34,332 research outputs found
Typhloiulus seewaldi Strasser 1967
No full text<i>Typhloiulus seewaldi</i> (Strasser, 1967) <p> <i>Alpityphlus seewaldi</i> Strasser, 1967 <i>Typhloiulus seewaldi</i>: Fritsch 1998</p> <p> <b>Distribution.</b> Austria: cave Hollerloch in Untersberg massif (type locality!), Obere Brangrabenhöhle (Fritsch, 1998).</p> <p> <b>Remarks.</b> This species was originally described in a monotypic genus— <i>Alpityphlus</i> Strasser, 1967. Fritsch (1998) synonymized <i>Alpityphlus</i> with <i>Typhloiulus</i>, but without stating any reasons for the proposed synonymy. Considering that Strasser’s description includes several diagnostic differences between <i>Alpityphlus</i> and <i>Typhloiulus</i>, <i>T. seewaldi</i> might indeed deserve treatment under a separate genus.</p>Published as part of <i>Vagalinski, Boyan, Stoev, Pavel & Enghoff, Henrik, 2015, A review of the millipede genus Typhloiulus Latzel, 1884 (Diplopoda: Julida: Julidae), with a description of three new species from Bulgaria and Greece, pp. 334-362 in Zootaxa 3999 (3)</i> on page 346, DOI: 10.11646/zootaxa.3999.3.2, <a href="http://zenodo.org/record/234012">http://zenodo.org/record/234012</a>
Binding of agonists and antagonists to mineralocorticoid receptors in human peripheral mononuclear leucocytes.
No full textThe binding of agonists (liquorice derivatives) and antagonists (spironolactones and cyproheptadine) to Type I aldosterone binding sites was evaluated in human mononuclear leucocytes and compared with data previously obtained using kidney cytosol or kidney slices from adrenalectomized rats. The affinity of spironolactones (spironolactone and canrenone) is equivalent in all the preparations. In contrast, carbenoxolone and glycyrrhizic acid show no affinity for aldosterone binding sites in mononuclear leucocytes, but bind to receptors in kidney cytosol. The possible explanation of the discrepancies is that, in cytosolic preparations, the two latter compounds may undergo hydrolysis into glycyrrhetinic acid which does possess a measurable affinity for mineralocorticoid receptors in all the preparations
Haasia stenopodium Strasser 1966
No full textNew data for Haasia stenopodium (Strasser, 1966) CROATIA: 1 ♂, 2 ♀♀, Pepelarica Pit, Middle Velebit, 4 Jul. 2015, leg. G. Rnjak (CBSS); 1 ♂, 3 ♀♀, Meduza Pit, Crikvena, North Velebit National Park, 4 Aug. 2015, leg. B. Jalžić (CBSS). SLOVENIA: 1 ♀, Velika Ledenica u Paradani Pit, Lokve, Batuje, Nova Gorica, 6 Apr. 2014, leg. T. Delić & Š. Borko (IZB); 1 ♂, same data except Jun. 2014, leg. Š. Borko (IZB); 2 ♂♂, 1 juvenile, Brezno Treh Src, Cifre, Snežnik, 12 Sep. 2015, leg. T. Delić (IZB); 1 ♂, 2 ♀♀, 2 juveniles, Brajnice Pit, Dobec, Bezuljak, 14 Nov. 2015, leg. T. Delić (IZB).Published as part of Dragan Ž. Antić, Tvrtko Dražina, Tonći Rađa, Luka R. Lučić & Slobodan E. Makarov, 2016, Taxonomic status of the family Biokoviellidae Mršić, 1992 (Diplopoda, Chordeumatida): reconsideration, with a description of one new species, pp. 1-23 in European Journal of Taxonomy 205 on page 18, DOI: 10.5852/ejt.2016.205, http://zenodo.org/record/26927
Down-regulation of Type-I Aldosterone Binding-sites In Circulating Mononuclear Leukocytes From Patients With Primary Aldosteronism and Cushings-syndrome
No full textThe IEEE IES Technical Committee Cluster of Energy
No full textThe IEEE Industrial Electronics Society (IES) Technical Committee (TC) Cluster of Energy was established at the 44th Annual Conference of the IEEE Industrial Electronics Society, 21-23 October 2018, in Washington, D.C. The worldwide challenges of energy shortage and global warming urgently require innovations in the energy field [1]. Applicationoriented multidisciplinary approaches are the key to addressing challenges and developing cutting-edge solutions. The IES is positioning itself as a leader in the energy field thanks to its wide coverage of expertise and the multidisciplinary nature of the Society
Aldosterone-receptor deficiency in pseudohypoaldosteronism.
No full textPseudohypoaldosteronism, a syndrome characterized by salt wasting and failure to thrive, usually presents in infancy as high urinary levels of sodium despite hyponatremia, hyperkalemia, hyperreninemia, and elevated aldosterone levels. We have investigated this syndrome for the possibility of abnormal Type I or "mineralocorticoid-like" receptors, which have intrinsic steroid specificity indistinguishable from that of renal mineralocorticoid receptors and are found in many tissues and cells, including mononuclear leukocytes. We have studied three patients with pseudohypoaldosteronism: the 28-year-old index case in Melbourne (Patient 1) and two siblings in Munich, eight and two years of age (Patients 2 and 3); clinically, Patient 3 had a less severe case than his sister. Percoll-separated control monocytes bound [3H]aldosterone with high affinity (Kd approximately 3 nM) and limited capacity (150 to 600 sites per cell). On repeated examination, no [3H]aldosterone binding was found in monocytes from Patients 1 and 2; in Patient 3, the levels were 62 sites per cell, more than 2 S.D. below those of the control. Levels in the parents of the Munich patients (first cousins) were normal. It appears that pseudohypoaldosteronism is caused by a Type I receptor defect, that the defect may be complete or partial, that transmission may be autosomal recessive, and that the study of patients with pseudohypoaldosteronism may indicate physiologic roles for Type I receptors in nonepithelial tissues
Exploiting knowledge of immune selection in HIV-1 to detect HIV-specific CD8 T-cell responses
No full textSince HLA-restricted cytotoxic T-cell responses select specific polymorphisms in HIV-1 sequences and HLA diversity is relatively static in human populations, we investigated the use of peptide epitopes based on sites of HLA-associated adaptation in HIV-1 sequences to stimulate and detect T-cell responses ex vivo. These "HLA-optimised" peptides captured more HIV-1 Nef-specific responses compared with overlapping peptides of a single consensus sequence, in interferon-γ enzyme linked immunospot assays. Sites of immune selection can reveal more immunogenic epitopes in HLA-diverse populations and offer insights into the nature of HLA-epitope targeting, which could be applied in vaccine design
A Research Roadmap for Model-Driven Design of Embedded Systems for Automation Components
No full textHeterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
No full textIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
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