2,984 research outputs found
Rev. Perry C. Bramlett Collection
No full textFinding aid of the Rev. Perry C. Bramlett manuscript collectionA graduate of Southern Seminary in Louisville, Kentucky; a noted author; and a dedicated and respected scholar, Rev. Perry C. Bramlett�s life work was taking C. S. Lewis to the local church. His widow, Joan Fine Bramlett of Fairhope, Alabama, selected Mercer University to house this collection to honor Bramlett�s work, to share the significance of Bramlett�s life, and to mark his contributions to the scholarship of C. S. Lewis and his friends and their influences
Commentary: Water: A Preventable Disaster
No full textEditor-in-Chief\u27s Note: The Texas Water Journal invited Texas state Senator Charles Perry, Chair of the Senate Committee on Water and Rural Affairs, to share his thoughts on the role of water in the coming 87th legislative session of the Texas Legislature. In the upcoming legislative session, Senator Perry said Texas will be navigating the continuing COVID-19 pandemic, the road to recovery and continuing water supply development. In the commentary, Senator Perry addresses how leveraging technology, public-private partnerships, and regulations will encourage the creation of new water sources while also expanding existing strategies. The opinion expressed in this commentary is the opinion of the individual author and not the opinion of the Texas Water Journal or the Texas Water Resources Institute.
Citation: Perry C. 2020. Commentary: Water: A Preventable Disaster. Texas Water Journal. 11(1):172-173. Available from: https://doi.org/10.21423/twj.v11i1.7129
Commentary: Water Fuels Our Future
No full textEditor-in-Chief\u27s Note: The opinion expressed in this commentary is the opinion of the individual author and not the opinion of the Texas Water Journal or the Texas Water Resources Institute.
Citation: Perry C. 2019. Commentary: Water Fuels Our Future. Texas Water Journal. 10(1):22-23. Available from: https://doi.org/10.21423/twj.v10i1.7091
Correspondence from Francine Perry and J. C. Fauntleroy to Vernon Jordan, April 1966
No full textCorrespondence from Francine Perry and J. C. Fauntleroy to Vernon Jordan. Enclosed is "A Background Report on the Newport News-Hampton SMSA for the Participants of the NAACP-National Student YWCA Project" written by Herbert H. Lindsay
A calm and peaceful land
No full textUPEI 091; [sound recording] / P. Batchilder, M. Hennessey, C. Perry.; 2 sound cassettes (125 min.; Contents : Introductions (Grant & Robb) -- The Belfast riots (Batchilder) -- "The artist" (Hennessey) -- Rum running days (Perry).; Introduction : William Grant ; Andy Robb.; Recorded at the Confederation of the Arts Centre, 13 March 1977.; The Belfast riotsSource type: Electronic(1
George Perry (c.1718-1771): industrialist, cartographer and naturalist
No full textGeorge Perry (c.1718–1771) is known for his involvement in the development of the iron and engineering industries of Coalbrookdale, Ironbridge Gorge, Shropshire and Liverpool, and also for his ambition to publish a history together with new maps of Liverpool. In 1758, Perry’s best known work, A description of Coalbrookdale in the County of Salop, with two perspective views thereof was published. The aforementioned views, produced in collaboration with Thomas Smith of Derby (1720–1767), are two of the earliest examples of industrial landscapes. Perry also pursued interests in geology and natural history. He maintained a correspondence and exchanged specimens of fossils with, among others, Emanuel Mendes da Costa (1717–1791), Thomas Pennant (1726–1798) and Gustavus Brander (c.1719–1787). His work on the history of Liverpool was absorbed into An essay towards the history of Leverpool drawn up from papers left by the late Mr. George Perry, and from other materials since collected by William Enfield (1773). His son, George Perry (1771–1823), was the author of Conchology, or the natural history of shells (1811). We record Perry’s busy life and career and attempt to give due weight to his several different interests
Northwest Perry Child Development Center, 1969
No full textThe following proposal entitled Northwest Perry Child Development CenterIs submitted to the United States Office of Health, Education, and Welfare, office of Economic Opportunity. The project has been designed for a one year period, under the direction of Mrs. Odinga Dalrobl, This project is requesting funds in the amount of $11,900.00. There will be eleven pro�fessional full-time staff members, three part-time professional and eleven non-professionals. The project will run from Sep�tember 1, 1969 to August 31. 1970.The proposed child Development Center will meet an acute need for day care in the Northwest Perry area in Atlanta, Georgia where no child care facility exists for low-income families. The center would serve fifty children from three to twelve years of age, freeing low-income mothers and fathers for the employ�ment market, between the hours of 7:00 A.M. and 12:00 midnight.There have been several attempts of welfare recipients and other low-income families to become self-sufficient through employment. Because they are unskilled, many are participating in re-training programs. Others must take jobs at night. What happens to their children during these hours or after they are dismissed from school? This project is worthy of support, because, children will receive the educational, social, and emotional attention due them through knowledgeable, and skilled professional workers. Children of school age will be able to receive free tutoring services in areas where educational weaknesses have been de�tected. This service will be provided by volunteer students and graduates from the Atlanta University Center. Child care which affords maximum opportunity to grow and develop, provides planned and well prepared meals, and assures exceptional physical care of children is the first priority of service given by the child development center, which is here proposed
Commentary: Water Infrastructure and Supply Are the Backbone or Achilles’ Heel of Texas’ Future: The Choice is Ours
No full textEditor-in-Chief\u27s Note: In every odd-numbered year, the Texas Legislature convenes in regular session for 140 days. With this in mind, the Texas Water Journal invited Senator Charles Perry, Chairman of the Senate Water, Agriculture, and Rural Affairs Committee to discuss his priorities and visions for Texas water and the regular session of the 88th Texas Legislature. The opinion expressed in this commentary is the opinion of the individual author and not the opinion of the Texas Water Journal or the Texas Water Resources Institute, or the Bureau of Economic Geology
Long term impact of systemic bacterial infection on the cerebral vasculature and microglia
No full textBackground: Systemic infection leads to generation of inflammatory mediators that result in metabolic and behavioural changes. Repeated or chronic systemic inflammation leads to a state of innate immune tolerance: a protective mechanism against over-activity of the immune system. In this study we investigated the immune adaptation of microglia and brain vascular endothelial cells in response to systemic inflammation or bacterial infection. Methods: Mice were given repeated doses of lipopolysaccharide (LPS) or a single injection of live Salmonella typhimurium. Inflammatory cytokines were measured in serum, spleen and brain, and microglial phenotype studied by immunohistochemistry.mice were infected with Salmonella typhimurium and subsequently challenged with a focal unilateral, intracerebral injection of LPS. Results: Repeated systemic LPS challenges resulted in increased brain IL-1?, TNF? and IL-12 levels, despite attenuated systemic cytokine production. Each LPS challenge induced significant changes in burrowing behaviour. In contrast, brain IL-1? and IL-12 levels in Salmonella typhimurium infected mice increased over three weeks, with high interferon-? levels in the circulation. Behavioural changes were only observed during the acute phase of the infection. Microglia and cerebral vasculature display an activated phenotype, and focal intracerebral injection of LPS 4 weeks after infection results in an exaggerated local inflammatory response when compared to non-infected mice. Conclusions: These studies reveal that the innate immune cells in the brain do not become tolerant to systemic infection, but are primed instead. This may lead to prolonged and damaging cytokine production that may have aprofound effect on the onset and/ or progression of pre-existing neurodegenerative disease.Humans and animals are regularly exposed to bacterial and viral pathogens that can have a considerable impact on our day-to-day living [1]. Upon infection, a set of immune, physiological, metabolic, and behavioural responses is initiated, representing a highly organized strategy of the organism to fight infection. Pro-inflammatory mediators generated in peripheral tissue communicate with the brain to modify behaviour [2], which aids our ability to fight and eliminate the pathogen. The communication pathways from the site of inflammation to the brain have been investigated in animal models and systemic challenge with lipopolysaccharide (LPS) or double stranded RNA (poly I:C) have been widely used to mimic aspects of bacterial and viral infection respectively [3, 4]. These studies have provided evidence that systemically generated inflammatory mediators signal to the brain via both neural and humoral routes, the latter signalling via the circumventricular organs or across the blood-brain barrier (BBB). Signalling into the brain via these routes evokes a response in the perivascular macrophages (PVMs) and microglia, which in turn synthesise diverse inflammatory mediators including cytokines, prostaglandins and nitric oxide [2, 5, 6]. Immune-to-brain communication also occurs in humans who show changes in mood and cognition following systemic inflammation or infection, which are associated with changes in activity in particular regions of the CNS [7-9]. While these changes are part of our normal homeostasis, it is increasingly evident that systemic inflammation has a detrimental effect in animals and also humans, that suffer from chronic neurodegeneration [10, 11]. We, and others, have shown that microglia become primed by on-going neuropathology in the brain, which increases their response towards subsequent inflammatory stimuli, including systemic inflammation [12, 13] Similar findings have been made in aged rodents [14, 15], where it has been shown that there is an exaggerated behavioural and innate immune response in the brainto systemic bacterial and viral infections, but the molecular mechanisms underlying the microglial priming under these conditions is far from understood.Humans and animals are rarely exposed to a single acute systemic inflammatory event: they rather encounter infectious pathogens that replicate in vivo or are exposed to low concentrations of LPS over a prolonged period of time. There is limited information on the impact of non-neurotrophic bacterial infections on the CNS and whether prolonged systemic inflammation will give rise to either a hyper-(priming) or hypo-(tolerance) innate immune response in the brain in response to a subsequent inflammatory stimulus.In this study we measured the levels of cytokines in the serum, spleen and brain as well as assessing sickness behaviour following a systemic bacterial infection using attenuated Salmonella typhimurium SL3261: we compared the effect to that of repeated LPS injections. We show that Salmonella typhimurium caused acute, transient behavioural changes and a robust peripheral immune response that peaks at day 7. Systemic inflammation resulted in a delayed increase in cytokine production in the brain and priming of microglia, which persisted up to four weeks post infection. These effects were not mimicked by repeated LPS challenges. It is well recognised that systemic bacterial and viral infections are significant contributors to morbidity in the elderly [16], and it has been suggested that primed microglia play a role in the increased clinical symptoms seen in patients with Alzheimer’s disease who have systemic inflammation or infections [11, 17]. We show here that systemic infection leads to prolonged cytokine synthesis in the brain and also priming of brain innate immune cells to a subsequent focal inflammatory challenge in the brain parenchyma
George Perry (1771–1823): architect and naturalist
No full textGeorge Perry (1771-1823) was an artist, architect and sculptor, with a deep interest in natural history and malacology. (His father, George Perry (c.1718-1771), was a pioneering industrialist, with a particular interest in geology and also the history of Liverpool.) He was the co-author (with John Corry) of The History of Liverpool (1807). He gave lectures on natural history and mineralogy and earned a living as an architect and sculptor. After bankruptcy in Liverpool in 1807, Perry re-established himself in London. There he published two books - A descriptive catalogue of the pictures in the collection of the Marquis of Stafford in London (1807) and Conchology, or the natural history of shells (1811). He also published the serial publication entitled Arcana, or, the Museum of Natural History (1810-1811). After this, he disappeared from the public record until his death in Chelsea in 1823. His life and his contributions to natural history are summarized here
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