140 research outputs found
Nella biblioteca di Hartmann Schedel: l'index librorum aldino del 1498 e le Decades rerum Venetarum di Marcantonio Sabellico
No full textThe contribution examines the first catalogue issued by Aldo Manuzio on 1 October 1498 and in particular the copy in the Österreichische Nationalbibliothek in Vienna (Ink. 7.A.13). A careful examination of the manuscript annotations, known to be by Hartmann Schedel, has enabled the author to identify the volume in which Schedel had the catalogue bound in his lifetime: a copy of Marcantonio Sabellico’s Decades rerum Venetarum (Venice, Andrea Torresani, 1487) also in the Österreichische Nationalbibliothek (Ink. 7.A.7). A detailed description of the item and Schedel's textual and graphic additions reveals for the first time what was one of the most significant books in the humanist's library and allow us to reconstruct the overall context of its use in the years immediately following its publication
Efgartigimod improved health-related quality of life in generalized myasthenia gravis: results from a randomized, double-blind, placebo-controlled, phase 3 study (ADAPT)
No full textThere are substantial disease and health-related quality-of-life (HRQoL) burdens for many patients with myasthenia gravis (MG), especially for those whose disease symptoms are not well controlled. HRQoL measures such as the Myasthenia Gravis Quality of Life 15-item revised (MG-QOL15r) and EuroQoL 5-Dimensions 5-Levels (EQ-5D-5L) are vital for evaluating the clinical benefit of therapeutic interventions in patients with MG, as they assess the burden of disease and the effectiveness of treatment, as perceived by patients. The phase 3 ADAPT study (NCT03669588) demonstrated that efgartigimod-a novel neonatal Fc receptor inhibitor-was well tolerated and that acetylcholine receptor antibody-positive (AChR-Ab+) participants who received efgartigimod had statistically significant improvements in MG-specific clinical scale scores. The ancillary data reported here, which cover an additional treatment cycle, show that these participants had similar significant improvements in HRQoL measures, the MG-QOL15r and EQ-5D-5L utility and visual analog scales, and that these improvements were maintained in the second treatment cycle. Positive effects on HRQoL were rapid, seen as early as the first week of treatment in both treatment cycles, and maintained for up to 4 weeks in the follow-up-only portion of treatment cycles. The pattern of improvements in HRQoL paralleled changes in immunoglobulin G level, and correlational analyses show that improvements were consistent across HRQoL measures and with clinical efficacy measures in the ADAPT study. The substantial and durable improvements in HRQoL end points in this study demonstrate the broader benefit of treatment with efgartigimod beyond relief of immediate signs and symptoms of gMG.Neurological Motor Disorder
Cognitive impairment in myotonic dystrophy type 1 is associated with white matter damage.
No full textTo investigate grey (GM) and white matter (WM) abnormalities and their effects on cognitive and behavioral deficits in a large, phenotypically and genotypically well-characterized cohort of classic adult (aDM1, age at onset ≥ 20 years) or juvenile (jDM1, age at onset <20 years) patients with myotonic dystrophy type 1 (DM1).A case-control study including 51 DM1 patients (17 jDM1 and 34 aDM1) and 34 controls was conducted at an academic medical center. Clinical, cognitive and structural MRI evaluations were obtained. Quantitative assessments of regional GM volumes, WM hyperintensities (WMHs), and microstructural WM tract damage were performed. The association between structural brain damage and clinical and cognitive findings was assessed.DM1 patients showed a high prevalence of WMHs, severe regional GM atrophy including the key nodes of the sensorimotor and main cognitive brain networks, and WM microstructural damage of the interhemispheric, corticospinal, limbic and associative pathways. WM tract damage extends well beyond the focal WMHs. While aDM1 patients had severe patterns of GM atrophy and WM tract damage, in jDM1 patients WM abnormalities exceeded GM involvement. In DM1, WMHs and microstructural damage, but not GM atrophy, correlated with cognitive deficits.WM damage, through a disconnection between GM structures, is likely to be the major contributor to cognitive impairment in DM1. Our MRI findings in aDM1 and jDM1 patients support the hypothesis of a degenerative (premature aging) origin of the GM abnormalities and of developmental changes as the principal substrates of microstructural WM alterations in DM1
STUDY OF THE ELECTRONIC GROUND STATE OF BY LASER EXCITED FLUORESCENCE FOURIER TRANSFORM SPECTROSCOPY
No full text C. Jungen, K-E.J. Hallin and A.J.Merer, Molec. Phys., 40, 25 (1980). G. Duxbury and R.N. Dixon, Molec. Phys., 43, 255 (1981). M. Peric, S.D. Peyerimhoff and R.J. Buenker, Molec.Phys. 49, 379 (1983).Author Institution: Herzberg Institute of Astrophysics, National Research Council of CanadaA large number of spin-rovibronic levels of the upper electronic state of have been excited with a single mode rhodamine 6G dye laser. Fluorescence spectra were obtained over a wide spectral range (12000-3700 cm-1) using a Fourier transform spectrometer. Levels of the bending vibration were observed from up to 10, showing the reordering of the K-structure at the barrier to linearity: their observed energies are in good agreement with the predictions of Jungen, Hallin and Merer1 , Duxbury and and Peric, Peyerimhoff and . Numerous vibrational levels involving and were also detected and approximate anharmonic parameters have been deduced
»Der Aufsatz […] war gar nicht so ›sexy‹ wie das Bild.«: Fotografien weiblicher Körper in der DDR-Zeitschrift "Das Magazin" in den 1950er Jahren
No full textTThe present essay features Das Magazin, a popular East German monthly magazine that appeared in the GDR for the first time in 1954. The author analyzes the photographic depiction of women in issues of the 1950s. This analysis starts with the magazine’s prominent and well-researched nude photographs, but later focuses on other images of female bodies, i.e. in photo montages, to explore the different variations in which women were depicted in Das Magazin. A close examination of the images in question, their position and contextualization within Das Magazin allows for a look beyond the pages of the printed product and sheds light on the work of the layout artists. In doing so, the author argues that its creators revived certain visual strategies that had already been cultivated by the popular press in the interwar period and which were also existent beyond the boundaries of the GDR press. Thus, the notion of GDR magazines’ production practices can be enriched by transnational and historical perspectives.The present essay features Das Magazin, a popular East German monthly magazine that appeared in the GDR for the first time in 1954. The author analyzes the photographic depiction of women in issues of the 1950s. This analysis starts with the magazine’s prominent and well-researched nude photographs, but later focuses on other images of female bodies, i.e. in photo montages, to explore the different variations in which women were depicted in Das Magazin. A close examination of the images in question, their position and contextualization within Das Magazin allows for a look beyond the pages of the printed product and sheds light on the work of the layout artists. In doing so, the author argues that its creators revived certain visual strategies that had already been cultivated by the popular press in the interwar period and which were also existent beyond the boundaries of the GDR press. Thus, the notion of GDR magazines’ production practices can be enriched by transnational and historical perspectives
Betrachten, Blättern, Enthüllen, Lauschen, Lesen.: Walter Scotts »THE TAPESTRIED CHAMBER«, das KEEPSAKE FOR MDCCCXXIX, sein zehnter Stahlstich und ihr interaktives Bedeutungsangebot
No full textThis article deals with the aesthetic effects that arise when reading, viewing and handling different media formats. It takes strongly divergent contemporary evaluations of a well-known gothic tale by Walter Scott, »THE TAPESTRIED CHAMBER«, as an opportunity to investigate the medial and material causes of these differences. The author concentrates on the first publication of the tale in autumn 1828 in the opulent annual gift book THE KEEPSAKE FOR MDCCCXXIX, with its numerous steel engravings, and on another early print of the text in the magazine THE OLIO, OR, MUSEUM OF ENTERTAINMENT, with its wood-engraved illustrations. Both prints organise the reading of »THE TAPESTRIED CHAMBER« in specific ways, each setting in motion specific processes of understanding, each stimulating specific aesthetic experiences. This can be traced back in particular to the illustrations placed alongside the prints of the narrative text, to their production, reproduction and presentation in the printed product, to the way in which they are integrated into the flow of reception, which senses of the recipients they address and to which specific forms of media interaction they invite.This article deals with the aesthetic effects that arise when reading, viewing and handling different media formats. It takes strongly divergent contemporary evaluations of a well-known gothic tale by Walter Scott, »THE TAPESTRIED CHAMBER«, as an opportunity to investigate the medial and material causes of these differences. The author concentrates on the first publication of the tale in autumn 1828 in the opulent annual gift book THE KEEPSAKE FOR MDCCCXXIX, with its numerous steel engravings, and on another early print of the text in the magazine THE OLIO, OR, MUSEUM OF ENTERTAINMENT, with its wood-engraved illustrations. Both prints organise the reading of »THE TAPESTRIED CHAMBER« in specific ways, each setting in motion specific processes of understanding, each stimulating specific aesthetic experiences. This can be traced back in particular to the illustrations placed alongside the prints of the narrative text, to their production, reproduction and presentation in the printed product, to the way in which they are integrated into the flow of reception, which senses of the recipients they address and to which specific forms of media interaction they invite
Phase noise in fiber-optic parametric amplifiers and converters and its impact on sensing and communication systems
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