297 research outputs found
Predatory colponemids are the sister group to all other alveolates
No full textAlveolates are a major supergroup of eukaryotes encompassing more than ten thousand free-living and parasitic species, including medically, ecologically, and economically important apicomplexans, dinoflagellates, and ciliates. These three groups are among the most widespread eukaryotes on Earth, and their environmental success can be linked to unique innovations that emerged early in each group. Understanding the emergence of these well-studied and diverse groups and their innovations has relied heavily on the discovery and characterization of early-branching relatives, which allow ancestral states to be inferred with much greater confidence. Here we report the phylogenomic analyses of 313 eukaryote protein-coding genes from transcriptomes of three members of one such group, the colponemids (Colponemidia), which support their monophyly and position as the sister lineage to all other known alveolates. Colponemid-related sequences from environmental surveys and our microscopical observations show that colponemids are not common in nature, but they are diverse and widespread in freshwater habitats around the world. Studied colponemids possess two types of extrusive organelles (trichocysts or toxicysts) for active hunting of other unicellular eukaryotes and potentially play an important role in microbial food webs. Colponemids have generally plesiomorphic morphology and illustrate the ancestral state of Alveolata. We further discuss their importance in understanding the evolution of alveolates and the origin of myzocytosis and plastids
Early Diversification of Membrane Intrinsic Proteins (MIPs) in Eukaryotes
No full textAbstract Membrane intrinsic proteins (MIPs), including aquaporins (AQPs) and aquaglyceroporins (GLPs), form an ancient family of transporters for water and small solutes across biological membranes. The evolutionary history and functions of MIPs have been extensively studied in vertebrates and land plants, but their widespread presence across the eukaryotic tree of life suggests both a more complex evolutionary history and a broader set of functions than previously thought. That said, the early evolution of MIPs remains obscure. The presence of one GLP and four AQP clades across both bacteria and archaea suggests that the first eukaryotes could have possessed up to five MIPs. Here, we report on a previously unknown richness in MIP diversity across all major eukaryotic lineages, including unicellular eukaryotes, which make up the bulk of eukaryotic diversity. Three MIP clades have likely deep evolutionary origins, dating back to the last eukaryotic common ancestor (LECA), and support the presence of a complex MIP repertoire in early eukaryotes. Overall, our findings highlight the growing complexity of the reconstructed LECA genome: the dynamic evolutionary history of MIPs was set in motion when eukaryotes were in their infancy followed by radiative bursts across all main eukaryotic lineages.Open-Access-Publikationsfonds 202
Visual Analysis of Multi-Field Data
No full textThis thesis investigates methods for the visualization of multi-field medical data. In the medical field, data complexity has been growing consistently over the past years. Not only the size of the data grows, but also the need to visualize beyond traditional boundaries. We present a number of novel facets that encompass a general approach to the exploration of multi-field data. We strongly believe that human-in-the-loop visual data analysis on large and complex datasets is best aided by multiple linked different representations. The presented techniques demonstrate how complex data from multiple modalities can be visualized and interactively explored. We explore the use of linked selections to aid in reducing the complexity of the visualizations. Using multiple-linked views, we can integrate multiple orthogonal representations of the data simultaneously. We have applied aforementioned techniques in the design and implementation of a number of prototype frameworks, with applications ranging from brain imaging for neurosurgical planning to the study of the behavior of marine animals through the use of sensor data. We also present a conceptual framework for studying complex longitudinal data, by means of aggregation and multi-level visualization. We successfully adapted techniques from information visualization in order to use them on datasets that are orders of magnitude larger than they are originally used for.Computer Science, Computer Graphics groupElectrical Engineering, Mathematics and Computer Scienc
A short case of a splenic arteriovenous fistula coexisting with portal hypertension secondary to hepatitis C: Radiologic diagnosis and treatment
No full textSummary Splenic arteriovenous fistula (SAVF) is a rare but potentially curable condition. Only a few cases have been reported in the English literature. SAVF can cause portal hypertension, ascites, gastrointestinal bleeding, and heart failure. An early diagnosis is essential to avoid life threatening complications. We hereby present a case of SAVF in a young female patient, with hepatitis C liver cirrhosis who presented with recurrent severe upper gastrointestinal bleeding. Such an association of liver cirrhosis and SAVF has not been previously reported. © 2010 The Royal Australian and New Zealand College of Radiologists.BLUM A, 1994, J RADIOL, V75, P245; BREDFELDT JE, 1980, J CLIN GASTROENTEROL, V2, P355, DOI 10.1097-00004836-198012000-00007; BUCKHOTTZ RP, 1958, ANN SURG, V149, P590; ENDRESS C, 1989, J CLIN ULTRASOUND, V17, P206, DOI 10.1002-jcu.1870170309; FURUTA Y, 1987, Gastroenterologia Japonica, V22, P374; GARCIATSAO G, 1985, HEPATOLOGY, V5, P419, DOI 10.1002-hep.1840050313; GROSZMANN RJ, 1990, GASTROENTEROLOGY, V9, P705; GUDMUNDSEN TE, 1988, ACTA CHIR SCAND, V154, P603; Hung CF, 1999, POSTGRAD MED J, V75, P355; KELLER FS, 1980, CARDIOVASC INTER RAD, V3, P97, DOI 10.1007-BF02552327; LAINE L, 1991, WESTERN J MED, V155, P274; MCCLARY RD, 1986, AM J GASTROENTEROL, V81, P572; PASTERNAK BM, 1978, ANGIOLOGY, V29, P367, DOI 10.1177-000331977802900503; Pietri J, 1990, Ann Vasc Surg, V4, P533, DOI 10.1016-S0890-5096(06)60834-0; Sharara AI, 2001, NEW ENGL J MED, V345, P669, DOI 10.1056-NEJMra003007; TAKAYASU K, 1985, GASTROENTEROLOGY, V88, P564; VANWAY CW, 1971, SURGERY, V70, P876; Vauthey JN, 1997, GASTROENTEROLOGY, V113, P1390, DOI 10.1053-gast.1997.v113.pm93225351
Sequentiële Monte Carlo Methoden (Sequential Monte Carlo Methods)
No full textEen studie naar Sequentiele Monte Carlo Methods toegepast op Hidden Markov Models. De Sequential Importance Sampling en Sequential Importance Resampling filters worden bestudeerd en de gebreken zoals weight degeneration en sample impoverishment worden aangetoond en bestreden. Afsluitend een model geconstrueerd voor Stochastische Volatiliteit.Applied mathematicsElectrical Engineering, Mathematics and Computer Scienc
The Politics of Global Governance in UN Peacekeeping
No full textThis article examines the allocation of roles and responsibilities in the construction of UN peacekeeping. The case is made that decision making in UN peacekeeping is not only fragmented between various states and institutional actors, but also critically lopsided, with an uneven distribution of responsibilities and the majority of political, military and strategic risks falling upon those countries least able to bear them – poor and weak states. States that hold decision-making power are not the states that have to implement those decisions. The article concludes by arguing that this governance structure is not a symptom of organizational dysfunction, but that it serves a political function by allowing influence to be wielded without risk
Neural regulation of intestinal nutrient absorption
No full textThe nervous system and the gastrointestinal (GI) tract share several common features including reciprocal interconnections and several neurotransmitters and peptides known as gut peptides, neuropeptides or hormones. The processes of digestion, secretion of digestive enzymes and then absorption are regulated by the neuro-endocrine system. Luminal glucose enhances its own absorption through a neuronal reflex that involves capsaicin sensitive primary afferent (CSPA) fibres. Absorbed glucose stimulates insulin release that activates hepatoenteric neural pathways leading to an increase in the expression of glucose transporters. Adrenergic innervation increases glucose absorption through α1 and β receptors and decreases absorption through activation of α2 receptors. The vagus nerve plays an important role in the regulation of diurnal variation in transporter expression and in anticipation to food intake. Vagal CSPAs exert tonic inhibitory effects on amino acid absorption. It also plays an important role in the mediation of the inhibitory effect of intestinal amino acids on their own absorption at the level of proximal or distal segment. However, chronic extrinsic denervation leads to a decrease in intestinal amino acid absorption. Conversely, adrenergic agonists as well as activation of CSPA fibres enhance peptides uptake through the peptide transporter PEPT1. Finally, intestinal innervation plays a minimal role in the absorption of fat digestion products. Intestinal absorption of nutrients is a basic vital mechanism that depends essentially on the function of intestinal mucosa. However, intrinsic and extrinsic neural mechanisms that rely on several redundant loops are involved in immediate and long-term control of the outcome of intestinal function. © 2011 Elsevier Ltd.Adibi SA, 1997, GASTROENTEROLOGY, V113, P332, DOI 10.1016-S0016-5085(97)70112-4; Adibi SA, 2003, AM J PHYSIOL-GASTR L, V285, pG779, DOI 10.1152-ajpgi.00056.2003; Au A, 2002, BIOCHEM J, V367, P247, DOI 10.1042-BJ20020393; Baglole CJ, 2005, CAN J PHYSIOL PHARM, V83, P389, DOI 10.1139-Y05-024; Barada KA, 1997, AM J PHYSIOL-GASTR L, V272, pG815; Barada KA, 2000, REGUL PEPTIDES, V90, P39, DOI 10.1016-S0167-0115(00)00103-8; Barada KA, 2001, LIFE SCI, V69, P3121, DOI 10.1016-S0024-3205(01)01418-7; BARADA KA, 2008, GUT, V57, pA221; Barada KA, 1998, AM J PHYSIOL-GASTR L, V275, pG822; BARRY MK, 1995, J SURG RES, V58, P425, DOI 10.1006-jsre.1995.1066; BARRY MK, 1993, J SURG RES, V54, P603, DOI 10.1006-jsre.1993.1092; BARRY MK, 1994, DIGEST DIS SCI, V39, P2368, DOI 10.1007-BF02087653; Bates SL, 1998, AM J PHYSIOL-GASTR L, V274, pG552; Berlioz F, 1999, J PHARMACOL EXP THER, V288, P1037; Berlioz F, 2000, J PHARMACOL EXP THER, V294, P466; Berlioz F, 2000, DRUG METAB DISPOS, V28, P1267; Berthoud HR, 2004, NEUROGASTROENT MOTIL, V16, P28, DOI 10.1111-j.1743-3150.2004.00471.x; BINDER HJ, 1984, AM J PHYSIOL, V247, pG432; Blackshaw LA, 2007, NEUROGASTROENT MOTIL, V19, P1, DOI 10.1111-j.1365-2982.2006.00871.x; Bornstein JC, 2006, J NEUROPHYSIOL, V96, P973, DOI 10.1152-jn.00511.2006; Braun T, 2007, GASTROENTEROLOGY, V132, P1890, DOI 10.1053-j.gastro.2007.02.036; Brookes SJH, 2001, ANAT RECORD, V262, P58; Buchan AMJ, 1999, AM J PHYSIOL-GASTR L, V277, pG1103; BURANT CF, 1994, J CLIN INVEST, V93, P578, DOI 10.1172-JCI117010; Cameron HL, 2007, NEUROGASTROENT MOTIL, V19, P47, DOI 10.1111-j.1365-2982.2006.00845.x; CASSUTO J, 1983, ACTA PHYSIOL SCAND, V117, P195, DOI 10.1111-j.1748-1716.1983.tb07197.x; Cheeseman CI, 1997, AM J PHYSIOL-REG I, V273, pR1965; COOKE HJ, 1986, GASTROENTEROLOGY, V90, P1057; Corpe CP, 1996, AM J PHYSIOL-GASTR L, V271, pG211; Damholt AB, 1998, ENDOCRINOLOGY, V139, P2085, DOI 10.1210-en.139.4.2085; Daniel H, 2004, ANNU REV PHYSIOL, V66, P361, DOI 10.1146-annurev.physiol.66.032102.144149; Diez-Sampedro A, 2003, P NATL ACAD SCI USA, V100, P11753, DOI 10.1073-pnas.1733027100; DiezSampedro A, 1997, J PHARM PHARMACOL, V49, P873; Diez-Sampedro A, 1998, J PHARM PHARMACOL, V50, P907; DOTY JE, 1988, GASTROENTEROLOGY, V94, P50; Drozdowski LA, 2006, WORLD J GASTROENTERO, V12, P1657; Ducroc R, 2007, DIABETES, V56, P2494, DOI 10.2337-db07-0614; Dumoulin V, 1998, ENDOCRINOLOGY, V139, P3780, DOI 10.1210-en.139.9.3780; Dyer J, 2003, EUR J BIOCHEM, V270, P3377, DOI 10.1046-j.1432-1033.2003.03721.x; Dyer J, 2007, BIOCHEM SOC T, V35, P1191, DOI 10.1042-BST0351191; Dyer J, 2003, BIOCHEM SOC T, V31, P1140; Dyer J, 2002, AM J PHYSIOL-GASTR L, V282, pG241; Dyer J, 1997, GUT, V41, P56; Eastwood C, 1998, NEUROSCI LETT, V254, P145, DOI 10.1016-S0304-3940(98)00666-1; EDWARDS JP, 1974, GUT, V15, P521, DOI 10.1136-gut.15.7.521; Ehrstrom M, 2005, J CLIN ENDOCR METAB, V90, P2370, DOI 10.1210-jc.2004-1408; ERICKSON RH, 1995, BIOCHEM BIOPH RES CO, V216, P249, DOI 10.1006-bbrc.1995.2617; FERRARIS RP, 1989, ANNU REV PHYSIOL, V51, P125, DOI 10.1146-annurev.physiol.51.1.125; Ferraris RP, 2001, BIOCHEM J, V360, P265, DOI 10.1042-0264-6021:3600265; Ferraris RP, 1997, PHYSIOL REV, V77, P257; Foley MK, 1998, SURGERY, V123, P321, DOI 10.1016-S0039-6060(98)70186-2; Fuller PM, 2008, SCIENCE, V320, P1074, DOI 10.1126-science.1153277; Furness JB, 2003, J COMP NEUROL, V455, P281, DOI 10.1002-cne.10415; Furness JB, 2002, CURR OPIN PHARMACOL, V2, P609, DOI 10.1016-S1471-4892(02)00231-X; Furness JB, 2004, PROG NEUROBIOL, V72, P143, DOI 10.1016-j.pneurobio.2003.12.004; Furness JB, 1999, AM J PHYSIOL-GASTR L, V277, pG922; Furness JB, 2003, ANAT REC PART A, V272A, P475, DOI 10.1002-ar.a.10064; Furness JB, 2002, CURR OPIN PHARMACOL, V2, P612, DOI 10.1016-S1471-4892(02)00219-9; Furness JB, 2006, AUTON NEUROSCI-BASIC, V125, P81, DOI 10.1016-j.autneu.2006.01.007; Gershon MD, 2007, GASTROENTEROLOGY, V132, P397, DOI 10.1053-j.gastro.2006.11.002; Glatzle J, 2002, AM J PHYSIOL-GASTR L, V282, pG86; Glatzle J, 2003, J PHYSIOL-LONDON, V550, P657, DOI 10.1113-jphysiol.2003.041673; Gooley JJ, 2006, NAT NEUROSCI, V9, P398, DOI 10.1038-nn1651; Goyal RK, 1996, NEW ENGL J MED, V334, P1106; GREENBERG GR, 1994, PANCREAS, V9, P531, DOI 10.1097-00006676-199407000-00018; Grundy D, 2006, CURR OPIN GASTROEN, V22, P102, DOI 10.1097-01.mog.0000208459.46395.16; Grundy D, 2006, AUTON NEUROSCI-BASIC, V125, P76, DOI 10.1016-j.autneu.2006.01.009; Grundy D, 1989, HDB PHYSL 6, V1, P593; Gulley S, 2005, PHYSIOL BEHAV, V86, P128, DOI 10.1016-j.physbeh.2005.07.001; Gutierrez-Aguilar R, 2011, CURR OPIN ENDOCRINOL, V18, P35, DOI 10.1097-MED.0b013e32834190b5; Hansen MB, 2003, PHARMACOL TOXICOL, V92, P105, DOI 10.1034-j.1600-0773.2003.t01-1-920301.x; Hansen MB, 2003, PHARMACOL TOXICOL, V92, P249, DOI 10.1034-j.1600-0773.2003.920601.x; Harcouet L, 1997, J PHARMACOL EXP THER, V281, P738; HARDCASTLE J, 1978, J PHYSIOL-LONDON, V285, P71; HAYASHI H, 1990, J LIPID RES, V31, P1613; HAYASHI H, 1990, AM J PHYSIOL, V259, pG709; HIRA T, 2009, AM J PHYSL GASTROINT; Houghton SG, 2006, SURGERY, V139, P542, DOI 10.1016-j.surg.2005.09.002; Hussain I, 2002, CELL TISSUE RES, V307, P139, DOI 10.1007-s00441-001-0473-z; Hussain MM, 2009, TRENDS ENDOCRIN MET, V20, P177, DOI 10.1016-j.tem.2009.01.001; INBERG MV, 1971, ACTA CHIR SCAND, V137, P361; Iqbal CW, 2009, SURGERY, V146, P100, DOI 10.1016-j.surg.2009.02.012; Iqbal J, 2009, AM J PHYSIOL-ENDOC M, V296, pE1183, DOI 10.1152-ajpendo.90899.2008; IQBAL J, 2010, J LIPID RES; Ishikawa Y, 1997, BBA-MOL CELL RES, V1357, P306, DOI 10.1016-S0167-4889(97)00043-8; JANCSO N, 1967, BRIT J PHARM CHEMOTH, V31, P138; JODAL M, 1993, GASTROENTEROLOGY, V105, P1286; Kalogeris TJ, 1999, AM J PHYSIOL-GASTR L, V277, pG1081; KALOGERIS TJ, 1994, J LIPID RES, V35, P1141; Kalogeris TJ, 1997, AM J PHYSIOL-REG I, V273, pR981; Kalogeris TJ, 1996, AM J PHYSIOL-GASTR L, V270, pG277; Kellett GL, 2008, ANNU REV NUTR, V28, P35, DOI 10.1146-annurev.nutr.28.061807.155518; Kidd M, 2008, AM J PHYSIOL-GASTR L, V295, pG260, DOI 10.1152-ajpgi.00056.2008; Kimm MH, 1996, J PHYSIOL-LONDON, V490, P243; Kimura Y, 2005, AM J PHYSIOL-GASTR L, V289, pG1007, DOI 10.1152-ajpgi.00085.2005; Kirchgessner AL, 1996, J COMP NEUROL, V371, P270; Kirchgessner AL, 1999, NEURON, V24, P941, DOI 10.1016-S0896-6273(00)81041-7; Kreydiyyeh SI, 1997, CAN J PHYSIOL PHARM, V75, P1312, DOI 10.1139-cjpp-75-12-1312; Kucera T, 2000, FEBS LETT, V474, P223, DOI 10.1016-S0014-5793(00)01608-2; Lang ME, 1996, J PHYSIOL-LONDON, V497, P161; Li XD, 2002, P NATL ACAD SCI USA, V99, P4692, DOI 10.1073-pnas.072090199; Libsch KD, 2005, J GASTROINTEST SURG, V9, P219, DOI 10.1016-j.gassur.2004.04.007; Lundgren O, 1997, COMP BIOCHEM PHYS A, V118, P319, DOI 10.1016-S0300-9629(96)00312-X; Mace OJ, 2009, J PHYSIOL-LONDON, V587, P195, DOI 10.1113-jphysiol.2008.159616; Mace OJ, 2007, J PHYSIOL-LONDON, V582, P379, DOI 10.1113-jphysiol.2007.130906; MAGGI CA, 1990, ARCH INT PHARMACOD T, V303, P157; Maillot F, 2005, DIABETES METAB, V31, P69, DOI 10.1016-S1262-3636(07)70169-6; Mao D, 2006, MOL PHARMACOL, V70, P1693, DOI 10.1124-mol.106.027458; Margolskee RF, 2007, P NATL ACAD SCI USA, V104, P15075, DOI 10.1073-pnas.0706678104; MEI N, 1978, J PHYSIOL-LONDON, V282, P485; Meyer G, 1997, CELL MOL LIFE SCI, V53, P769, DOI 10.1007-s000180050097; Mourad FH, 2009, AM J PHYSIOL-GASTR L, V297, pG292, DOI 10.1152-ajpgi.00100.2009; Nano JL, 2000, PFLUG ARCH EUR J PHY, V439, P547, DOI 10.1007-s004240050976; NASSAR CF, 1995, AM J PHYSIOL-GASTR L, V268, pG695; Nelson DW, 2007, ENDOCRINOLOGY, V148, P1954, DOI 10.1210-en.2006-1232; Nelson G, 2002, NATURE, V416, P199, DOI 10.1038-nature726; NEWSON B, 1982, ACTA PHYSIOL SCAND, V114, P161, DOI 10.1111-j.1748-1716.1982.tb06967.x; Ogihara H, 1996, BIOCHEM BIOPH RES CO, V220, P848, DOI 10.1006-bbrc.1996.0493; Oishi AJ, 1996, DIGEST DIS SCI, V41, P1915, DOI 10.1007-BF02093590; Ouedraogo R, 2003, DIABETES, V52, P111, DOI 10.2337-diabetes.52.1.111; Pan XY, 2004, J NUTR, V134, P2211; Pan XY, 2002, AM J PHYSIOL-GASTR L, V283, pG57, DOI 10.1152-ajpgi.00545.2001; Pan XY, 2009, J LIPID RES, V50, P1800, DOI 10.1194-jlr.M900085-JLR200; Pan XY, 2007, J BIOL CHEM, V282, P24707, DOI 10.1074-jbc.M701305200; PARIS H, 1990, J PHARMACOL EXP THER, V254, P888; Parker HE, 2010, EXPERT REV MOL MED, V12, DOI 10.1017-S146239940900132X; Patterson LM, 2002, ANAT REC, V266, P10, DOI 10.1002-ar.10026; PHILPOTT DJ, 1992, CAN J PHYSIOL PHARM, V70, P1201; Qandeel HG, 2009, J GASTROINTEST SURG, V13, P1976, DOI 10.1007-s11605-009-0984-6; Qandeel HG, 2009, J SURG RES, V156, P123, DOI 10.1016-j.jss.2009.03.052; Randich A, 2000, AM J PHYSIOL-REG I, V278, pR34; Raybould H.E., 2002, GUT, V51, pi11; Raybould HE, 2006, AUTON NEUROSCI-BASIC, V125, P28, DOI 10.1016-j.autneu.2006.01.016; Raybould HE, 1998, AM J PHYSIOL-REG I, V274, pR1834; Raybould HE, 1998, NEWS PHYSIOL SCI, V13, P275; RAYBOULD HE, 1995, NEUROGASTROENT MOTIL, V7, P9, DOI 10.1111-j.1365-2982.1995.tb00203.x; Reimann F, 2008, CELL METAB, V8, P532, DOI 10.1016-j.cmet.2008.11.002; Rhoads DB, 1998, J BIOL CHEM, V273, P9510, DOI 10.1074-jbc.273.16.9510; Rocca AS, 1999, ENDOCRINOLOGY, V140, P1687, DOI 10.1210-en.140.4.1687; Rozengurt E, 2007, CURR OPIN PHARMACOL, V7, P557, DOI 10.1016-j.coph.2007.10.002; Rozengurt E, 2006, AM J PHYSIOL-GASTR L, V291, pG171, DOI 10.1152-ajpgi.00073.2006; Saito H, 1995, J PHARMACOL EXP THER, V275, P1631; Sakurai T, 1998, CELL, V92, P573, DOI 10.1016-S0092-8674(00)80949-6; Sang Q, 1997, J ANAT, V190, P209, DOI 10.1046-j.1469-7580.1997.19020209.x; Sayegh AI, 2003, PEPTIDES, V24, P237, DOI 10.1016-S0196-9781(03)00035-4; Sayegh AI, 2004, AUTON NEUROSCI-BASIC, V115, P54, DOI 10.1016-j.autneu.2004.08.006; Scholtka B, 1999, GUT, V44, P490; SEE NA, 1993, J AUTONOM NERV SYST, V42, P33, DOI 10.1016-0165-1838(93)90339-V; Sharp PA, 1996, GUT, V39, P545, DOI 10.1136-gut.39.4.545; SHIRAZIBEECHEY SP, 1991, J PHYSIOL-LONDON, V437, P699; ShiraziBeechey SP, 1996, BIOCHEM SOC T, V24, P389; SJOVALL H, 1984, ACTA PHYSIOL SCAND, V120, P437, DOI 10.1111-j.1748-1716.1984.tb07404.x; SJOVALL H, 1983, ACTA PHYSIOL SCAND, V119, P39, DOI 10.1111-j.1748-1716.1983.tb07303.x; Skowronski MT, 2000, J PHARMACOL EXP THER, V293, P128; SOLBERG DH, 1987, AM J PHYSIOL, V252, pG574; Stearns AT, 2008, AM J PHYSIOL-GASTR L, V294, pG1078, DOI 10.1152-ajpgi.00591.2007; Stumpel F, 1996, GASTROENTEROLOGY, V110, P1863, DOI 10.1053-gast.1996.v110.pm8964412; Stumpel F, 1999, AM J PHYSIOL-GASTR L, V277, pG285; Stumpel F, 2000, ANN NY ACAD SCI, V915, P111; Stumpel F, 1997, FEBS LETT, V410, P515, DOI 10.1016-S0014-5793(97)00628-5; SURPRENANT A, 1994, ANNU REV PHYSIOL, V56, P117, DOI 10.1146-annurev.physiol.56.1.117; Tavakkolizadeh A, 2001, AM J PHYSIOL-GASTR L, V280, pG209; Tavakkolizadeh A, 2005, J SURG RES, V129, P73, DOI 10.1016-j.jss.2005.05.023; Thorens B, 2004, CURR OPIN CLIN NUTR, V7, P471, DOI 10.1097-01.mco.0000134368.91900.B4; Timmermans JP, 1997, COMP BIOCHEM PHYS A, V118, P331, DOI 10.1016-S0300-9629(96)00314-3; Tobin V, 2008, DIABETES, V57, P555, DOI 10.2337-db07-0928; VALET P, 1993, J CLIN INVEST, V91, P2049, DOI 10.1172-JCI116427; Voisin T, 2003, CELL MOL LIFE SCI, V60, P72, DOI 10.1007-s000180300005; WEINBERG RB, 1990, GASTROENTEROLOGY, V98, P17; Weiss SL, 1998, P NATL ACAD SCI USA, V95, P2117, DOI 10.1073-pnas.95.5.2117; Wong TP, 2007, J PHYSIOL-LONDON, V584, P613, DOI 10.1113-jphysiol.2007.138578; Wright EM, 1997, J EXP BIOL, V200, P28755
Intertemporal competitive equilibrium: a reappraisal of a basic source of instability
No full textAbstract This paper resumes a source of instability of intertemporal equilibrium which was anticipated by Garegnani (2003) and criticized by Schefold (2004). The author points out that a non orthodox tâtonnement pricing must be accepted if the theory has to be consistent with the Jevons’s law of unique price. Such tâtonnement prescribes that the rule for adjusting the relative prices of commodities available at different times is different from the rule applied to the relative prices of contemporary commodities. The working of such a mechanism can be a fundamental source of instability of the intertemporal equilibria. This result seems to be a challenge for the stability of general equilibrium also in the context of more realistic nontâtonnement disequilibrium processes. Final version of this working paper: S.Parrinello, “Intertemporal Competitive Equilibrium, Capital and the Stability of Tâtonnement Pricing Revisited”, Metroeconomica 56:4 (2005). Further development: S. Parrinello, Numeraire, Savings and the Instability of a Competitive Equilibrium”, Metroeconomica 62:2 (2011) 328–355.Intertemporal equilibrium; instability; savings; capital
Atorvastatin-induced severe gastric ulceration: A case report
No full textA 41-year-old man presented with severe gastric ulceration 3 mo after beginning treatment with atorvastatin 20 mg once daily for hypercholesterolemia. The patient was not taking any ulcerogenic drugs and had no evidence of Helicobacter pylori infection. Proton pump inhibitor therapy was initiated and atorvastatin was replaced by simvastatin with complete resolution of gastrointestinal symptoms. To our knowledge, this is the first report of atorvastatin-induced gastric ulceration, which should be looked for in patients who develop abdominal pain while on this drug. © 2005 The WJG Press and Elsevier Inc. All rights reserved.Adcock B B, 2001, J Am Board Fam Pract, V14, P148; Andrejak M, 2003, THERAPIE, V58, P77, DOI 10.2515-therapie:2003011; Anliker MD, 2002, ALLERGY, V57, P366, DOI 10.1034-j.1398-9995.2002.1n3628.x; Belaiche G, 2000, GASTROEN CLIN BIOL, V24, P471; Chazerain P, 2001, JOINT BONE SPINE, V68, P430, DOI 10.1016-S1297-319X(01)00300-1; Gonzalez-Ponte ML, 1998, LANCET, V352, P1284, DOI 10.1016-S0140-6736(05)70491-8; Jimenez-Alonso J, 1999, ARCH INTERN MED, V159, P1811, DOI 10.1001-archinte.159.15.1811-a; LACY C, 2001, DRUG INFORM HDB, P109; Malinowski JM, 1998, AM J HEALTH-SYST PH, V55, P2253; Nakad A, 1999, LANCET, V353, P1763, DOI 10.1016-S0140-6736(99)00569-3; Negevesky G J, 2000, Arch Ophthalmol, V118, P427; Noel B, 2001, AM J MED, V110, P670, DOI 10.1016-S0002-9343(01)00711-2; Pfeiffer CM, 1998, JAMA-J AM MED ASSOC, V279, P1613, DOI 10.1001-jama.279.20.1613-a; Segal AS, 2002, AM J MED, V113, P171, DOI 10.1016-S0002-9343(02)01135-X; Sinzinger H, 2002, WIEN KLIN WOCHENSCHR, V114, P943; Sulem P, 2001, ANN PHARMACOTHER, V35, P1292; Ziajka PE, 1998, SOUTHERN MED J, V91, P66774
- …
