2,541 research outputs found
Steven Ferguson Interview
No full textSteven V. Ferguson served with the U.S. Navy, four years active and two years Reserve, serving his career on the U.S.S. Gearing DD-710. This interview covers his Naval career
De afsluiting van het Haringvliet
No full textIr. H. A. Ferguson - Ten geleide ** H. J. Stuvel - BoIwerk en hoafdkraan ** Ir. P. Santema - De Haringvlietafsluiting aIs instrument vaor regionalewaterbeheersing in Zuidwest-Nedefland ** Prof. ir. P. A. van de Velde - Het ontwerp in hoofdlijnen vaor de uitwateringssluis ** H. J . Stuvel - De kraan van de Delta ** Ir. J. E. Prins - Haringvlietproject stuwde waterloopkundig ondefzoek naar hager plan ** lr. F. Spaargaren en iT. J. J. Vinje - Waterloopkundig onderzoek ten behoeve van vormgeving kunstwerk, vorm bouwput en vonn sluitgat ** H. J. Stroband, ing. - De'Deltar' ** Ir. P. H. van der Weele- De bodembescherming ter weerszijden van de spuisluizen ** W. Drooger - Mechanisch zinken ** Ir. C. A. ZuMerwijk - 'Grootgrondverzet' in het Haringvliet ** Ir. P. Blokland - De problemen van de schaalvergroting bij het ontwerpen en bouwen van de spnisluis in het Haringvliet ** H. J. Stuvel - De produktie van de nablaliggers ** Ir. A. van Dam en ir. Ph. Diderich - Terugblik op een inspirerende opdracht ** Ir. drs. H. Kuiper - De segmentschuiven met elektro-hydraulische aandrijving ** fr. M. Geleedst en ir. W. A. Venis - OnderLoek naar het dynamisch gedrag van de Haringvlietsluis ** Ir. R.I. Schor - De vervaardiging van de schuiven ** Ir. J. ter Brugge - De montage van de schuiven ** Ir. P. H. van der Weele - De kabelbaan ** Ir. T. G. van der Meer - De sluiling van het Rak van Scheelhoek ** Ir. A. 1. Woestenenk - Bijzondere toerassing van zandasfalt in de waterbouw ** Ir. J.J. Pilon- De Hydrometische begeleiding van de Haringvlietwerken ** W. A. A. van Eyden en ir. F. Langeweg - De functie van de Haringvlietsluizen binnen het waterbeheersingssysteem van het noordelijk Deltabekken ** Prof. ir. P. Ph. Jansen - Een historisch gebeurenDeltawerke
Perspectives on Identity, Migration, and Displacement
No full textPerspectives on Identity, Migration, and Displacement -- edited by Steven Tötösy de Zepetnek, I-Chun Wang, and Hsiao-Yu Sun (Kaohsiung: National Sun Yat-sen University Press, 2010. ISBN 9789860235418 209 pages, bibliography, index) is a collection of articles about sociological and literary aspects of identity formation as a consequence of (im)migration. (Im)migration results in the problematics of assimilation and hybridity and in postcolonial scholarship, in particular, attention is paid to the concept of migration termed Creolization on the ground that cultural contact, cultural transmission, and cultural transformation result in the creation of new cultures. Copyright release by National Sun Yat-sen University to the authors 2013
Cardiomyopathy in farmed Norwegian salmon
No full textThis paper describes the gross findings, histopathology, and ultrastructural and scanning electron microscopical (SEM) appearance of farmed Norwegian Atlantic salmon dying from a disease known locally as 'acute heart failure'. Pathological findings were mainly cardiac, and some fish showed haemopericardium due to rupture of the atrial wall. Lesions were largely restricted to the spongy portion of ventricle and atrium, and comprised myocardial degeneration and necrosis, with variable degrees of endocardial-associated hypercellularity, plus macrophage and lymphocyte infiltration; epicarditis was also present in most fish. Transmission electron microscope findings confirmed the myofibrillar disruption, while the SEM showed crater-like discontinuities in the endocardial plasmalemma. The cause and pathogenesis of these severe lesions are unknown; whether they are primarily degenerative or inflammatory requires more detailed study. Until more is known, the term cardiomyopathy syndrome seems most appropriate..RE: 13 ref.; SC: ZA; VE; CA; 0I; 0V; 2VSource type: Electronic(1) http://upei-resolver.asin-risa.ca?sid=SP:CABI&id=pmid:&id=&issn=0177-5103&isbn=&volume=8&issue=3&spage=225&pages=225-231&date=1990&title=Diseases%20of%20Aquatic%20Organisms&atitle=Cardiomyopathy%20in%20farmed%20Norwegian%20salmon.&aulast=Ferguson&pid=%3Cauthor%3EFerguson%2c%20H%20W%3bPoppe%2c%20T%3bSpeare%2c%20D%20J%3C%2Fauthor%3E%3CAN%3E19922260438%3C%2FAN%3E%3CDT%3EJournal%20article%3C%2FDT%3
Light and electron microscopical observations of the effects of high-density lipoprotein on growth of Plasmodium falciparum in vitro
No full textAuthor Posting. © Cambridge University Press, 2004. This article is posted here by permission of Cambridge University Press for personal use, not for redistribution. The definitive version was published in Parasitology 128 (2004): 577-584, doi:10.1017/S0031182004005025.Human serum high-density lipoprotein (HDL) is necessary and sufficient for the short-term maintenance of Plasmodium falciparum in in vitro culture. However, at high concentrations it is toxic to the parasite. A heat-labile component is apparently responsible for the stage-specific toxicity to parasites within infected erythrocytes 12–42 h after invasion, i.e. during trophozoite maturation. The effects of HDL on parasite metabolism (as determined by nucleic acid synthesis) are evident at about 30 h after invasion. Parasites treated with HDL show gross abnormalities by light and electron microscopy.Professor Hajduk was supported by NIH. Professor Day
was supported by a Research Leave Fellowship from The
Wellcome Trust. Dr Imrie and Ms Carter were supported
by Programme Grant funding awarded to Professor Day
from The Wellcome Trust. Dr Ferguson was supported by
an equipment grant from The Wellcome Trust
Haemorrhagic kidney syndrome of Atlantic salmon, Salmo salar L.
No full textThis report describes a new syndrome affecting farmed Atlantic salmon on the Canadian east coast that has resulted in increased morbidity and mortality in affected stocks. The major pathological findings are apparent only microscopically and include renal interstitial haemorrhage and acute tubular necrosis and tubular casting. As a result, the disease has become known as haemorrhagic kidney syndrome (HKS). Affected fish are lethargic and anorectic, and lark external lesions. Clinically, HKS fish are anaemic, hypoproteinaemic and hyperosmolalic, with increased serum concentrations of sodium and chloride. At necropsy, internal changes ranged from apparently normal to include one or several of the following: swelling and/or patchy reddening of the kidney, pale gills, exophthalmos, serosanguinous ascites, darkening of the posterior intestine and splenomegaly. Ultrastructurally, viral inclusions were found in the cytoplasm of erythrocytes of HKS fish, and there were unusual electron-dense inclusions within the tips of renal tubular microvilli of HKS fish. The significance and relevance of the ultrastructural findings to HKS are unknown. Virus isolation was attempted using CHSE, RTG-2, FH-10, BE and EPC cell lines; no virus was isolated. Bacteriological analysis failed to reveal significant pathogens. Analysis of tissues for heavy metals and pesticides was negative. Assays for clostridial toxins, lipopolysaccharide and verotoxins were negative. The aetiology of HKS remains unresolved.PT: J; CR: AHNE W, 1989, VIRUSES LOWER VERTEB, V3 ARMSTRONG R, 1993, CAN VET J, V34, P312 AUSTIN B, 1993, BACTERIAL FISH PATHO BOVO G, 1995, DIS AQUAT ORGAN, V21, P115 CONFER AW, 1995, THOMSONS SPECIAL VET, P209 DANNEVIG BH, 1995, J GEN VIROL, V76, P1353 EATON WD, 1993, J GEN VIROL, V74, P2299 EVENSEN O, 1991, RES VET SCI, V51, P215 FERGUSON HW, 1982, VET PATHOL, V19, P687 FOOTT JS, 1992, J AQUAT ANIM HEALTH, V4, P306 HETRICK FM, 1993, ANN REV FISH DIS, V3, P187 KIMURA T, 1986, DIS AQUAT ORGAN, V1, P209 KIMURA T, 1989, VIRUSES LOWER VERTEB, V3 KOSKI P, 1992, BULL EUR ASSN FISH P, V12, P177 LAMAS J, 1995, J FISH DIS, V18, P425 MEIER W, 1994, ANN REV FISH DIS, V4, P359 NOUGAYREDE P, 1992, B EUROPEAN ASS FISH, V12, P5 PINTO RA, 1992, J AQUATIC ANIMAL HLT, V4, P292 ROBERTS RJ, 1994, RECENT ADV AQUACULTU, V5 SANO T, 1995, AQUACULTURE, V132, P43 SMITH LS, 1975, MISCELLANEOUS SPECIA, V27 SPEILBERG L, 1995, VET PATHOL, V32, P466 THOESEN JC, 1994, BLUE BOOK SUGGESTED TISHER CC, 1989, RENAL PATHOLOGY CLIN, V1 WADDELL TE, 1996, INFECT IMMUN, V64, P1714 WOLF K, 1988, FISH VIRUSES FISH VI WOOD CM, 1995, PHYSL ECOLOGY PACIFI; NR: 27; TC: 29; J9: J FISH DISEASES; PG: 11; GA: 170XZSource type: Electronic(1
Author Correction: Results of the phase IIa RADICAL trial of the FGFR inhibitor AZD4547 in endocrine resistant breast cancer (Nature Communications, (2022), 13, 1, (3246), 10.1038/s41467-022-30666-0)
No full text\ua9 The Author(s) 2023.In the original version of this article, the following author (Veronica Ferguson) was omitted from the author list. Author list, Author contributions and competing interests statements have now been updated in both the PDF and HTML versions of the article
Investigating the mechanism of FOXG1 in glioblastoma stem cells
No full textGlioblastoma multiforme (GBM) is the most common and aggressive primary brain cancer in adults. Relapse after conventional surgery and chemo/radiotherapy is thought to be driven by glioblastoma stem cells (GSCs).
GSCs have phenotypic sumularities to normal neural stem cells (NSCs) and frequently overexpress many key neurodevelopmental transcription factors, including FOXG1, a key forebrain transcription factor with reporgramming activity. Evidence points to an important funtional role of FOXG1 in driving the NSC-like identity of GSCs. Here we explore the mechanisms by which FOXG1 acts, by characterising its key downstream transcritional targets and protein-protein interactions. Analysis of the transcriptional changes induced by FOXG1 overexpression identified key targets, including cell cycle and epigenetic regulators, such as Fox06 and Chd3. Fox06 was identified as a clear downstream target with a functional role in enabling FOXG1 to drive exit from quiescence. This also revealed the FOXG1, a transcriptional repressor, can lead to gene activation. The H3K4 demethylase JARID1B (KDM5B/PLU-1), a negative regulator of promoter activation, is thought to be a protein partner of FOXG1. We hypothesised that FOXG1 may activate gene expression by sequestration of this repressor. However, our studies suggest JARID1B is not essential for FOXG1's ability to drive a proliferative NS cell-like state, nor transcriptional activiation of Fox06 or Chd3. FOXG1 immunoprecipitation studies highlighted difficulties in obtaining good quality, protein-specific antibodies for characterising protein partners. we therefore exploited CRISPR/Cas9 technology to epitope-tag endogenous FOXG1 in patient-derived glioblastoma NS (GNS) cells. These cellular models can now be used in future studies to define FOXG1's key protein partners and aid the identification of ways to therapeutically target FOXG1 in GBM
Youth, education, and marginality: Local and global expressions
No full textYouth, Education, and Marginality: Local and Global Expressions is a close examination of the lives of marginalized young people in schools. Essays by scholars and educators provide international insights grounded in educational and community practice and policy. They cover the range and intersections of marginalization: poverty, Aboriginal cultures, immigrants and newcomers, gay/lesbian youth, ruralurban divides, mental health, and so forth. Presenting challenges faced by marginalized youth alongside initiatives for mitigating their impact, the contributors critique existing systems and engage in a dialogue about where to go from here. Youth poetry, prose, and visual art complement the essays
- …
