1,721,056 research outputs found
Heterotopic Transcatheter Tricuspid Valve Implantation: A Useful Bailout Strategy After Failed Transcatheter Tricuspid Valve Repair?
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Mortality benefit with different antithrombotic therapies in patients with stable vascular disease: From pathophysiology to the clinical impact in the real world. The COMPASS study
No full textThe evaluation and application of antithrombotic strategies able to reduce total and cardiovascular mortality in patients with documented vascular disease have an important clinical and epidemiological role and may also impact on health costs. In the COMPASS trial, the association of rivaroxaban at the dose of 2.5 mg twice daily with aspirin in a population with stable vascular disease has significantly reduced the incidence of cardiovascular events compared to the standard regimen of aspirin alone; this reduction translated into greater cardiovascular and total survival. Such mortality benefit was not observed in previous randomized trials that in this setting of patients had previously evaluated antiplatelet strategies alternative to aspirin (with clopidogrel) or had compared a dual antiplatelet therapy with aspirin plus clopidogrel, vorapaxar, or ticagrelor vs a single antiplatelet treatment with aspirin. The results of the COMPASS trial strengthen the role of antithrombotic strategies that, beside the platelet phase, also involve the coagulative phase with the aim at preventing the recurrence of cardiovascular, atherothrombotic events at the site of polyvascular beds, with a degree of benefit proportional to the baseline risk of the patient
Optical coherence tomography
No full textOptical coherence tomography (OCT) is a light-based imaging modality which shows tremendous potential in the setting of coronary imaging. Compared to intravascular ultrasound (IVUS), OCT has a ten-fold higher image resolution. OCT has the ability to characterise the structure and extent of coronary artery disease in unprecedented detail as the various components of atherosclerotic plaques have different optical properties. Typically, calcified, fibrous and lipid-rich plaque components can be distinguished, as well as the presence of dense macrophage infiltration, neovascularisation and mural or intraluminal thrombi.
These diagnostic capabilities are being applied to study patients with ACS and STEMI in order to improve our understanding of the pathophysiology and progression of atherosclerosis. Likewise, OCT allows the detailed analysis of coronary stents, their interaction with the vessel wall and their long-term outcome. In daily clinical practices, OCT may be efficient in complex interventions. Preliminary data indicates that OCT can change the operator’s intention-to-treat and modify the overall revascularisation strategy, potentially avoiding unnecessary interventional procedures. Recent studies shed light on the role of OCT as an instrumental tool to study plaque composition, particularly the extension of calcific components and select the most appropriate interventional device. This burden of information can ameliorate stent deployment and improve clinical outcome after coronary interventions. As such, OCT may emerge, along with its undisputed position in research, as the tool of choice in all clinical scenarios where angiography is limited by its nature as a two-dimensional luminogram
Contributors to survival benefit of dual versus single antithrombotic therapy in chronic coronary syndrome: Survival benefit of dual antithrombotic therapy in CCS
No full textThrombus aspiration in primary percutaneous coronary intervention: Still a valid option with improved technique in selected patients!
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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