1,720,980 research outputs found
Raspberry-Pi based system for propofol monitoring
No full textInduction of anesthesia with propofol is a largely adopted technique in hospital environments. The correct dosage of this compound is essential to avoid under- or over-anesthesia that may result in serious side-effects. Therefore, in clinical settings, long-term monitoring of propofol is of great importance. To this aim, in this work, we present the design and the validation of a custom-made, low-cost and portable Point-of-Care (PoC) system based on electrochemical detection for propofol monitoring. Fouling phenomenon due to phenolic oxidation of propofol has been overcome by adopting a Pencil Graphite Electrode (PGE) 3H as sensor. The validation of the system focused on testing the measurement speed through scan-rate analysis, which is important due to the fast clearance of propofol; and interference study with Paracetamol(APAP), since it is an analgesic compound frequently administered with propofol in medical practices.LSI1LSI
Quasi-Digital Biosensor-Interface for a Portable Pen to Monitor Anaesthetics Delivery
Full text linkMonitoring of patient response to the anaesthetic drugs is an attractive improvement for achieving a correct balance of sedation level, increasing the chance of success in the right
procedure of anaesthesia. Nowadays, there are no commercial tools able to offer real-time monitoring of anaesthetics, indeed, there is still a lack in sensing technologies able to maintain high performances in long term monitoring within a portable miniaturised hardware system. To overcome these limitations, we are here presenting the innovative concept of a portable pen-device able to sense anaesthetic compounds over time. This study is based on an electrochemical sensor to be fully integrated into a complete pen-shaped point-of-care for the monitoringof anaesthesia delivery. The design of the system is based on a bio-inspired event-based approach that is guaranteeing low complexity, low power consumption and is therefore suitable to be scaled to fit the barrel of a pen. An exhaustive comparison between the proposed system and a lab instrument proves that the presented approach obtains comparable performances in terms of sensitivity and resolution with the ones obtained by expensive commercial instrumentation, meanwhile, the results show a 95 % power consumption reduction and a 92 % area decrease w.r.t. previously presented implementation
New Approach for Making Standard the Development of Biosensing Devices by a Modular Multi-Purpose Design
Full text linkThe fast widening of biosensing applications, such as healthcare, drug delivery, food, and military industries, is increasing the need for generality and compatibility among different sensors. To address this challenge, we present here an innovative approach for the fast development of new electronic biosensing systems, linking a custom-designed front-end with a multi-purpose system. We envision an open tool to help designers to focus on the target molecule and related detection method instead of designing each time a dedicated electronic device. The architecture of the proposed system is based on a modular approach, where only the front-end and the software need to be custom re-designed according to the application. Considering current research and applying a rigorous definition of the technical requirements, the core of the system is designed to fit the highest number of biosensing methods. The flexibility of this approach is successfully demonstrated with three different types of biosensors, i.e., amperometric, ion-sensitive, and memristive
Architecture and procedures for pH and temperature monitoring in medical applications
No full textTemperature (T) and pH variations affect the function of electrochemical sensors. The study of their effects on point-of-care medical sensors is vital due to their delicate use. An example comes from anesthesia where difficult-to-dose drugs are infused in patient's blood, e.g. propofol. In this case, a drug concentration monitoring system is required. However, blood pH and T can vary during anesthesia, with respect to the patient's clinical situation. A portable, low-cost and easy-to-reproduce Printed Circuit Board (PCB) is here designed for the first time up to now for anesthesia, in order to continuously keep under control pH and T variations while a dedicated system constantly monitors the drug level. The board is driven by a Raspberry Pi (RPi). Measurements in different pH and T conditions validated the proposed system
An IoT Solution for Online Monitoring of Anesthetics in Human Serum Based on an Integrated Fluidic Bioelectronic System
No full textIn this paper, we present the design, the implementation and the validation of a novel Internet of Things (IoT) drug monitoring system for the online continuous and simultaneous detection of two main anesthetics, e.g., propofol and paracetamol, in undiluted human serum. The described full system consists of a custom-built electronic Raspberry Pi (RPi) based Printed Circuit Board (PCB) that drives and reads out the signal from an electrochemical sensing platform integrated into a fluidic system. Thanks to the Polydimethylsiloxane (PDMS) fluidic device, the analyzed sample is automatically fluxed on the sensing site. The IoT network is supported by a Cloud system, which allows the doctor to control and share all the patient’s data through a dedicated Android application and a smart watch. The validation closes with the first ever demonstration that our system successfully works for the simultaneous monitoring of propofol and paracetamol in undiluted human serum by measuring the concentration trends of these two drugs in fluxing conditions over time.LSI1LSI
IoT for Telemedicine Practices enabled by an Android (TM) Application with Cloud System Integration
No full textConnected medical devices are already paving the way towards the realization of Smart Hospitals where patient care is improved thanks to Internet of Things (IoT) solutions. Following this trend, in this paper we propose an IoT cloud-based network for anesthesia on-line monitoring. This architecture allows the anesthesiologist to remain simultaneously connected to all the sedated patients through an Android app. Moreover, medical data from the patients can be shared on a cloud solution accessible by a web application enabling teleconsulting. Hence, by accessing the cloud, medical specialists can consult the shared data from everywhere and at any time. The flexibility and the portability of our monitoring architecture ensure the possibility to interface with any medical device which can wirelessly send the measured data. Therefore, other medical monitoring applications can also be addressed.ICLA
Raspberry Pi Based System for Portable and Simultaneous Monitoring of Anesthetics and Therapeutic Compounds
No full textPersonalized drug dosage is crucial to ensure optimal benefit in patient's treatments. Therefore, many efforts are done in developing integrated, low-cost and portable point- of-care sensing systems able to continuously monitor the drug concentration. To satisfy this request, a portable multi-channel system is here presented and validated. The system is able to run different electrochemical techniques independently on each channel. Thanks to the flexibility of the system it is possible to configure it for different medical applications, as for anesthesia practices. The Raspberry Pi has been chosen as main control unit since it offers high performances and excellent features with low- costs
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Wearable System for Spinal Cord Injury Rehabilitation with Muscle Fatigue Feedback
No full textThe design, realization and verification of a system for personalized rehabilitation of Spinal Cord Injury (SCI) patients are here presented. It consists of two main parts: (i) one induces in the patient the physiotherapic movement proposed by the trainer with Functional Electrical Stimulation (FES) and (ii) the other integrates a muscle fatigue feedback evaluator based on acustic principle by wearable microphone. The importance of this fatigue feedback is crucial since SCI patients are unable to feel muscle soreness, which is an important parameter in FES rehabilitation. Indeed, the efficacy of this treatment is limited by the capacity of the muscle fibers to carry out the induced task. To optimize the feedback module, the performance of two different condenser microphones (analogic and digital) were compared each other as well as with the traditional method based on Electromyogram (EMG). Among these techniques, it was found that the digital microphone provides the best performance in fatigue estimation over time.LSI1LSI2ICLA
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