not specific~illy directed to vows’ of r~overtv, cha’stity, and obedience, as are the.vows of religious. Still it implies that Sodalists practice these three virtues to a higher degree than ordinary Christi~ins. A special obedience to the hierarchy of the Church is requi.red by the Sodality’s character as Catholic Action, and. was referred to by PiusXII as a prominent feature of Sodalities. A relative indifferdnce to material goods, is obviously necessary for the practice of a constant apostolate. Lastly, chastity--according to one’s state, which doesn’t necessarily mean celibacy--is naturally the ideal of one speci.all’y dedicated to.Mary. ¯ The Sodality, too, has its ~novitiate," call~d the probati6n. It is required of all candidates before admission. A religiolis,novitiate mus~ be a year lbng, and man~, orders and congregations require two years. How long is the Sodality probation? "Not less than two months" is required by.Sodality rules, but most effective Sodalitles ,171 NICHOLA~ H, RIEMAN " ~ x Revieu2 for’Reli~Tious rriake it.six months and quite a few of tlqem, especially thoke for hi~h" school students a.full ,year. The purpose of the Sodality p~b-bation is the same as that of a religious novitiate: tb acquaint, to test. t6 train. " " "It acquaints_ tl-i~’aspiraht with what the Sodality is.~ind how. it functions.’so that he can bi~tter "decide whether .hE wants to make-the" sacrifices inv~lved..It tests the candidate, and tries to find out whether~ he~ha~iwhat it takes.,to livEforevek the Sodality v~ay of life.. It. trains him in" devotion to. Mary, in spiritual exercises ahd apostolic activi-ti~;: so that if- he ,is accepted, he ,will already-h’ave largely~, acquired the attitudes .and habits nee-ded to li,¢e and’act as/a Sodalist ghould. dust like.a, religlous novitiate. the Sodality ’probation is’ heavily. weighted’on’the spiritual side. It stresses ingtructi’on, direction. ’and above, allT-prayer. ’ " " ’. ¯ -Like a religious.’order, or congregation. the S0dalit~ has its, rules. They.’are not-as demanding’ as the rules of religious, btit tt~ey do clearly aim at a,high degree’of spirituality. They are all-in the pam-ph! et. Sodalit~l"Rule~. ’In his A1fostolic. Constitution of 1948 Pius XII.refers to them 25. times. It is clear that in. his mind an easy test of the calibre of"a Sodality..is whether it really keeps the rules. In a Sod~dity as."in religious orders the ~pirjt of the rules is always more important tha~~ the letter, and’so Sodality rules w,hich refer only ,to procedure at, meetings and such topics should n’ot bd applied wood-enly .... Yet the:rules embbdy the. spiril~ .of an organization, and if" th~yfallinto disregard and disuse, the rd’sult will be as disastrbus toa SQdality as: it would be to, a religigus’order.~ ¯ :-.. In .its spiritual practices, and .to a. smaller exteni i~ its apostolic a.ctivity a °Sddality, clgsely parallels religious.c.ongreg~tions.- First, let.’us ’ma’ke a thorough survey of"it.s spiritual.exercises, for they are the dynamo on’wh.ich Sodality activities depend. Most .of these dai.ly duties are containe_d’in R.u:le 34 of the Sodality. This rule deserves to be quo,ted in full: ":Sodalist~ must be very careful, to p~actice’~hose exercises of piel~y which are most necess.a.ry for fervbl of life. Every morning.on ~i~jng,,let"them make ’the. acts of faith, hope, and’ch~r-ity; thank God our Lord for His..benefits:: offer Him their labors~ with the" intention of-gaining all",.the mdu.lgences~ they.can~.through-out that day;, and invoke ’t~’e Blessed. Virgin’. by reciting thd Hail Mary three times. Le~t. tbem.’:devote at least a quarter of an hour td mental prayer: be presenL if they can: a’~the adoiable Sacri}ice of,the Mass; and recite the most HolyoRosary, or some Office of Our’I2ady. 172 "dul~], 1952- PARALLEL VOCATIONS In the evening before retiring, let them carefully examine their con-science and make a fervent act of contrition, for the sins of-their whole life and especially for those committed on that day." The t~rst item mentioned on the day’s spiritual schedule of a So-dalist is the prayers on rising:, faith, hope, love, thanksgiving, offering’of works, three Hail Marys. The aim of these brief vocal prayers is of.course to start the d~iy r.igbt, with and for God..They remind us at once of the "morning prayers~ .... morning visit," or "first visit," of religious..They are a dedication of.the day to God. Next is mentioned daily mental prayer "at least a quarter of an hour:’" All religious institutes have, I believe, a half-hour of mental prayer, and some have more. The Sodality rule demanding daily mental prayer is as clear and unconditional as the rule of reli-gious c6n’gregations on. this point. The’only difference is in the length of time. The conclusion ought to be obvious. If a’ religious-would not admit to vows a novice who did not regularly perform his meditation, why should we expect h S6dality to admit candi-dates who are not reasonably faithful in fulfilling this clear Sodality demand? Again, if novices need instruction in the bow-when-where- why of mental prayer to enable them to perform it profitably, won’t Sodalists need the same? A Sodality in which the members are’ faithful to their rule on mental prayer will be a Sodality that can move spiritual mountains, even if i~ has’only fifty members or even only ten. Further, says the rule, Sodalists must attend daily Ma~s "if they can." This practice, too. is modelled on that of religious.. How-- ever,, for religious the "if they can" is gefierally an unneeded addi-tion: since their ~ommon life and work assignments are arranged so that it is a!ways possible for them to do so. Though daily Mass may sometimes be impossible for this or that Sodalist, such cases are rare. The trouble is that too often the ’.’if they can" of the rule is taken to mean,"if th.ey choose’: or’"if they do not find it incon-venient." But the John Carroll Univeisity Sodality, and marly another too, has sfiown that practically all Sodalists can atterld Mass seven days.a week if they want to. Daily Holy Cohamunion, of course, cannot be required of.Sodal-ists any more than it can of religious.. But Sodalists in iheir Rule39, as all religious somewhere in their rules, are strongly urged to fre- ¯ quent and even daily Communion. Most Sodalities that observe the rules and require daily Mass find that all their members receive Corn- NICHOLAS H. RIEMAN . °. Reoie~o for ReligiO~s" .muni6n freq~uently, and the great majority of l~he.m~daily. Next the)..Sodality rule requires daily, recitation of the rosary, or an Office of. Our La~y----~.g.; theOffice 6f the Ihamac~late .Concep-., tion. On day, s w.hen~the Sodality meets, such an Office, or part of it, is sometimes said or sung in common. ]3ut in their daily prac-tice, most Sodalists piefer the rosarY, and this .dail~ du.ty is o~ten perforrfied in"an ideal Way, with one’s family. In religious orders and’congregation~, the daily rosary also forms, either by rule or by ¯ custom, part of th~ spiri(ual exercises, at least where the Office of Our Lady.is not required. Like most religious orders, the Sodality rules requir~.a daily ex-~¯ . amination of conscience at night. The reason is the same., We all know how a daily check on.our faults or virtues helps us to fiaake ,our following 0f Christ .a, practical thing, a love of deeds,and not. merely of imagination. The particular examen too, which focuses our attenti6n’or~ a "single virtue or fault, and in° which we religious find so much value, ought to be offerdd by us to Sodalists as well. A Sodalist, like a relig!ous,needs direction in this business;’ of striving for p.erfection.. Both need a ~piritual directo? to answer p.r~b~lems,.instruct, enc~ourgge. This i~ particul.arly trfie for the reli-gious nowce or the Sodality probationer, but it is true also for those who have already made their’lifetime consecration. S6dalists ought, to..~o to confession often; and to’get real spiritual direction from regular confessor. Rule 36 of the ~ddality is very clea~,on tl’Jis mat~ ter. .How, ever, although one’s spiritual director is always a priest,~ still just as a novice-mistress can help her charges.greatly in their ori-entationto.~ eligious life, so fdr example in a girls’ school, if’the So-dality moderator is a nun, she c~in on a more limited scale greatly "help her incoming Sodalists, ¯or those who are.already ’rnemb~rs, in their spiritual life.¯ Sodalis~s must make an annual retreat. Rule 9, which imposes" this i3b.ligat~on, does not set a specific l~ngtl~ of ti.me, b~t only says,¯ "There shall be a retreat every year for some days.-.. " This rule does, however, str, ongly advise a clo~ed [etreat,° not fia~rely an ope,n retreat’in wl~ich the retreatants go home in the afterfioons. Also,-it cl,e.arly expects .tha~ the Sodali~(s’ not only listen to t.alks, but perform meditations during the retreat~. For best rest.Its, too, the retreat h~uld, be fdr Sodalists only, just as theretreat a nun to be for nuns of her institute¯ only, not for a mixed gathering of nuns, priests, ’ and .lay people. If such oa Sodality *r~treat is really im- 174- ¯ July, 19~2 -,~ PARALLEL VOCATIONS’ possible, then even during the regular school or coll~ge retreat, Sodalists could make some speci~il m~ditations on their Sodality way of life,’ and assign a special time for examen and for some spiritual readingdirected to" their own spiritual level. For~among Sodalists as ¯ -among re!igious the retre~it should be a powerhouse that makes its fotce’felt all through (he yea.r. It can do this best if it is adapted. to their’Sc~dality way of life., Closely" parallel in their spiritualduties a~d practices, the Sodal- .ity and.religious communities are para.llel, too,-though much less so,. .’in.their work, their apostolate. This is r;ot true of strict °contem-i~ lative orders engaging irf no outside activity, for while the prayer and penance and union with God of such contempla, tives’have an apostolic as well as a personal motive and .are in fact a tremenddus . apostolic weapon, yet they cannot, be called.external activity. ’But with religious communities engaging in external works, the Sodal, ity in its apostolate has certain likenesses. If’well understood, these, simi~ " larities will help us to cohceive,the Sodality more correctly; and mo~e.~ ¯ easily share with Sodalists our Own apostoli.c outlook, ’energy, and techniques. Apostolic work is, first of ,all, just as essential to the Sodality as to acfive:~eligious c~mmunities, and it is as deeply .rootedin pe"r-sonal sanctity.. A teaching Brother who¯ recites~fill his pra~;e.rs me-ticulously but who is careless about preparing fo~ his classes is not’ living.his rel~igious life f.ully.~ .Nor do~s a nursing ~ister have a-true view of he.r life..if she thifiks of holiness only as something personal,¯ and. does not see that.her.work demands sanctity, and depends 9n it. So .to_6 a Sodalist must see Sodality meetings and projects and his own day-to-d~iy contacts With his friends as part of his Sodality vo-. cation. He must clearly grasp, too, that ~11 Sodality action, since its aim is. to develop in men the grace-life, depends less on clever tech-niques. ~ban .on souls charged, with the grace of God. In the S0- dalit~ as in an active, religiohs ~c0mmunity, the spiritual and .the apostolic do not existside by side unrelated to each Other. The So~" dality does,riot have two goals; buta single goal; a spirit.ual- .apostolic goal. The.two facets, of that g0al are mutually dependent. One cannot exist without the other. Also, in the Sodality .as in religion, the apostolate is organized. ’Since the work of most S6dalists study and class, nursing,, office work, factory, work,, homemaking is riot, like the work ofia reli- ~ gious, °.directly. assigned by religious superiors, the activity-of the , 175 NICHOLAS .H. RIEMAN Reoiew ?or Religious S0dalists is both organized and individual. It .may be strictl~i or-ganized, that is, not only pl~nned in a meeting but carried out by a group. Such would be a weekly trip by S0dalists to theLittle Sis-ters of the Poor to help them care for their’ charges. Sodality action may be planned together but cariied out individually, as in the con-tacting of busines~ firms to have them halt sexy advertisingor dis, play Christmas cribs. Or it may be completely indiv, idual, though inspired by Sodality ideals, as when a Sodalist persuades his or her non-Catholic roommate to go to Mass sometimes. Since we reli- -gious. even thdugh our work be hssigned, to some extent use these various apost’olic approaches ourselves, we can and should help So-d~ lli~ts with whom we deal to do the same. ’"Among the primary ends of So
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