187,135 research outputs found
The sequence manipulation suite: JavaScript programs for analyzing and formatting protein and DNA sequences
No full textJavaScript is an object-based scripting language that can be interpreted by most commonly used Web browsers, including Netscape® Navigator® and Internet Explorer®. In conjunction with HTML form elements, JavaScript can be used to make flexible and easy-to-use applications that can be accessed by anyone connected to the Internet (3). The Sequence Manipulation Suite (http://www.ualberta.ca/~stothard/javascript/) is a collection of freely available JavaScript applications for molecular biologists. It consists of over 30 utilities for analyzing and manipulating sequence data...
Schistosomiasis In sub-Saharan Africa: The Under Fives Need Praziquantel - 24 Jan 2012
No full textPHILADELPHIA - Scientists in the UK and Uganda have now completed a three year study showing that young children are at continued risk of intestinal schistosomiasis - also known as bilharzia - between the ages of 6-months and five years. In fact, these children should be treated routinely with the anthelminthic praziquantel, just as in older children and adults, for it is proven both safe and efficacious. The Schistosomiasis In Mothers and Infants (SIMI) study was conducted by the Liverpool School of Tropical Medicine and the London School of Hygiene and Tropical Medicine working with the Vector Control Division, Ministry of Health, in Uganda and was reported at the American Society of Tropical Medicine and Hygiene annual conference in Philadelphia. Professor Russell Stothard discussed some of the key findings with Peter Goodwin
Nootka Chiefs Callicum and Maquinna, Nootka Sound, British Columbia, in engraving made 1788
No full textPhotograph of engraving of two men clasping hands, in front of shore with masted vessel & rowboat. The men wear tunics fastened at shoulder, earrings & bracelets; man on left has conical hat. Maquinna also in NA3887
Caption on image: Callicum and Maquilla [sic]. Chiefs of Nootka Sound.
Image from John Meare's Voyages made in the years 1788 and 1789, from China to the north west coast of America, 1790, p. 108
Note from unidentified source: Stothard not on voyage; from drawing by unknown artis
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Development of a serious computer game based training module and its integration into working at heights mine site induction - Paper II
No full textThis paper reports the findings of a collaborative project that developed and demonstrated a serious computer game (SCG) based simulation training module for mine site inductions. It is the second of two papers. The project was collaboration between the University of New South Wales, the University of Adelaide, BHP Billiton Olympic Dam Expansion, Resources and Engineering Skills Alliance, Training and Further Education South Australia and SkillsDMC. The pilot project was aimed at improving mine site inductions by developing a prototype SCG for trainers to incorporate into their regular training activities. The outcome was a high quality generic SCG that provides an interactive visualisation of an Australian mine site operation under construction. The SCG was tested under controlled conditions and subsequently deployed on site.P. Stothard and A. van den Henge
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Genomic analysis and relatedness of P2-like phages of the Burkholderia cepacia complex
No full textBackground The Burkholderia cepacia complex (BCC) is comprised of at least seventeen Gram-negative species that cause infections in cystic fibrosis patients. Because BCC bacteria are broadly antibiotic resistant, phage therapy is currently being investigated as a possible alternative treatment for these infections. The purpose of our study was to sequence and characterize three novel BCC-specific phages: KS5 (vB_BceM-KS5 or vB_BmuZ-ATCC 17616), KS14 (vB_BceM-KS14) and KL3 (vB_BamM-KL3 or vB_BceZ-CEP511). Results KS5, KS14 and KL3 are myoviruses with the A1 morphotype. The genomes of these phages are between 32317 and 40555 base pairs in length and are predicted to encode between 44 and 52 proteins. These phages have over 50% of their proteins in common with enterobacteria phage P2 and so can be classified as members of the Peduovirinae subfamily and the \"P2-like viruses\" genus. The BCC phage proteins similar to those encoded by P2 are predominantly structural components involved in virion morphogenesis. As prophages, KS5 and KL3 integrate into an AMP nucleosidase gene and a threonine tRNA gene, respectively. Unlike other P2-like viruses, the KS14 prophage is maintained as a plasmid. The P2 E+E' translational frameshift site is conserved among these three phages and so they are predicted to use frameshifting for expression of two of their tail proteins. The lysBC genes of KS14 and KL3 are similar to those of P2, but in KS5 the organization of these genes suggests that they may have been acquired via horizontal transfer from a phage similar to λ. KS5 contains two sequence elements that are unique among these three phages: an ISBmu2-like insertion sequence and a reverse transcriptase gene. KL3 encodes an EcoRII-C endonuclease/methylase pair and Vsr endonuclease that are predicted to function during the lytic cycle to cleave non-self DNA, protect the phage genome and repair methylation-induced mutations. Conclusions KS5, KS14 and KL3 are the first BCC-specific phages to be identified as P2-like. As KS14 has previously been shown to be active against Burkholderia cenocepacia in vivo, genomic characterization of these phages is a crucial first step in the development of these and similar phages for clinical use against the BCC
An update on female and male genital schistosomiasis and a call to integrate efforts to escalate diagnosis, treatment and awareness in endemic and non-endemic settings: The time is now
No full textThe last decades have brought important insight and updates in the diagnosis, management and immunopathology of female genital schistosomiasis (FGS) and male genital schistosomiasis (MGS). Despite sharing a common parasitic aetiological agent, FGS and MGS have typically been studied separately. Infection with Schistosoma haematobium manifests with gender-specific clinical manifestations and consequences of infection, albeit having a similar pathogenesis within the human genital tract. Schistosoma haematobium is a known urinary bladder carcinogen, but its potential causative role in other types of neoplasia, such as cervical cancer, is not fully understood. Furthermore, the impact of praziquantel treatment on clinical outcomes remains largely underexplored, as is the interplay of FGS/MGS with relevant reproductive tract infections such as HIV and Human Papillomavirus. In non-endemic settings, travel and immigrant health clinics need better guidance to correctly identify and treat FGS and MGS. Our review outlines the latest advances and remaining knowledge gaps in FGS and MGS research. We aim to pave a way forward to formulate more effective control measures and discuss elimination targets. With a growing community awareness in health practitioners, scientists and epidemiologists, alongside the sufferers from these diseases, we aspire to witness a new generation of young women and men free from the downstream disabling manifestations of disease.</p
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